<b><span>Background:</span></b><span> The patients’ age is considered a modified risk factor that causes periodontal disease, dental caries, and their development.</span><b...<b><span>Background:</span></b><span> The patients’ age is considered a modified risk factor that causes periodontal disease, dental caries, and their development.</span><b><span> Objective:</span></b><span> The present study was designed to evaluate the impact of salivary pH value and dental caries index on periodontal status among adult age groups of patients from Aseer region, Saudi Arabia</span><span>.</span><span> </span><b><span>Methods:</span></b><span> A cross-sectional analysi</span><span>s carried out in the college of dentistry, King Khalid University on 750 </span><span>adult patients (400 males and 350 females). The adults patients were divided into three equal groups according to the patients’ age: group I (20 - 30 years), group I</span><span>I (31 - 40 years), and group III (41 - 50 years).</span><span> </span><span>Plaque index (PLI), gingi</span><span>val index (GI), clinical attachment loss (CAL), and the dental caries index (DMFT)</span><span> recorded as w</span><span>ell as salivary pH. All findings collected, then analyzed by an</span><span> ANOVA test and the t</span><span>-test. A p-value at <0.05 was considered a statistical significance level.</span><span> </span><b><span>R</span></b><b><span>esults:</span></b><b><span> </span></b><span>The clinical findings of the current study showed that there were statistically significant differences in the patients’ age of both males and females. Moreover, there were statistically significant diffe</span><span>rences in GI. On the other hand, there were highly statistically significant differences in PLI and DMFS, but there were no significant differences</span><span> in CAL of both males and females </span><span>Moreover, there were no statistically significant differences in salivary pH</span><span>.</span><span> </span><b><span>Conclusion:</span></b><span> We concluded that DMFT Index correlated to periodontal and oral hea</span><span>lth status and, it increased with the progression of the pat</span><span>ient’s age and</span><span> can be used in the epidemiological evaluation of periodontal and o</span><span>ral health status.展开更多
A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,t...A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.展开更多
The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, the elderly have compromised immune systems and often suffer from chronic underly...The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, the elderly have compromised immune systems and often suffer from chronic underlying diseases, which makes them more vulnerable. This study aims to assess variation in COVID-19 vaccine distribution patterns across different age groups in European countries and to understand the extent to which European countries have prioritized vulnerable age groups (age > 70) in their vaccination programs. The study utilized open data from the European Center for Disease Prevention and Control (ECDC) and employed an observational, retrospective study design to examine the distribution of the COVID-19 vaccine among various age groups in several European countries from September 2021 to September 2023. Results reveal that vaccination rates increase with age, peaking at the 25 - 49 age group (1.34 × 10−4), after which there was a decline in vaccination rate. Analysis of variance (ANOVA) was used to investigate the equality of vaccination rates across the 29 countries in Europe, which resulted in a p-value of 70) during the study period as no country achieved the 70% coverage aimed by WHO. Continuous efforts must be made to ensure larger coverage of COVID-19 vaccination among this vulnerable population in order to protect them from severe outcomes in this region.展开更多
Introduction:Multivariate time series prediction of infectious diseases is significant to public health,and the deep learning method has attracted increasing attention in this research field.Material and methods:An ad...Introduction:Multivariate time series prediction of infectious diseases is significant to public health,and the deep learning method has attracted increasing attention in this research field.Material and methods:An adaptively temporal graph convolution(ATGCN)model,which leams the contact patterns of multiple age groups in a graph-based approach,was proposed for COVID-19 and influenza prediction.We compared ATGCN with autoregressive models,deep sequence learning models,and experience-based ATGCN models in short-term and long-term prediction tasks.Results:Results showed that the ATGCN model performed better than the autoregressive models and the deep sequence learning models on two datasets in both short-term(12.5%and 10%improvements on RMSE)and longterm(12.4%and 5%improvements on RMSE)prediction tasks.And the RMSE of ATGCN predictions fluctuated least in different age groups of COVID-19(0.029±0.003)and influenza(0.059±0.008).Compared with the Ones-ATGCN model or the Pre-ATGCN model,the ATGCN model was more robust in performance,with RMSE of 0.0293 and 0.06 on two datasets when horizon is one.Discussion:Our research indicates a broad application prospect of deep learning in the field of infectious disease prediction.Transmission characteristics and domain knowledge of infectious diseases should be further applied to the design of deep learning models and feature selection.Conclusion:The ATGCN model addressed the multivariate time series forecasting in a graph-based deep learning approach and achieved robust prediction on the confirmed cases of multiple age groups,indicating its great potentials for exploring the implicit interactions of multivariate variables.展开更多
The age of the Longzhaogou and Jixi Groups of coal measures in eastern Heilongjiang were previouslyconsidered to be Jurassic or mainly Jurassic. But there occur Middle Barremian-Early Albian Aucellina(bivalvia) fossil...The age of the Longzhaogou and Jixi Groups of coal measures in eastern Heilongjiang were previouslyconsidered to be Jurassic or mainly Jurassic. But there occur Middle Barremian-Early Albian Aucellina(bivalvia) fossils in the Upper Yunshan Formation of the Longzhaogou Group and the Lower Chengzihe For-mation of the Jixi Group, and the Qihulin Formation of the Longzhaogou Group yields Early Cretaceousbivalve and ammonite fossils. Consequently, the geological ages of the two groups are mainly, or even all, Ear-ly Cretaceous.展开更多
Colon cancer is one of the most prevalent cancers globally,especially in the older age group.A large number of older patients undergoing surgery for colon cancer suffer from postoperative cognitive dysfunction(POCD).T...Colon cancer is one of the most prevalent cancers globally,especially in the older age group.A large number of older patients undergoing surgery for colon cancer suffer from postoperative cognitive dysfunction(POCD).The trial by Bu et al demonstrated that dexmedetomidine(Dex)significantly reduced the incidence of POCD compared to placebo in individuals undergoing colon cancer surgery.Additionally,better cerebral oxygenation and lower cerebral injury markers were reported with the use of Dex.The trial has some limitations,such as a single-center design and a smaller sample size,and further studies with larger patient populations and robust multi-center designs are warranted to establish these findings.展开更多
Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional...Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and areas.Frequently,these studies compared young individuals with older subjects,but few studies compared different age groups only in older populations.The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted.Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old.The oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other groups.This occurred possibly because of compensatory mechanism in brain functioning.This study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity characteristics.Approval for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval No.PSI2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively.展开更多
The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the ...The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the relationship between the urban environment and the pleasure of running.We collected 8260 street view images from 153 running routes in Beijing and invited more than 400 volunteers of different genders and ages to rate their sense of pleasure in street view images of the urban running environment through an online survey.Then,the proportion of visual elements in street images was extracted based on semantic segmentation,and the landscape was divided.Finally,a linear mixed model was used to predict the pleasure scores of different gender and age groups for different landscapes.The results show significant differences in the pleasure scores for different landscapes and age groups.Middle-aged people’s sense of pleasure was lower than that of the young and the elderly.More greenery was associated with a higher pleasure score,while the proportion of urban elements such as buildings was negatively correlated with the pleasure score.The results indicate that running in a natural landscape is pleasurable and beneficial for mental health.展开更多
