Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursi...Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursing interventions using a quantitative scoring system.Methods:A retrospective analysis was performed on 65 cancer patients who received PD-1 therapy at the Oncology Department of Baotou Cancer Hospital from December 2023 to December 2024.The study examined the clinical features and blood test results related to irAEs.The National Cancer Institute’s Common Terminology Criteria for Adverse Events(NCI-CTCAE)was used to grade the severity of these events,which were classified into five levels.Based on the NCI-CTCAE scores,appropriate nursing measures were implemented,and a comprehensive risk assessment framework was developed.Results:The study group showed lower complication rates,overall incidence,and average hospital stay compared to the control group(P<0.05).Among the 65 patients,twenty-eight(43.07%)experienced a total of 35 irAEs,with 2(5.71%)being grade 3 or 4.The most frequent irAEs were dermatological conditions(34.29%),particularly rash with itching.The occurrence of irAEs did not correlate with patient gender,age,blood parameters(hemoglobin,white blood cell count,platelet count,etc.),or liver function(P>0.05),but it was associated with tumor type(P<0.05).Conclusion:PD-1 treatment is generally safe,with a low incidence of severe(grade 3 or higher)irAEs.Close monitoring is essential to ensure early detection,intervention,and management of irAEs,thereby maintaining a low level of adverse events and enhancing the safety and efficacy of PD-1 therapy.Implementing a quantitative risk scoring system for nursing care can decrease the rate of complications,enhance patient safety,and potentially reduce hospital stays and medical costs.展开更多
Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have diffe...Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.展开更多
Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to a...Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to antibiotics between August 2021 and August 2023.The types of antibiotics that caused adverse reactions were analyzed,and the symptoms of adverse reactions and measures for rational use of antibiotics were summarized.Results:Among the analyzed cases of adverse reactions to antibiotics,the highest rate was observed in patients aged 61–75 years,accounting for 38.33%,followed by patients aged 51–60 years,accounting for 20.00%.In terms of the types of antibiotics that caused adverse reactions,cephalosporins were the most common,accounting for 40.00%,followed by penicillins,accounting for 18.33%.Analysis of the systems involved in adverse reactions showed that skin and appendage disorders were the most common,accounting for 36.67%,followed by the digestive system,accounting for 28.33%.Conclusion:Irrational use of antibiotics can lead to adverse drug reactions.Therefore,it is necessary to analyze strategies for the rational use of antibiotics to reduce adverse drug reactions and ensure the safety of antibiotic use.展开更多
Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and care.Methods:A questionnaire was used to random...Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and care.Methods:A questionnaire was used to randomly select 229 adults who were vaccinated with the inactivated novel coronavirus vaccine(Vero cells)at Xi’an People’s Hospital(Xi’an Fourth Hospital).The adverse reactions were statistically analyzed.Results:Among the 229 adults vaccinated with the inactivated novel coronavirus vaccine(Vero cells),30 experienced vaccination reactions.The main reaction was local induration at the inoculation site,and dizziness was the primary systemic symptom.Conclusion:To reduce the incidence of adverse reactions to the inactivated novel coronavirus vaccine(Vero cells),it is necessary to effectively evaluate the health status of adults before vaccination,select the correct vaccination site,and strictly implement the rules of 3-inspections,7-checks,and 1-verification.Standardizing the operation process and providing thorough health education after vaccination can effectively reduce the occurrence of adverse reactions.展开更多
Although most people believe that herbal remedies are relatively safe to use, some are toxic or possess adverse reactions, especially when used incorrectly.Commonly used TCM herbs with known adverse reactions, as well...Although most people believe that herbal remedies are relatively safe to use, some are toxic or possess adverse reactions, especially when used incorrectly.Commonly used TCM herbs with known adverse reactions, as well as the most toxic herbs in the Pharmacopoeia of People’s Republic of China are listed as follows:展开更多
