1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a u...1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a unique case among them as it evolved into the largest rift basin.The rift basin filling of SB includes Huoshiling Formation,Shahezi Formation,and Yingcheng Formation in ascending order.The mega-rifting was controlled by the Mongol-Okhotsk Collisional Belt to the north and northwest and the Pacific Subduction Zone to the east(Wang PJ et al.,2016).As the first rifting succession,the Huoshiling Formation contains key information about the formation of the rifting basins and records the evolution of the Mongol-Okhotsk Collisional Belt and the Pacific Subduction Zone.However,the geological period of the Huoshiling Formation has not been well constrained for two main reasons.First,it is easily confused with the Yingcheng Formation,as both are dominated by volcanogenic-sedimentary successions.Second,there is lack of reliable dating samples from the uppermost part of the Huoshiling Formation due to its considerable burial depth.展开更多
It has been shown that the age of minerals in which U±Th are a major(e.g.,uraninite,pitchblende and thorite)or minor(e.g.,monazite,xenotime)component can be calculated from the concentrations of U±Th and Pb ...It has been shown that the age of minerals in which U±Th are a major(e.g.,uraninite,pitchblende and thorite)or minor(e.g.,monazite,xenotime)component can be calculated from the concentrations of U±Th and Pb rather than their isotopes,and such ages are referred to as chemical ages.Although equations for calculating the chemical ages have been well established and various computation programs have been reported,there is a lack of software that can not only calculate the chemical ages of individual analytical points but also provide an evaluation of the errors of individual ages as well as the whole dataset.In this paper,we develop a software for calculating and assessing the chemical ages of uranium minerals(CAUM),an open-source Python-based program with a friendly Graphical User Interface(GUI).Electron probe microanalysis(EPMA)data of uranium minerals are first imported from Excel files and used to calculate the chemical ages and associated errors of individual analytical points.The age data are then visualized to aid evaluating if the dataset comprises one or multiple populations and whether or not there are meaningful correlations between the chemical ages and impurities.Actions can then be taken to evaluate the errors within individual populations and the significance of the correlations.The use of the software is demonstrated with examples from published data.展开更多
Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects o...Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, the more severe the pain. 4) Scar condition: Scar formation was evaluated 1, 3, and 6 months after wound healing using the VAS scale, with a total score of 15 points. The higher the score, the more severe the scar. 5) Detect the expression of AGEs in wound tissue. Results: The wound healed 14.03 ± 2.28 days after eschar removal, with a cure rate of 97.8%. No infection occurred in the wound after eschar removal in all patients. The wound healing time ranged from 9 to 23 days, with an average healing time of 28.41 ± 1.45 days. The healing quality was satisfactory. The Vancouver Scar Scale scored the wound healing scar as 0.81 ± 0.73 points. Western blot was used to detect the expression of AGEs, (receptor for advanced glycation end products) RAGE, and protein in the wound tissue. Results After 7, 14, and 28 days of medication, the wounds of diabetic patients healed well. The drug treatment efficacy and hydroxyproline content showed an upward trend, and the expression levels of AGEs, RAGE, and HIF-1a proteins showed a downward trend. Compared with day 0, the hydroxyproline content of the wound granulation tissue on days 7, 14, and 28 was significantly increased (P< 0.01), and the expression levels of AGEs, RAGE, and HIF-1α proteins were significantly downregulated (P< 0.05 or P< 0.01). Conclusion: Monitoring the expression levels of AGEs and RAGE can reflect the wound-healing effect of patients with second-degree burns, and the prognosis of the wound is closely related to the expression levels of AGEs, RAGE, and scab abrasion. In the treatment of second-degree burn wounds, scab abrasion can grasp the level of necrotic scab removal, can achieve “relatively accurate” removal of necrotic tissue, maximally protect the ecological tissue between wounds and retaining normal tissue, and can play a positive role in promoting the healing process of burn wounds;at the same time, nanosilver dressings have good antibacterial properties and high safety, and mussel mucin has anti-inflammatory and antioxidant activities and the characteristics of blocking nerve endings, which can effectively relieve the burning, stinging, and itching of sensitive skin and effectively promote wound healing.展开更多
