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RankXLAN:An explainable ensemble-based machine learning framework for biomarker detection,therapeutic target identification,and classification using transcriptomic and epigenomic stomach cancer data
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作者 Kasmika Borah Himanish Shekhar Das +1 位作者 Mudassir Khan Saurav Mallik 《Medical Data Mining》 2026年第1期13-31,共19页
Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-through... Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-throughput sequencing technology have become prominent in biomedical research,and they reveal molecular aspects of cancer diagnosis and therapy.Despite the development of advanced sequencing technology,the presence of high-dimensionality in multi-omics data makes it challenging to interpret the data.Methods:In this study,we introduce RankXLAN,an explainable ensemble-based multi-omics framework that integrates feature selection(FS),ensemble learning,bioinformatics,and in-silico validation for robust biomarker detection,potential therapeutic drug-repurposing candidates’identification,and classification of SC.To enhance the interpretability of the model,we incorporated explainable artificial intelligence(SHapley Additive exPlanations analysis),as well as accuracy,precision,F1-score,recall,cross-validation,specificity,likelihood ratio(LR)+,LR−,and Youden index results.Results:The experimental results showed that the top four FS algorithms achieved improved results when applied to the ensemble learning classification model.The proposed ensemble model produced an area under the curve(AUC)score of 0.994 for gene expression,0.97 for methylation,and 0.96 for miRNA expression data.Through the integration of bioinformatics and ML approach of the transcriptomic and epigenomic multi-omics dataset,we identified potential marker genes,namely,UBE2D2,HPCAL4,IGHA1,DPT,and FN3K.In-silico molecular docking revealed a strong binding affinity between ANKRD13C and the FDA-approved drug Everolimus(binding affinity−10.1 kcal/mol),identifying ANKRD13C as a potential therapeutic drug-repurposing target for SC.Conclusion:The proposed framework RankXLAN outperforms other existing frameworks for serum biomarker identification,therapeutic target identification,and SC classification with multi-omics datasets. 展开更多
关键词 stomach cancer BIOINFORMATICS ensemble learning classifier BIOMARKER targets
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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine Learning Models 被引量:1
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作者 Duc-Dam Nguyen Nguyen Viet Tiep +5 位作者 Quynh-Anh Thi Bui Hiep Van Le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期467-500,共34页
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear... This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making. 展开更多
关键词 Landslide susceptibility map spatial analysis ensemble modelling information values(IV)
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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives 被引量:2
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作者 Chuanping Lin Jun Xu +4 位作者 Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei 《Journal of Energy Chemistry》 2025年第1期739-759,共21页
The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational per... The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ensemble methods for battery SOH estimation. The convergence of advanced machine learning with ensemble learning is anticipated to yield valuable avenues for research. Accelerated research in ensemble learning holds promising prospects for achieving more accurate and reliable battery SOH estimation under real-world conditions. 展开更多
关键词 Lithium-ion battery State-of-health estimation DATA-DRIVEN Machine learning ensemble learning ensemble diversity
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不平衡集成算法LASSO-EasyEnsemble在冠心病预后预测中的应用及可解释性研究
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作者 昝家昕 杨弘 +4 位作者 田晶 闫晶晶 和紫铉 杜宇涛 张岩波 《中国卫生统计》 北大核心 2025年第2期197-203,共7页
目的 针对冠心病预后预测中遇到的高噪声、类间不平衡的特点,通过LASSO特征筛选后,构建EasyEnsemble不平衡集成模型并对模型性能进行评估。方法 基于2009—2018年美国健康与营养调查公共数据库的调查数据,随访时间截止到2019年。预后有... 目的 针对冠心病预后预测中遇到的高噪声、类间不平衡的特点,通过LASSO特征筛选后,构建EasyEnsemble不平衡集成模型并对模型性能进行评估。方法 基于2009—2018年美国健康与营养调查公共数据库的调查数据,随访时间截止到2019年。预后有无因病死亡作为结局,通过LASSO进行特征选择,使用筛选后特征构建EasyEnsemble不平衡集成预测模型和SMOTE+LightGBM、XGBoost、Random Forest预测模型,采用网格搜索法对每个模型进行参数优化,通过AUC、精确率、特异度、G-mean和性能曲线评价其分类性能;应用SHAP(shapley additive explanation)进行模型可解释性分析。结果 EasyEnsemble模型的综合性能最高,AUC为0.80(95%CI:0.79~0.82),精确率为0.86(95%CI:0.78~0.93),特异度为0.99(95%CI:0.98~0.99)和G-mean为0.79(95%CI:0.76~0.83),性能曲线也显示最高。同时,年龄、血清磷、糖尿病、白蛋白等是影响患者预后的重要因素。结论 基于LASSO-EasyEnsemble的不平衡集成模型能够实现对冠心病患者预后的精准预测,结合SHAP可以帮助临床医生更好地评估疾病严重程度和识别高危人群以便实现患者个性化管理。 展开更多