Objective: To observe the efficacy of Shenmai injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer (NSCLC). Methods: 45 NSCLC patients with stages IIIb-IV were random...Objective: To observe the efficacy of Shenmai injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer (NSCLC). Methods: 45 NSCLC patients with stages IIIb-IV were randomly divided into two groups: the treatment group (treated by chemotherapy combined with Shenmai injection) and the control group (treated by chemotherapy only). The efficacy of the two groups was evaluated after 3 cycles of treatment. Results: There was no significant difference between the two groups in the recent curative effects (P > 0.05), while there were significant differences between them in Karnofsky score and weight (P < 0.05). The treatment group was better than the control group in preventing leucopenia and decreased hemoglobin, and significant differences were found between them (P < 0.05). The incidence of thrombocytopenia, nausea and vomiting, hepatic and renal dysfunction in the treatment group was lower than that in the control group, but no significant differences were found between them (P > 0.05). Conclusion: Shenmai injection would not influence the efficacy of chemotherapy on advanced NSCLC patients, while it could improve the quality of life, increase the body weight of patients, alleviate adverse reactions of chemotherapy as myelosuppression so as to improve the tolerance of organism to chemotherapy.展开更多
This study aimed to investigate the protective effect of oral steroid premedication in terms of adverse reactions to non-ionic contrast media. We investigated the incidence of adverse reactions among patients who unde...This study aimed to investigate the protective effect of oral steroid premedication in terms of adverse reactions to non-ionic contrast media. We investigated the incidence of adverse reactions among patients who underwent contrast-enhanced computed tomography. Patients in the premedication group took 30 mg of prednisolone orally the night before and on the morning of the scheduled computed tomography. Sixty-five patients received the same contrast media. Among them, 56 took prednisolone orally prior to the procedure (premedication without change of contrast media group) and nine without premedication (no premedication and no change of contrast media group). In total, 379 patients received different contrast media. Among them, 340 took prednisolone orally (premedication with change of contrast media group), while 39 did not take the premedication (no premedication with change of contrast media group). The adverse reaction rates in the premedication with change of contrast media and no premedication with change of contrast media groups were 1.8% (6/340 cases) and 2.6% (1/39 cases) (P = 0.54), respectively. The incidence of adverse reaction after the administration of non-ionic iodinated contrast media did not differ significantly based on whether an oral steroid was administered prior to compute tomography. Our evaluation is limited due to the small sample size of the contrast media-changed group. However, even if premedication with steroids is effective, it may only result in an adverse reaction reduction rate of ≤3%.展开更多
Objective:To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019(COVID-19)vaccination.Methods:We systematically searched PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFan...Objective:To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019(COVID-19)vaccination.Methods:We systematically searched PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFang Data,and VIP Database from the inception of each database to August 31,2021.Randomized controlled clinical trials(RCTs)on the safety of different types of COVID-19 vaccines were retrieved and analyzed.A random or fixed-effects model was used with an odds ratio as the effect size.The quality of each reference was evaluated.The incidence of the adverse reactions of the placebo group and the vaccination group was compared.Heterogeneity and publication bias were taken care of by meta-regression and sub-group analyses.Results:A total of 13 articles were included,with 81287 subjects.Compared with the placebo group,the vaccination group showed a higher combined risk ratio(RR)of total adverse reactions(RR=1.67,95%CI:1.46-1.91,P<0.01),local adverse reactions(RR=2.86,95%CI:2.11-3.87,P<0.01),systemic adverse reactions(RR=1.25,95%CI:0.92-1.72,P=0.16),pain(RR=2.55,95%CI:1.75-3.70,P<0.01),swelling(RR=4.16,95%CI:1.71-10.17,P=0.002),fever(RR=2.34,95%CI:1.84-2.97,P<0.01),fatigue(RR=1.36,95%CI:1.32-1.41,P<0.01)and headache(RR=1.22,95%CI:1.18-1.26,P<0.01).The subgroup analysis showed the incidence of adverse reactions of the vaccination group after injection of the three COVID-19 vaccines(inactivated viral vaccines,mRNA vaccines and adenovirus vector vaccines)was higher than that of the placebo group,and the difference between the placebo group and the vaccination group in the mRNA vaccine subgroup and the adenovirus vector vaccine subgroup was statistically significant(P<0.01).The incidence of adverse reactions after injection of COVID-19 vaccine in subgroups of different ages was significantly higher than that in the placebo group(P<0.01).Conclusions:COVID-19 vaccines have a good safety,among which adenovirus vector vaccine has the highest incidence of adverse reactions.Both adolescents and adults vaccinated with novel coronavirus vaccine have a certain proportion of adverse reactions,but the symptoms are mild and can be relieved by themselves.Our meta-analysis can help boost global awareness of vaccine safety,promote mass vaccination,help build regional and global immune barriers and effectively curb the recurrency of COVID-19.展开更多