This study aimed to compare the complications of preterm twins versus singletons and analyze differences across gestational ages.Preterm twins delivered between 2 March 2022 and 6 November 2022 were compared to an age...This study aimed to compare the complications of preterm twins versus singletons and analyze differences across gestational ages.Preterm twins delivered between 2 March 2022 and 6 November 2022 were compared to an age-matched control group of singletons,involving 65 twins and 103 singletons.The most common complication in premature infants was neonatal jaundice(87.72%),followed by patent foramen ovale(79.76%)and neonatal respiratory distress syndrome(NRDS)(57.14%).Twins had significantly higher Apgar scores at 1,5,and 10 minutes compared to singletons.However,twins showed a higher incidence of ventricular septal defect(VSD)(7.69%)than singletons,with a statistically significant difference.In contrast,twins exhibited significantly lower rates of neonatal jaundice(78.46%),electrolyte imbalance(18.4%),and acid-base imbalance(9.23%)compared to singletons.Furthermore,as gestational age increased,the incidence of intrauterine infection,electrolyte and acid-base imbalances,neonatal coagulation disorders,patent ductus arteriosus(PDA),anemia,and NRDS in preterm infants gradually decreased,with all differences reaching statistical significance(P<0.05).These findings highlight the importance of close monitoring and timely management of complications in premature infants to prevent severe outcomes.展开更多
Brain age is an effective biomarker for diagnosing Alzheimer’s disease(AD).Aimed at the issue that the existing brain age detection methods are inconsistent with the biological hypothesis that AD is the accelerated a...Brain age is an effective biomarker for diagnosing Alzheimer’s disease(AD).Aimed at the issue that the existing brain age detection methods are inconsistent with the biological hypothesis that AD is the accelerated aging of the brain,a mutual information—support vector regression(MI-SVR)brain age prediction model is proposed.First,the age deviation is introduced according to the biological hypothesis of AD.Second,fitness function is designed based on mutual information criterion.Third,support vector regression and fitness function are used to obtain the predicted brain age and fitness value of the subjects,respectively.The optimal age deviation is obtained by maximizing the fitness value.Finally,the proposed method is compared with some existing brain age detection methods.Experimental results show that the brain age obtained by the proposed method has better separability,can better reflect the accelerated aging of AD,and is more helpful for improving the diagnostic accuracy of AD.展开更多
Microstructures and properties of mortar using ammonium phosphate and potassium phosphate were tested and compared in this case.Moreover,two cementitious additions and two lightweight aggregates,including fly ash,redi...Microstructures and properties of mortar using ammonium phosphate and potassium phosphate were tested and compared in this case.Moreover,two cementitious additions and two lightweight aggregates,including fly ash,redispersible latex powder,ceramsite sand,and rubber powder,were respectively tried to be applied in magnesium ammonium phosphate cement mortar in order to modify the microstructures and properties.The experimental results show that potassium phosphate is not suitable for magnesium phosphate cement mortar for cold region construction purpose.Although fly ash can bring positive modification in the condition of normal temperature curing,it brings negative effects in the condition of sub-zero temperature curing.Either redispersible latex powder or ceramsite sand can improve the freeze-thaw cycling resistance of magnesium phosphate cement mortar in the conditions of low temperature coupled with freeze-thaw cycling,but only the ceramsite sand can improve both mechanical properties and freeze-thaw cycling resistance.The modification caused by ceramsite sand is mainly due to the exceptional bonding strength between hardened cement paste and the porous surface of ceramsite and the porous structure of ceramsite for the release of frost heave stress.展开更多
