In this paper, the existence of periodic solutions for a time dependent age-structured population model is studied. The averaged net reproductive number is introduced as the main parameter to determine the dynamical b...In this paper, the existence of periodic solutions for a time dependent age-structured population model is studied. The averaged net reproductive number is introduced as the main parameter to determine the dynamical behaviors of the model. The existence of a global parameterized branch of periodic solutions of the model is obtained by using the contracting mapping theorem in a periodic and continuous function space. The global stability of the trivial equilibrium is studied and a very practical stability criteria for the model is obtained. The dynamics of the linear time-periodic model is similar to that of the linear model.展开更多
In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asy...In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting.展开更多
Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigat...Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigates the muscle strength performance(MSP)of 289 adult and teenage CA,exercisers,and physically inactive individuals(PI),and proposes predictive models of MSP for adults.Methods:Muscle maximal,speed,and explosive strength(MMS/MSS/MES)at unilateral maximal concentric flexion and extension contraction(FC/EC)were evaluated using Biodex System 3 PRO^(TM)at 60°/s,180°/s,and 300°/s,while additional performance markers were assessed through field ergometric testing.Participants were interviewed about their lifestyle,dietary habits,physical activity,injury,and medical history.Body composition was assessed via bioelectrical impedance.gDNA was extracted from biochemical samples and then genotyped.Statistical analysis was conducted using IBM SPSS Statistics v21.0 and R.Results:Age,fitness,and sex impacted correlations of MSP with body composition and anthropometric measurements(p<0.05).Among CA,females outperformed males in accuracy(p<0.001)while,males outperformed females in anaerobic power,MSP,speed,and endurance(p<0.001).Adult CA outperformed exercisers and PI in MMS,MSS,and MES(p<0.05).Multiple linear regression models,with predictors age,FFM,body extremity,training load explained the majority of variation in MMS(R^(2)_(adj):71.4%–88.9%),MSS(R^(2)_(adj):64.8%–78.4%),and MES(R^(2)_(adj):52.7%–68.4%)at EC,FC,and their mean(p<0.001).Conclusions:Muscle-strengthening strategies should be customized according to individual fitness levels,body composition,and anthropometric measurements.The innovative sex-specific regression models assessing MMS,MSS,and MES at EC and FC provide a framework for personalizing rehabilitation and skill-specific training strategies.展开更多
This paper presents a novel analysis for the solution of nonlinear age-structured prob- lem which is of extreme importance in biological sciences. The presented model is very useful but quite complicated. Modified var...This paper presents a novel analysis for the solution of nonlinear age-structured prob- lem which is of extreme importance in biological sciences. The presented model is very useful but quite complicated. Modified variational iteration method （MVIM） coupled with auxiliary parameter is used to cope with the complexity of the model which subse- quently shows better results as compared to some existing results available in literature. Furthermore, an appropriate way is used for the identification of auxiliary parameter by means of residual function. Numerical examples are presented for the analysis of the pro- posed algorithm. Graphical results along with the discussions re-confirm the efficiency of proposed algorithm. The work proposes a new algorithm where He＇s polynomials and an auxiliary parameter are merged with correction functional. The suggested scheme is implemented on nonlinear age-structured population models. Graphs are plotted for the residual function that reflects the accuracy and convergence of the presented algorithm.展开更多
In this study, Haar wavelet method is implemented for solving the nonlinear age- structured population model which is the nonclassic type of partial differential equation associated with boundary integral equation. Th...In this study, Haar wavelet method is implemented for solving the nonlinear age- structured population model which is the nonclassic type of partial differential equation associated with boundary integral equation. This paper develops the flexibility of Haar wavelet method for reduction of the partial differential equation with nonlocal boundary conditions to an algebraic system. In fact, the simple structure of piecewise orthogonM Haar basis functions which leads to sparse matrices causes the convergence and com- putational efficiency. Some illustrative results show the reliability and accuracy of the presented method.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
Bangladesh has a denser population in comparison with many other countries. Though the rate of population increase has been regarded as a concerning issue, estimation of the population instability in the upcoming year...Bangladesh has a denser population in comparison with many other countries. Though the rate of population increase has been regarded as a concerning issue, estimation of the population instability in the upcoming years may be useful for national planning. To predict Bangladesh’s future population, this study compares the estimated populations of two popular population models, the Malthusian and the logistic population models, with the country’s census population published by BBS. We also tried to find out which model gives a better approximation for forecasting the past, present, and future population between these two models.展开更多
