Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physio...Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited.A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy.Using the model organisms Saccharomyces cerevisiae and mammalian cells,we found that cellular reactive oxygen species(ROS),DNA damage sensor Mec1,and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation.This review aims to provide a concise overview of these research findings.展开更多
基金supported by the Zhejiang Provincial Natural Science Foundation of China(No.LR21C070001)the National Natural Science Foundation of China(Nos.32122028,92254307,32070739,and 32100600)。
文摘Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited.A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy.Using the model organisms Saccharomyces cerevisiae and mammalian cells,we found that cellular reactive oxygen species(ROS),DNA damage sensor Mec1,and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation.This review aims to provide a concise overview of these research findings.
