In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.T...In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.The designed distributed controller consists of two parts:a dynamic average consensus part that asymptotically reproduces the unknown NE,and an adaptive reference-tracking module responsible for steering EL systems’positions to track a desired trajectory.The generalized Barbalat’s Lemma is used to overcome the discontinuity of the closed-loop system caused by the switching networks.The proposed algorithm is illustrated by a sensor network deployment problem.展开更多
To broaden the frequency width and increase the damping coefficient of a dynamic pressure damper, we designed an aggregative dynamic pressure damper (ADPD). Combined with the advantages of traditional dynamic pressure...To broaden the frequency width and increase the damping coefficient of a dynamic pressure damper, we designed an aggregative dynamic pressure damper (ADPD). Combined with the advantages of traditional dynamic pressure dampers (TDPD), ADPD can not only increase the damping coefficient in wide frequency range for valve control system, but also absorb partial pressure pulsations and impacts in the low and high frequency fields. Based on the theoretical research and the analysis compared with TDPD, we concluded that the ADPD was superior to the TDPD in the middle high frequency field, and the main parameters influencing the performance of the damper were the damping stiffness, orifice flow coefficient, pre-charge pressure, and the volume of the damper accumulator.展开更多
To analyze China’s fluctuating situation of the factor input and aggregative productivity is not only the main method to seek the source of the economic growth but also the main way to weigh the level of economic gro...To analyze China’s fluctuating situation of the factor input and aggregative productivity is not only the main method to seek the source of the economic growth but also the main way to weigh the level of economic growth quality.As to economic growth ofa country,the improvementofthe productivity is extremely important.The growth of the output can be realized through two kinds of ways: increasing the quantity of factor input of or improving the efficiency of the input and output.There fore, the level of economic growth quality does not mainly depend on the amount of invested factor,but the importance of improving the productivity since resources are rare. The relative improvement of efficiency in use of the invested factor marks the economic growing quality.So,in order to understand the economic growth quality of China to some extent, it must analyze Chinese factor input and aggregative productivity. This is the main topic that this text will be probed into.展开更多
BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organizatio...BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organization.The epidemic quickly spread,causing a worldwide pandemic.Scientists and clinicians across the globe have shifted their research efforts towards understanding the virus itself and its epidemiology.CASE SUMMARY In mid-January 2020,a Chinese family made a visit to a local city,and within the next 2 wk one after another fell ill with COVID-19.At the beginning of their first illness onset,the family had eaten in a restaurant,which led to the subsequent illness onset in another two families.All cases were diagnosed as COVID-19 by real-time fluorescent reverse transcription-polymerase chain reaction.Epidemiological investigation showed that the transmission chain was complete.CONCLUSION This chain of social exposure highlights the danger of group aggregative behavior for spread of COVID-19.展开更多
Enteroaggregative Escherichia coli (EAggEC) strains cause the persistent diarrhea in infants and compromised hosts in developing countries. These strains are currently defined as E. coli that adheres to HEp-2 cells in...Enteroaggregative Escherichia coli (EAggEC) strains cause the persistent diarrhea in infants and compromised hosts in developing countries. These strains are currently defined as E. coli that adheres to HEp-2 cells in an aggregative adherence (AA) pattern. In this study, we compared 4 different rapid methods for the detection of EAggEC using a PCR assay, clump formation test, glass slide adherence assay, and the HEp-2 cell adherence assay. Out of 683 E. coli strains isolated from diarrheal stool samples, we detected 17 aggR and/or clump-positive strains, and identified 2 aggR-positive, clump-negative strains and 2 aggR-negative, clump-positive strains. All the aggR positive and clump positive strains also showed positive results in glass slide adherence and HEp-2 cell adherence assays. From all these results, we suggest the following procedure for the rapid identification of EAggEC strains: first, screen E. coli strains with the clump formation test and subsequently perform the glass slide adherence assay to observe AA for confirmation.展开更多
Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To s...Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To seek the generalized Nash equilibrium(GNE),a projectionbased distributed algorithm via constant step-sizes is developed with linear convergence.In particular,a variable tracking technique is incorporated to estimate the aggregative function,and an event-triggered mechanism is designed to reduce the communication cost.Finally,a numerical example demonstrates the theoretical results.展开更多
Game theory-based models and design tools have gained substantial prominence for controlling and optimizing behavior within distributed engineering systems due to the inherent distribution of decisions among individua...Game theory-based models and design tools have gained substantial prominence for controlling and optimizing behavior within distributed engineering systems due to the inherent distribution of decisions among individuals.In non-cooperative settings,aggregative games serve as a mathematical framework model for the interdependent optimal decision-making problem among a group of non-cooperative players.In such scenarios,each player's decision is influenced by an aggregation of all players'decisions.Nash equilibrium(NE)seeking in aggregative games has emerged as a vibrant topic driven by applications that harness the aggregation property.This paper presents a comprehensive overview of the current research on aggregative games with a focus on communication topology.A systematic classification is conducted on distributed algorithm research based on communication topologies such as undirected networks,directed networks,and time-varying networks.Furthermore,it sorts out the challenges and compares the algorithms'convergence performance.It also delves into real-world applications of distributed optimization techniques grounded in aggregative games.Finally,it proposes several challenges that can guide future research directions.展开更多
Generally,energy trading in smart grid is realized by microgrids.Correspondingly,energy trading in energy internet relies on small-scale energy systems,named as Weenergies(WEs).Previous works on the distributed energy...Generally,energy trading in smart grid is realized by microgrids.Correspondingly,energy trading in energy internet relies on small-scale energy systems,named as Weenergies(WEs).Previous works on the distributed energy trading focused on the trading platform or trading mechanism based on distributed communication.However,most ignored the fact that there is no express delivery of energy trading,and the transmission of energy depends on a fixed physical topology.Energy transactions without considering the transmission distance will increase the difficulty of energy scheduling and the transmission cost of energy.Aiming at this problem,an aggregation game among WEs is proposed for two-way multi-energy trading,and a distributed algorithm is designed to solve the Nash equilibrium.Since each WE only needs to communicate with its neighbors to exchange information,this distributed process reduces communication burden and improves information security.Furthermore,a multi-energy transmission optimization model is established to determine the transmission path of the transmission energy,which can minimize the transmission cost.Subsequently,to reduce the influence of real-time fluctuations of renewable energy and load,a receding horizon control algorithm is designed to improve the reliability of the proposed game.Finally,the effectiveness in dealing with two-way multi-energy trading of the proposed strategy is verified through simulations on the five connected WEs.展开更多
Distributed Nash equilibrium seeking of aggregative games is investigated and a continuous-time algorithm is proposed.The algorithm is designed by virtue of projected gradient play dynamics and aggregation tracking dy...Distributed Nash equilibrium seeking of aggregative games is investigated and a continuous-time algorithm is proposed.The algorithm is designed by virtue of projected gradient play dynamics and aggregation tracking dynamics,and is applicable to games with constrained strategy sets and weight-balanced communication graphs.The key feature of our method is that the proposed projected dynamics achieves exponential convergence,whereas such convergence results are only obtained for non-projected dynamics in existing works on distributed optimization and equilibrium seeking.Numerical examples illustrate the effectiveness of our methods.展开更多
In this paper,we consider the Nash equilibrium(NE)seeking problem for aggregative games and design a distributed heavy-ball algorithm to solve it.This algorithm has faster convergence rate than the well-known distribu...In this paper,we consider the Nash equilibrium(NE)seeking problem for aggregative games and design a distributed heavy-ball algorithm to solve it.This algorithm has faster convergence rate than the well-known distributed first-order algorithms for aggregative games.In order to seek the NE,each player needs to exchange information with its neighbours as well as a cen-tral aggregation.For aggregative games,the aggregative term can be either linear or nonlinear in this paper.Furthermore,we consider the generalised Nash equilibrium seeking problem for aggregative games by taking into account the linear coupled constraints among players,and modify our initial algorithm to include game constraints.展开更多