关键词 冠心病 不平衡数据 集成学习 预后预测 可解释性
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Ensemble Deep Learning Approaches in Health Care:A Review 被引量:1
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作者 Aziz Alotaibi 《Computers, Materials & Continua》 2025年第3期3741-3771,共31页
Deep learning algorithms have been rapidly incorporated into many different applications due to the increase in computational power and the availability of massive amounts of data.Recently,both deep learning and ensem... Deep learning algorithms have been rapidly incorporated into many different applications due to the increase in computational power and the availability of massive amounts of data.Recently,both deep learning and ensemble learning have been used to recognize underlying structures and patterns from high-level features to make predictions/decisions.With the growth in popularity of deep learning and ensemble learning algorithms,they have received significant attention from both scientists and the industrial community due to their superior ability to learn features from big data.Ensemble deep learning has exhibited significant performance in enhancing learning generalization through the use of multiple deep learning algorithms.Although ensemble deep learning has large quantities of training parameters,which results in time and space overheads,it performs much better than traditional ensemble learning.Ensemble deep learning has been successfully used in several areas,such as bioinformatics,finance,and health care.In this paper,we review and investigate recent ensemble deep learning algorithms and techniques in health care domains,medical imaging,health care data analytics,genomics,diagnosis,disease prevention,and drug discovery.We cover several widely used deep learning algorithms along with their architectures,including deep neural networks(DNNs),convolutional neural networks(CNNs),recurrent neural networks(RNNs),and generative adversarial networks(GANs).Common healthcare tasks,such as medical imaging,electronic health records,and genomics,are also demonstrated.Furthermore,in this review,the challenges inherent in reducing the burden on the healthcare system are discussed and explored.Finally,future directions and opportunities for enhancing healthcare model performance are discussed. 展开更多
关键词 Deep learning ensemble learning deep ensemble learning deep learning approaches for health care health care
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Navigating the pathways:TAR-DNA-binding-protein-43 aggregation,axonal transport,and local synthesis in amyotrophic lateral sclerosis pathology
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作者 Ori Bar Avi Eran Perlson 《Neural Regeneration Research》 SCIE CAS 2025年第10期2921-2922,共2页
Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and m... Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and intensity.Such mechanisms include axonal transport,local synthesis,and liquid-liquid phase separations.Alterations and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS). 展开更多
关键词 SYNTHESIS LOCAL aggregation
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Steel Surface Defect Recognition in Smart Manufacturing Using Deep Ensemble Transfer Learning-Based Techniques
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作者 Tajmal Hussain Jongwon Seok 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期231-250,共20页
Smart manufacturing and Industry 4.0 are transforming traditional manufacturing processes by utilizing innovative technologies such as the artificial intelligence(AI)and internet of things(IoT)to enhance efficiency,re... Smart manufacturing and Industry 4.0 are transforming traditional manufacturing processes by utilizing innovative technologies such as the artificial intelligence(AI)and internet of things(IoT)to enhance efficiency,reduce costs,and ensure product quality.In light of the recent advancement of Industry 4.0,identifying defects has become important for ensuring the quality of products during the manufacturing process.In this research,we present an ensemble methodology for accurately classifying hot rolled steel surface defects by combining the strengths of four pre-trained convolutional neural network(CNN)architectures:VGG16,VGG19,Xception,and Mobile-Net V2,compensating for their individual weaknesses.We evaluated our methodology on the Xsteel surface defect dataset(XSDD),which