Traditional educational paradigms prioritize age-based progression and early specialization as key indicators of academic potential,especially in STEM.This study challenges this norm by analyzing university entrance a...Traditional educational paradigms prioritize age-based progression and early specialization as key indicators of academic potential,especially in STEM.This study challenges this norm by analyzing university entrance ages of 226 Nobel Physics Laureates(1901-2024).Results reveal a right-skewed distribution(Median=18;Mean=18.8;SD=2.4)with substantial variance(14-25 years),including outliers like Lev Landau(14)and Arthur Ashkin(24).Notably,figures such as Guglielmo Marconi achieved breakthroughs without formal university entry,relying on self-directed learning.Using survival analysis and multinomial regression,we find“non-traditional”timelines,accelerated,delayed,or non-formal pathways,correlate with distinct creative advantages.This suggests current“timeliness”metrics poorly predict transformative scientific achievement.We propose an“Optimal Chrono-Diversity”framework advocating flexible entry systems,enhanced adult learner support,and recognition of autodidactic potential to inform educational policy and cultivate innovative STEM talent.展开更多
基金supported by the National Natural Science Foundation of China(42102135,42072140,42202122 and 41790453)Science and Technology Research Program of Chongqing Municipal Education Commission(KJZD-M202101502,KJQN202201549 and KJQN202101535)+1 种基金Natural Science Foundation of Chongqing(CSTB2022NSCQ-JQX0031 and CSTB2022NSCQMSX1586)China Scholarship Council(202208505055)。
文摘1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a unique case among them as it evolved into the largest rift basin.The rift basin filling of SB includes Huoshiling Formation,Shahezi Formation,and Yingcheng Formation in ascending order.The mega-rifting was controlled by the Mongol-Okhotsk Collisional Belt to the north and northwest and the Pacific Subduction Zone to the east(Wang PJ et al.,2016).As the first rifting succession,the Huoshiling Formation contains key information about the formation of the rifting basins and records the evolution of the Mongol-Okhotsk Collisional Belt and the Pacific Subduction Zone.However,the geological period of the Huoshiling Formation has not been well constrained for two main reasons.First,it is easily confused with the Yingcheng Formation,as both are dominated by volcanogenic-sedimentary successions.Second,there is lack of reliable dating samples from the uppermost part of the Huoshiling Formation due to its considerable burial depth.
基金supported by the Natural Science Foundation Program of China(42173072,41503037,U1967207)Postgraduate Innovative Cultivation Program(CDUT2023BJCX013)Uranium Resources Exploration and Exploitation Innovation Center&and Everest Scientific Research Program(CDUT).
文摘It has been shown that the age of minerals in which U±Th are a major(e.g.,uraninite,pitchblende and thorite)or minor(e.g.,monazite,xenotime)component can be calculated from the concentrations of U±Th and Pb rather than their isotopes,and such ages are referred to as chemical ages.Although equations for calculating the chemical ages have been well established and various computation programs have been reported,there is a lack of software that can not only calculate the chemical ages of individual analytical points but also provide an evaluation of the errors of individual ages as well as the whole dataset.In this paper,we develop a software for calculating and assessing the chemical ages of uranium minerals(CAUM),an open-source Python-based program with a friendly Graphical User Interface(GUI).Electron probe microanalysis(EPMA)data of uranium minerals are first imported from Excel files and used to calculate the chemical ages and associated errors of individual analytical points.The age data are then visualized to aid evaluating if the dataset comprises one or multiple populations and whether or not there are meaningful correlations between the chemical ages and impurities.Actions can then be taken to evaluate the errors within individual populations and the significance of the correlations.The use of the software is demonstrated with examples from published data.