The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dis...The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments.展开更多
Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the tra...Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the transmission dynamics and population dynamics with consideration of the impact of both of the changing number of online social network users and different levels of user activity. We numerically simulate the rumor spreading process. The results of numerical simulation show that the improved SIS model can successfully characterize the rumor spreading behavior in online social networks. We also give the effective strategies of curbing the rumor spreading in online social networks.展开更多
In this paper, the Adomian＇s decomposition method （ADM） is presented for finding the exact solutions of a more general biological population models. A new solution is constructed in power series. The fractional der...In this paper, the Adomian＇s decomposition method （ADM） is presented for finding the exact solutions of a more general biological population models. A new solution is constructed in power series. The fractional derivatives are described in the Caputo sense. To illustrate the reliability of the method, some examples are provided.展开更多
The spatialization of population of counties in China is significant. Firstly, we can gain the estimated values of population density adaptive to different kinds of regions. Secondly, we can integrate effectively popu...The spatialization of population of counties in China is significant. Firstly, we can gain the estimated values of population density adaptive to different kinds of regions. Secondly, we can integrate effectively population data with other data including natural resources, environment, society and economy, build 1km GRIDs of natural resources reserves per person, population density and other economic and environmental data, which are necessary to the national management and macro adjustment and control of natural resources and dynamic monitoring of population. In order to establish population information system serving national decision making, three steps ought to be followed:1) establishing complete geographical spatial data foundation infrastructure including the establishment of electric map of residence with high resolution using topographical map with large scale and high resolution satellite remote sensing data, the determination of attribute information of housing and office buildings, and creating complete set of attribute database and rapid data updating; 2) establishing complete census systems including improving the transformation efficiency from census data to digital database and strengthening the link of census database and geographical spatial database, meanwhile, the government should attach great importance to the establishment and integration of population migration database; 3) considering there is no GIS software specially serving the analysis and management of population data, a practical approach is to add special modules to present software system, which works as a bridge actualizing the digitization and spatialization of population geography research.展开更多
Epilepsy is believed to be caused by a lack of balance between excitation and inhibitation in the brain. A promising strategy for the control of the disease is closed-loop brain stimulation. How to determine the stimu...Epilepsy is believed to be caused by a lack of balance between excitation and inhibitation in the brain. A promising strategy for the control of the disease is closed-loop brain stimulation. How to determine the stimulation control parameters for effective and safe treatment protocols remains, however, an unsolved question. To constrain the complex dynamics of the biological brain, we use a neural population model（NPM）. We propose that a proportional-derivative（PD） type closed-loop control can successfully suppress epileptiform activities. First, we determine the stability of root loci, which reveals that the dynamical mechanism underlying epilepsy in the NPM is the loss of homeostatic control caused by the lack of balance between excitation and inhibition. Then, we design a PD type closed-loop controller to stabilize the unstable NPM such that the homeostatic equilibriums are maintained; we show that epileptiform activities are successfully suppressed. A graphical approach is employed to determine the stabilizing region of the PD controller in the parameter space, providing a theoretical guideline for the selection of the PD control parameters. Furthermore, we establish the relationship between the control parameters and the model parameters in the form of stabilizing regions to help understand the mechanism of suppressing epileptiform activities in the NPM. Simulations show that the PD-type closed-loop control strategy can effectively suppress epileptiform activities in the NPM.展开更多