comprises seven different classes.The ensemble methodology integrated the predictions of individual models through two methods:model averaging and weighted averaging.Our evaluation showed that the model averaging ensemble achieved an accuracy of 98.89%,a recall of 98.92%,a precision of 99.05%,and an F1-score of 98.97%,while the weighted averaging ensemble reached an accuracy of 99.72%,a recall of 99.74%,a precision of 99.67%,and an F1-score of 99.70%.The proposed weighted averaging ensemble model outperformed the model averaging method and the individual models in detecting defects in terms of accuracy,recall,precision,and F1-score.Comparative analysis with recent studies also showed the superior performance of our methodology. 展开更多
关键词 Smart manufacturing CNN steel defects ensemble models
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MMHCA:Multi-feature representations based on multi-scale hierarchical contextual aggregation for UAV-view geo-localization 被引量:1
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作者 Nanhua CHEN Tai-shan LOU Liangyu ZHAO 《Chinese Journal of Aeronautics》 2025年第6期517-532,共16页
In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The e... In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The essence of cross-view geo-localization resides in matching images containing the same geographical targets from disparate platforms,such as UAV-view and satellite-view images.However,images of the same geographical targets may suffer from occlusions and geometric distortions due to variations in the capturing platform,view,and timing.The existing methods predominantly extract features by segmenting feature maps,which overlook the holistic semantic distribution and structural information of objects,resulting in loss of image information.To address these challenges,dilated neighborhood attention Transformer is employed as the feature extraction backbone,and Multi-feature representations based on Multi-scale Hierarchical Contextual Aggregation(MMHCA)is proposed.In the proposed MMHCA method,the multiscale hierarchical contextual aggregation method is utilized to extract contextual information from local to global across various granularity levels,establishing feature associations of contextual information with global and local information in the image.Subsequently,the multi-feature representations method is utilized to obtain rich discriminative feature information,bolstering the robustness of model in scenarios characterized by positional shifts,varying distances,and scale ambiguities.Comprehensive experiments conducted on the extensively utilized University-1652 and SUES-200 benchmarks indicate that the MMHCA method surpasses the existing techniques.showing outstanding results in UAV localization and navigation. 展开更多
关键词 Geo-localization Image retrieval UAV Hierarchical contextual aggregation Multi-feature representations
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TELL-Me:A time-series-decomposition-based ensembled lightweight learning model for diverse battery prognosis and diagnosis 被引量:1
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作者 Kun-Yu Liu Ting-Ting Wang +2 位作者 Bo-Bo Zou Hong-Jie Peng Xinyan Liu 《Journal of Energy Chemistry》 2025年第7期1-8,共8页
As batteries become increasingly essential for energy storage technologies,battery prognosis,and diagnosis remain central to ensure reliable operation and effective management,as well as to aid the in-depth investigat... As batteries become increasingly essential for energy storage technologies,battery prognosis,and diagnosis remain central to ensure reliable operation and effective management,as well as to aid the in-depth investigation of degradation mechanisms.However,dynamic operating conditions,cell-to-cell inconsistencies,and limited availability of labeled data have posed significant challenges to accurate and robust prognosis and diagnosis.Herein,we introduce a time-series-decomposition-based ensembled lightweight learning model(TELL-Me),which employs a synergistic dual-module framework to facilitate accurate and reliable forecasting.The feature module formulates features with physical implications and sheds light on battery aging mechanisms,while the gradient module monitors capacity degradation rates and captures aging trend.TELL-Me achieves high accuracy in end-of-life prediction using minimal historical data from a single battery without requiring offline training dataset,and demonstrates impressive generality and robustness across various operating conditions and battery types.Additionally,by correlating feature contributions with degradation mechanisms across different datasets,TELL-Me is endowed with the diagnostic ability that not only enhances prediction reliability but also provides critical insights into the design and optimization of next-generation batteries. 展开更多