文摘Objective: To evaluate the improvement effect of combined treatment of eschar abrasion, nanosilver dressing, and mussel mucin spray on wound healing in patients with second-degree burns, and to explore their effects on the expression level of (advanced glycation end products) AGEs in wound tissue, so as to provide a basis for the application of AGEs expression level in wound tissue in the future clinical treatment of second-degree burns. Methods: Patients with second-degree burns admitted to the Department of Burns and Plastic Surgery of the Second Affiliated Hospital of Shantou University Medical College from July 2023 to July 2024 were selected as the research subjects. This study was a non-double-blind study, and both patients and researchers were aware of the treatment methods. They were randomly divided into Group A (control group) and Group B (study group). According to the order of their visits, the patients were numbered in advance;then the seed number was taken, and 70 random numbers were generated on the computer using SAS, the first 35 corresponding to group A, and the last 35 corresponding to group B;the random numbers were arranged from small to large, and the rank of the random numbers was the patient number;finally, the patient numbers were arranged from small to large, and the corresponding groups were the grouping scheme. 1) Wound healing time: The wound healing was observed every day, and the wound healing time was calculated when the wound was completely epithelialized. 2) Wound healing: The wound healing area was measured 1, 7, and 14 days after treatment, and transparent paper was used to record combined with a computer-assisted imaging system. Wound healing rate = wound healing area (cm2)/total wound area before treatment (cm2) × 100%. The time for complete wound healing was recorded in the two groups of patients. 3) Pain: The pain was evaluated at 1, 7, and 14 days after treatment using the visual analogue scale (VAS). The higher the score, the more severe the pain. 4) Scar condition: Scar formation was evaluated 1, 3, and 6 months after wound healing using the VAS scale, with a total score of 15 points. The higher the score, the more severe the scar. 5) Detect the expression of AGEs in wound tissue. Results: The wound healed 14.03 ± 2.28 days after eschar removal, with a cure rate of 97.8%. No infection occurred in the wound after eschar removal in all patients. The wound healing time ranged from 9 to 23 days, with an average healing time of 28.41 ± 1.45 days. The healing quality was satisfactory. The Vancouver Scar Scale scored the wound healing scar as 0.81 ± 0.73 points. Western blot was used to detect the expression of AGEs, (receptor for advanced glycation end products) RAGE, and protein in the wound tissue. Results After 7, 14, and 28 days of medication, the wounds of diabetic patients healed well. The drug treatment efficacy and hydroxyproline content showed an upward trend, and the expression levels of AGEs, RAGE, and HIF-1a proteins showed a downward trend. Compared with day 0, the hydroxyproline content of the wound granulation tissue on days 7, 14, and 28 was significantly increased (P< 0.01), and the expression levels of AGEs, RAGE, and HIF-1α proteins were significantly downregulated (P< 0.05 or P< 0.01). Conclusion: Monitoring the expression levels of AGEs and RAGE can reflect the wound-healing effect of patients with second-degree burns, and the prognosis of the wound is closely related to the expression levels of AGEs, RAGE, and scab abrasion. In the treatment of second-degree burn wounds, scab abrasion can grasp the level of necrotic scab removal, can achieve “relatively accurate” removal of necrotic tissue, maximally protect the ecological tissue between wounds and retaining normal tissue, and can play a positive role in promoting the healing process of burn wounds;at the same time, nanosilver dressings have good antibacterial properties and high safety, and mussel mucin has anti-inflammatory and antioxidant activities and the characteristics of blocking nerve endings, which can effectively relieve the burning, stinging, and itching of sensitive skin and effectively promote wound healing.
文摘This study aimed to compare the complications of preterm twins versus singletons and analyze differences across gestational ages.Preterm twins delivered between 2 March 2022 and 6 November 2022 were compared to an age-matched control group of singletons,involving 65 twins and 103 singletons.The most common complication in premature infants was neonatal jaundice(87.72%),followed by patent foramen ovale(79.76%)and neonatal respiratory distress syndrome(NRDS)(57.14%).Twins had significantly higher Apgar scores at 1,5,and 10 minutes compared to singletons.However,twins showed a higher incidence of ventricular septal defect(VSD)(7.69%)than singletons,with a statistically significant difference.In contrast,twins exhibited significantly lower rates of neonatal jaundice(78.46%),electrolyte imbalance(18.4%),and acid-base imbalance(9.23%)compared to singletons.Furthermore,as gestational age increased,the incidence of intrauterine infection,electrolyte and acid-base imbalances,neonatal coagulation disorders,patent ductus arteriosus(PDA),anemia,and NRDS in preterm infants gradually decreased,with all differences reaching statistical significance(P<0.05).These findings highlight the importance of close monitoring and timely management of complications in premature infants to prevent severe outcomes.