Objective In this study,we aimed to determine the incidence of adverse drug reactions(ADRs)of atezolizumab,identify ADR signals that are significantly related to atezolizumab,and provide a reference for the rational u...Objective In this study,we aimed to determine the incidence of adverse drug reactions(ADRs)of atezolizumab,identify ADR signals that are significantly related to atezolizumab,and provide a reference for the rational use of atezolizumab in the clinic through the statistical analysis of its adverse drug events(ADEs)reported in the American Food and Drug Administration(FDA)Adverse Event Reporting System(FAERS)database.Methods In total,4796 cases of atezolizumab ADEs reported in the American FAERS database from 2017 to 2019 were retrospectively analyzed.Results The top three ADEs were febrile neutropenia(3.7%),anemia(2.9%),and acute renal failure(2.3%).In addition,the incidence rates of some ADEs were significantly different according to sex and age.The systematic organ classification of atezolizumab ADEs involved 32 systems,among which the top three were blood and lymphatic system disorders(585 cases,12.2%),gastrointestinal disorders(433 cases,9.0%),and infections and infestations(401 cases,8.4%).The reporting odds ratio(ROR)method was used to detect the ADR signals of atezolizumab.The ROR(95%confidence interval)of the top ADE,febrile neutropenia,was 39.236(33.757–45.604).In addition,we found 121 cases of complications associated with immune-related ADEs.Conclusion The ADRs of atezolizumab reported in the FAERS database were consistent with those mentioned in the instructions for atezolizumab use,suggesting that atezolizumab has an acceptable and controllable drug effect.展开更多
The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases.First of all,100 patients with malignant skin tumor ...The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases.First of all,100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20,2018 to September 18,2018 were selected,and all of them adopted photodynamic therapy.The 100 patients included 40 cases of basal cell carcinoma,14 cases of squamous cell carcinoma,7 cases of proliferative erythema,9 cases of Bowen’s disease and 39 cases of solar keratosis.Among the 100 patients,77 cases had excellent curative effect,18 cases had good effect and 5 cases had poor effect,and the overall effective rate was 95%(95/100).After 6 months of follow-up,5 cases of basal cell carcinoma,2 cases of squamous cell carcinoma,0 cases of proliferative erythra,1 case of Bowen’s disease and 3 cases of solar keratosis recurred,with an overall recurrence rate of 14%(14/100).The adverse reactions of pruritus were 90%(90/100),81%(81/100),90%(90/100)and 3%(3/100).Therefore,the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective,but also safe and not easy to relapse.展开更多
Gastrodin(4-hydroxymethylphenyl-β-d-glucopyranoside)is an active ingredient with high content,which is isolated from the rhizome of Gastrodia elata.Gastrodin injections,tablets and capsules are currently the main gas...Gastrodin(4-hydroxymethylphenyl-β-d-glucopyranoside)is an active ingredient with high content,which is isolated from the rhizome of Gastrodia elata.Gastrodin injections,tablets and capsules are currently the main gastrodin-related preparations in clinical practice,and gastrodin injections are the most widely used.This article will summarize pharmacology and adverse reactions of gastrodin to evaluate its safety,effectiveness and quality control.Gastrodin has pharmacological effects on central nervous system(vertigo,headache,insomnia,neurasthenia,convulsions and epilepsy,etc.),cardiovascular system and other diseases(osteoporosis,osteoarthritis and bone injury,etc.),but we still need to pay attention to its clinical adverse reactions(some patients may have dry mouth and nose,dizziness and stomach discomfort).In addition,further research is needed in other fields,such as health products,food,cosmetics,etc.We also need to further develop and explore the new pharmacological effects of gastrodin and expand its medicinal value.展开更多
Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug react...Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.展开更多
Objective: to summarize the implementation effect of esomeprazole and the effect of effective treatment on the patient's serum index. Methods: in January of 2019 to December of this year, 98 patients coming to our...Objective: to summarize the implementation effect of esomeprazole and the effect of effective treatment on the patient's serum index. Methods: in January of 2019 to December of this year, 98 patients coming to our hospital for gastric ulcer were included for investigation and analysis. Patients were divided into two groups according to the actual situation, and 49 patients were included in treatment 1 and 2.The treatment pattern used in treatment group 1 was conventional treatment, and that used in treatment group 2 was esomeprazole. Explore and analyze the excellence and effect of the two treatment options. Results: (1) Through the analysis and statistics of this survey, the treatment composition ratio of 1 treatment group was 79.59%, which was lower than that of 97.96% of 2 treatment group. Therefore, the difference was very significant and with statistical significance and value (P-value <0.05).(2) The composition of adverse reactions in group 1 group was 20.41% and that of 4.08%, with very significant differences and statistical significance and value (P-value <0.05).Conclusion: gastric ulcer is a common disease, and esomeprazole should be the preferred regimen in disease treatment. This regimen can improve the treatment effect and clinical symptoms, which is worthy of clinical application and popularization.展开更多