关键词 Battery prognosis Interpretable machine learning Degradation diagnosis ensemble learning Online prediction Lightweight model
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Anomaly Detection of Controllable Electric Vehicles through Node Equation against Aggregation Attack
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作者 Jing Guo Ziying Wang +1 位作者 Yajuan Guo Haitao Jiang 《Computers, Materials & Continua》 SCIE EI 2025年第1期427-442,共16页
The rapid proliferation of electric vehicle(EV)charging infrastructure introduces critical cybersecurity vulnerabilities to power grids system.This study presents an innovative anomaly detection framework for EV charg... The rapid proliferation of electric vehicle(EV)charging infrastructure introduces critical cybersecurity vulnerabilities to power grids system.This study presents an innovative anomaly detection framework for EV charging stations,addressing the unique challenges posed by third-party aggregation platforms.Our approach integrates node equations-based on the parameter identification with a novel deep learning model,xDeepCIN,to detect abnormal data reporting indicative of aggregation attacks.We employ a graph-theoretic approach to model EV charging networks and utilize Markov Chain Monte Carlo techniques for accurate parameter estimation.The xDeepCIN model,incorporating a Compressed Interaction Network,has the ability to capture complex feature interactions in sparse,high-dimensional charging data.Experimental results on both proprietary and public datasets demonstrate significant improvements in anomaly detection performance,with F1-scores increasing by up to 32.3%for specific anomaly types compared to traditional methods,such as wide&deep and DeepFM(Factorization-Machine).Our framework exhibits robust scalability,effectively handling networks ranging from 8 to 85 charging points.Furthermore,we achieve real-time monitoring capabilities,with parameter identification completing within seconds for networks up to 1000 nodes.This research contributes to enhancing the security and reliability of renewable energy systems against evolving cyber threats,offering a comprehensive solution for safeguarding the rapidly expanding EV charging infrastructure. 展开更多
关键词 Anomaly detection electric vehicle aggregation attack deep cross-network
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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation
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作者 Congcong Wang Chen Wang +1 位作者 Wenying Zheng Wei Gu 《Computers, Materials & Continua》 SCIE EI 2025年第1期799-816,共18页
As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy protection.Current research emphasizes data security and use... As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy protection.Current research emphasizes data security and user privacy concerns within smart grids.However,existing methods struggle with efficiency and security when processing large-scale data.Balancing efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent challenge.This paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data modalities.The approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user privacy.It also explores the application of Boneh Lynn Shacham(BLS)signatures for user authentication.The proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis. 展开更多
关键词 Smart grid data security privacy protection artificial intelligence data aggregation
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Medical Diagnosis Based on Multi-Attribute Group Decision-Making Using Extension Fuzzy Sets,Aggregation Operators and Basic Uncertainty Information Granule
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作者 Anastasios Dounis Ioannis Palaiothodoros Anna Panagiotou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期759-811,共53页