Background:Carbon(C),nitrogen(N),and phosphorus(P)stoichiometry is a key indicator of nutrient utilization in plants,and C/N/P ratios are related to the life histories and adaptation strategies of tree species.However...Background:Carbon(C),nitrogen(N),and phosphorus(P)stoichiometry is a key indicator of nutrient utilization in plants,and C/N/P ratios are related to the life histories and adaptation strategies of tree species.However,no consensus has been reached on how leaf stoichiometric characteristics are affected by forest type and stand ages.The relationships between leaf stoichiometry and geographical,meteorological,and soil factors also remain poorly understood.Methods:Leaf and soil were sampled from forest stands of different age groups(young,middle-aged,near-mature,and mature)in two forest types(Chinese fir(Cunninghamia lanceolata)forests and evergreen broadleaved forests).The relationships between leaf C,N,and P stoichiometric parameters and geographical,meteorological,and soil factors were analysed by using redundancy analysis(RDA)and stepwise linear regression analysis.Results:Leaf C concentrations peaked in the near-mature stands with increasing age irrespective of forest type.Leaf N and P concentrations fluctuated with a rising trend in Chinese fir forests,while decreased first and increased later from young to mature phases in natural evergreen broadleaved forests.Chinese fir forests were primarily limited by N and P,while natural evergreen broadleaved forests were more susceptible to P limitation.Leaf C,N,and P stoichiometric characteristics in Chinese fir forests were mainly affected by the soil total P concentration(SP),longitude(LNG),growing season precipitation(GSP)and mean temperature in July(JUT).The leaf C concentration was mainly affected by GSP and JUT;leaf N and P concentrations were both positively correlated with LNG;and leaf P was positively correlated with SP.In evergreen broadleaved forests,however,leaf stoichiometric parameters displayed significant correlations with latitude(LAT)and mean annual precipitation(MAP).Conclusions:Leaf stoichiometry differed among forest stands of different age groups and forest types.Leaf C,N,and P stoichiometry was primarily explained by the combinations of SP,LNG,GSP and JUT in Chinese fir forests.LAT and MAP were the main controlling factors affecting the variations in the leaf C,N,and P status in natural evergreen broadleaved forests,which supports the temperature-plant physiological hypothesis.These findings improve the understanding of the distribution patterns and driving mechanisms of leaf stoichiometry linked with stand age and forest type.展开更多
Aim: To detect the most common musculoskeletal disorders and to explore the common injury and indication of different musculoskeletal systems, and then to obtain the causes of disorders by observing clinical indicatio...Aim: To detect the most common musculoskeletal disorders and to explore the common injury and indication of different musculoskeletal systems, and then to obtain the causes of disorders by observing clinical indications via images. Methodology: The subjects in this project consisted of both genders—males and females and were investigated randomly by collecting data from the PACS unit that exists in the radiology department at KAUH. The participants had a mean age of 7.4 ± 0.3 years, a mean height of 118.2 ± 2.5 cm, a mean mass of 27.8 ± 1.5 kg, and a mean BMI of 19.6 ± 0.8 kg/m2. The author settled the study plan by building a special, appropriate questionnaire to be handed out to the patients and covered mainly the prospective studies of randomly selected patients who came to the emergency unit and the outpatient units from other departments at KAUH in Jeddah. Results: The ratio of injuries in male children (77%) against females (23%) is 3:1, and this ratio is considered significant between age groups for males when compared with females. The injuries existed most in the age groups of 4 to 6 years old and 8 to 10 years old with approximately the same percentage of the total subjects as about 21% for each age group. Trauma injury was significant (81%) compared to other types of causes in all age groups. There was a significant relationship between the causes of injuries and the age groups in pediatrics (p 0.05) between the site of injuries and age groups. The significant site that resulted from trauma was the knee (100%), out of the total traumas’ subject. There was a highly significant relationship between the site of injuries and its causes (p = 0.006, i.e. p < 0.05) that were expected. Conclusion: More awareness and understanding in the society are needed and we should concentrate on increasing the knowledge of such by providing them with more learning courses.展开更多
Objectives: The objective of this study is to assess patients’ opinion of the information technologies (IT) electronic registration systems at the “Centro poliklinika” and Seskine outpatient clinics in Vilnius City...Objectives: The objective of this study is to assess patients’ opinion of the information technologies (IT) electronic registration systems at the “Centro poliklinika” and Seskine outpatient clinics in Vilnius City. Material and Methods: The survey was conducted in May-June, 2012. In the course of the primary survey, one questionnaire was handed out to one in tenth of the newly arrived patients. Total number of 650 questionnaires was distributed. 563 respondents participated in the survey (feedback rate—86.6%). Statistical analysis of data was performed by means of personal computer using SPSS software package. Results: 54.7% of respondents state that they make use of the possibility of online registration with the family doctor. 85.05% of respondents indicate that a doctor, when making the next appointment or referring to the medical specialist, registers a patient on site by means of computer. Upon arrival of a respondent to the reception desk of the medical establishment, 90.3% of respondents are registered by means of computer. 72.4% of respondents say that they have a choice to telephone and inquire about the time of visit if they have forgotten the visit time or lost the appointment sheet. Majority of respondents using the online registration option belong to the age group between 21 and 40 years—35.3%. Conclusions: Answers by the respondents and the breakdown between “Centro poliklinika” and Seskine outpatient clinics are very similar and no essential differences have been determined.展开更多
Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopa...Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopathological features and survival outcomes of thymoma patients. Methods: We reviewed the clinical data of 1984 chest thymoma patients from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. In accordance with the World Health Organization age brackets, the patients were divided into young (group A, 0 - 44-year-old);middle-aged (group B, 45 - 59-year-old);old (group C, 60 - 74-year-old);and seniors (group D 75 - 84-year-old). Single-factor and multivariate analysis were performed using the Kaplan-Meier method, and a multivariate Cox regression model was generated to assess patient prognosis. Results: In total, 1984 patients were included. The median follow-up time was 156.0 months (range: 0 - 492 months). Group C (60 - 74-year-old) had the most patients (35.1%), and Group D had the fewest patients (12.3%). Among all age groups, the proportion of white people and men with thymoma increased with age, while the proportion of black people and women showed a downward trend. Univariate and multivariate analyses showed that the overall survival rate of thymoma patients was negatively correlated with age. The overall survival times of the four groups were significantly different (p Conclusion: Age is an important prognostic factor for survival in thymoma patients, and younger patients have a survival advantage over older patients.展开更多
Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stag...Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stage stratified cluster sampling approach,we conducted a nationwide crosssectional survey across representative provincial-level administrative divisions(PLADs)and prefecture-level cities,encompassing 26 district/county survey sites.The questionnaire collected information on demographic characteristics,menopausal status,and symptoms.Data analysis employed means and standard deviations(X±S)or rates and proportion ratios to describe menopausal symptom occurrence,with group differences analyzed using Mann-Whitney or Kruskal-Wallis tests.Results:The study included 42,304 women with a mean age of 49.9±5.7 years.The overall prevalence of menopausal symptoms was 46.3%[95%confidence interval(CI):45.8%,46.7%],predominantly mild to moderate in severity.The prevalence of mild to severe symptoms began increasing in women over age 44,peaking at age 52.Moderate to severe symptoms showed an uptick after age 46,also peaking at 52 years,while severe symptoms increased after age 48,reaching maximum prevalence at age 56.The most commonly reported symptoms were insomnia(50.0%,95%CI:49.5%,50.5%),fatigue(48.2%,95%CI:47.7%,48.7%),and nervousness(46.9%,95%CI:46.5%,47.4%).Significant differences in symptom severity between premenopausal and postmenopausal women were observed in the 45-49(P<0.001)and 50-54(P=0.019<0.05)age groups.Conclusions:The study revealed distinct patterns in the prevalence,severity,and manifestation of menopausal symptoms across different age groups in China.The age-related progression of symptoms provides a scientific foundation for developing targeted healthcare interventions for women at various stages of menopause.展开更多
Objective To analyze the etiology and risk factors of Zang nationality cerebral infarction patients of different ages in Xizang Autonomous Region,so as to provide basis for more targeted diagnosis,treatmentat nd preve...Objective To analyze the etiology and risk factors of Zang nationality cerebral infarction patients of different ages in Xizang Autonomous Region,so as to provide basis for more targeted diagnosis,treatmentat nd prevention of cerebral infarction in this region.Methods The clinical data of 500 Zang nationality cerebral infarction patients hospitalized in Xizang Autonomous Region People's Hospital from January 2019 to December 2023 were retrospectively analyzed.According to age,they were divided into young and middle-aged group(18-59 years old)and elderly group(60-75 years old).Baseline data,laboratory data and imaging results of patients in each group were collected and retrospectively analyzed.Results The proportion of males in the young and middle-aged group(n=267)[188(70.41%)]was higher than that in the elderly group(n=233)[130(55.79%),X^(2)=11.485,P=0.001].The proportion of smokers[131(49.06%)us 74(31.76%),X^(2)=15.401],drinkers[121(45.32%)us 84(36.05%),X^(2)=4.417],high altitude polycythemia(HAPC)[51(19.10%)us 23(9.87%),X^(2)=8.406],hyperuricemia(HUA)[61(28.90%)vs 34(19.32%),X^(2)=4.766],increased hemoglobin[152(56.93%)vs 97(41.63%),X^(2)=6.677],hypertiglyceridemia[47(17.60%)us 18(7.73%),X^(2)=10.734],hypercholesterolemia[12(4.94%)us 3(1.29%),X^(2)=4.397],hyperlipidemia[79(29.59%)us 43(18.45%),X^(2)=8.360]in the young and middle-aged group was higher than that in the elderly group(all P<0.05).The proportion of hypertension[108(40.44%)us 158(67.81%),X^(2)=37.413],atrial fibrillation[5(1.87%)vs 20(8.58%),X^(2)=11.797],hyperhomocysteinemia(HHcy)[159(59.55%)us 168(72.10%),X^(2)=8.664],abnormal creatinine[18(6.74%)us 29(12.45%),X^(2)=4.755],atherosclerosis[113(42.32%)us 145(62.23%),X^(2)=19.748],heart disease[135(50.56%)vs 150(64.38%),X^(2)=9.690]in the young and middle-aged group was lower than that in the elderly group(all P<0.05).Multivariate Logistic regression analysis showed that hypertension(OR=2.865,95%CI 1.742-4.710)and HHcy(OR=1.968,95%CI 1.177-3.290)were risk factors of cerebral infarction in the elderly group.Smoking(OR=1.848,95%CI 1.017-3.360),HAPC(0R=1.993,95%CI 1.991-4.011),HUA(0R=1.863,95%CI 1.015-3.419)and living at the extremely high altitude(OR=2.405,95%CI 1.207-4.791)were risk factors of cerebral infarctionintheyoung and middle-aged group.According to the TOAST etiological classification,the causes of stroke of other determined etiology and stroke of other undetermined etiology were complex and diverse,which were more common in the young and middle-aged group,while cardiac embolism was more common in the elderlygroup.ConclusionThere are significant differences in the risk factors and etiology of cerebral infarction in different age groups in Xizang Autonomous Region.The occurrence of cerebral infarction in elderly patients is significantly related to hypertension and HHcy,while the occurrence of cerebral infarction in young and middle-aged patients is significantly related to smoking,HAPC,HUA,and living in extremely high altitude areas.In clinical practice,diagnosis and treatment of cerebral infarction patients in different age groups should have different focuses.展开更多
Background: Primary immunodeficiency disorders (PIDs) or inborn errors of immunity (IEI) are inherited disorders that impair the immune response in children. PIDs are much more common than it was previously estimated....Background: Primary immunodeficiency disorders (PIDs) or inborn errors of immunity (IEI) are inherited disorders that impair the immune response in children. PIDs are much more common than it was previously estimated. Unfortunately, the majority of these patients remain undiagnosed and untreated. Objective: To assess the demography, clinical profiles, and sub-types of PID cases. Method: It was a retrospective study conducted in the pediatric rheumatology division of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2012 to June 2020. All the diagnosed immune-deficient patients who fulfilled the inclusion criteria were included in this study. The PID patients were screened for CBC, serum immunoglobulin classes and subset of lymphocytes, including the T-B-NK cell markers, detected by flow cytometric analysis. Result: Among twenty-five PID cases included in this study, majority were antibody deficiency (40%) and combined immunodeficiency disorders (32%), followed by complement deficiencies, NK cell defect, and autoinflammatory disorders (CANDLE syndrome). Recurrent respiratory tract infection, ear infection, sinusitis and skin infection were the common clinical manifestations of this cohort. Late presentation and late diagnosis were found in almost every case. A comparison with PIDs reported from other countries showed that predominantly antibody deficiency cases were more common in those countries, but combined immunodeficiency was the most common (32%) sub-type in our country. Conclusion: Antibody deficiency and combined immune deficiency disorders were the predominant types of PIDs in this cohort. Late presentation and late diagnosis with different systemic infections in the disease course were observed.展开更多
Rare earth elements （REEs） in recent decade are widely used and lead to the accumulation of REE in the environment and human body. The aim of this study was to evaluate the concentrations of REEs in soil and human b...Rare earth elements （REEs） in recent decade are widely used and lead to the accumulation of REE in the environment and human body. The aim of this study was to evaluate the concentrations of REEs in soil and human body （scalp hair and urine） of peo-ple living in agricultural soil near smelting and mining areas in Hezhang County, China. The results showed that mean concentrations of determined REEs in agricultural soil from smelting areas were higher than background. However, concentration was slightly higher in soil in mining area. In addition, REEs concentrations of hair and urine in smelting areas were higher than those in mining areas.ΣREEs for soil in mining and smelting areas were 177.79 and 277.06 mg/kg, respectively.ΣREEs for hair in mining and smelting were 1.13 and 1.55 mg/kg, respectively, andΣREEs for urine in mining and smelting were 0.58 and 0.59 μg/L, respectively. Results showed that La, Ce and Nd were enriched in soil, hair and urine. Eu in smelting area showed a positive anomaly. In smelting and mining areas, females were more likely than male to expose to REEs. The relationship between REEs concentration and age group showed that hair’s high concentrations of REE existed in 18–40 years age for people from smelting areas and females from mining areas. While high concentrations distributed in the age of 41–65 for males from mining area. However, urine did not present similar distribution for different age group. Compared with hair and urine, soil showed the same distribution of REEs. And according to the Ce/Ce＊ value vs. LaN/YbN ratio showed that hair and soil tended to increase, with the stability of Ce/Ce＊ value. Thus the distri-bution of REEs in soil was closely related with the accumulation in human body. This is a preliminary study which may be suggested to the other research, and this study data may be useful for adding up the data pool on REEs levels in China.展开更多