Objective: to analyze the adverse reactions of DPT vaccination in children, and to explore the relevant preventive countermeasures and application effect. Methods: in January 2020, Lianyun District began to actively i...Objective: to analyze the adverse reactions of DPT vaccination in children, and to explore the relevant preventive countermeasures and application effect. Methods: in January 2020, Lianyun District began to actively implement the preventive intervention measures of adverse reactions to pediatric DPT vaccination, Children who have completed the vaccination of prevention countermeasures in Lianyun District before the implementation of this study (January 1,2017 to December 31,2019) and after the implementation (January 1,2020 to December 31,2021). As the routine guidance group (23,921 doses) and the preventive intervention group (11,383 doses), monitoring the adverse reactions and satisfaction with vaccination care in both groups, analyze the effects of the preventive intervention. Results: the general response (0.31%) and total incidence of adverse reaction (0.31%) were significantly lower than the conventional guidance group (0.18%, 0.18%) (P <0.05), and the incidence of abnormal response between the two groups (P> 0.05). Parent satisfaction with vaccination care in the preventive intervention group (99.90%) was significantly higher than that in the conventional guidance group (92.75%) (P <0.05). Conclusion: there are some risks of adverse reactions after vaccination with DPT vaccine, mainly general reactions, which can reduce the risk of adverse reactions and have high application value, which is worth promotion and reference.展开更多
Objective: to study the adverse reactions of roxithromycin and azithromycin. Methods: among the patients investigated in our hospital, 200 cases were selected for the study. In terms of drug use, roxithromycin and azi...Objective: to study the adverse reactions of roxithromycin and azithromycin. Methods: among the patients investigated in our hospital, 200 cases were selected for the study. In terms of drug use, roxithromycin and azithromycin were respectively used in the two groups. Patients were selected in April 2019 and April 2020 to observe the adverse reactions. Results: the overall adverse reactions of azithromycin and roxithromycin were analyzed in 200 patients. Adverse reactions occurred in 10 patients after intravenous administration, compared with 6 patients after oral administration. Adverse reactions included nervous system, digestive system and gastrointestinal tract reactions. Digestive system reaction was the majority of adverse reactions, with a total of 7 cases and an incidence of 43.75%. In addition, all patients had more adverse reactions within 30 minutes of drug use. There were 11 persons, accounting for 68.75% of the total population. After a few days of drug use, the adverse reactions gradually decreased. After the adverse reactions occurred in the patients, 4 patients stopped taking drugs, 6 patients cooperated with antiallergic drugs, and 6 patients cooperated with antipyretic drugs. In terms of drug types, gastrointestinal reactions were more common in patients treated with azithromycin. Conclusion: in clinical practice, the incidence of adverse reactions of roxithromycin and azithromycin is not high, but according to the different types of drugs, different ways will lead to adverse reactions in patients, therefore, it is necessary to supervise the use method and dose of roxithromycin and azithromycin, to rational drug use.展开更多
Objective: to observe the effect of intravenous infusion speed on adverse reactions in the treatment of azithromycin. Methods: 100 patients treated with azithromycin in our hospital were selected for the experiment, a...Objective: to observe the effect of intravenous infusion speed on adverse reactions in the treatment of azithromycin. Methods: 100 patients treated with azithromycin in our hospital were selected for the experiment, and the patient time was 2020.5-2021.5. According to the method of drawing lots, the patients were divided into routine group and analysis group. The number of patients between the groups was 50, which were administered by intravenous infusion. The infusion speed of the routine group was the standard value, and the infusion speed of the analysis group was lower than the standard value. The adverse reactions between the groups were observed and analyzed. Results: through observation and statistics, it can be determined that there were fewer adverse reactions in the analysis group, that is, the incidence of adverse reactions was lower than that in the routine group (P < 0.05). Among the 21 patients with adverse drug reactions, 61.80% had adverse gastrointestinal reactions, 19.05% had local reactions, 9.52% had skin reactions and 4.76% had other adverse reactions. Conclusion: when azithromycin is provided to patients through intravenous infusion, the infusion speed should be strictly controlled, and the changes of physical signs should be observed. This can reduce the incidence of adverse reactions and improve the safety of medication.展开更多
Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hi...Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded picmice.The pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality control.Hirudin has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female infertility.However,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).展开更多