Accurate medical diagnosis,which involves identifying diseases based on patient symptoms,is often hindered by uncertainties in data interpretation and retrieval.Advanced fuzzy set theories have emerged as effective to... Accurate medical diagnosis,which involves identifying diseases based on patient symptoms,is often hindered by uncertainties in data interpretation and retrieval.Advanced fuzzy set theories have emerged as effective tools to address these challenges.In this paper,new mathematical approaches for handling uncertainty in medical diagnosis are introduced using q-rung orthopair fuzzy sets(q-ROFS)and interval-valued q-rung orthopair fuzzy sets(IVq-ROFS).Three aggregation operators are proposed in our methodologies:the q-ROF weighted averaging(q-ROFWA),the q-ROF weighted geometric(q-ROFWG),and the q-ROF weighted neutrality averaging(qROFWNA),which enhance decision-making under uncertainty.These operators are paired with ranking methods such as the similarity measure,score function,and inverse score function to improve the accuracy of disease identification.Additionally,the impact of varying q-rung values is explored through a sensitivity analysis,extending the analysis beyond the typical maximum value of 3.The Basic Uncertain Information(BUI)method is employed to simulate expert opinions,and aggregation operators are used to combine these opinions in a group decisionmaking context.Our results provide a comprehensive comparison of methodologies,highlighting their strengths and limitations in diagnosing diseases based on uncertain patient data. 展开更多
关键词 Medical diagnosis multi-attribute group decision-making(MAGDM) q-ROFS IVq-ROFS BUI aggregation operators similarity measures inverse score function
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Weighted Voting Ensemble Model Integrated with IoT for Detecting Security Threats in Satellite Systems and Aerial Vehicles
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作者 Raed Alharthi 《Journal of Computer and Communications》 2025年第2期250-281,共32页
Small-drone technology has opened a range of new applications for aerial transportation. These drones leverage the Internet of Things (IoT) to offer cross-location services for navigation. However, they are susceptibl... Small-drone technology has opened a range of new applications for aerial transportation. These drones leverage the Internet of Things (IoT) to offer cross-location services for navigation. However, they are susceptible to security and privacy threats due to hardware and architectural issues. Although small drones hold promise for expansion in both civil and defense sectors, they have safety, security, and privacy threats. Addressing these challenges is crucial to maintaining the security and uninterrupted operations of these drones. In this regard, this study investigates security, and preservation concerning both the drones and Internet of Drones (IoD), emphasizing the significance of creating drone networks that are secure and can robustly withstand interceptions and intrusions. The proposed framework incorporates a weighted voting ensemble model comprising three convolutional neural network (CNN) models to enhance intrusion detection within the network. The employed CNNs are customized 1D models optimized to obtain better performance. The output from these CNNs is voted using a weighted criterion using a 0.4, 0.3, and 0.3 ratio for three CNNs, respectively. Experiments involve using multiple benchmark datasets, achieving an impressive accuracy of up to 99.89% on drone data. The proposed model shows promising results concerning precision, recall, and F1 as indicated by their obtained values of 99.92%, 99.98%, and 99.97%, respectively. Furthermore, cross-validation and performance comparison with existing works is also carried out. Findings indicate that the proposed approach offers a prospective solution for detecting security threats for aerial systems and satellite systems with high accuracy. 展开更多
关键词 Intrusion Detection Cyber-Physical Systems Drone Security Weighted ensemble Voting Unmanned Vehicles Security Strategies
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FISHER INFORMATION AMONG β-ENSEMBLES
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作者 Yutao MA 《Acta Mathematica Scientia》 2025年第2期493-513,共21页
In this paper,we consider the Fisher informations among three classical type β-ensembles when β>0 scales with n satisfying lim βn=∞.We offer the exact order of-the corresponding two Fisher informations,which in... In this paper,we consider the Fisher informations among three classical type β-ensembles when β>0 scales with n satisfying lim βn=∞.We offer the exact order of-the corresponding two Fisher informations,which indicates that theβ-Laguerre ensembles do not satisfy the logarithmic Sobolev inequality.We also give some limit theorems on the extremals of β-Jacobi ensembles for β>0 fixed. 展开更多
关键词 β-Hermite ensemble βB-Laguerre ensemble β-Jacobi ensemble Fisher information Tracy-Widom law