Length-frequency data of eight commercial fish species in the Beibu Gulf （Golf of Tonkin）, northern South China Sea, were collected during 2006-2007. Length-weight relationships and growth and mortality parameters w...Length-frequency data of eight commercial fish species in the Beibu Gulf （Golf of Tonkin）, northern South China Sea, were collected during 2006-2007. Length-weight relationships and growth and mortality parameters were analyzed using FiSAT II software. Five species had isometric growth, two species had negative allometric growth, and one species had positive allometric growth. Overall, the exploitation rates of the eight species were lower in 2006 2007 than in 1997-1999： for four species （Saurida tumbil, Saurida undosquamis, Argyrosomus macrocephalus, and Nemipterus virgatus） it was lower in 2006-2007 than in 1997 1999, for two species （Parargyrops edita and Trichiurus haumela） it remained the same, and for the other two species （Trachurus japonicus and Decapterus maruadsi） it was higher in 2006~007 than in 1997-1999. The exploitation rates might have declined because of the decline in fishing intensity caused by high crude oil prices. The optimum exploitation rate, estimated using Beverton-Holt dynamic pool models, indicated that although fishes in the Beibu Gulf could sustain high exploitation rates, the under-size fishes at first capture resulted in low yields. To increase the yield per recruitment, it is more effective to increase the size at first capture than to control fishing effort.展开更多
Based on the infectious disease model with disease latency, this paper proposes a new model for the rumor spreading process in online social network. In this paper what we establish an SEIR rumor spreading model to de...Based on the infectious disease model with disease latency, this paper proposes a new model for the rumor spreading process in online social network. In this paper what we establish an SEIR rumor spreading model to describe the online social network with varying total number of users and user deactivation rate. We calculate the exact equilibrium points and reproduction number for this model. Furthermore, we perform the rumor spreading process in the online social network with increasing population size based on the original real world Facebook network. The simulation results indicate that the SEIR model of rumor spreading in online social network with changing total number of users can accurately reveal the inherent characteristics of rumor spreading process in online social network.展开更多
Hepatocellular carcinoma （HCC） is a malignant disease with limited therapeutic options due to its aggressive progression. It places heaW burden on most low and middle income countries to treat HCC patients. Nowadays...Hepatocellular carcinoma （HCC） is a malignant disease with limited therapeutic options due to its aggressive progression. It places heaW burden on most low and middle income countries to treat HCC patients. Nowadays accurate HCC risk predictions can help making decisions on the need for HCC surveillance and antiviral therapy. HCC risk prediction models based on major risk factors of HCC are useful and helpful in providing adequate surveillance strategies to individuals who have different risk levels. Several risk prediction models among cohorts of different populations for estimating HCC incidence have been presented recently by using simple, efficient, and ready-to-use parameters. Moreover, using predictive scoring systems to assess HCC development can provide suggestions to improve clinical and public health approaches, making them more cost-effective and effort-effective, for inducing personalized surveillance programs according to risk stratification. In this review, the features of risk prediction models of HCC across different populations were summarized, and the perspectives of HCC risk prediction models were discussed as well.展开更多
In this study,based on the Luo bubble coalescence model,a model correction factor C_e for pressures according to the literature experimental results was introduced in the bubble coalescence efficiency term.Then,a coup...In this study,based on the Luo bubble coalescence model,a model correction factor C_e for pressures according to the literature experimental results was introduced in the bubble coalescence efficiency term.Then,a coupled modified population balance model(PBM) with computational fluid dynamics(CFD) was used to simulate a high-pressure bubble column.The simulation results with and without C_e were compared with the experimental data.The modified CFD-PBM coupled model was used to investigate its applicability to broader experimental conditions.These results showed that the modified CFD-PBM coupled model can predict the hydrodynamic behaviors under various operating conditions.展开更多
The population balance modeling is regarded as a universally accepted mathematical framework for dynamic simulation of various particulate processes, such as crystallization, granulation and polymerization. This artic...The population balance modeling is regarded as a universally accepted mathematical framework for dynamic simulation of various particulate processes, such as crystallization, granulation and polymerization. This article is concerned with the application of the method of characteristics (MOC) for solving population balance models describing batch crystallization process. The growth and nucleation are considered as dominant phenomena, while the breakage and aggregation are neglected. The numerical solutions of such PBEs require high order accuracy due to the occurrence of steep moving fronts and narrow peaks in the solutions. The MOC has been found to be a very effective technique for resolving sharp discontinuities. Different case studies are carried out to analyze the accuracy of proposed algorithm. For validation, the results of MOC are compared with the available analytical solutions and the results of finite volume schemes. The results of MOC were found to be in good agreement with analytical solutions and superior than those obtained by finite volume schemes.展开更多
