WH EN 58-year-old Jiang Heping set his foot on African soil for the first time in 2006. he dreamed that one day rice and golden corn would boost the continent＇s food security, saving people from starvation and comfor...WH EN 58-year-old Jiang Heping set his foot on African soil for the first time in 2006. he dreamed that one day rice and golden corn would boost the continent＇s food security, saving people from starvation and comforting crying children.展开更多
In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at h...In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at home and abroad was analyzed and studied from the perspective of application in textiles. The application of lavender essential oil to bed curtains through the microcapsule technique was put forward to allow lavender essential oil to play its role of helping sleep in bed curtains. This paper expounded the material selection and preparation technique of lavender microcapsule agents, and put forward the preparation method of microcapsules with mixed solutions of pure Chinese medicine extracts and natural essences as core material and high-viscosity epoxy resin as wall materials. The post-processing techniques and the spray ironing method for clothing were studied and developed, and these techniques and methods were applied to bed curtains, and good results were obtained.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
China and Laos are close neighbors with a long-standing friendship.Since the early 2000s,China has supported Laos'economic and social development through wide-ranging cooperation projects,all guided by the vision ...China and Laos are close neighbors with a long-standing friendship.Since the early 2000s,China has supported Laos'economic and social development through wide-ranging cooperation projects,all guided by the vision of a community with a shared future.As this vision takes deeper root,many aid projects have moved from blueprint to reality,delivering tangible benefits across towns and villages and improving the lives of ordinary Lao people while further strengthening bilateral ties.展开更多
To enhance the anti-resistance efficacy of our previously disclosed naphthyl-triazine 5,structure-based drug design strategy was rationally conducted to design a series of novel biphenyl-piperidine-triazinecontaining ...To enhance the anti-resistance efficacy of our previously disclosed naphthyl-triazine 5,structure-based drug design strategy was rationally conducted to design a series of novel biphenyl-piperidine-triazinecontaining non-nucleoside reverse transcriptase inhibitors.Remarkably,several of these compounds demonstrated single-digit nanomolar antiviral potency against both wild-type(WT)human immunodeficiency virus-1(HIV-1)and five clinically relevant mutant strains.Among these,compound 11s emerged as the most potent inhibitor,showing remarkable efficacy against WT HIV-1(50%effective concentration(EC_(50))=2 nmol/L)and five mutant strains(EC_(50)=0.003-0.073μmol/L),which was significantly superior to that of compound 5.This optimized derivative demonstrated substantially improved pharmacological properties compared to existing drugs etravirine(ETR)and rilpivirine(RPV),showing a 4-fold reduction in cytotoxicity alongside 6-fold enhancement in selectivity index(50%cytotoxic concentration(CC_(50))=19.69μmol/L,selectivity index(SI)=7438).The compound's metabolic profile revealed exceptional stability,with an elimination half-life(t_(1/2)=41.4 min)more than double that of RPV(t_(1/2)=16.03min).Comprehensive safety evaluation indicated minimal cytochrome P450(CYP)enzymes interference,low cardiac ion channel activity,and no observable acute toxicity,collectively suggesting a reduced risk profile for therapeutic applications.These promising characteristics significantly advance the development potential of biphenyl-piperidine-triazine derivatives as next-generation non-nucleoside reverse transcriptase inhibitors(NNRTIs),offering enhanced efficacy,improved safety,and favorable pharmacokinetic properties for antiretroviral therapy.展开更多
Chinese food aid nourishes over 188,000 Zambians In the arid terrain of Shang’ombo District,approximately 850 km west of Lusaka,Zambia’s capital,Charity Imbuwa received a Chinese food-aid pack and shared it with her...Chinese food aid nourishes over 188,000 Zambians In the arid terrain of Shang’ombo District,approximately 850 km west of Lusaka,Zambia’s capital,Charity Imbuwa received a Chinese food-aid pack and shared it with her children at their home near the Angola border.展开更多
Objective:To understand the current awareness and willingness to learn about the use of out-of-hospital automated external defibrillators(AEDs)in Deyang City,providing a basis for improving the success rate of rescue ...Objective:To understand the current awareness and willingness to learn about the use of out-of-hospital automated external defibrillators(AEDs)in Deyang City,providing a basis for improving the success rate of rescue operations.Methods:A questionnaire survey was conducted among residents in Deyang City from January 2025 to October 2025,covering residents’basic information,awareness of AED-related knowledge,and attitudes towards AED usage.Results:A total of 1,886 questionnaires were collected,with 1,823 valid questionnaires,yielding an effective rate of 96.66%.Among the 1,823 respondents,692(37.96%)had received cardiopulmonary resuscitation(CPR)-related learning or training,619(33.96%)could accurately describe the name of an AED,417(22.87%)could clearly describe the function of an AED,and 308(16.89%)could accurately describe how to use an AED.Among them,1,549(84.97%)were willing to provide assistance to patients experiencing cardiac arrest;1,731(94.95%)were willing to provide assistance under the premise of knowing how to use an AED;and 1,750(95.99%)were willing to learn about AED-related knowledge.Among the 91 individuals unwilling to provide rescue,75 responded with reasons.Among them,36 cases(48.00%)were reluctant to rescue due to a lack of relevant first aid knowledge,32 cases(42.67%)expressed concerns about exacerbating the patient’s condition due to improper operation,and 4 cases(5.33%)were unwilling to interact with strangers due to personal reasons.Conclusion:Currently,residents in Deyang City have limited knowledge about AEDs but demonstrate a strong willingness to learn and apply them.Measures need to be taken to enhance their understanding and application of AEDs.展开更多
Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentia...Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.展开更多
目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细...目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。展开更多
文摘WH EN 58-year-old Jiang Heping set his foot on African soil for the first time in 2006. he dreamed that one day rice and golden corn would boost the continent＇s food security, saving people from starvation and comforting crying children.