Disturbance by rodents alters the morphologies and nutrients of plants as well as the physical-chemical properties of the soils.Changes in plants are considered to be mechanisms of defense against the disturbance by r...Disturbance by rodents alters the morphologies and nutrients of plants as well as the physical-chemical properties of the soils.Changes in plants are considered to be mechanisms of defense against the disturbance by rodents.Rodents gnaw on the assimilating branches of Haloxylon ammodendron(CA Mey.)Bunge and burrow under the bushes in the desert ecosystems of Xinjiang,China.However,eco-physiological responses of different age groups of H.ammodendron to the disturbance by rodents are not well understood.In this study,soil physical-chemical properties under the shrubs and the above-ground morphological,physiological and biochemical features of assimilating branches of H.ammodendron of different age groups(i.e.,young,30−100 cm;middle-aged,100−200 cm;and mature,>200 cm)in burrowed and non-burrowed(control)areas were studied in 2018.We found that disturbance by rodents significantly increased the crown width and total branching rates of young and middle-aged H.ammodendron.Photosynthetic pigment contents of assimilating branches of H.ammodendron were significantly reduced under the disturbance by rodents.In term of plant nutrients,the main differences among different age groups of H.ammodendron under the disturbance by rodents occurred in the total soluble sugar and reducing sugar contents that decreased in young plants,increased in middle-aged plants,and did not affect in mature plants.Crude protein and phosphorus contents significantly increased,while crude fiber and calcium contents significantly decreased in young plants.Crude fat and calcium contents significantly decreased in middle-aged plants.Soil organic matter(SOM),total nitrogen(TN),available nitrogen(AN)and available potassium(AK)contents in the topsoil(0–20 cm),which are conducive to forming''fertile islands'',also increased under the disturbance by rodents.In particular,soil AN and AK were the major factors affecting the above-ground morphological characteristics of H.ammodendron in burrowed areas.Overall,the response and defense strategies of H.ammodendron to the disturbance by rodents differed among different age groups,and the effect of the disturbance by rodents on H.ammodendron gradually weakened with the increasing plant age.展开更多
Urban greenspace has a profound impact on public health by purifying the air,blocking bacteria,and creating activity venues.Due to people's different position,the greenspace exposure to different age groups change...Urban greenspace has a profound impact on public health by purifying the air,blocking bacteria,and creating activity venues.Due to people's different position,the greenspace exposure to different age groups changes at various times.In this study,we combined NDVI(normalized difference vegetation index)and GVI(green view index)green indices with mobile signaling big data to evaluate the greenspace exposure of 3 age groups in Shanghai at different times.A dynamic assessment model for greenspace exposure has been adopted in this study.April 2021 and April 2022 were selected as the study periods,representing the non-lockdown period and the lockdown period,respectively.The results indicate that greenspace exposure changes slightly during the lockdown period.During lockdown,the NDVI exposure in the age groups of 31 to 50,51,and above was higher than that during non-lockdown.However,the NDVI exposure of people aged 0 to 30 during lockdown is lower than that during non-lockdown.The GVI exposure of people aged 51 and above is lower than that of the other age group.Whether it is under lockdown or not,from 8:00 to 17:00,the NDVI exposure showed a slightly higher value than at other hours.The value of GVI exposure fluctuates steadily during 6:00 to 24:00.This study enriches the evaluation dimensions of urban greenspace exposure.展开更多
AIM： TO elucidate the age-distribution of anti-hepatitis A virus （HAY） seroprevalence across different socioeconomic status （SES） categories in Bangladesh which, despite scarce data, is generally deemed to have h...AIM： TO elucidate the age-distribution of anti-hepatitis A virus （HAY） seroprevalence across different socioeconomic status （SES） categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity. METHODS： Blood samples of 818 subjects from a stratified samp#e of schools and hospitals, comprising different age categories and SES were collected. They were assayed for total anti-HAV antibodies. Social and medical history data were obtained using a questionnaire. RESULTS： Overall anti-HAV seroprevalence was 69.6%, increasing with age from 1-5 years （40.4%） to 〉 30 years （98.4%）. Seroprevalence was lowest （49.8%） in the high SES group and highest （96.5%） in the rural lower-middle SES group. Among subjects aged 6-20 years, anti-HAV seroprevalence was lowest in urban private school children （43.0%）, followed by urban government school children （76.2%） and rural school children （96.5%） （P 〈 0.01）. Within the high SESgroup, anti-HAV seroprevalence was 32.3% in subjects 〈 10 years and 51.7% in those aged 11-20 years. Until now Bangladesh has been deemed to have high endemicity for HAV. CONCLUSION： The transition from high to intermediate HAV endemicity may be underway; high SES adolescents and adults remain particularly at risk of symptomatic illness. Preventive measures need consideration.展开更多
Climate, weather, and its attributes such as temperature and number of rainy days are essential for the success of many tourism destinations. As climate scientists have determined that climate changes are inevitable, ...Climate, weather, and its attributes such as temperature and number of rainy days are essential for the success of many tourism destinations. As climate scientists have determined that climate changes are inevitable, tourism destinations need to determine how to best manage these changes and mitigate any negative consequences. In addition, the perceived weather and/or climate at a destination can have as much weight on an individual＇s travel experience as the actual weather. The purpose of this study was to examine climate attributes and their importance on a traveler＇s behavior and satisfaction. Two hundred and sixty four surveys were gathered in the Mediterranean regions of Europe in the summer of 2009. Regression analysis revealed that climate attributes play a role in a traveler＇s satisfaction with their choice of a destination, but the traveler does not feel that climate changes are affecting their destinations as a whole. Analysis of variance （ANOVA） determined generational age differences in importance of climate attributes and if climate changes are affecting destinations. Management considerations for destination planners are explored.展开更多
文摘<b><span>Background:</span></b><span> The patients’ age is considered a modified risk factor that causes periodontal disease, dental caries, and their development.</span><b><span> Objective:</span></b><span> The present study was designed to evaluate the impact of salivary pH value and dental caries index on periodontal status among adult age groups of patients from Aseer region, Saudi Arabia</span><span>.</span><span> </span><b><span>Methods:</span></b><span> A cross-sectional analysi</span><span>s carried out in the college of dentistry, King Khalid University on 750 </span><span>adult patients (400 males and 350 females). The adults patients were divided into three equal groups according to the patients’ age: group I (20 - 30 years), group I</span><span>I (31 - 40 years), and group III (41 - 50 years).</span><span> </span><span>Plaque index (PLI), gingi</span><span>val index (GI), clinical attachment loss (CAL), and the dental caries index (DMFT)</span><span> recorded as w</span><span>ell as salivary pH. All findings collected, then analyzed by an</span><span> ANOVA test and the t</span><span>-test. A p-value at <0.05 was considered a statistical significance level.</span><span> </span><b><span>R</span></b><b><span>esults:</span></b><b><span> </span></b><span>The clinical findings of the current study showed that there were statistically significant differences in the patients’ age of both males and females. Moreover, there were statistically significant diffe</span><span>rences in GI. On the other hand, there were highly statistically significant differences in PLI and DMFS, but there were no significant differences</span><span> in CAL of both males and females </span><span>Moreover, there were no statistically significant differences in salivary pH</span><span>.</span><span> </span><b><span>Conclusion:</span></b><span> We concluded that DMFT Index correlated to periodontal and oral hea</span><span>lth status and, it increased with the progression of the pat</span><span>ient’s age and</span><span> can be used in the epidemiological evaluation of periodontal and o</span><span>ral health status.