The soybean aphid, Aphis glycines Matsumura(Hemiptera: Aphididae), is one of the greatest threats to soybean production, and both trend analysis and periodic analysis of its population dynamics are important for integ...The soybean aphid, Aphis glycines Matsumura(Hemiptera: Aphididae), is one of the greatest threats to soybean production, and both trend analysis and periodic analysis of its population dynamics are important for integrated pest management(IPM). Based on systematically investigating soybean aphid populations in the field from 2018 to 2020, this study adopted the inverse logistic model for the first time, and combined it with the classical logistic model to describe the changes in seasonal population abundance from colonization to extinction in the field. Then, the increasing and decreasing phases of the population fluctuation were divided by calculating the inflection points of the models, which exhibited distinct seasonal trends of the soybean aphid populations in each year. In addition, multifactor logistic models were then established for the first time, in which the abundance of soybean aphids in the field changed with time and relevant environmental conditions. This model enabled the prediction of instantaneous aphid abundance at a given time based on relevant meteorological data. Taken as a whole, the successful approaches implemented in this study could be used to build a theoretical framework for practical IPM strategies for controlling soybean aphids.展开更多
In this paper, the qualitative behavior of solutions of the bobwhite quail pop-ulation modelwhere 0<a < 1 < a + 6,p, c ∈ (0, ∞) and k is a nonnegative integer, is investigated. Some necessary and sufficient...In this paper, the qualitative behavior of solutions of the bobwhite quail pop-ulation modelwhere 0<a < 1 < a + 6,p, c ∈ (0, ∞) and k is a nonnegative integer, is investigated. Some necessary and sufficient as well as sufficient conditions for all solutions of the model to oscillate and some sufficient conditions for all positive solutions of the model to be nonoscillatory and the convergence of nonoscillatory solutions are derived. Furthermore, the permanence of every positive solution of the model is also showed. Many known results are improved and extended and some new results are obtained for G. Ladas' open problems.展开更多
Existing quantitative migration studies are mainly at the inter-region or inter-province level for lacking of detailed geo-referenced migration data.Meanwhile,few of them integrate explorative spatial data analysis an...Existing quantitative migration studies are mainly at the inter-region or inter-province level for lacking of detailed geo-referenced migration data.Meanwhile,few of them integrate explorative spatial data analysis and spatial regression model into migration analysis.Based on aggregated registered floating population data from 2005 to 2008,the phenomena that population floating to Yiwu City in Zhejiang Province is analyzed at the provincial and county levels.The spatial layout of Yiwu's pull forces is proved as a V-shaped pattern excluding Sichuan Province based on map visualization method.Using the migration ratio in 2007 as an explanatory variable,two models are compared using ordinary least square,spatial error model and spatial lag model methods for county-level data in Jiangxi and Anhui provinces.The model with migration stock provides an improved fitting over the model without migration stock according to the model fitting results.The floating population flocking into Yiwu City from Jiangxi is determined mostly by migration stock while the determinant factors are migration stock and distance to Yiwu City for Anhui.The distance-decay effect is true for migration flow from Anhui to Yiwu City while the distance rule is not confirmed in Jiangxi with the best fitting model.The correlation between per capita net income of rural labor forces and migration ratio is not significant in Jiangxi and significant but at the 0.1 level only in Anhui.Further analysis shows that the distance,income and man-land ratio are important factors to explain population floating at earlier stage.However,as the dynamic population floating process evolves,the determinant factor would be migration stock.展开更多
文摘In this paper, the existence of periodic solutions for a time dependent age-structured population model is studied. The averaged net reproductive number is introduced as the main parameter to determine the dynamical behaviors of the model. The existence of a global parameterized branch of periodic solutions of the model is obtained by using the contracting mapping theorem in a periodic and continuous function space. The global stability of the trivial equilibrium is studied and a very practical stability criteria for the model is obtained. The dynamics of the linear time-periodic model is similar to that of the linear model.
