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Distributed continuous-time aggregative optimization and its applications to power generation systems
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作者 XIAN Chengxin ZHAO Yu LIU Yongfang 《Journal of Systems Engineering and Electronics》 2026年第1期1-8,共8页
This paper investigates the distributed continuoustime aggregative optimization problem for second-order multiagent systems,where the local cost function is not only related to its own decision variables,but also to t... This paper investigates the distributed continuoustime aggregative optimization problem for second-order multiagent systems,where the local cost function is not only related to its own decision variables,but also to the aggregation of the decision variables of all the agents.By using the gradient descent method,the distributed average tracking(DAT)technique and the time-base generator(TBG)technique,a distributed continuous-time aggregative optimization algorithm is proposed.Subsequently,the optimality of the system's equilibrium point is analyzed,and the convergence of the closed-loop system is proved using the Lyapunov stability theory.Finally,the effectiveness of the proposed algorithm is validated through case studies on multirobot systems and power generation systems. 展开更多
关键词 distributed continuous-time aggregative optimization distributed average tracking(DAT) time-base generator(TBG)
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Distributed Event-Triggered Nash Equilibrium Seeking for Aggregative Game With Second-Order Dynamics
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作者 Yi Huang Jian Sun Qing Fei 《IEEE/CAA Journal of Automatica Sinica》 2025年第7期1519-1521,共3页
Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To s... Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To seek the generalized Nash equilibrium(GNE),a projectionbased distributed algorithm via constant step-sizes is developed with linear convergence.In particular,a variable tracking technique is incorporated to estimate the aggregative function,and an event-triggered mechanism is designed to reduce the communication cost.Finally,a numerical example demonstrates the theoretical results. 展开更多
关键词 generalized nash equilibrium gne estimate aggregative functionand linear convergencein aggregative gamein distributed event triggered control reduce th distributed nash equilibrium seeking projectionbased distributed algorithm
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Distributed algorithms for aggregative games with multiple uncertain Euler–Lagrange systems over switching networks 被引量:1
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作者 Zhaocong Liu Jie Huang 《Journal of Automation and Intelligence》 2025年第1期2-9,共8页
In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.T... In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.The designed distributed controller consists of two parts:a dynamic average consensus part that asymptotically reproduces the unknown NE,and an adaptive reference-tracking module responsible for steering EL systems’positions to track a desired trajectory.The generalized Barbalat’s Lemma is used to overcome the discontinuity of the closed-loop system caused by the switching networks.The proposed algorithm is illustrated by a sensor network deployment problem. 展开更多
关键词 aggregative games Euler-Lagrange systems Jointly connected networks Adaptive control
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A Survey of Distributed Algorithms for Aggregative Games
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作者 Huaqing Li Jun Li +2 位作者 Liang Ran Lifeng Zheng Tingwen Huang 《IEEE/CAA Journal of Automatica Sinica》 2025年第5期859-871,共13页
Game theory-based models and design tools have gained substantial prominence for controlling and optimizing behavior within distributed engineering systems due to the inherent distribution of decisions among individua... Game theory-based models and design tools have gained substantial prominence for controlling and optimizing behavior within distributed engineering systems due to the inherent distribution of decisions among individuals.In non-cooperative settings,aggregative games serve as a mathematical framework model for the interdependent optimal decision-making problem among a group of non-cooperative players.In such scenarios,each player's decision is influenced by an aggregation of all players'decisions.Nash equilibrium(NE)seeking in aggregative games has emerged as a vibrant topic driven by applications that harness the aggregation property.This paper presents a comprehensive overview of the current research on aggregative games with a focus on communication topology.A systematic classification is conducted on distributed algorithm research based on communication topologies such as undirected networks,directed networks,and time-varying networks.Furthermore,it sorts out the challenges and compares the algorithms'convergence performance.It also delves into real-world applications of distributed optimization techniques grounded in aggregative games.Finally,it proposes several challenges that can guide future research directions. 展开更多