Objective: diabetes belongs to one of the higher clinical incidence of endocrine diseases, the identity of diabetes patients for long-term hyperglycemia. At the same time, diabetes patients in the early disease have n...Objective: diabetes belongs to one of the higher clinical incidence of endocrine diseases, the identity of diabetes patients for long-term hyperglycemia. At the same time, diabetes patients in the early disease have no obvious clinical symptoms. Therefore, early diabetes patients usually do not realize the existence of the disease, and until the condition is serious, affect the normal life to medical patients was found. Clinical usually use oral hypoglycemic treatment of patients, but patients in the process of taking hypoglycemic drugs easily a variety of adverse reactions, and different drugs to the patient body adverse reactions. This article will be based on the type of oral hypoglycemic drugs to its adverse reactions, analyze its research progress, to provide reference for clinical treatment of diabetes patients.展开更多
Objective: to analyze the causes of adverse reactions after unpaid blood donation. Methods: the data of 24114 unpaid blood donors were analyzed retrospectively, and the number of adverse reactions was counted. Single ...Objective: to analyze the causes of adverse reactions after unpaid blood donation. Methods: the data of 24114 unpaid blood donors were analyzed retrospectively, and the number of adverse reactions was counted. Single factor and multifactor logistic regression analysis was used to identify the causes of adverse reactions. Results: among 24114 blood donors who donated blood free of charge from June 2020 to June 2021 in this station, 178 had adverse reactions according to statistics, with the incidence rate of 0.74%. Class A, B, C and D accounted for 45.51%, 30.90%, 12.36% and 11.24% respectively. The final analysis results showed that the weight of the blood donors, the time and season of blood donation, as well as the food status, sleep quality, anxiety and social support level before blood donation were the main causes of adverse reactions to blood donation (P0.05). Conclusion: low personal weight, inappropriate time or season of blood donation, blood donation on an empty stomach and poor physical and mental status of unpaid blood donors are important reasons for adverse reactions.展开更多
AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinical data were collected from cases that presented with serious adverse reactions to telbivudine. W...AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinical data were collected from cases that presented with serious adverse reactions to telbivudine. We analyzed general information and medicine status, clinical features, results of examination, and misdiagnosis. RESULTS: Out of 105 patients who were treated with telbivudine for hepatitis B in an outpatient department from January, 2007 to January, 2008, five presented with serious adverse drug reactions. Most of these five patients had used other nucleoside analogues in the past. Four were treated with a combination of telbivudine and interferon or another nucleoside analogue, while the other received an increased dose of telbivudine. The main adverse reactions were myalgia and general weakness. This was accompanied by cardiac arrhythmia in one patient, and nervous symptoms in three. Serum creatine kinase was elevated. The rate of misdiagnosis was high. CONCLUSION: The adverse reactions were related to telbivudine, but the biological mechanism of the reactions is not yet clear. Combination therapy with interferon or another nucleoside analogue and a high dose may increase the risk of adverse reactions.展开更多
基金Baotou City Health Science and Technology Plan(Project No.:2023wsjkkj109)。
文摘Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursing interventions using a quantitative scoring system.Methods:A retrospective analysis was performed on 65 cancer patients who received PD-1 therapy at the Oncology Department of Baotou Cancer Hospital from December 2023 to December 2024.The study examined the clinical features and blood test results related to irAEs.The National Cancer Institute’s Common Terminology Criteria for Adverse Events(NCI-CTCAE)was used to grade the severity of these events,which were classified into five levels.Based on the NCI-CTCAE scores,appropriate nursing measures were implemented,and a comprehensive risk assessment framework was developed.Results:The study group showed lower complication rates,overall incidence,and average hospital stay compared to the control group(P<0.05).Among the 65 patients,twenty-eight(43.07%)experienced a total of 35 irAEs,with 2(5.71%)being grade 3 or 4.The most frequent irAEs were dermatological conditions(34.29%),particularly rash with itching.The occurrence of irAEs did not correlate with patient gender,age,blood parameters(hemoglobin,white blood cell count,platelet count,etc.),or liver function(P>0.05),but it was associated with tumor type(P<0.05).Conclusion:PD-1 treatment is generally safe,with a low incidence of severe(grade 3 or higher)irAEs.Close monitoring is essential to ensure early detection,intervention,and management of irAEs,thereby maintaining a low level of adverse events and enhancing the safety and efficacy of PD-1 therapy.Implementing a quantitative risk scoring system for nursing care can decrease the rate of complications,enhance patient safety,and potentially reduce hospital stays and medical costs.