基金Supported by the National Natural Science Foundation of China(12261018)Universities Key Laboratory of Mathematical Modeling and Data Mining in Guizhou Province(2023013)。
文摘In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting.
文摘Purpose:ATLAS is a cross-sectional study aiming to investigate environmental and genetic determinants of athletic performance in healthy Greek competitive athletes(CA).This article presents the study design,investigates the muscle strength performance(MSP)of 289 adult and teenage CA,exercisers,and physically inactive individuals(PI),and proposes predictive models of MSP for adults.Methods:Muscle maximal,speed,and explosive strength(MMS/MSS/MES)at unilateral maximal concentric flexion and extension contraction(FC/EC)were evaluated using Biodex System 3 PRO^(TM)at 60°/s,180°/s,and 300°/s,while additional performance markers were assessed through field ergometric testing.Participants were interviewed about their lifestyle,dietary habits,physical activity,injury,and medical history.Body composition was assessed via bioelectrical impedance.gDNA was extracted from biochemical samples and then genotyped.Statistical analysis was conducted using IBM SPSS Statistics v21.0 and R.Results:Age,fitness,and sex impacted correlations of MSP with body composition and anthropometric measurements(p<0.05).Among CA,females outperformed males in accuracy(p<0.001)while,males outperformed females in anaerobic power,MSP,speed,and endurance(p<0.001).Adult CA outperformed exercisers and PI in MMS,MSS,and MES(p<0.05).Multiple linear regression models,with predictors age,FFM,body extremity,training load explained the majority of variation in MMS(R^(2)_(adj):71.4%–88.9%),MSS(R^(2)_(adj):64.8%–78.4%),and MES(R^(2)_(adj):52.7%–68.4%)at EC,FC,and their mean(p<0.001).Conclusions:Muscle-strengthening strategies should be customized according to individual fitness levels,body composition,and anthropometric measurements.The innovative sex-specific regression models assessing MMS,MSS,and MES at EC and FC provide a framework for personalizing rehabilitation and skill-specific training strategies.
文摘This paper presents a novel analysis for the solution of nonlinear age-structured prob- lem which is of extreme importance in biological sciences. The presented model is very useful but quite complicated. Modified variational iteration method （MVIM） coupled with auxiliary parameter is used to cope with the complexity of the model which subse- quently shows better results as compared to some existing results available in literature. Furthermore, an appropriate way is used for the identification of auxiliary parameter by means of residual function. Numerical examples are presented for the analysis of the pro- posed algorithm. Graphical results along with the discussions re-confirm the efficiency of proposed algorithm. The work proposes a new algorithm where He＇s polynomials and an auxiliary parameter are merged with correction functional. The suggested scheme is implemented on nonlinear age-structured population models. Graphs are plotted for the residual function that reflects the accuracy and convergence of the presented algorithm.
文摘In this study, Haar wavelet method is implemented for solving the nonlinear age- structured population model which is the nonclassic type of partial differential equation associated with boundary integral equation. This paper develops the flexibility of Haar wavelet method for reduction of the partial differential equation with nonlocal boundary conditions to an algebraic system. In fact, the simple structure of piecewise orthogonM Haar basis functions which leads to sparse matrices causes the convergence and com- putational efficiency. Some illustrative results show the reliability and accuracy of the presented method.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
文摘Bangladesh has a denser population in comparison with many other countries. Though the rate of population increase has been regarded as a concerning issue, estimation of the population instability in the upcoming years may be useful for national planning. To predict Bangladesh’s future population, this study compares the estimated populations of two popular population models, the Malthusian and the logistic population models, with the country’s census population published by BBS. We also tried to find out which model gives a better approximation for forecasting the past, present, and future population between these two models.