关键词 aggregative game distributed algorithm Nash equilibrium(NE) networked control
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Theoretical research on aggregative dynamic pressure damper 被引量:2
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作者 胡军华 《Journal of Chongqing University》 CAS 2009年第3期188-194,共7页
To broaden the frequency width and increase the damping coefficient of a dynamic pressure damper, we designed an aggregative dynamic pressure damper (ADPD). Combined with the advantages of traditional dynamic pressure... To broaden the frequency width and increase the damping coefficient of a dynamic pressure damper, we designed an aggregative dynamic pressure damper (ADPD). Combined with the advantages of traditional dynamic pressure dampers (TDPD), ADPD can not only increase the damping coefficient in wide frequency range for valve control system, but also absorb partial pressure pulsations and impacts in the low and high frequency fields. Based on the theoretical research and the analysis compared with TDPD, we concluded that the ADPD was superior to the TDPD in the middle high frequency field, and the main parameters influencing the performance of the damper were the damping stiffness, orifice flow coefficient, pre-charge pressure, and the volume of the damper accumulator. 展开更多
关键词 aggregative dynamic pressure damper damping coefficient pressure pulsation
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Positive Research on China’s Economic Growth Quality——Analyze the Fluctuating Situation of the Factor Input and Aggregative Productivity 被引量:2
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作者 LiBtanhua 《Ecological Economy》 2005年第1期98-105,共8页
To analyze China’s fluctuating situation of the factor input and aggregative productivity is not only the main method to seek the source of the economic growth but also the main way to weigh the level of economic gro... To analyze China’s fluctuating situation of the factor input and aggregative productivity is not only the main method to seek the source of the economic growth but also the main way to weigh the level of economic growth quality.As to economic growth ofa country,the improvementofthe productivity is extremely important.The growth of the output can be realized through two kinds of ways: increasing the quantity of factor input of or improving the efficiency of the input and output.There fore, the level of economic growth quality does not mainly depend on the amount of invested factor,but the importance of improving the productivity since resources are rare. The relative improvement of efficiency in use of the invested factor marks the economic growing quality.So,in order to understand the economic growth quality of China to some extent, it must analyze Chinese factor input and aggregative productivity. This is the main topic that this text will be probed into. 展开更多
关键词 factor input contribution rate of factors aggregative productivity quality of increasing
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Risk of group aggregative behavior during COVID-19 outbreak: A case report
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作者 Hui Zuo Zhi-Bing Hu Feng Zhu 《World Journal of Clinical Cases》 SCIE 2021年第1期170-174,共5页
BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organizatio... BACKGROUND At the end of 2019,a new epidemic of viral pneumonia emerged in China and was determined to be caused by a novel coronavirus,which was named coronavirus disease 2019(COVID-19)by the World Health Organization.The epidemic quickly spread,causing a worldwide pandemic.Scientists and clinicians across the globe have shifted their research efforts towards understanding the virus itself and its epidemiology.CASE SUMMARY In mid-January 2020,a Chinese family made a visit to a local city,and within the next 2 wk one after another fell ill with COVID-19.At the beginning of their first illness onset,the family had eaten in a restaurant,which led to the subsequent illness onset in another two families.All cases were diagnosed as COVID-19 by real-time fluorescent reverse transcription-polymerase chain reaction.Epidemiological investigation showed that the transmission chain was complete.CONCLUSION This chain of social exposure highlights the danger of group aggregative behavior for spread of COVID-19. 展开更多