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.展开更多
We investigated the effects of fly ash(FA)content on the mechanical properties of recycled aggregate concrete(RAC)and its regeneration potential under freeze and thaw(F-T)cycles.The physical properties of second-gener...We investigated the effects of fly ash(FA)content on the mechanical properties of recycled aggregate concrete(RAC)and its regeneration potential under freeze and thaw(F-T)cycles.The physical properties of second-generation recycled concrete aggregates(RCA)were used to analyze the regeneration potential of RAC after F-T cycles.Scanning electron microscopy was used to study the interfacial transition zone microstructure of RAC after F-T cycles.Results showed that adding 20%FA to RAC significantly enhanced its mechanical properties and frost resistance.Before the F-T cycles,the compressive strength of RAC with 20%FA reached 48.3 MPa,exceeding research strength target of 40 MPa.A majority of second-generation RCA with FA had been verified to attain class Ⅲ,which enabled their practical application in non-structural projects such as backfill trenches and road pavement.However,the second-generation RCA with 20%FA can achieve class Ⅱ,making it ideal for 40 MPa structural concrete.展开更多
Crushing waste coral concrete into recycled aggregates to create recycled coral aggregate concrete(RCAC)contributes to sustainable construction development on offshore islands and reefs.To investigate the impact of re...Crushing waste coral concrete into recycled aggregates to create recycled coral aggregate concrete(RCAC)contributes to sustainable construction development on offshore islands and reefs.To investigate the impact of recycled coral aggregate on concrete properties,this study performed a comprehensive analysis of the physical properties of recycled coral aggregate and the basic mechanical properties and microstructure of RCAC.The test results indicate that,compared to coral debris,the crushing index of recycled coral aggregate was reduced by 9.4%,while porosity decreased by 33.5%.Furthermore,RCAC retained the early strength characteristics of coral concrete,with compressive strength and flexural strength exhibiting a notable increase as the water-cement ratio decreased.Under identical conditions,the compressive strength and flexural strength of RCAC were 12.7% and 2.5% higher than coral concrete's,respectively,with porosity correspondingly reduced from 3.13% to 5.11%.This enhancement could be attributed to the new mortar filling the recycled coral aggregate.Scanning electron microscopy(SEM)analysis revealed three distinct interface transition zones within RCAC,with the‘new mortar-old mortar’interface identified as the weakest.The above findings provided a reference for the sustainable use of coral concrete in constructing offshore islands.展开更多
Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated ...Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated to neuroinflammation,such as Alzheimer's disease,it is now shown to precede pathological protein aggregations.展开更多
Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unco...Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unconventional secretion pathways,focusing on secretory autophagy and its role in secreting protein aggregates associated with neurodegenerative disorders.We also explore additional neuronal functions of secretory autophagy beyond the release of protein aggregates.We propose autophagosomes as transport organelles that deliver cargo material directly from the endoplasmatic reticulum(ER)to the plasma membrane rather than solely to lysosomes.展开更多
Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and migration.HSPB8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective autophagy.In line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and aggregation.In cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under investigation.Moreover,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar hemorrhage.Of note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other diseases.This is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial homeostasis.This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its modulation.Drug-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.展开更多
This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging...This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability.The results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly charging.Additionally,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.展开更多
