Obesity can be induced by the accumulation of adipose tissue via overconsumption of high-energy intake,and unbalanced synthesis of various hormones.Recently,seaweed algae have attracted researchers’attention due to t...Obesity can be induced by the accumulation of adipose tissue via overconsumption of high-energy intake,and unbalanced synthesis of various hormones.Recently,seaweed algae have attracted researchers’attention due to their health-beneficial effects,however,the antiobesity effects of Ascophyllum nososum are still controversial.We conducted two experiments with 3T3-L1 cell line and obese mouse model to elucidate the exact mechanism of seaweed algae extract(AE).In the in vivo study,dietary AE supplementation decreased body weight without affecting feed consumption.AE reduced the total mass,fat mass,and gonadal fat of the mice without changing the lean mass weight.Additionally,dietary AE addition could restore serum markers related to lipid metabolism(triglycerides and total cholesterol)as much as those of control mice.Furthermore,the in vitro study with 3T3-L1 cells suggested that AE treatment significantly suppressed adi-pogenesis by decreasing expression levels of lipogenesis-related genes and lipid-utilization genes with increasing the ratio of phosphorylated AMPK to AMPK and phosphorylated ACC to ACC.Collectively,Ascophyllum nodosum extract could restore obesity induced by a high-fat diet,which might be due to the decrease in lipogenesis with the increase in lipid utilization through the AMPK-ACC signaling pathway.展开更多
This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applic...This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applications.Novel composite materials,MSN@Fucoidan,MSN@Agar,and MSN@Ulvan,were synthesized and characterized for their anti-tyrosinase,moisturizing,antioxidant,and anti-collagenase activities.Thermogravi-metric analysis revealed high loading capacities of these polysaccharides into MSN,as well as MSN into agar.In vitro experiments demonstrated the biocompatibility of the materials and their ability to inhibit melanin pro-duction while promoting collagen synthesis.Among them,MSN@Agar exhibited the most promising results,suggesting the potential of these composite materials for skincare formulations.This study highlights the sig-nificance of natural biopolymers and nanotechnology in developing effective and safe cosmetics targeting skin health.展开更多
基金supported by a National Research Foundation of Korea Grant,funded by the Korean government(MEST)(NRF-2021R1A2C301105)Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Edu-cation(2022M3A9I5018286).
文摘Obesity can be induced by the accumulation of adipose tissue via overconsumption of high-energy intake,and unbalanced synthesis of various hormones.Recently,seaweed algae have attracted researchers’attention due to their health-beneficial effects,however,the antiobesity effects of Ascophyllum nososum are still controversial.We conducted two experiments with 3T3-L1 cell line and obese mouse model to elucidate the exact mechanism of seaweed algae extract(AE).In the in vivo study,dietary AE supplementation decreased body weight without affecting feed consumption.AE reduced the total mass,fat mass,and gonadal fat of the mice without changing the lean mass weight.Additionally,dietary AE addition could restore serum markers related to lipid metabolism(triglycerides and total cholesterol)as much as those of control mice.Furthermore,the in vitro study with 3T3-L1 cells suggested that AE treatment significantly suppressed adi-pogenesis by decreasing expression levels of lipogenesis-related genes and lipid-utilization genes with increasing the ratio of phosphorylated AMPK to AMPK and phosphorylated ACC to ACC.Collectively,Ascophyllum nodosum extract could restore obesity induced by a high-fat diet,which might be due to the decrease in lipogenesis with the increase in lipid utilization through the AMPK-ACC signaling pathway.
基金support provided through grants 106-2113-M-019-003,107-2113-M-019-001,108-2113-M-019-002,109-2113-M-019-002,110-2113-M-019-006-,111-2113-M-019-003,112-2113-M-019-001-,113-2113-M-019-003-,114-2113-M-019-001-.
文摘This study investigates the potential of marine algae-derived polysaccharides,specifically the biological mac-romolecules fucoidan,agar,and ulvan,encapsulated in mesoporous silica nanoparticles(MSN)for cosmetic applications.Novel composite materials,MSN@Fucoidan,MSN@Agar,and MSN@Ulvan,were synthesized and characterized for their anti-tyrosinase,moisturizing,antioxidant,and anti-collagenase activities.Thermogravi-metric analysis revealed high loading capacities of these polysaccharides into MSN,as well as MSN into agar.In vitro experiments demonstrated the biocompatibility of the materials and their ability to inhibit melanin pro-duction while promoting collagen synthesis.Among them,MSN@Agar exhibited the most promising results,suggesting the potential of these composite materials for skincare formulations.This study highlights the sig-nificance of natural biopolymers and nanotechnology in developing effective and safe cosmetics targeting skin health.