文摘Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.
文摘Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to antibiotics between August 2021 and August 2023.The types of antibiotics that caused adverse reactions were analyzed,and the symptoms of adverse reactions and measures for rational use of antibiotics were summarized.Results:Among the analyzed cases of adverse reactions to antibiotics,the highest rate was observed in patients aged 61–75 years,accounting for 38.33%,followed by patients aged 51–60 years,accounting for 20.00%.In terms of the types of antibiotics that caused adverse reactions,cephalosporins were the most common,accounting for 40.00%,followed by penicillins,accounting for 18.33%.Analysis of the systems involved in adverse reactions showed that skin and appendage disorders were the most common,accounting for 36.67%,followed by the digestive system,accounting for 28.33%.Conclusion:Irrational use of antibiotics can lead to adverse drug reactions.Therefore,it is necessary to analyze strategies for the rational use of antibiotics to reduce adverse drug reactions and ensure the safety of antibiotic use.
文摘Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and care.Methods:A questionnaire was used to randomly select 229 adults who were vaccinated with the inactivated novel coronavirus vaccine(Vero cells)at Xi’an People’s Hospital(Xi’an Fourth Hospital).The adverse reactions were statistically analyzed.Results:Among the 229 adults vaccinated with the inactivated novel coronavirus vaccine(Vero cells),30 experienced vaccination reactions.The main reaction was local induration at the inoculation site,and dizziness was the primary systemic symptom.Conclusion:To reduce the incidence of adverse reactions to the inactivated novel coronavirus vaccine(Vero cells),it is necessary to effectively evaluate the health status of adults before vaccination,select the correct vaccination site,and strictly implement the rules of 3-inspections,7-checks,and 1-verification.Standardizing the operation process and providing thorough health education after vaccination can effectively reduce the occurrence of adverse reactions.
文摘Although most people believe that herbal remedies are relatively safe to use, some are toxic or possess adverse reactions, especially when used incorrectly.Commonly used TCM herbs with known adverse reactions, as well as the most toxic herbs in the Pharmacopoeia of People’s Republic of China are listed as follows:
文摘Objective: To observe the efficacy of Shenmai injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer (NSCLC). Methods: 45 NSCLC patients with stages IIIb-IV were randomly divided into two groups: the treatment group (treated by chemotherapy combined with Shenmai injection) and the control group (treated by chemotherapy only). The efficacy of the two groups was evaluated after 3 cycles of treatment. Results: There was no significant difference between the two groups in the recent curative effects (P > 0.05), while there were significant differences between them in Karnofsky score and weight (P < 0.05). The treatment group was better than the control group in preventing leucopenia and decreased hemoglobin, and significant differences were found between them (P < 0.05). The incidence of thrombocytopenia, nausea and vomiting, hepatic and renal dysfunction in the treatment group was lower than that in the control group, but no significant differences were found between them (P > 0.05). Conclusion: Shenmai injection would not influence the efficacy of chemotherapy on advanced NSCLC patients, while it could improve the quality of life, increase the body weight of patients, alleviate adverse reactions of chemotherapy as myelosuppression so as to improve the tolerance of organism to chemotherapy.