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Explainable artificial intelligence and ensemble learning for hepatocellular carcinoma classification:State of the art,performance,and clinical implications
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作者 Sami Akbulut Cemil Colak 《World Journal of Hepatology》 2025年第11期11-25,共15页
Hepatocellular carcinoma(HCC)remains a leading cause of cancer-related mortality globally,necessitating advanced diagnostic tools to improve early detection and personalized targeted therapy.This review synthesizes ev... Hepatocellular carcinoma(HCC)remains a leading cause of cancer-related mortality globally,necessitating advanced diagnostic tools to improve early detection and personalized targeted therapy.This review synthesizes evidence on explainable ensemble learning approaches for HCC classification,emphasizing their integration with clinical workflows and multi-omics data.A systematic analysis[including datasets such as The Cancer Genome Atlas,Gene Expression Omnibus,and the Surveillance,Epidemiology,and End Results(SEER)datasets]revealed that explainable ensemble learning models achieve high diagnostic accuracy by combining clinical features,serum biomarkers such as alpha-fetoprotein,imaging features such as computed tomography and magnetic resonance imaging,and genomic data.For instance,SHapley Additive exPlanations(SHAP)-based random forests trained on NCBI GSE14520 microarray data(n=445)achieved 96.53%accuracy,while stacking ensembles applied to the SEER program data(n=1897)demonstrated an area under the receiver operating characteristic curve of 0.779 for mortality prediction.Despite promising results,challenges persist,including the computational costs of SHAP and local interpretable model-agnostic explanations analyses(e.g.,TreeSHAP requiring distributed computing for metabolomics datasets)and dataset biases(e.g.,SEER’s Western population dominance limiting generalizability).Future research must address inter-cohort heterogeneity,standardize explainability metrics,and prioritize lightweight surrogate models for resource-limited settings.This review presents the potential of explainable ensemble learning frameworks to bridge the gap between predictive accuracy and clinical interpretability,though rigorous validation in independent,multi-center cohorts is critical for real-world deployment. 展开更多
关键词 Hepatocellular carcinoma Artificial intelligence Explainable artificial intelligence ensemble learning Explainable ensemble learning
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Age-dependent alpha-synuclein aggregation and Lewy body formation in Parkinson's disease
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作者 Chun Chau Sung Kenny K.K.Chung 《Neural Regeneration Research》 2025年第12期3533-3534,共2页
Parkinson's disease (PD) is a common degenerative disorder that is becoming increasingly prevalent because of the global aging population.The exact cause of the disorder is unknown;however,recent studies have sugg... Parkinson's disease (PD) is a common degenerative disorder that is becoming increasingly prevalent because of the global aging population.The exact cause of the disorder is unknown;however,recent studies have suggested that multiple factors may contribute to its pathogenesis.PD is characterized by a movement disorder that primarily affects motor control;pathologically,the disease is marked by the presence of Lewy bodies (LBs) in the brain. 展开更多
关键词 PATHOGENESIS aggregation BECOMING
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LMSA:A Lightweight Multi-Key Secure Aggregation Framework for Privacy-Preserving Healthcare AIoT
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作者 Hyunwoo Park Jaedong Lee 《Computer Modeling in Engineering & Sciences》 2025年第4期827-847,共21页
Integrating Artificial Intelligence of Things(AIoT)in healthcare offers transformative potential for real-time diagnostics and collaborative learning but presents critical challenges,including privacy preservation,com... Integrating Artificial Intelligence of Things(AIoT)in healthcare offers transformative potential for real-time diagnostics and collaborative learning but presents critical challenges,including privacy preservation,computational efficiency,and regulatory compliance.Traditional approaches,such as differential privacy,homomorphic encryption,and secure multi-party computation,often fail to balance performance and privacy,rendering them unsuitable for resource-constrained healthcare AIoT environments.This paper introduces LMSA(Lightweight Multi-Key Secure Aggregation),a novel framework designed to address these challenges and enable efficient,secure federated learning across