基金the Natural Science Foundation of Chongqing(No.cstb2022nscq-msx1575)the Science and Technology Research Program of Chongqing Municipal Education Commission(Nos.KJQN202201512,KJQN202001523 and KJZD-M202101501)+1 种基金the Chongqing University of Science and Technology Research Funding Projects(Nos.CKRC2022019 and CKRC2019042)the Open Foundation of the Chongqing Key Laboratory for Oil and Gas Production Safety and Risk Control(No.cqsrc202113)。
文摘Brain age is an effective biomarker for diagnosing Alzheimer’s disease(AD).Aimed at the issue that the existing brain age detection methods are inconsistent with the biological hypothesis that AD is the accelerated aging of the brain,a mutual information—support vector regression(MI-SVR)brain age prediction model is proposed.First,the age deviation is introduced according to the biological hypothesis of AD.Second,fitness function is designed based on mutual information criterion.Third,support vector regression and fitness function are used to obtain the predicted brain age and fitness value of the subjects,respectively.The optimal age deviation is obtained by maximizing the fitness value.Finally,the proposed method is compared with some existing brain age detection methods.Experimental results show that the brain age obtained by the proposed method has better separability,can better reflect the accelerated aging of AD,and is more helpful for improving the diagnostic accuracy of AD.
基金Funded by the National Natural Science Foundation of China(No.51878227)。
文摘Microstructures and properties of mortar using ammonium phosphate and potassium phosphate were tested and compared in this case.Moreover,two cementitious additions and two lightweight aggregates,including fly ash,redispersible latex powder,ceramsite sand,and rubber powder,were respectively tried to be applied in magnesium ammonium phosphate cement mortar in order to modify the microstructures and properties.The experimental results show that potassium phosphate is not suitable for magnesium phosphate cement mortar for cold region construction purpose.Although fly ash can bring positive modification in the condition of normal temperature curing,it brings negative effects in the condition of sub-zero temperature curing.Either redispersible latex powder or ceramsite sand can improve the freeze-thaw cycling resistance of magnesium phosphate cement mortar in the conditions of low temperature coupled with freeze-thaw cycling,but only the ceramsite sand can improve both mechanical properties and freeze-thaw cycling resistance.The modification caused by ceramsite sand is mainly due to the exceptional bonding strength between hardened cement paste and the porous surface of ceramsite and the porous structure of ceramsite for the release of frost heave stress.
基金Inner Mongolia Natural Science Foundation of China(Project No.:2023QN01015).
文摘Traditional educational paradigms prioritize age-based progression and early specialization as key indicators of academic potential,especially in STEM.This study challenges this norm by analyzing university entrance ages of 226 Nobel Physics Laureates(1901-2024).Results reveal a right-skewed distribution(Median=18;Mean=18.8;SD=2.4)with substantial variance(14-25 years),including outliers like Lev Landau(14)and Arthur Ashkin(24).Notably,figures such as Guglielmo Marconi achieved breakthroughs without formal university entry,relying on self-directed learning.Using survival analysis and multinomial regression,we find“non-traditional”timelines,accelerated,delayed,or non-formal pathways,correlate with distinct creative advantages.This suggests current“timeliness”metrics poorly predict transformative scientific achievement.We propose an“Optimal Chrono-Diversity”framework advocating flexible entry systems,enhanced adult learner support,and recognition of autodidactic potential to inform educational policy and cultivate innovative STEM talent.