关键词 COVID-19 Epidemiological investigation Group aggregative behavior Novel coronavirus PANDEMIC Social exposure Case report
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Rapid Detection Method for Enteroaggregative <i>Escherichia coli</i>Using Simple Clump Formation and Aggregative Assay
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作者 Miyuki Fujioka Chowdhury Rafiqul Ahsan Yoshimitsu Otomo 《Advances in Microbiology》 2013年第8期552-556,共5页
Enteroaggregative Escherichia coli (EAggEC) strains cause the persistent diarrhea in infants and compromised hosts in developing countries. These strains are currently defined as E. coli that adheres to HEp-2 cells in... Enteroaggregative Escherichia coli (EAggEC) strains cause the persistent diarrhea in infants and compromised hosts in developing countries. These strains are currently defined as E. coli that adheres to HEp-2 cells in an aggregative adherence (AA) pattern. In this study, we compared 4 different rapid methods for the detection of EAggEC using a PCR assay, clump formation test, glass slide adherence assay, and the HEp-2 cell adherence assay. Out of 683 E. coli strains isolated from diarrheal stool samples, we detected 17 aggR and/or clump-positive strains, and identified 2 aggR-positive, clump-negative strains and 2 aggR-negative, clump-positive strains. All the aggR positive and clump positive strains also showed positive results in glass slide adherence and HEp-2 cell adherence assays. From all these results, we suggest the following procedure for the rapid identification of EAggEC strains: first, screen E. coli strains with the clump formation test and subsequently perform the glass slide adherence assay to observe AA for confirmation. 展开更多
关键词 ESCHERICHIA coli aggregative ADHERENCE CLUMP FORMATION Rapid Detection
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Distributed Multi-Energy Trading in Energy Internet:An Aggregative Game Approach 被引量:1
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作者 Jingwei Hu Enhui An +1 位作者 Qiuye Sun Bonan Huang 《CSEE Journal of Power and Energy Systems》 2025年第4期1786-1796,共11页
Generally,energy trading in smart grid is realized by microgrids.Correspondingly,energy trading in energy internet relies on small-scale energy systems,named as Weenergies(WEs).Previous works on the distributed energy... Generally,energy trading in smart grid is realized by microgrids.Correspondingly,energy trading in energy internet relies on small-scale energy systems,named as Weenergies(WEs).Previous works on the distributed energy trading focused on the trading platform or trading mechanism based on distributed communication.However,most ignored the fact that there is no express delivery of energy trading,and the transmission of energy depends on a fixed physical topology.Energy transactions without considering the transmission distance will increase the difficulty of energy scheduling and the transmission cost of energy.Aiming at this problem,an aggregation game among WEs is proposed for two-way multi-energy trading,and a distributed algorithm is designed to solve the Nash equilibrium.Since each WE only needs to communicate with its neighbors to exchange information,this distributed process reduces communication burden and improves information security.Furthermore,a multi-energy transmission optimization model is established to determine the transmission path of the transmission energy,which can minimize the transmission cost.Subsequently,to reduce the influence of real-time fluctuations of renewable energy and load,a receding horizon control algorithm is designed to improve the reliability of the proposed game.Finally,the effectiveness in dealing with two-way multi-energy trading of the proposed strategy is verified through simulations on the five connected WEs. 展开更多
关键词 aggregative game multi-energy trading multienergy transmission Nash equilibrium we-energy
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A Compressed Gradient Tracking Method for Distributed Aggregative Optimization
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作者 WANG Tongyu LEI Jinlong 《Journal of Systems Science & Complexity》 2025年第6期2428-2453,共26页
In this paper,the authors propose a distributed gradient tracking algorithm with compressed communication to address an aggregative optimization problem under communication constraints.The problem involves minimizing ... In this paper,the authors propose a distributed gradient tracking algorithm with compressed communication to address an aggregative optimization problem under communication constraints.The problem involves minimizing the sum of local cost functions,where each cost function depends on both local and global state variables.The authors aim to solve this optimization problem through local computation and efficient communication among agents in a network,without the need for a central coordinator.The proposed algorithm combines the variable tracking method to estimate global state variables and a compressed communication scheme to reduce communication costs during the optimization process.Among which,the compressed scheme can encompass both biased and unbiased compressors.Despite the loss of some transmitting information due to quantization,the proposed algorithm can still achieve the exact optimal solution with a linear convergence rate.The authors validate the theoretical results through simulation experiments on an optimal placement problem. 展开更多