Low porosity is very significant for cementitious composite materials(CCM)under freeze-thaw conditions.To reduce the porosity of CCM,we used wollastonite mineral fibers as a partial replacement for cement and aggregat...Low porosity is very significant for cementitious composite materials(CCM)under freeze-thaw conditions.To reduce the porosity of CCM,we used wollastonite mineral fibers as a partial replacement for cement and aggregate.The five combinations,in which 10%,32%,and 48%Wollastonite were added,were made for scanning using both scanning electron microscopy(SEM)and computed tomography scan technology(CT).Then,the 2D SEM pictures and the 3D pore distribution curves are obtained before and after the freezing and thawing processes,where the micro-pores in the CCM materials are shown.The fractal dimension is used to quantify the topography image in two dimensions,as well as the pore distribution in three dimensions.This method allows for the determination of both surface porosity and volume porosity,both of which show an increase in response to an escalation of freeze-thaw cycles.It is also found that the micro-damage in the concrete is of self-similarity,and in the context of the fractal dimension,the pore evolution can be quantitatively characterized across different sizes,ranging from local to global levels,before and after freezing and thawing.展开更多
In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The e...In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The essence of cross-view geo-localization resides in matching images containing the same geographical targets from disparate platforms,such as UAV-view and satellite-view images.However,images of the same geographical targets may suffer from occlusions and geometric distortions due to variations in the capturing platform,view,and timing.The existing methods predominantly extract features by segmenting feature maps,which overlook the holistic semantic distribution and structural information of objects,resulting in loss of image information.To address these challenges,dilated neighborhood attention Transformer is employed as the feature extraction backbone,and Multi-feature representations based on Multi-scale Hierarchical Contextual Aggregation(MMHCA)is proposed.In the proposed MMHCA method,the multiscale hierarchical contextual aggregation method is utilized to extract contextual information from local to global across various granularity levels,establishing feature associations of contextual information with global and local information in the image.Subsequently,the multi-feature representations method is utilized to obtain rich discriminative feature information,bolstering the robustness of model in scenarios characterized by positional shifts,varying distances,and scale ambiguities.Comprehensive experiments conducted on the extensively utilized University-1652 and SUES-200 benchmarks indicate that the MMHCA method surpasses the existing techniques.showing outstanding results in UAV localization and navigation.展开更多
Both soil organic carbon (SOC) and iron (Fe) oxide content, among other factors, drive the formation and stability of soil aggregates.However, the mechanism of these drivers in greenhouse soil fertilized with organic ...Both soil organic carbon (SOC) and iron (Fe) oxide content, among other factors, drive the formation and stability of soil aggregates.However, the mechanism of these drivers in greenhouse soil fertilized with organic fertilizer is not well understood.In a 3-year field experiment, we aimed to investigate the factors which drive the stability of soil aggregates in greenhouse soil.To explore the impact of organic fertilizer on soil aggregates, we established four treatments:no fertilization (CK);inorganic fertilizer (CF);organic fertilizer (OF);and combined application of inorganic and organic fertilizers(COF).The application of organic fertilizer significantly enhanced the stability of aggregates, that is it enhanced the mean weight diameter, geometric mean diameter and aggregate content (%) of>0.25 mm aggregate fractions.OF and COF treatments increased the concentration of SOC, especially the aliphatic-C, aromatic-C and polysaccharide-C components of SOC, particularly in>0.25 mm aggregates.Organic fertilizer application significantly increased the content of free Fe(Fed), reactive Fe (Feo), and non-crystalline Fe in both bulk soil and aggregates.Furthermore, non-crystalline Fe showed a positive correlation with SOC content in both bulk soil and aggregates.Both non-crystalline Fe and SOC were significantly positively correlated with>2 mm mean weight diameter.Overall, we believe that the increase of SOC, aromatic-C, and non-crystal ine Fe concentrations in soil after the application of organic fertilizer is the reason for improving soil aggregate stability.展开更多
基金supported by the Research Grants Council of the Hong Kong Special Administration Region under the Grant No.14201621。
文摘In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.The designed distributed controller consists of two parts:a dynamic average consensus part that asymptotically reproduces the unknown NE,and an adaptive reference-tracking module responsible for steering EL systems’positions to track a desired trajectory.The generalized Barbalat’s Lemma is used to overcome the discontinuity of the closed-loop system caused by the switching networks.The proposed algorithm is illustrated by a sensor network deployment problem.
