Photodynamic therapy(PDT)holds significant promise as a medical treatment approach in human diseases.Recently,PDT has received attention to harness light-induced reactive oxygen species and,subsequently,modify amyloid...Photodynamic therapy(PDT)holds significant promise as a medical treatment approach in human diseases.Recently,PDT has received attention to harness light-induced reactive oxygen species and,subsequently,modify amyloidogenic peptides implicated in human degenerative diseases.Here we report a series of strategically designed photosensitizers comprised of boron-dipyrromethene(BODIPY)scaffolds conjugated with transition metal ions.Our comprehensive biophysical and biochemical investigations demonstrate the efficacy of the photosensitizers in generating reactive oxygen species(ROS),such as singlet oxygen(^(1)O_(2)),superoxide anion radicals(O_(2)^(·-)),and hydroxyl radicals(·OH),upon photoactivation at a relatively longer wavelength,resulting in the oxidation of amyloid-β(Aβ).Consequently,the induced oxidation brings about significant alterations in the aggregation pathways and morphologies of the peptides.Moreover,Aβspecies produced by treating the metal complex,Ir-BDP,exhibiting the highest ROS generation efficiency and photoactivation,are less toxic than the complex-free Aβspecies.Overall,our findings underscore the therapeutic potential of these newly designed photosensitizers in addressing amyloid-related diseases.展开更多
Compact transmitter and receiver optical sub-assemblies（TOSA and ROSA） are fabricated in our laboratory and have an aggregated capacity of 100 Gb/s. Specially, directly modulated laser（DML） drivers with two layers...Compact transmitter and receiver optical sub-assemblies（TOSA and ROSA） are fabricated in our laboratory and have an aggregated capacity of 100 Gb/s. Specially, directly modulated laser（DML） drivers with two layers of electrical circuit boards are designed to inject RF signals and bias currents separately. For all the lanes, the3 dB bandwidth of the cascade of the TOSA and ROSA exceeds 9 GHz, which allows the 12.5 Gb/s operation.With the 12.5 Gb/s × 8-lane operation, clear eye diagrams for back-to-back and 30-km amplified transmission with a dispersion compensation fiber are achieved. Low cost and simple processing technology make it possible to realize commercial production.展开更多
基金work was supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government[NRF-2022R1I1A1A01064065(G.G.)NRF-2022R1A3B1077319(M.H.L.)+2 种基金NRF-2021R1A2C1011731(C.Y.L.)NRF-2022R1A2C1011793(Y.-H.L.)]the Sejong Science Fellowship Grants(RS-2023-00214034).
文摘Photodynamic therapy(PDT)holds significant promise as a medical treatment approach in human diseases.Recently,PDT has received attention to harness light-induced reactive oxygen species and,subsequently,modify amyloidogenic peptides implicated in human degenerative diseases.Here we report a series of strategically designed photosensitizers comprised of boron-dipyrromethene(BODIPY)scaffolds conjugated with transition metal ions.Our comprehensive biophysical and biochemical investigations demonstrate the efficacy of the photosensitizers in generating reactive oxygen species(ROS),such as singlet oxygen(^(1)O_(2)),superoxide anion radicals(O_(2)^(·-)),and hydroxyl radicals(·OH),upon photoactivation at a relatively longer wavelength,resulting in the oxidation of amyloid-β(Aβ).Consequently,the induced oxidation brings about significant alterations in the aggregation pathways and morphologies of the peptides.Moreover,Aβspecies produced by treating the metal complex,Ir-BDP,exhibiting the highest ROS generation efficiency and photoactivation,are less toxic than the complex-free Aβspecies.Overall,our findings underscore the therapeutic potential of these newly designed photosensitizers in addressing amyloid-related diseases.
基金supported by the National High-Tech Research and Development Program of China(No.2013AA014201)the National Natural Science Foundation of China(Nos.61575186 and 61635001)
文摘Compact transmitter and receiver optical sub-assemblies（TOSA and ROSA） are fabricated in our laboratory and have an aggregated capacity of 100 Gb/s. Specially, directly modulated laser（DML） drivers with two layers of electrical circuit boards are designed to inject RF signals and bias currents separately. For all the lanes, the3 dB bandwidth of the cascade of the TOSA and ROSA exceeds 9 GHz, which allows the 12.5 Gb/s operation.With the 12.5 Gb/s × 8-lane operation, clear eye diagrams for back-to-back and 30-km amplified transmission with a dispersion compensation fiber are achieved. Low cost and simple processing technology make it possible to realize commercial production.