基金Supported by Undergraduate Training Program for Innovation and Entrepreneurship of Guangxi University of Chinese Medicine in 2023(S202310600084)。
文摘In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at home and abroad was analyzed and studied from the perspective of application in textiles. The application of lavender essential oil to bed curtains through the microcapsule technique was put forward to allow lavender essential oil to play its role of helping sleep in bed curtains. This paper expounded the material selection and preparation technique of lavender microcapsule agents, and put forward the preparation method of microcapsules with mixed solutions of pure Chinese medicine extracts and natural essences as core material and high-viscosity epoxy resin as wall materials. The post-processing techniques and the spray ironing method for clothing were studied and developed, and these techniques and methods were applied to bed curtains, and good results were obtained.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
基金supported by the Yunnan Provincial Philosophy and Social Science Planning Projectthe Yunnan Academy of Social Sciences。
文摘China and Laos are close neighbors with a long-standing friendship.Since the early 2000s,China has supported Laos'economic and social development through wide-ranging cooperation projects,all guided by the vision of a community with a shared future.As this vision takes deeper root,many aid projects have moved from blueprint to reality,delivering tangible benefits across towns and villages and improving the lives of ordinary Lao people while further strengthening bilateral ties.
基金financially supported by National Natural Science Foundation of China(No.82304297)the State Key Laboratory of Natural and Biomimetic Drugs(No.K202408)。
文摘To enhance the anti-resistance efficacy of our previously disclosed naphthyl-triazine 5,structure-based drug design strategy was rationally conducted to design a series of novel biphenyl-piperidine-triazinecontaining non-nucleoside reverse transcriptase inhibitors.Remarkably,several of these compounds demonstrated single-digit nanomolar antiviral potency against both wild-type(WT)human immunodeficiency virus-1(HIV-1)and five clinically relevant mutant strains.Among these,compound 11s emerged as the most potent inhibitor,showing remarkable efficacy against WT HIV-1(50%effective concentration(EC_(50))=2 nmol/L)and five mutant strains(EC_(50)=0.003-0.073μmol/L),which was significantly superior to that of compound 5.This optimized derivative demonstrated substantially improved pharmacological properties compared to existing drugs etravirine(ETR)and rilpivirine(RPV),showing a 4-fold reduction in cytotoxicity alongside 6-fold enhancement in selectivity index(50%cytotoxic concentration(CC_(50))=19.69μmol/L,selectivity index(SI)=7438).The compound's metabolic profile revealed exceptional stability,with an elimination half-life(t_(1/2)=41.4 min)more than double that of RPV(t_(1/2)=16.03min).Comprehensive safety evaluation indicated minimal cytochrome P450(CYP)enzymes interference,low cardiac ion channel activity,and no observable acute toxicity,collectively suggesting a reduced risk profile for therapeutic applications.These promising characteristics significantly advance the development potential of biphenyl-piperidine-triazine derivatives as next-generation non-nucleoside reverse transcriptase inhibitors(NNRTIs),offering enhanced efficacy,improved safety,and favorable pharmacokinetic properties for antiretroviral therapy.
文摘Chinese food aid nourishes over 188,000 Zambians In the arid terrain of Shang’ombo District,approximately 850 km west of Lusaka,Zambia’s capital,Charity Imbuwa received a Chinese food-aid pack and shared it with her children at their home near the Angola border.