文摘To broaden the frequency width and increase the damping coefficient of a dynamic pressure damper, we designed an aggregative dynamic pressure damper (ADPD). Combined with the advantages of traditional dynamic pressure dampers (TDPD), ADPD can not only increase the damping coefficient in wide frequency range for valve control system, but also absorb partial pressure pulsations and impacts in the low and high frequency fields. Based on the theoretical research and the analysis compared with TDPD, we concluded that the ADPD was superior to the TDPD in the middle high frequency field, and the main parameters influencing the performance of the damper were the damping stiffness, orifice flow coefficient, pre-charge pressure, and the volume of the damper accumulator.
文摘To analyze China’s fluctuating situation of the factor input and aggregative productivity is not only the main method to seek the source of the economic growth but also the main way to weigh the level of economic growth quality.As to economic growth ofa country,the improvementofthe productivity is extremely important.The growth of the output can be realized through two kinds of ways: increasing the quantity of factor input of or improving the efficiency of the input and output.There fore, the level of economic growth quality does not mainly depend on the amount of invested factor,but the importance of improving the productivity since resources are rare. The relative improvement of efficiency in use of the invested factor marks the economic growing quality.So,in order to understand the economic growth quality of China to some extent, it must analyze Chinese factor input and aggregative productivity. This is the main topic that this text will be probed into.
基金The Guangzhou Science and Technology Program Key Projects,No.201704030132.
文摘BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organization.The epidemic quickly spread,causing a worldwide pandemic.Scientists and clinicians across the globe have shifted their research efforts towards understanding the virus itself and its epidemiology.CASE SUMMARY In mid-January 2020,a Chinese family made a visit to a local city,and within the next 2 wk one after another fell ill with COVID-19.At the beginning of their first illness onset,the family had eaten in a restaurant,which led to the subsequent illness onset in another two families.All cases were diagnosed as COVID-19 by real-time fluorescent reverse transcription-polymerase chain reaction.Epidemiological investigation showed that the transmission chain was complete.CONCLUSION This chain of social exposure highlights the danger of group aggregative behavior for spread of COVID-19.
文摘Enteroaggregative Escherichia coli (EAggEC) strains cause the persistent diarrhea in infants and compromised hosts in developing countries. These strains are currently defined as E. coli that adheres to HEp-2 cells in an aggregative adherence (AA) pattern. In this study, we compared 4 different rapid methods for the detection of EAggEC using a PCR assay, clump formation test, glass slide adherence assay, and the HEp-2 cell adherence assay. Out of 683 E. coli strains isolated from diarrheal stool samples, we detected 17 aggR and/or clump-positive strains, and identified 2 aggR-positive, clump-negative strains and 2 aggR-negative, clump-positive strains. All the aggR positive and clump positive strains also showed positive results in glass slide adherence and HEp-2 cell adherence assays. From all these results, we suggest the following procedure for the rapid identification of EAggEC strains: first, screen E. coli strains with the clump formation test and subsequently perform the glass slide adherence assay to observe AA for confirmation.
基金supported by the National Natural Science Foundation of China(62473048,61925303,62088101,62273195,U19B2029).
文摘Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To seek the generalized Nash equilibrium(GNE),a projectionbased distributed algorithm via constant step-sizes is developed with linear convergence.In particular,a variable tracking technique is incorporated to estimate the aggregative function,and an event-triggered mechanism is designed to reduce the communication cost.Finally,a numerical example demonstrates the theoretical results.
基金supported in part by the Fundamental Research Funds for the Central Universities(SWU-XDJH202312)the National Natural Science Foundation of China(62173278)the Chongqing Science Fund for Distinguished Young Scholars(2024NSCQJQX0103).