基金Supported by National Natural Science Foundation of China(61911530398,12231012)Consultancy Project by the Chinese Academy of Engineering(2022-JB-06,2023-JB-12)+3 种基金the Natural Science Foundation of Fujian Province of China(2021J01621)Special Projects of the Central Government Guiding Local Science and Technology Development(2021L3018)Royal Society of Edinburgh(RSE1832)Engineering and Physical Sciences Research Council(EP/W522521/1).
文摘A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.
文摘The emergence of the SARS-CoV-2 virus resulted in a health and economic crisis worldwide. Although everyone is susceptible to COVID-19, the elderly have compromised immune systems and often suffer from chronic underlying diseases, which makes them more vulnerable. This study aims to assess variation in COVID-19 vaccine distribution patterns across different age groups in European countries and to understand the extent to which European countries have prioritized vulnerable age groups (age > 70) in their vaccination programs. The study utilized open data from the European Center for Disease Prevention and Control (ECDC) and employed an observational, retrospective study design to examine the distribution of the COVID-19 vaccine among various age groups in several European countries from September 2021 to September 2023. Results reveal that vaccination rates increase with age, peaking at the 25 - 49 age group (1.34 × 10−4), after which there was a decline in vaccination rate. Analysis of variance (ANOVA) was used to investigate the equality of vaccination rates across the 29 countries in Europe, which resulted in a p-value of 70) during the study period as no country achieved the 70% coverage aimed by WHO. Continuous efforts must be made to ensure larger coverage of COVID-19 vaccination among this vulnerable population in order to protect them from severe outcomes in this region.
基金This work was supported in part by grants from the National Natural Science Foundation of China(Grants No.72025404 and 71621002)Beijing Natural Science Foundation(Grant No.LI92012)Beijing Nova Program(Grant No.Z201100006820085).
文摘Introduction:Multivariate time series prediction of infectious diseases is significant to public health,and the deep learning method has attracted increasing attention in this research field.Material and methods:An adaptively temporal graph convolution(ATGCN)model,which leams the contact patterns of multiple age groups in a graph-based approach,was proposed for COVID-19 and influenza prediction.We compared ATGCN with autoregressive models,deep sequence learning models,and experience-based ATGCN models in short-term and long-term prediction tasks.Results:Results showed that the ATGCN model performed better than the autoregressive models and the deep sequence learning models on two datasets in both short-term(12.5%and 10%improvements on RMSE)and longterm(12.4%and 5%improvements on RMSE)prediction tasks.And the RMSE of ATGCN predictions fluctuated least in different age groups of COVID-19(0.029±0.003)and influenza(0.059±0.008).Compared with the Ones-ATGCN model or the Pre-ATGCN model,the ATGCN model was more robust in performance,with RMSE of 0.0293 and 0.06 on two datasets when horizon is one.Discussion:Our research indicates a broad application prospect of deep learning in the field of infectious disease prediction.Transmission characteristics and domain knowledge of infectious diseases should be further applied to the design of deep learning models and feature selection.Conclusion:The ATGCN model addressed the multivariate time series forecasting in a graph-based deep learning approach and achieved robust prediction on the confirmed cases of multiple age groups,indicating its great potentials for exploring the implicit interactions of multivariate variables.
基金Director Foundation of Nanjing Institute of Geology and Palaeontology,Academin Sinica.
文摘The age of the Longzhaogou and Jixi Groups of coal measures in eastern Heilongjiang were previouslyconsidered to be Jurassic or mainly Jurassic. But there occur Middle Barremian-Early Albian Aucellina(bivalvia) fossils in the Upper Yunshan Formation of the Longzhaogou Group and the Lower Chengzihe For-mation of the Jixi Group, and the Qihulin Formation of the Longzhaogou Group yields Early Cretaceousbivalve and ammonite fossils. Consequently, the geological ages of the two groups are mainly, or even all, Ear-ly Cretaceous.
文摘Colon cancer is one of the most prevalent cancers globally,especially in the older age group.A large number of older patients undergoing surgery for colon cancer suffer from postoperative cognitive dysfunction(POCD).The trial by Bu et al demonstrated that dexmedetomidine(Dex)significantly reduced the incidence of POCD compared to placebo in individuals undergoing colon cancer surgery.Additionally,better cerebral oxygenation and lower cerebral injury markers were reported with the use of Dex.The trial has some limitations,such as a single-center design and a smaller sample size,and further studies with larger patient populations and robust multi-center designs are warranted to establish these findings.
基金the Grup de Recerca en Tecniques Estadistiques Avancades Aplicades a la Psicologia(GTEAAP)members of the Generalitat de Catalunya’s 2014 SGR 326 Consolidated Research Group(GRC)the PSI2013-41400-P project of Ministerio de Economia y Competitividad of the Spanish Government
文摘Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and areas.Frequently,these studies compared young individuals with older subjects,but few studies compared different age groups only in older populations.The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted.Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old.The oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other groups.This occurred possibly because of compensatory mechanism in brain functioning.This study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity characteristics.Approval for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval No.PSI2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively.