文摘Objective:To understand the current awareness and willingness to learn about the use of out-of-hospital automated external defibrillators(AEDs)in Deyang City,providing a basis for improving the success rate of rescue operations.Methods:A questionnaire survey was conducted among residents in Deyang City from January 2025 to October 2025,covering residents’basic information,awareness of AED-related knowledge,and attitudes towards AED usage.Results:A total of 1,886 questionnaires were collected,with 1,823 valid questionnaires,yielding an effective rate of 96.66%.Among the 1,823 respondents,692(37.96%)had received cardiopulmonary resuscitation(CPR)-related learning or training,619(33.96%)could accurately describe the name of an AED,417(22.87%)could clearly describe the function of an AED,and 308(16.89%)could accurately describe how to use an AED.Among them,1,549(84.97%)were willing to provide assistance to patients experiencing cardiac arrest;1,731(94.95%)were willing to provide assistance under the premise of knowing how to use an AED;and 1,750(95.99%)were willing to learn about AED-related knowledge.Among the 91 individuals unwilling to provide rescue,75 responded with reasons.Among them,36 cases(48.00%)were reluctant to rescue due to a lack of relevant first aid knowledge,32 cases(42.67%)expressed concerns about exacerbating the patient’s condition due to improper operation,and 4 cases(5.33%)were unwilling to interact with strangers due to personal reasons.Conclusion:Currently,residents in Deyang City have limited knowledge about AEDs but demonstrate a strong willingness to learn and apply them.Measures need to be taken to enhance their understanding and application of AEDs.
基金supported by the National Natural Science Foundation of China(No.82274474)。
文摘Despite effective antiretroviral therapy(ART),many individuals with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)achieve viral suppression but fail to fully restore cluster of differentiation 4(CD4)^(+)T lymphocyte(CD4 cell)counts—a condition known as immunological non-response(INRs).INRs are associated with elevated health risks,including increased susceptibility to AIDS-related and non-AIDS-related complications.The pathogenesis of INRs remains incompletely understood,and no established therapeutic interventions exist,posing a major challenge in contemporary HIV/AIDS management.Emerging evidence indicates that INRs exhibit significant alterations in gut microbiota composition.Dysbiosis of the gut microbiota may contribute to persistent immune activation,cytokine imbalance,and cellular pyroptosis,all of which could impair immune reconstitution in people living with HIV/AIDS.Traditional Chinese medicine(TCM)has demonstrated potential immunomodulatory effects and is increasingly utilized in the management of INRs.Targeting the gut microbiota and elucidating the mechanisms by which TCM modulates this microbial ecosystem may offer new avenues for preventing and treating INRs.This review explores the interplay between gut microbiota and TCM,examines the association between gut dysbiosis and INRs,discusses the mechanistic pathways through which microbiota imbalance contributes to INRs development,and highlights how TCM interventions regulate gut microbiota to promote immune recovery.By focusing on the gut microbiota as a therapeutic interface,this article provides novel insights into TCM-based strategies for improving outcomes in INRs and supports the development of innovative treatment approaches.
文摘目的 基于巨噬细胞自噬探讨参芩龙清肺培元颗粒的作用机制。方法 选择人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并肺部感染痰热壅肺证患者36例,应用流式细胞术检测治疗前后患者外周血T淋巴细胞亚群中CD4^(+)及CD8^(+)T淋巴细胞计数,巨噬细胞亚群CD11b、CD86、CD206的表达及巨噬细胞自噬探针CD11b+DALGreen、CD86+DALGreen、CD206+DALGreen的表达。ELISA法检测治疗前后血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-10、转化生长因子(TGF)-β1等炎性因子的表达。采用荧光定量PCR法检测治疗前后患者外周血中组蛋白去乙酰化酶(HDAC)2 m RNA、Unc-51样激酶1(ULK1)m RNA的表达。结果 治疗后,患者CD11b、CD206、CD11b+DALGreen、CD206+DALGreen、ULK1 m RNA表达明显升高(P<0.05);CD86、TNF-α、IL-1β、HDAC2 m RNA的表达明显下降(P<0.05);CD4^(+)T淋巴细胞计数、IL-10、TGF-β1表达呈上升趋势(P>0.05)。结论 参芩龙清肺培元颗粒可能通过调节HDAC2/ULK1信号轴,促进巨噬细胞自噬,调节M1/M2的平衡,抑制炎症反应,从而发挥治疗HIV/AIDS患者合并肺部感染的作用。