关键词 aggregative optimization compression communication distributed algorithm gradient tracking
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Exponentially convergent distributed Nash equilibrium seeking for constrained aggregative games 被引量:2
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作者 Shu Liang Peng Yi +1 位作者 Yiguang Hong Kaixiang Peng 《Autonomous Intelligent Systems》 2022年第1期71-78,共8页
Distributed Nash equilibrium seeking of aggregative games is investigated and a continuous-time algorithm is proposed.The algorithm is designed by virtue of projected gradient play dynamics and aggregation tracking dy... Distributed Nash equilibrium seeking of aggregative games is investigated and a continuous-time algorithm is proposed.The algorithm is designed by virtue of projected gradient play dynamics and aggregation tracking dynamics,and is applicable to games with constrained strategy sets and weight-balanced communication graphs.The key feature of our method is that the proposed projected dynamics achieves exponential convergence,whereas such convergence results are only obtained for non-projected dynamics in existing works on distributed optimization and equilibrium seeking.Numerical examples illustrate the effectiveness of our methods. 展开更多
关键词 Distributed algorithms aggregative games Projected gradient play Weight-balanced graph Exponential convergence
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Numerical Investigation of Porosity and Aggregate Volume Ratio Effects on the Mechanical Behavior of Lightweight Aggregate Concrete
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作者 Safwan Al-sayed Xi Wang +2 位作者 Yijiang Peng Esraa Hyarat Ahmad Ali AlZubi 《Computers, Materials & Continua》 2026年第3期574-602,共29页
In modern construction,Lightweight Aggregate Concrete(LWAC)has been recognized as a vital material of concern because of its unique properties,such as reduced density and improved thermal insulation.Despite the extens... In modern construction,Lightweight Aggregate Concrete(LWAC)has been recognized as a vital material of concern because of its unique properties,such as reduced density and improved thermal insulation.Despite the extensive knowledge regarding its macroscopic properties,there is a wide knowledge gap in understanding the influence of microscale parameters like aggregate porosity and volume ratio on the mechanical response of LWAC.This study aims to bridge this knowledge gap,spurred by the need to enhance the predictability and applicability of LWAC in various construction environments.With the help of advanced numerical methods,including the finite element method and a random circular aggregate model,this study critically evaluates the role played by these microscale factors.We found that an increase in the aggregate porosity from 23.5%to 48.5%leads to a drastic change of weakness from the bonding interface to the aggregate,reducing compressive strength by up to 24.2%and tensile strength by 27.8%.Similarly,the increase in the volume ratio of lightweight aggregate from 25%to 40%leads to a reduction in compressive strength by 13.0%and tensile strength by 9.23%.These results highlight the imperative role of microscale properties on the mechanical properties of LWAC.By supplying precise quantitative details on the effect of porosity and aggregate volume ratio,this research makes significant contributions to construction materials science by providing useful recommendations for the creation and optimization of LWAC with improved performance and sustainability in construction. 展开更多
关键词 Lightweight aggregate concrete aggregate porosity mechanical properties finite element method aggregate volume ratio
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Distributed heavy-ball algorithm of Nash equilibrium seeking for aggregative games
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作者 Xu Yang Wei Ni 《Journal of Control and Decision》 EI 2022年第4期489-501,共13页
