Cyclometallated platinum(Ⅱ)complexes,[(C^N^N)Pt^(Ⅱ)(L)]^(n+)(n=0 or 1),have attracted much attention due to their potency as luminescent probes for nucleic acids and anticancer agents.Reported herein are four[(C^N^N...Cyclometallated platinum(Ⅱ)complexes,[(C^N^N)Pt^(Ⅱ)(L)]^(n+)(n=0 or 1),have attracted much attention due to their potency as luminescent probes for nucleic acids and anticancer agents.Reported herein are four[(C^N^N)Pt^(Ⅱ)(L)]^(+)complexes(5-8,L=4-anilinoquinazoline derivative)which exhibit a weak fluorescence emission over 605 to 627 nm upon excitation at 405 nm.The ligation of the cyclometallated platinum cores with EGFR-inhibiting anilinoquinazolines not only confers the resulting complexes with excellent EGFR-inhibiting potency with IC_(50)values at the nanomolar level.展开更多
基金NSFC(Grant No.21135006,21127901,21575145 and 21621062)the 973 Program of MOST(2013CB531805)for supportProf.Dihua Shangguan and Dr Tao Bing at the Institute of Chemistry,Chinese Academy of Sciences for the gift of the Pu27 quadruplex DNA and BPBC fluorescence probe.
文摘Cyclometallated platinum(Ⅱ)complexes,[(C^N^N)Pt^(Ⅱ)(L)]^(n+)(n=0 or 1),have attracted much attention due to their potency as luminescent probes for nucleic acids and anticancer agents.Reported herein are four[(C^N^N)Pt^(Ⅱ)(L)]^(+)complexes(5-8,L=4-anilinoquinazoline derivative)which exhibit a weak fluorescence emission over 605 to 627 nm upon excitation at 405 nm.The ligation of the cyclometallated platinum cores with EGFR-inhibiting anilinoquinazolines not only confers the resulting complexes with excellent EGFR-inhibiting potency with IC_(50)values at the nanomolar level.