基金China’s National Key Research and Development Program,No.2017YFB0503500National Natural Science Foundation of China,No.41901321。
文摘The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the relationship between the urban environment and the pleasure of running.We collected 8260 street view images from 153 running routes in Beijing and invited more than 400 volunteers of different genders and ages to rate their sense of pleasure in street view images of the urban running environment through an online survey.Then,the proportion of visual elements in street images was extracted based on semantic segmentation,and the landscape was divided.Finally,a linear mixed model was used to predict the pleasure scores of different gender and age groups for different landscapes.The results show significant differences in the pleasure scores for different landscapes and age groups.Middle-aged people’s sense of pleasure was lower than that of the young and the elderly.More greenery was associated with a higher pleasure score,while the proportion of urban elements such as buildings was negatively correlated with the pleasure score.The results indicate that running in a natural landscape is pleasurable and beneficial for mental health.
基金supported by the National Natural Science Foundation of China(No.31971643)the Industry-University Cooperation Project of Fujian Science and Technology Department(Nos.2020N5008,2019N5009)+2 种基金the General program of Natural Science Foundation of Fujian Province of China(No.2018J01737)Special Funding Project of Fujian Provincial Department of Finance(SC-299)Minjiang Scholar Programme.
文摘Background:Carbon(C),nitrogen(N),and phosphorus(P)stoichiometry is a key indicator of nutrient utilization in plants,and C/N/P ratios are related to the life histories and adaptation strategies of tree species.However,no consensus has been reached on how leaf stoichiometric characteristics are affected by forest type and stand ages.The relationships between leaf stoichiometry and geographical,meteorological,and soil factors also remain poorly understood.Methods:Leaf and soil were sampled from forest stands of different age groups(young,middle-aged,near-mature,and mature)in two forest types(Chinese fir(Cunninghamia lanceolata)forests and evergreen broadleaved forests).The relationships between leaf C,N,and P stoichiometric parameters and geographical,meteorological,and soil factors were analysed by using redundancy analysis(RDA)and stepwise linear regression analysis.Results:Leaf C concentrations peaked in the near-mature stands with increasing age irrespective of forest type.Leaf N and P concentrations fluctuated with a rising trend in Chinese fir forests,while decreased first and increased later from young to mature phases in natural evergreen broadleaved forests.Chinese fir forests were primarily limited by N and P,while natural evergreen broadleaved forests were more susceptible to P limitation.Leaf C,N,and P stoichiometric characteristics in Chinese fir forests were mainly affected by the soil total P concentration(SP),longitude(LNG),growing season precipitation(GSP)and mean temperature in July(JUT).The leaf C concentration was mainly affected by GSP and JUT;leaf N and P concentrations were both positively correlated with LNG;and leaf P was positively correlated with SP.In evergreen broadleaved forests,however,leaf stoichiometric parameters displayed significant correlations with latitude(LAT)and mean annual precipitation(MAP).Conclusions:Leaf stoichiometry differed among forest stands of different age groups and forest types.Leaf C,N,and P stoichiometry was primarily explained by the combinations of SP,LNG,GSP and JUT in Chinese fir forests.LAT and MAP were the main controlling factors affecting the variations in the leaf C,N,and P status in natural evergreen broadleaved forests,which supports the temperature-plant physiological hypothesis.These findings improve the understanding of the distribution patterns and driving mechanisms of leaf stoichiometry linked with stand age and forest type.
文摘Aim: To detect the most common musculoskeletal disorders and to explore the common injury and indication of different musculoskeletal systems, and then to obtain the causes of disorders by observing clinical indications via images. Methodology: The subjects in this project consisted of both genders—males and females and were investigated randomly by collecting data from the PACS unit that exists in the radiology department at KAUH. The participants had a mean age of 7.4 ± 0.3 years, a mean height of 118.2 ± 2.5 cm, a mean mass of 27.8 ± 1.5 kg, and a mean BMI of 19.6 ± 0.8 kg/m2. The author settled the study plan by building a special, appropriate questionnaire to be handed out to the patients and covered mainly the prospective studies of randomly selected patients who came to the emergency unit and the outpatient units from other departments at KAUH in Jeddah. Results: The ratio of injuries in male children (77%) against females (23%) is 3:1, and this ratio is considered significant between age groups for males when compared with females. The injuries existed most in the age groups of 4 to 6 years old and 8 to 10 years old with approximately the same percentage of the total subjects as about 21% for each age group. Trauma injury was significant (81%) compared to other types of causes in all age groups. There was a significant relationship between the causes of injuries and the age groups in pediatrics (p 0.05) between the site of injuries and age groups. The significant site that resulted from trauma was the knee (100%), out of the total traumas’ subject. There was a highly significant relationship between the site of injuries and its causes (p = 0.006, i.e. p < 0.05) that were expected. Conclusion: More awareness and understanding in the society are needed and we should concentrate on increasing the knowledge of such by providing them with more learning courses.
文摘Objectives: The objective of this study is to assess patients’ opinion of the information technologies (IT) electronic registration systems at the “Centro poliklinika” and Seskine outpatient clinics in Vilnius City. Material and Methods: The survey was conducted in May-June, 2012. In the course of the primary survey, one questionnaire was handed out to one in tenth of the newly arrived patients. Total number of 650 questionnaires was distributed. 563 respondents participated in the survey (feedback rate—86.6%). Statistical analysis of data was performed by means of personal computer using SPSS software package. Results: 54.7% of respondents state that they make use of the possibility of online registration with the family doctor. 85.05% of respondents indicate that a doctor, when making the next appointment or referring to the medical specialist, registers a patient on site by means of computer. Upon arrival of a respondent to the reception desk of the medical establishment, 90.3% of respondents are registered by means of computer. 72.4% of respondents say that they have a choice to telephone and inquire about the time of visit if they have forgotten the visit time or lost the appointment sheet. Majority of respondents using the online registration option belong to the age group between 21 and 40 years—35.3%. Conclusions: Answers by the respondents and the breakdown between “Centro poliklinika” and Seskine outpatient clinics are very similar and no essential differences have been determined.
文摘Background: Age is an important prognostic factor for thymoma;however, few studies have specifically focused on age-related survival outcomes in thymoma patients. This study explored the effect of age on the clinicopathological features and survival outcomes of thymoma patients. Methods: We reviewed the clinical data of 1984 chest thymoma patients from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. In accordance with the World Health Organization age brackets, the patients were divided into young (group A, 0 - 44-year-old);middle-aged (group B, 45 - 59-year-old);old (group C, 60 - 74-year-old);and seniors (group D 75 - 84-year-old). Single-factor and multivariate analysis were performed using the Kaplan-Meier method, and a multivariate Cox regression model was generated to assess patient prognosis. Results: In total, 1984 patients were included. The median follow-up time was 156.0 months (range: 0 - 492 months). Group C (60 - 74-year-old) had the most patients (35.1%), and Group D had the fewest patients (12.3%). Among all age groups, the proportion of white people and men with thymoma increased with age, while the proportion of black people and women showed a downward trend. Univariate and multivariate analyses showed that the overall survival rate of thymoma patients was negatively correlated with age. The overall survival times of the four groups were significantly different (p Conclusion: Age is an important prognostic factor for survival in thymoma patients, and younger patients have a survival advantage over older patients.