distributed healthcare institutions.LMSA incorporates three key innovations:(1)a lightweight multikey management system leveraging Diffie-Hellman key exchange and SHA3-256 hashing,achieving O(n)complexity with AES(Advanced Encryption Standard)-256-level security;(2)a privacy-preserving aggregation protocol employing hardware-accelerated AES-CTR(CounTeR)encryption andmodular arithmetic for securemodel weight combination;and(3)a resource-optimized implementation utilizing AES-NI(New Instructions)instructions and efficient memory management for real-time operations on constrained devices.Experimental evaluations using the National Institutes of Health(NIH)Chest X-ray dataset demonstrate LMSA’s ability to train multi-label thoracic disease prediction models with Vision Transformer(ViT),ResNet-50,and MobileNet architectures across distributed healthcare institutions.Memory usage analysis confirmed minimal overhead,with ViT(327.30 MB),ResNet-50(89.87 MB),and MobileNet(8.63 MB)maintaining stable encryption times across communication rounds.LMSA ensures robust security through hardware acceleration,enabling real-time diagnostics without compromising patient confidentiality or regulatory compliance.Future research aims to optimize LMSA for ultra-low-power devices and validate its scalability in heterogeneous,real-world environments.LMSA represents a foundational advancement for privacy-conscious healthcare AI applications,bridging the gap between privacy and performance. 展开更多
关键词 Secure aggregation LIGHTWEIGHT federated learning
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Ensemble learning-driven multi-objective optimization of the co-pyrolysis process of biomass and coal for high economic and environmental performance
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作者 Qingchun Yang Dongwen Rong +2 位作者 Qiwen Guo Runjie Bao Dawei Zhang 《Chinese Journal of Chemical Engineering》 2025年第8期23-34,共12页
The biomass and coal co-pyrolysis (BCP) technology combines the advantages of both resources, achieving efficient resource complementarity, reducing reliance on coal, and minimizing pollutant emissions. However, this ... The biomass and coal co-pyrolysis (BCP) technology combines the advantages of both resources, achieving efficient resource complementarity, reducing reliance on coal, and minimizing pollutant emissions. However, this process still encounters numerous challenges in attaining optimal economic and environmental performance. Therefore, an ensemble learning (EL) framework is proposed for the BCP process in this study to optimize the synergistic benefits while minimizing negative environmental impacts. Six different ensemble learning models are developed to investigate the impact of input features, such as biomass characteristics, coal characteristics, and pyrolysis conditions on the product profit and CO_(2) emissions of the BCP processes. The Optuna method is further employed to automatically optimize the hyperparameters of BCP process models for enhancing their predictive accuracy and robustness. The results indicate that the categorical boosting (CAB) model of the BCP process has demonstrated exceptional performance in accurately predicting its product profit and CO_(2) emission (R2>0.92) after undergoing five-fold cross-validation. To enhance the interpretability of this preferred model, the Shapley additive explanations and partial dependence plot analyses are conducted to evaluate the impact and importance of biomass characteristics, coal characteristics, and pyrolysis conditions on the product profitability and CO_(2) emissions of the BCP processes. Finally, the preferred model coupled with a reference vector guided evolutionary algorithm is carried to identify the optimal conditions for maximizing the product profit of BCP process products while minimizing CO_(2) emissions. It indicates the optimal BCP process can achieve high product profits (5290.85 CNY·t−1) and low CO_(2) emissions (7.45 kg·t^(−1)). 展开更多
关键词 BIOMASS PYROLYSIS Optimal design ensemble learning Economic analysis
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Understanding the initial conditions contributing to the rapid intensification of typhoons through ensemble sensitivity analysis
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作者 Yixuan Ren Lili Lei +2 位作者 Jian-Feng Gu Zhe-Min Tan Yi Zhang 《Atmospheric and Oceanic Science Letters》 2025年第2期36-42,共7页