文摘Game theory-based models and design tools have gained substantial prominence for controlling and optimizing behavior within distributed engineering systems due to the inherent distribution of decisions among individuals.In non-cooperative settings,aggregative games serve as a mathematical framework model for the interdependent optimal decision-making problem among a group of non-cooperative players.In such scenarios,each player's decision is influenced by an aggregation of all players'decisions.Nash equilibrium(NE)seeking in aggregative games has emerged as a vibrant topic driven by applications that harness the aggregation property.This paper presents a comprehensive overview of the current research on aggregative games with a focus on communication topology.A systematic classification is conducted on distributed algorithm research based on communication topologies such as undirected networks,directed networks,and time-varying networks.Furthermore,it sorts out the challenges and compares the algorithms'convergence performance.It also delves into real-world applications of distributed optimization techniques grounded in aggregative games.Finally,it proposes several challenges that can guide future research directions.
基金supported by the National Key Research and Development Program of China(2018YFA0702200)National Natural Science Foundation of China(No.62073065).
文摘Generally,energy trading in smart grid is realized by microgrids.Correspondingly,energy trading in energy internet relies on small-scale energy systems,named as Weenergies(WEs).Previous works on the distributed energy trading focused on the trading platform or trading mechanism based on distributed communication.However,most ignored the fact that there is no express delivery of energy trading,and the transmission of energy depends on a fixed physical topology.Energy transactions without considering the transmission distance will increase the difficulty of energy scheduling and the transmission cost of energy.Aiming at this problem,an aggregation game among WEs is proposed for two-way multi-energy trading,and a distributed algorithm is designed to solve the Nash equilibrium.Since each WE only needs to communicate with its neighbors to exchange information,this distributed process reduces communication burden and improves information security.Furthermore,a multi-energy transmission optimization model is established to determine the transmission path of the transmission energy,which can minimize the transmission cost.Subsequently,to reduce the influence of real-time fluctuations of renewable energy and load,a receding horizon control algorithm is designed to improve the reliability of the proposed game.Finally,the effectiveness in dealing with two-way multi-energy trading of the proposed strategy is verified through simulations on the five connected WEs.
基金This work was partially supported by the National Natural Science Foundation of China under Grant 61903027,72171171,62003239Shanghai Municipal Science and Technology Major Project under Grant 2021SHZDZX0100Shanghai Sailing Program under Grant 20YF1453000.
文摘Distributed Nash equilibrium seeking of aggregative games is investigated and a continuous-time algorithm is proposed.The algorithm is designed by virtue of projected gradient play dynamics and aggregation tracking dynamics,and is applicable to games with constrained strategy sets and weight-balanced communication graphs.The key feature of our method is that the proposed projected dynamics achieves exponential convergence,whereas such convergence results are only obtained for non-projected dynamics in existing works on distributed optimization and equilibrium seeking.Numerical examples illustrate the effectiveness of our methods.
基金supported by NSFC[grant numbers 61663026,61963028,62066026,61866023]Jiangxi NSF[grant number 20192BAB207025].
文摘In this paper,we consider the Nash equilibrium(NE)seeking problem for aggregative games and design a distributed heavy-ball algorithm to solve it.This algorithm has faster convergence rate than the well-known distributed first-order algorithms for aggregative games.In order to seek the NE,each player needs to exchange information with its neighbours as well as a cen-tral aggregation.For aggregative games,the aggregative term can be either linear or nonlinear in this paper.Furthermore,we consider the generalised Nash equilibrium seeking problem for aggregative games by taking into account the linear coupled constraints among players,and modify our initial algorithm to include game constraints.
文摘Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive.
基金Funded by the Natural Science Foundation of Jiangsu Province(No.BK20220626)the National Natural Science Foundation of China(No.52078068)+2 种基金Science and Technology Innovation Foundation of NIT(No.KCTD006)Jiangsu Marine Structure Service Performance Improvement Engineering Research CenterKey Laboratory of Jiangsu"Marine Floating Wind Power Technology and Equipment"。
文摘We investigated the effects of fly ash(FA)content on the mechanical properties of recycled aggregate concrete(RAC)and its regeneration potential under freeze and thaw(F-T)cycles.The physical properties of second-generation recycled concrete aggregates(RCA)were used to analyze the regeneration potential of RAC after F-T cycles.Scanning electron microscopy was used to study the interfacial transition zone microstructure of RAC after F-T cycles.Results showed that adding 20%FA to RAC significantly enhanced its mechanical properties and frost resistance.Before the F-T cycles,the compressive strength of RAC with 20%FA reached 48.3 MPa,exceeding research strength target of 40 MPa.A majority of second-generation RCA with FA had been verified to attain class Ⅲ,which enabled their practical application in non-structural projects such as backfill trenches and road pavement.However,the second-generation RCA with 20%FA can achieve class Ⅱ,making it ideal for 40 MPa structural concrete.