基金Supported by the National Key R&D Program of China(2022YFC2703801).
文摘Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stage stratified cluster sampling approach,we conducted a nationwide crosssectional survey across representative provincial-level administrative divisions(PLADs)and prefecture-level cities,encompassing 26 district/county survey sites.The questionnaire collected information on demographic characteristics,menopausal status,and symptoms.Data analysis employed means and standard deviations(X±S)or rates and proportion ratios to describe menopausal symptom occurrence,with group differences analyzed using Mann-Whitney or Kruskal-Wallis tests.Results:The study included 42,304 women with a mean age of 49.9±5.7 years.The overall prevalence of menopausal symptoms was 46.3%[95%confidence interval(CI):45.8%,46.7%],predominantly mild to moderate in severity.The prevalence of mild to severe symptoms began increasing in women over age 44,peaking at age 52.Moderate to severe symptoms showed an uptick after age 46,also peaking at 52 years,while severe symptoms increased after age 48,reaching maximum prevalence at age 56.The most commonly reported symptoms were insomnia(50.0%,95%CI:49.5%,50.5%),fatigue(48.2%,95%CI:47.7%,48.7%),and nervousness(46.9%,95%CI:46.5%,47.4%).Significant differences in symptom severity between premenopausal and postmenopausal women were observed in the 45-49(P<0.001)and 50-54(P=0.019<0.05)age groups.Conclusions:The study revealed distinct patterns in the prevalence,severity,and manifestation of menopausal symptoms across different age groups in China.The age-related progression of symptoms provides a scientific foundation for developing targeted healthcare interventions for women at various stages of menopause.
文摘Objective To analyze the etiology and risk factors of Zang nationality cerebral infarction patients of different ages in Xizang Autonomous Region,so as to provide basis for more targeted diagnosis,treatmentat nd prevention of cerebral infarction in this region.Methods The clinical data of 500 Zang nationality cerebral infarction patients hospitalized in Xizang Autonomous Region People's Hospital from January 2019 to December 2023 were retrospectively analyzed.According to age,they were divided into young and middle-aged group(18-59 years old)and elderly group(60-75 years old).Baseline data,laboratory data and imaging results of patients in each group were collected and retrospectively analyzed.Results The proportion of males in the young and middle-aged group(n=267)[188(70.41%)]was higher than that in the elderly group(n=233)[130(55.79%),X^(2)=11.485,P=0.001].The proportion of smokers[131(49.06%)us 74(31.76%),X^(2)=15.401],drinkers[121(45.32%)us 84(36.05%),X^(2)=4.417],high altitude polycythemia(HAPC)[51(19.10%)us 23(9.87%),X^(2)=8.406],hyperuricemia(HUA)[61(28.90%)vs 34(19.32%),X^(2)=4.766],increased hemoglobin[152(56.93%)vs 97(41.63%),X^(2)=6.677],hypertiglyceridemia[47(17.60%)us 18(7.73%),X^(2)=10.734],hypercholesterolemia[12(4.94%)us 3(1.29%),X^(2)=4.397],hyperlipidemia[79(29.59%)us 43(18.45%),X^(2)=8.360]in the young and middle-aged group was higher than that in the elderly group(all P<0.05).The proportion of hypertension[108(40.44%)us 158(67.81%),X^(2)=37.413],atrial fibrillation[5(1.87%)vs 20(8.58%),X^(2)=11.797],hyperhomocysteinemia(HHcy)[159(59.55%)us 168(72.10%),X^(2)=8.664],abnormal creatinine[18(6.74%)us 29(12.45%),X^(2)=4.755],atherosclerosis[113(42.32%)us 145(62.23%),X^(2)=19.748],heart disease[135(50.56%)vs 150(64.38%),X^(2)=9.690]in the young and middle-aged group was lower than that in the elderly group(all P<0.05).Multivariate Logistic regression analysis showed that hypertension(OR=2.865,95%CI 1.742-4.710)and HHcy(OR=1.968,95%CI 1.177-3.290)were risk factors of cerebral infarction in the elderly group.Smoking(OR=1.848,95%CI 1.017-3.360),HAPC(0R=1.993,95%CI 1.991-4.011),HUA(0R=1.863,95%CI 1.015-3.419)and living at the extremely high altitude(OR=2.405,95%CI 1.207-4.791)were risk factors of cerebral infarctionintheyoung and middle-aged group.According to the TOAST etiological classification,the causes of stroke of other determined etiology and stroke of other undetermined etiology were complex and diverse,which were more common in the young and middle-aged group,while cardiac embolism was more common in the elderlygroup.ConclusionThere are significant differences in the risk factors and etiology of cerebral infarction in different age groups in Xizang Autonomous Region.The occurrence of cerebral infarction in elderly patients is significantly related to hypertension and HHcy,while the occurrence of cerebral infarction in young and middle-aged patients is significantly related to smoking,HAPC,HUA,and living in extremely high altitude areas.In clinical practice,diagnosis and treatment of cerebral infarction patients in different age groups should have different focuses.
文摘Background: Primary immunodeficiency disorders (PIDs) or inborn errors of immunity (IEI) are inherited disorders that impair the immune response in children. PIDs are much more common than it was previously estimated. Unfortunately, the majority of these patients remain undiagnosed and untreated. Objective: To assess the demography, clinical profiles, and sub-types of PID cases. Method: It was a retrospective study conducted in the pediatric rheumatology division of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2012 to June 2020. All the diagnosed immune-deficient patients who fulfilled the inclusion criteria were included in this study. The PID patients were screened for CBC, serum immunoglobulin classes and subset of lymphocytes, including the T-B-NK cell markers, detected by flow cytometric analysis. Result: Among twenty-five PID cases included in this study, majority were antibody deficiency (40%) and combined immunodeficiency disorders (32%), followed by complement deficiencies, NK cell defect, and autoinflammatory disorders (CANDLE syndrome). Recurrent respiratory tract infection, ear infection, sinusitis and skin infection were the common clinical manifestations of this cohort. Late presentation and late diagnosis were found in almost every case. A comparison with PIDs reported from other countries showed that predominantly antibody deficiency cases were more common in those countries, but combined immunodeficiency was the most common (32%) sub-type in our country. Conclusion: Antibody deficiency and combined immune deficiency disorders were the predominant types of PIDs in this cohort. Late presentation and late diagnosis with different systemic infections in the disease course were observed.