In this paper,we consider the Nash equilibrium(NE)seeking problem for aggregative games and design a distributed heavy-ball algorithm to solve it.This algorithm has faster convergence rate than the well-known distribu... In this paper,we consider the Nash equilibrium(NE)seeking problem for aggregative games and design a distributed heavy-ball algorithm to solve it.This algorithm has faster convergence rate than the well-known distributed first-order algorithms for aggregative games.In order to seek the NE,each player needs to exchange information with its neighbours as well as a cen-tral aggregation.For aggregative games,the aggregative term can be either linear or nonlinear in this paper.Furthermore,we consider the generalised Nash equilibrium seeking problem for aggregative games by taking into account the linear coupled constraints among players,and modify our initial algorithm to include game constraints. 展开更多
关键词 aggregative games distributed heavy-ball algorithm Nash equilibrium coupled constraint generalised Nash equilibrium
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Effects of freeze-thaw cycles on aggregate stability of sandy loam on the Eastern Qinghai-Tibet Plateau
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作者 FENG Xiao DUN Yaoquan +2 位作者 QU Jianjun TIAN Qin DONG Lili 《Journal of Mountain Science》 2026年第1期417-433,共17页
Freeze-thaw cycles(FTCs)have an important effect on soil aggregate stability by altering soil structures,thereby influencing soil wind and water erosion on the eastern Qinghai-Tibet Plateau.However,the effects of FTCs... Freeze-thaw cycles(FTCs)have an important effect on soil aggregate stability by altering soil structures,thereby influencing soil wind and water erosion on the eastern Qinghai-Tibet Plateau.However,the effects of FTCs on the stability of these soils remain unclear.Here,we conducted freeze-thaw simulations in laboratory to investigate the effects of FTCs(0 to 15 cycles)on the wet-and dry-sieving aggregate stability of undisturbed sandy loam from Maqu county,which was treated with different initial soil moisture contents(1%to 25%in increments of 4%)and initial aggregate diameters(<2,2-5,5-10,and 10-15 mm).Results show that soil aggregates with initial diameters larger than 2 mm exhibit higher soil organic carbon contents(1.45%-1.57%)and silt contents(34.63%-35.52%)than those smaller than 2 mm(0.93%and 31.38%,respectively).The stability of both wet-and dry-sieving aggregates increases with larger initial diameters.Increasing initial soil moisture content from 1%to 25%reduces aggregate stability,with reductions of 2.4%-88.0%for wet-sieving aggregates and 2.1%-25.5%for dry-sieving aggregates(>2 mm).With increasing FTCs,wet-sieving aggregate(>2 mm)stability exhibits a fluctuating upward trend,with increases of 79.2%-87.4%after 15 FTCs,while dry-sieving aggregate(>2 mm)stability decreases significantly(5.7%-21.7%)upon the first FTC and remains unchanged thereafter.The stability of both the wet-and dry-sieving aggregates smaller than 2 mm remains unchanged with increasing FTCs(p>0.05).SOC content decreases by 22.3%on average with increasing FTCs from 1 to 15 and shows no significant correlations with wet-and dry-sieving aggregate stability.Higher silt content(r=0.39,p<0.05)and lower sand content(r=-0.38,p<0.05)enhances the wet-sieving aggregate stability of sandy loam.Frequent FTCs tend to improve wet-sieving aggregate stability but reduce dry-sieving aggregate stability in the sandy loam.The findings provide certain guidance for preventing freeze-thaw-induced wind erosion. 展开更多
关键词 Freeze-thaw cycles Sandy loam Soil aggregate stability Initial aggregate diameter Soil erosion Soil organic carbon
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Stress signaling caused by mitochondrial import malfunction can be terminated by SIFI:Importance of stress response silencing
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作者 Grace Hohman Michael Shahid Mohamed A.Eldeeb 《Neural Regeneration Research》 2026年第2期673-674,共2页
Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a... Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et al.,2022).This molecular event is believed to lead to activation of stress pathways ultimately resulting in cellular dysfunction(Eldeeb et al.,2022).Accordingly,many lines of research investigations focused on dampening the formation of protein aggregates or augmenting the clearance of protein aggregates as a potential therapeutic strategy to counteract the progression of neurodegenerative diseases,albeit with little success(Costa-Mattioli and Walter,2020).Cell stress cues such as the accumulation of protein aggregates lead to the activation of stress response pathways that aid cells in responding to the damage.Despite the notion that the transient activation of these pathways helps cells cope with stressors,persistent activation can induce unwanted apoptosis of cells and reduce overall tissue strength as well as lead to an accumulation of aggregation-prone proteins(Hetz and Papa,2018).Mutations in proteins involved in stress signaling termination can cause conditions like ataxia and early-onset dementia(Conroy et al.,2014).Therefore,it is crucial for stress response signaling to be turned off once conditions have improved.Nevertheless,the mechanisms by which cells silence these signals are still elusive. 展开更多