基金Funded by Natural Science Foundation of Guangxi(No.2025GXNSFBA069565)Guangxi Science and Technology Program(No.AD25069101)Guangxi Bagui Scholars Fund。
文摘Crushing waste coral concrete into recycled aggregates to create recycled coral aggregate concrete(RCAC)contributes to sustainable construction development on offshore islands and reefs.To investigate the impact of recycled coral aggregate on concrete properties,this study performed a comprehensive analysis of the physical properties of recycled coral aggregate and the basic mechanical properties and microstructure of RCAC.The test results indicate that,compared to coral debris,the crushing index of recycled coral aggregate was reduced by 9.4%,while porosity decreased by 33.5%.Furthermore,RCAC retained the early strength characteristics of coral concrete,with compressive strength and flexural strength exhibiting a notable increase as the water-cement ratio decreased.Under identical conditions,the compressive strength and flexural strength of RCAC were 12.7% and 2.5% higher than coral concrete's,respectively,with porosity correspondingly reduced from 3.13% to 5.11%.This enhancement could be attributed to the new mortar filling the recycled coral aggregate.Scanning electron microscopy(SEM)analysis revealed three distinct interface transition zones within RCAC,with the‘new mortar-old mortar’interface identified as the weakest.The above findings provided a reference for the sustainable use of coral concrete in constructing offshore islands.
基金supported by FWO(Fonds voor Wetenschappelijk Onderzoek),grant number G07562NFWO(to BB)。
文摘Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated to neuroinflammation,such as Alzheimer's disease,it is now shown to precede pathological protein aggregations.
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)grant LU 2347/3-1(to PL).
文摘Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS).This perspective introduces unconventional secretion pathways,focusing on secretory autophagy and its role in secreting protein aggregates associated with neurodegenerative disorders.We also explore additional neuronal functions of secretory autophagy beyond the release of protein aggregates.We propose autophagosomes as transport organelles that deliver cargo material directly from the endoplasmatic reticulum(ER)to the plasma membrane rather than solely to lysosomes.
基金supported by:Fondazione Telethon-Italy(No.GGP19128 to AP)Fondazione Cariplo-Italy(No.2021-1544 to RC)+14 种基金Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to APTarget-RAN to AP)Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP)Kennedy’s Disease Association-USA(2018 grant to RC2020 grant to MG)Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to APNo.2022EFLFL8 to APNo.2020PBS5MJ to VCNo.2022KSJZF5 to VC)PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC)CN3:RNA-Codice Proposta:CN_00000041Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP)Progetto Dipartimenti di Eccellenza(to DiSFeB)Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP)Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).
文摘Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and migration.HSPB8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective autophagy.In line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and aggregation.In cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under investigation.Moreover,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar hemorrhage.Of note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other diseases.This is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial homeostasis.This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its modulation.Drug-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.
基金State Grid Henan Power Company Science and Technology Project‘Key Technology and Demonstration Application of Multi-Domain Electric Vehicle Aggregated Charging Load Dispatch’(5217L0240003).
文摘This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability.The results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly charging.Additionally,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.