基金the National Natural Science Foundation of China (No. 81173009)the Technology Bureau in Shenyang (No. ZCJJ2013402)the Project for New Century Excellent Talents of Ministry of Education (No. NCET-12-1015)
文摘The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments.
基金Supported by National Natural Science Foundation of China under Grant Nos.11275017 and 11173028
文摘Based on the characteristics of rumor spreading in online social networks, this paper proposes a new rumor spreading model. This is an improved SIS rumor spreading model in online social networks that combines the transmission dynamics and population dynamics with consideration of the impact of both of the changing number of online social network users and different levels of user activity. We numerically simulate the rumor spreading process. The results of numerical simulation show that the improved SIS model can successfully characterize the rumor spreading behavior in online social networks. We also give the effective strategies of curbing the rumor spreading in online social networks.
文摘In this paper, the Adomian＇s decomposition method （ADM） is presented for finding the exact solutions of a more general biological population models. A new solution is constructed in power series. The fractional derivatives are described in the Caputo sense. To illustrate the reliability of the method, some examples are provided.
文摘The spatialization of population of counties in China is significant. Firstly, we can gain the estimated values of population density adaptive to different kinds of regions. Secondly, we can integrate effectively population data with other data including natural resources, environment, society and economy, build 1km GRIDs of natural resources reserves per person, population density and other economic and environmental data, which are necessary to the national management and macro adjustment and control of natural resources and dynamic monitoring of population. In order to establish population information system serving national decision making, three steps ought to be followed:1) establishing complete geographical spatial data foundation infrastructure including the establishment of electric map of residence with high resolution using topographical map with large scale and high resolution satellite remote sensing data, the determination of attribute information of housing and office buildings, and creating complete set of attribute database and rapid data updating; 2) establishing complete census systems including improving the transformation efficiency from census data to digital database and strengthening the link of census database and geographical spatial database, meanwhile, the government should attach great importance to the establishment and integration of population migration database; 3) considering there is no GIS software specially serving the analysis and management of population data, a practical approach is to add special modules to present software system, which works as a bridge actualizing the digitization and spatialization of population geography research.
基金supported by the National Natural Science Foundation of China(Grant Nos.61473208,61025019,and 91132722)ONR MURI N000141010278NIH grant R01EY016281
文摘Epilepsy is believed to be caused by a lack of balance between excitation and inhibitation in the brain. A promising strategy for the control of the disease is closed-loop brain stimulation. How to determine the stimulation control parameters for effective and safe treatment protocols remains, however, an unsolved question. To constrain the complex dynamics of the biological brain, we use a neural population model（NPM）. We propose that a proportional-derivative（PD） type closed-loop control can successfully suppress epileptiform activities. First, we determine the stability of root loci, which reveals that the dynamical mechanism underlying epilepsy in the NPM is the loss of homeostatic control caused by the lack of balance between excitation and inhibition. Then, we design a PD type closed-loop controller to stabilize the unstable NPM such that the homeostatic equilibriums are maintained; we show that epileptiform activities are successfully suppressed. A graphical approach is employed to determine the stabilizing region of the PD controller in the parameter space, providing a theoretical guideline for the selection of the PD control parameters. Furthermore, we establish the relationship between the control parameters and the model parameters in the form of stabilizing regions to help understand the mechanism of suppressing epileptiform activities in the NPM. Simulations show that the PD-type closed-loop control strategy can effectively suppress epileptiform activities in the NPM.