关键词 activation stress pathways neurodegenerative disorders protein aggregatesmitochondrial import stress stress signaling protein aggregates goiran protein aggregates protein aggr neurodegenerative diseasesincluding
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Recent Efforts on the Compressive and Tensile Strength Behavior of Thermoplastic-Based Recycled Aggregate Concrete toward Sustainability in Construction Materials
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作者 Mahmoud Alhashash Abdullah Alariyan +3 位作者 Ameen Mokhles Youns Favzi Ghreivati Ahed Habib Maan Habib 《Structural Durability & Health Monitoring》 2026年第1期23-46,共24页
Concrete production often relies on natural aggregates,which can lead to resource depletion and environmental harm.In addition,improper disposal of thermoplastic waste exacerbates ecological problems.Although signific... Concrete production often relies on natural aggregates,which can lead to resource depletion and environmental harm.In addition,improper disposal of thermoplastic waste exacerbates ecological problems.Although significant attention has recently been given to recycling various waste materials into concrete,studies specifically addressing thermoplastic recycled aggregates are still trending.This underscores the need to comprehensively review existing literature,identify research trends,and recognize gaps in understanding the mechanical performance of thermoplastic-based recycled aggregate concrete.Accordingly,this review summarizes recent investigations focused on the mechanical properties of thermoplastic-based recycled aggregate concrete,emphasizing aspects such as compressive strength,tensile behavior,modulus of elasticity,and durability characteristics.The primary aim is to consolidate scattered research findings,identify key parameters influencing mechanical behavior,and propose future research directions.Understanding the influence of recycled thermoplastic aggregates on concrete performance significantly supports sustainable construction practices by reducing dependency on virgin aggregates and mitigating environmental impacts associated with waste disposal.In addition,assessing mechanical performance contributes to confidence in the practical application,encouraging the broader adoption of thermoplastic-based recycled aggregate concrete in construction projects.Through this critical synthesis,the review guides researchers and industry practitioners toward informed decisions on the feasibility and reliability of integrating thermoplastic waste into concrete,thereby promoting sustainable infrastructure development. 展开更多
关键词 THERMOPLASTIC RECYCLING AGGREGATES concrete SUSTAINABILITY
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An Efficient Certificateless Authentication Scheme with Enhanced Security for NDN-IoT Environments
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作者 Feihong Xu Jianbo Wu +3 位作者 Qing An Fei Zhu Zhaoyang Han Saru Kumari 《Computers, Materials & Continua》 2026年第4期1788-1801,共14页
The large-scale deployment of Internet of Things(IoT)technology across various aspects of daily life has significantly propelled the intelligent development of society.Among them,the integration of IoT and named data ... The large-scale deployment of Internet of Things(IoT)technology across various aspects of daily life has significantly propelled the intelligent development of society.Among them,the integration of IoT and named data networks(NDNs)reduces network complexity and provides practical directions for content-oriented network design.However,ensuring data integrity in NDN-IoT applications remains a challenging issue.Very recently,Wang et al.(Entropy,27(5),471(2025))designed a certificateless aggregate signature(CLAS)scheme for NDN-IoT environments.Wang et al.stated that their construction was provably secure under various types of security attacks.Using theoretical analysis methods,in this work,we reveal that their CLAS design fails to meet unforgeability,a core security requirement for CLAS schemes.In particular,we demonstrate that their scheme is vulnerable to amalicious public-key replacement attack,enabling an adversary to produce authentic signatures for arbitrary fraudulent messages.Therefore,Wang et al.’s design cannot achieve its goal.To address the issue,we systematically examine the root causes behind the vulnerability and propose a security-enhanced CLAS construction for NDN-IoT environments.We prove the security ofour improveddesignunder the standard security assumptionandalsoanalyze its practicalperformanceby comparing the computational and communication costs with several related works.The comparison results show the practicality of our design. 展开更多