While steady improvements have been achieved for the track forecasts of typhoons,there has been a lack of improvement for intensity forecasts.One challenge for intensity forecasts is to capture the rapid intensificati... While steady improvements have been achieved for the track forecasts of typhoons,there has been a lack of improvement for intensity forecasts.One challenge for intensity forecasts is to capture the rapid intensification(RI),whose nonlinear characteristics impose great difficulties for numerical models.The ensemble sensitivity analysis(ESA)method is used here to analyze the initial conditions that contribute to typhoon intensity forecasts,especially with RI.Six RI processes from five typhoons(Chaba,Haima,Meranti,Sarika,and Songda)in 2016,are applied with ESA,which also gives a composite initial condition that favors subsequent RI.Results from individual cases have generally similar patterns of ESA,but with different magnitudes,when various cumulus parameterization schemes are applied.To draw the initial conditions with statistical significance,sample-mean azimuthal components of ESA are obtained.Results of the composite sensitivity show that typhoons that experience RI in 24 h favor enhanced primary circulation from low to high levels,intensified secondary circulation with increased radial inflow at lower levels and increased radial outflow at upper levels,a prominent warm core at around 300 hPa,and increased humidity at low levels.As the forecast lead time increases,the patterns of ESA are retained,while the sensitivity magnitudes decay.Given the general and quantitative composite sensitivity along with associated uncertainties for different cumulus parameterization schemes,appropriate sampling of the composite sensitivity in numerical models could be beneficial to capturing the RI and improving the forecasting of typhoon intensity. 展开更多
关键词 TYPHOON Rapid intensification ensemble sensitivity analysis Composite sensitivity
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Heart Disease Prediction Model Using Feature Selection and Ensemble Deep Learning with Optimized Weight
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作者 Iman S.Al-Mahdi Saad M.Darwish Magda M.Madbouly 《Computer Modeling in Engineering & Sciences》 2025年第4期875-909,共35页
Heart disease prediction is a critical issue in healthcare,where accurate early diagnosis can save lives and reduce healthcare costs.The problem is inherently complex due to the high dimensionality of medical data,irr... Heart disease prediction is a critical issue in healthcare,where accurate early diagnosis can save lives and reduce healthcare costs.The problem is inherently complex due to the high dimensionality of medical data,irrelevant or redundant features,and the variability in risk factors such as age,lifestyle,andmedical history.These challenges often lead to inefficient and less accuratemodels.Traditional predictionmethodologies face limitations in effectively handling large feature sets and optimizing classification performance,which can result in overfitting poor generalization,and high computational cost.This work proposes a novel classification model for heart disease prediction that addresses these challenges by integrating feature selection through a Genetic Algorithm(GA)with an ensemble deep learning approach optimized using the Tunicate Swarm Algorithm(TSA).GA selects the most relevant features,reducing dimensionality and improvingmodel efficiency.Theselected features are then used to train an ensemble of deep learning models,where the TSA optimizes the weight of each model in the ensemble to enhance prediction accuracy.This hybrid approach addresses key challenges in the field,such as high dimensionality,redundant features,and classification performance,by introducing an efficient feature selection mechanism and optimizing the weighting of deep learning models in the ensemble.These enhancements result in a model that achieves superior accuracy,generalization,and efficiency compared to traditional methods.The proposed model demonstrated notable advancements in both prediction accuracy and computational efficiency over traditionalmodels.Specifically,it achieved an accuracy of 97.5%,a sensitivity of 97.2%,and a specificity of 97.8%.Additionally,with a 60-40 data split and 5-fold cross-validation,the model showed a significant reduction in training time(90 s),memory consumption(950 MB),and CPU usage(80%),highlighting its effectiveness in processing large,complex medical datasets for heart disease prediction. 展开更多
关键词 Heart disease prediction feature selection ensemble deep learning optimization genetic algorithm(GA) ensemble deep learning tunicate swarm algorithm(TSA) feature selection
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