基金supported by National Natural Science Foundation of China(41173113,41473122)the Hundred Talents Programs of Chinese Academy of Sciences
文摘Rare earth elements （REEs） in recent decade are widely used and lead to the accumulation of REE in the environment and human body. The aim of this study was to evaluate the concentrations of REEs in soil and human body （scalp hair and urine） of peo-ple living in agricultural soil near smelting and mining areas in Hezhang County, China. The results showed that mean concentrations of determined REEs in agricultural soil from smelting areas were higher than background. However, concentration was slightly higher in soil in mining area. In addition, REEs concentrations of hair and urine in smelting areas were higher than those in mining areas.ΣREEs for soil in mining and smelting areas were 177.79 and 277.06 mg/kg, respectively.ΣREEs for hair in mining and smelting were 1.13 and 1.55 mg/kg, respectively, andΣREEs for urine in mining and smelting were 0.58 and 0.59 μg/L, respectively. Results showed that La, Ce and Nd were enriched in soil, hair and urine. Eu in smelting area showed a positive anomaly. In smelting and mining areas, females were more likely than male to expose to REEs. The relationship between REEs concentration and age group showed that hair’s high concentrations of REE existed in 18–40 years age for people from smelting areas and females from mining areas. While high concentrations distributed in the age of 41–65 for males from mining area. However, urine did not present similar distribution for different age group. Compared with hair and urine, soil showed the same distribution of REEs. And according to the Ce/Ce＊ value vs. LaN/YbN ratio showed that hair and soil tended to increase, with the stability of Ce/Ce＊ value. Thus the distri-bution of REEs in soil was closely related with the accumulation in human body. This is a preliminary study which may be suggested to the other research, and this study data may be useful for adding up the data pool on REEs levels in China.
基金The study was funded by the National Natural Science Foundation of China(41561010,31560177)。
文摘Disturbance by rodents alters the morphologies and nutrients of plants as well as the physical-chemical properties of the soils.Changes in plants are considered to be mechanisms of defense against the disturbance by rodents.Rodents gnaw on the assimilating branches of Haloxylon ammodendron(CA Mey.)Bunge and burrow under the bushes in the desert ecosystems of Xinjiang,China.However,eco-physiological responses of different age groups of H.ammodendron to the disturbance by rodents are not well understood.In this study,soil physical-chemical properties under the shrubs and the above-ground morphological,physiological and biochemical features of assimilating branches of H.ammodendron of different age groups(i.e.,young,30−100 cm;middle-aged,100−200 cm;and mature,>200 cm)in burrowed and non-burrowed(control)areas were studied in 2018.We found that disturbance by rodents significantly increased the crown width and total branching rates of young and middle-aged H.ammodendron.Photosynthetic pigment contents of assimilating branches of H.ammodendron were significantly reduced under the disturbance by rodents.In term of plant nutrients,the main differences among different age groups of H.ammodendron under the disturbance by rodents occurred in the total soluble sugar and reducing sugar contents that decreased in young plants,increased in middle-aged plants,and did not affect in mature plants.Crude protein and phosphorus contents significantly increased,while crude fiber and calcium contents significantly decreased in young plants.Crude fat and calcium contents significantly decreased in middle-aged plants.Soil organic matter(SOM),total nitrogen(TN),available nitrogen(AN)and available potassium(AK)contents in the topsoil(0–20 cm),which are conducive to forming''fertile islands'',also increased under the disturbance by rodents.In particular,soil AN and AK were the major factors affecting the above-ground morphological characteristics of H.ammodendron in burrowed areas.Overall,the response and defense strategies of H.ammodendron to the disturbance by rodents differed among different age groups,and the effect of the disturbance by rodents on H.ammodendron gradually weakened with the increasing plant age.
基金supported by the National Key R&D Program of China(2022YFC3802600 and 2022YFC3802603)China National Forestry and Grassland Administration,Forestry and Grassland Science and Technology Youth Talent Project(2024132024)
文摘Urban greenspace has a profound impact on public health by purifying the air,blocking bacteria,and creating activity venues.Due to people's different position,the greenspace exposure to different age groups changes at various times.In this study,we combined NDVI(normalized difference vegetation index)and GVI(green view index)green indices with mobile signaling big data to evaluate the greenspace exposure of 3 age groups in Shanghai at different times.A dynamic assessment model for greenspace exposure has been adopted in this study.April 2021 and April 2022 were selected as the study periods,representing the non-lockdown period and the lockdown period,respectively.The results indicate that greenspace exposure changes slightly during the lockdown period.During lockdown,the NDVI exposure in the age groups of 31 to 50,51,and above was higher than that during non-lockdown.However,the NDVI exposure of people aged 0 to 30 during lockdown is lower than that during non-lockdown.The GVI exposure of people aged 51 and above is lower than that of the other age group.Whether it is under lockdown or not,from 8:00 to 17:00,the NDVI exposure showed a slightly higher value than at other hours.The value of GVI exposure fluctuates steadily during 6:00 to 24:00.This study enriches the evaluation dimensions of urban greenspace exposure.
文摘AIM： TO elucidate the age-distribution of anti-hepatitis A virus （HAY） seroprevalence across different socioeconomic status （SES） categories in Bangladesh which, despite scarce data, is generally deemed to have high endemicity. METHODS： Blood samples of 818 subjects from a stratified samp#e of schools and hospitals, comprising different age categories and SES were collected. They were assayed for total anti-HAV antibodies. Social and medical history data were obtained using a questionnaire. RESULTS： Overall anti-HAV seroprevalence was 69.6%, increasing with age from 1-5 years （40.4%） to 〉 30 years （98.4%）. Seroprevalence was lowest （49.8%） in the high SES group and highest （96.5%） in the rural lower-middle SES group. Among subjects aged 6-20 years, anti-HAV seroprevalence was lowest in urban private school children （43.0%）, followed by urban government school children （76.2%） and rural school children （96.5%） （P 〈 0.01）. Within the high SESgroup, anti-HAV seroprevalence was 32.3% in subjects 〈 10 years and 51.7% in those aged 11-20 years. Until now Bangladesh has been deemed to have high endemicity for HAV. CONCLUSION： The transition from high to intermediate HAV endemicity may be underway; high SES adolescents and adults remain particularly at risk of symptomatic illness. Preventive measures need consideration.
文摘Climate, weather, and its attributes such as temperature and number of rainy days are essential for the success of many tourism destinations. As climate scientists have determined that climate changes are inevitable, tourism destinations need to determine how to best manage these changes and mitigate any negative consequences. In addition, the perceived weather and/or climate at a destination can have as much weight on an individual＇s travel experience as the actual weather. The purpose of this study was to examine climate attributes and their importance on a traveler＇s behavior and satisfaction. Two hundred and sixty four surveys were gathered in the Mediterranean regions of Europe in the summer of 2009. Regression analysis revealed that climate attributes play a role in a traveler＇s satisfaction with their choice of a destination, but the traveler does not feel that climate changes are affecting their destinations as a whole. Analysis of variance （ANOVA） determined generational age differences in importance of climate attributes and if climate changes are affecting destinations. Management considerations for destination planners are explored.