关键词 IOT certificateless signature public-key replacement attack data integrity AGGREGATION
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DNAJB6:A guardian against neurodegeneration
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作者 JónváHentze Anna Gelman +1 位作者 Tomasz Brudek Christian Hansen 《Neural Regeneration Research》 2026年第6期2169-2177,共9页
Amyloid protein aggregation plays a major role in multiple neurodegenerative diseases and is likely the primary driving force for the progression of most of these diseases.Multiple recent studies have highlighted that... Amyloid protein aggregation plays a major role in multiple neurodegenerative diseases and is likely the primary driving force for the progression of most of these diseases.Multiple recent studies have highlighted that the DNAJ homolog subfamily B member 6(DNAJB6)chaperone is particularly interesting,when it comes to preventing amyloidogenic proteins from aggregating.It has been shown that DNAJB6 can prevent the aggregation of polyglutamine-expanded proteins in models of Huntington’s disease.Likewise,it can suppress aggregation ofα-synuclein in models of Parkinson’s disease and other synucleinopathies.Finally,it has been shown that DNAJB6 can block aggregation of multiple additional amyloid proteins involved in Alzheimer’s disease and other tauopathies as well.We believe there is yet much to learn about the protective role of DNAJB6 in the brain,but this focused review summarizes,what we know so far of this chaperone.It describes the biological role of DNAJB6 in the brain and its interaction with Hsp70,with particular emphasis on the studies that show its ability to prevent amyloid protein aggregation in vitro and in vivo.Moreover,recent work on dysregulation of the expression of DNAJB6 in brain clinical tissue is discussed.Finally,we discuss potential therapeutic perspectives as we believe this protein is a promising druggable target. 展开更多
关键词 AGGREGATION CHAPERONES clinical tissues DNAJB6 human brain NEURODEGENERATION neurodegenerative diseases therapeutic target
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Effect of Fly Ash on Frost Resistance and Regeneration of Recycled Aggregate Concrete
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作者 ZHU Pinghua CHRISTIAN Bihoza +3 位作者 CHEN Xintong WANG Xingjie LIU Hui YAN Xiancui 《Journal of Wuhan University of Technology(Materials Science)》 2026年第1期138-146,共9页
We investigated the effects of fly ash(FA)content on the mechanical properties of recycled aggregate concrete(RAC)and its regeneration potential under freeze and thaw(F-T)cycles.The physical properties of second-gener... We investigated the effects of fly ash(FA)content on the mechanical properties of recycled aggregate concrete(RAC)and its regeneration potential under freeze and thaw(F-T)cycles.The physical properties of second-generation recycled concrete aggregates(RCA)were used to analyze the regeneration potential of RAC after F-T cycles.Scanning electron microscopy was used to study the interfacial transition zone microstructure of RAC after F-T cycles.Results showed that adding 20%FA to RAC significantly enhanced its mechanical properties and frost resistance.Before the F-T cycles,the compressive strength of RAC with 20%FA reached 48.3 MPa,exceeding research strength target of 40 MPa.A majority of second-generation RCA with FA had been verified to attain class Ⅲ,which enabled their practical application in non-structural projects such as backfill trenches and road pavement.However,the second-generation RCA with 20%FA can achieve class Ⅱ,making it ideal for 40 MPa structural concrete. 展开更多
关键词 fly-ash content frost resistance recycled aggregate concrete MICROSTRUCTURE regeneration potential
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Land use type shapes carbon pathways in Tibetan alpine ecosystems:Characterization of ^(13)C abundance in aggregates and density fractions
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作者 Xin Wan Dangjun Wang +7 位作者 Junya Li Shuaiwen Zhang Linyang Li Minghui He Zhiguo Li Hao Jiang Peng Chen Yi Liu 《Journal of Integrative Agriculture》 2026年第2期448-459,共12页
Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ... Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its ^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and ^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions. 展开更多
关键词 land use type soil aggregate density fractions carbon transfer Tibetan Plateau
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