文摘Low porosity is very significant for cementitious composite materials(CCM)under freeze-thaw conditions.To reduce the porosity of CCM,we used wollastonite mineral fibers as a partial replacement for cement and aggregate.The five combinations,in which 10%,32%,and 48%Wollastonite were added,were made for scanning using both scanning electron microscopy(SEM)and computed tomography scan technology(CT).Then,the 2D SEM pictures and the 3D pore distribution curves are obtained before and after the freezing and thawing processes,where the micro-pores in the CCM materials are shown.The fractal dimension is used to quantify the topography image in two dimensions,as well as the pore distribution in three dimensions.This method allows for the determination of both surface porosity and volume porosity,both of which show an increase in response to an escalation of freeze-thaw cycles.It is also found that the micro-damage in the concrete is of self-similarity,and in the context of the fractal dimension,the pore evolution can be quantitatively characterized across different sizes,ranging from local to global levels,before and after freezing and thawing.
基金supported by the National Natural Science Foundation of China(Nos.12072027,62103052,61603346 and 62103379)the Henan Key Laboratory of General Aviation Technology,China(No.ZHKF-230201)+3 种基金the Funding for the Open Research Project of the Rotor Aerodynamics Key Laboratory,China(No.RAL20200101)the Key Research and Development Program of Henan Province,China(Nos.241111222000 and 241111222900)the Key Science and Technology Program of Henan Province,China(No.232102220067)the Scholarship Funding from the China Scholarship Council(No.202206030079).
文摘In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The essence of cross-view geo-localization resides in matching images containing the same geographical targets from disparate platforms,such as UAV-view and satellite-view images.However,images of the same geographical targets may suffer from occlusions and geometric distortions due to variations in the capturing platform,view,and timing.The existing methods predominantly extract features by segmenting feature maps,which overlook the holistic semantic distribution and structural information of objects,resulting in loss of image information.To address these challenges,dilated neighborhood attention Transformer is employed as the feature extraction backbone,and Multi-feature representations based on Multi-scale Hierarchical Contextual Aggregation(MMHCA)is proposed.In the proposed MMHCA method,the multiscale hierarchical contextual aggregation method is utilized to extract contextual information from local to global across various granularity levels,establishing feature associations of contextual information with global and local information in the image.Subsequently,the multi-feature representations method is utilized to obtain rich discriminative feature information,bolstering the robustness of model in scenarios characterized by positional shifts,varying distances,and scale ambiguities.Comprehensive experiments conducted on the extensively utilized University-1652 and SUES-200 benchmarks indicate that the MMHCA method surpasses the existing techniques.showing outstanding results in UAV localization and navigation.
基金supported by the Shenyang Municipal Science and Technology Project,China(23-409-2-03)the Liaoning Provincial Department of Science and Technology Project,China(Z20230183)the Liaoning Provincial Applied Basic Research Program,China(2022JH2/101300173).
文摘Both soil organic carbon (SOC) and iron (Fe) oxide content, among other factors, drive the formation and stability of soil aggregates.However, the mechanism of these drivers in greenhouse soil fertilized with organic fertilizer is not well understood.In a 3-year field experiment, we aimed to investigate the factors which drive the stability of soil aggregates in greenhouse soil.To explore the impact of organic fertilizer on soil aggregates, we established four treatments:no fertilization (CK);inorganic fertilizer (CF);organic fertilizer (OF);and combined application of inorganic and organic fertilizers(COF).The application of organic fertilizer significantly enhanced the stability of aggregates, that is it enhanced the mean weight diameter, geometric mean diameter and aggregate content (%) of>0.25 mm aggregate fractions.OF and COF treatments increased the concentration of SOC, especially the aliphatic-C, aromatic-C and polysaccharide-C components of SOC, particularly in>0.25 mm aggregates.Organic fertilizer application significantly increased the content of free Fe(Fed), reactive Fe (Feo), and non-crystalline Fe in both bulk soil and aggregates.Furthermore, non-crystalline Fe showed a positive correlation with SOC content in both bulk soil and aggregates.Both non-crystalline Fe and SOC were significantly positively correlated with>2 mm mean weight diameter.Overall, we believe that the increase of SOC, aromatic-C, and non-crystal ine Fe concentrations in soil after the application of organic fertilizer is the reason for improving soil aggregate stability.