基金Supported by the Chinese Ministry of Agriculture under the Investigation of Fishery Stocks in China Seas Program (No. 070404)the Special Project of the Social Commonwealth Research National Institute (Nos.2009TS08, 2010YD10)
文摘Length-frequency data of eight commercial fish species in the Beibu Gulf （Golf of Tonkin）, northern South China Sea, were collected during 2006-2007. Length-weight relationships and growth and mortality parameters were analyzed using FiSAT II software. Five species had isometric growth, two species had negative allometric growth, and one species had positive allometric growth. Overall, the exploitation rates of the eight species were lower in 2006 2007 than in 1997-1999： for four species （Saurida tumbil, Saurida undosquamis, Argyrosomus macrocephalus, and Nemipterus virgatus） it was lower in 2006-2007 than in 1997 1999, for two species （Parargyrops edita and Trichiurus haumela） it remained the same, and for the other two species （Trachurus japonicus and Decapterus maruadsi） it was higher in 2006~007 than in 1997-1999. The exploitation rates might have declined because of the decline in fishing intensity caused by high crude oil prices. The optimum exploitation rate, estimated using Beverton-Holt dynamic pool models, indicated that although fishes in the Beibu Gulf could sustain high exploitation rates, the under-size fishes at first capture resulted in low yields. To increase the yield per recruitment, it is more effective to increase the size at first capture than to control fishing effort.
基金Supported by National Natural Science Foundation of China under Grant Nos.11275017 and 11173028
文摘Based on the infectious disease model with disease latency, this paper proposes a new model for the rumor spreading process in online social network. In this paper what we establish an SEIR rumor spreading model to describe the online social network with varying total number of users and user deactivation rate. We calculate the exact equilibrium points and reproduction number for this model. Furthermore, we perform the rumor spreading process in the online social network with increasing population size based on the original real world Facebook network. The simulation results indicate that the SEIR model of rumor spreading in online social network with changing total number of users can accurately reveal the inherent characteristics of rumor spreading process in online social network.
基金supported by funds from the National Key Basic Research Program "973 project" (2015CB554000)the State Key Project Specialized for Infectious Diseases of China (No.2008ZX10002-015 and 2012ZX10002008-002)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No.81421001)
文摘Hepatocellular carcinoma （HCC） is a malignant disease with limited therapeutic options due to its aggressive progression. It places heaW burden on most low and middle income countries to treat HCC patients. Nowadays accurate HCC risk predictions can help making decisions on the need for HCC surveillance and antiviral therapy. HCC risk prediction models based on major risk factors of HCC are useful and helpful in providing adequate surveillance strategies to individuals who have different risk levels. Several risk prediction models among cohorts of different populations for estimating HCC incidence have been presented recently by using simple, efficient, and ready-to-use parameters. Moreover, using predictive scoring systems to assess HCC development can provide suggestions to improve clinical and public health approaches, making them more cost-effective and effort-effective, for inducing personalized surveillance programs according to risk stratification. In this review, the features of risk prediction models of HCC across different populations were summarized, and the perspectives of HCC risk prediction models were discussed as well.
基金Supported by the National Natural Science Foundation of China(91634101)The Project of Construction of Innovative TeamsTeacher Career Development for Universities and Colleges under Beijing Municipality(IDHT20180508)
文摘In this study,based on the Luo bubble coalescence model,a model correction factor C_e for pressures according to the literature experimental results was introduced in the bubble coalescence efficiency term.Then,a coupled modified population balance model(PBM) with computational fluid dynamics(CFD) was used to simulate a high-pressure bubble column.The simulation results with and without C_e were compared with the experimental data.The modified CFD-PBM coupled model was used to investigate its applicability to broader experimental conditions.These results showed that the modified CFD-PBM coupled model can predict the hydrodynamic behaviors under various operating conditions.
文摘The population balance modeling is regarded as a universally accepted mathematical framework for dynamic simulation of various particulate processes, such as crystallization, granulation and polymerization. This article is concerned with the application of the method of characteristics (MOC) for solving population balance models describing batch crystallization process. The growth and nucleation are considered as dominant phenomena, while the breakage and aggregation are neglected. The numerical solutions of such PBEs require high order accuracy due to the occurrence of steep moving fronts and narrow peaks in the solutions. The MOC has been found to be a very effective technique for resolving sharp discontinuities. Different case studies are carried out to analyze the accuracy of proposed algorithm. For validation, the results of MOC are compared with the available analytical solutions and the results of finite volume schemes. The results of MOC were found to be in good agreement with analytical solutions and superior than those obtained by finite volume schemes.
基金supported by the Chinese National Special Fund for Agro-scientific Research in the Public Interest (201003025 and 201103022)the National Key Research and Development Program of China (2018YFD0201004)the Discipline Construction Project of Liaoning Academy of Agricultural Sciences, China (2019DD082612)。
文摘The soybean aphid, Aphis glycines Matsumura(Hemiptera: Aphididae), is one of the greatest threats to soybean production, and both trend analysis and periodic analysis of its population dynamics are important for integrated pest management(IPM). Based on systematically investigating soybean aphid populations in the field from 2018 to 2020, this study adopted the inverse logistic model for the first time, and combined it with the classical logistic model to describe the changes in seasonal population abundance from colonization to extinction in the field. Then, the increasing and decreasing phases of the population fluctuation were divided by calculating the inflection points of the models, which exhibited distinct seasonal trends of the soybean aphid populations in each year. In addition, multifactor logistic models were then established for the first time, in which the abundance of soybean aphids in the field changed with time and relevant environmental conditions. This model enabled the prediction of instantaneous aphid abundance at a given time based on relevant meteorological data. Taken as a whole, the successful approaches implemented in this study could be used to build a theoretical framework for practical IPM strategies for controlling soybean aphids.
基金This work is supported by NNSFC(10071022), Mathemat- ical Tianyuan Foundation of China (TY10026002-01-05-03) Shanghai Priority Academic Discipline.
文摘In this paper, the qualitative behavior of solutions of the bobwhite quail pop-ulation modelwhere 0<a < 1 < a + 6,p, c ∈ (0, ∞) and k is a nonnegative integer, is investigated. Some necessary and sufficient as well as sufficient conditions for all solutions of the model to oscillate and some sufficient conditions for all positive solutions of the model to be nonoscillatory and the convergence of nonoscillatory solutions are derived. Furthermore, the permanence of every positive solution of the model is also showed. Many known results are improved and extended and some new results are obtained for G. Ladas' open problems.
基金Under the auspices of National Natural Science Foundation of China(No.41001314)Youth Science Funds of State Key Laboratory of Resources and Environmental Information System,Chinese Academy of Sciences(No.KA11040101)National Key Technology R&D Program of China(No.2012BAI32B07)
文摘Existing quantitative migration studies are mainly at the inter-region or inter-province level for lacking of detailed geo-referenced migration data.Meanwhile,few of them integrate explorative spatial data analysis and spatial regression model into migration analysis.Based on aggregated registered floating population data from 2005 to 2008,the phenomena that population floating to Yiwu City in Zhejiang Province is analyzed at the provincial and county levels.The spatial layout of Yiwu's pull forces is proved as a V-shaped pattern excluding Sichuan Province based on map visualization method.Using the migration ratio in 2007 as an explanatory variable,two models are compared using ordinary least square,spatial error model and spatial lag model methods for county-level data in Jiangxi and Anhui provinces.The model with migration stock provides an improved fitting over the model without migration stock according to the model fitting results.The floating population flocking into Yiwu City from Jiangxi is determined mostly by migration stock while the determinant factors are migration stock and distance to Yiwu City for Anhui.The distance-decay effect is true for migration flow from Anhui to Yiwu City while the distance rule is not confirmed in Jiangxi with the best fitting model.The correlation between per capita net income of rural labor forces and migration ratio is not significant in Jiangxi and significant but at the 0.1 level only in Anhui.Further analysis shows that the distance,income and man-land ratio are important factors to explain population floating at earlier stage.However,as the dynamic population floating process evolves,the determinant factor would be migration stock.