文摘This study aimed to investigate the protective effect of oral steroid premedication in terms of adverse reactions to non-ionic contrast media. We investigated the incidence of adverse reactions among patients who underwent contrast-enhanced computed tomography. Patients in the premedication group took 30 mg of prednisolone orally the night before and on the morning of the scheduled computed tomography. Sixty-five patients received the same contrast media. Among them, 56 took prednisolone orally prior to the procedure (premedication without change of contrast media group) and nine without premedication (no premedication and no change of contrast media group). In total, 379 patients received different contrast media. Among them, 340 took prednisolone orally (premedication with change of contrast media group), while 39 did not take the premedication (no premedication with change of contrast media group). The adverse reaction rates in the premedication with change of contrast media and no premedication with change of contrast media groups were 1.8% (6/340 cases) and 2.6% (1/39 cases) (P = 0.54), respectively. The incidence of adverse reaction after the administration of non-ionic iodinated contrast media did not differ significantly based on whether an oral steroid was administered prior to compute tomography. Our evaluation is limited due to the small sample size of the contrast media-changed group. However, even if premedication with steroids is effective, it may only result in an adverse reaction reduction rate of ≤3%.
基金funded the Province Natural Science key Foundation of Hainan(No:ZDYFXGFY2020004 and No:ZDYF 2019125)the National Natural Science Foundation of China(No:81960351)Hainan Province Clinical Medical Center.
文摘Objective:To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019(COVID-19)vaccination.Methods:We systematically searched PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFang Data,and VIP Database from the inception of each database to August 31,2021.Randomized controlled clinical trials(RCTs)on the safety of different types of COVID-19 vaccines were retrieved and analyzed.A random or fixed-effects model was used with an odds ratio as the effect size.The quality of each reference was evaluated.The incidence of the adverse reactions of the placebo group and the vaccination group was compared.Heterogeneity and publication bias were taken care of by meta-regression and sub-group analyses.Results:A total of 13 articles were included,with 81287 subjects.Compared with the placebo group,the vaccination group showed a higher combined risk ratio(RR)of total adverse reactions(RR=1.67,95%CI:1.46-1.91,P<0.01),local adverse reactions(RR=2.86,95%CI:2.11-3.87,P<0.01),systemic adverse reactions(RR=1.25,95%CI:0.92-1.72,P=0.16),pain(RR=2.55,95%CI:1.75-3.70,P<0.01),swelling(RR=4.16,95%CI:1.71-10.17,P=0.002),fever(RR=2.34,95%CI:1.84-2.97,P<0.01),fatigue(RR=1.36,95%CI:1.32-1.41,P<0.01)and headache(RR=1.22,95%CI:1.18-1.26,P<0.01).The subgroup analysis showed the incidence of adverse reactions of the vaccination group after injection of the three COVID-19 vaccines(inactivated viral vaccines,mRNA vaccines and adenovirus vector vaccines)was higher than that of the placebo group,and the difference between the placebo group and the vaccination group in the mRNA vaccine subgroup and the adenovirus vector vaccine subgroup was statistically significant(P<0.01).The incidence of adverse reactions after injection of COVID-19 vaccine in subgroups of different ages was significantly higher than that in the placebo group(P<0.01).Conclusions:COVID-19 vaccines have a good safety,among which adenovirus vector vaccine has the highest incidence of adverse reactions.Both adolescents and adults vaccinated with novel coronavirus vaccine have a certain proportion of adverse reactions,but the symptoms are mild and can be relieved by themselves.Our meta-analysis can help boost global awareness of vaccine safety,promote mass vaccination,help build regional and global immune barriers and effectively curb the recurrency of COVID-19.
文摘Objective In this study,we aimed to determine the incidence of adverse drug reactions(ADRs)of atezolizumab,identify ADR signals that are significantly related to atezolizumab,and provide a reference for the rational use of atezolizumab in the clinic through the statistical analysis of its adverse drug events(ADEs)reported in the American Food and Drug Administration(FDA)Adverse Event Reporting System(FAERS)database.Methods In total,4796 cases of atezolizumab ADEs reported in the American FAERS database from 2017 to 2019 were retrospectively analyzed.Results The top three ADEs were febrile neutropenia(3.7%),anemia(2.9%),and acute renal failure(2.3%).In addition,the incidence rates of some ADEs were significantly different according to sex and age.The systematic organ classification of atezolizumab ADEs involved 32 systems,among which the top three were blood and lymphatic system disorders(585 cases,12.2%),gastrointestinal disorders(433 cases,9.0%),and infections and infestations(401 cases,8.4%).The reporting odds ratio(ROR)method was used to detect the ADR signals of atezolizumab.The ROR(95%confidence interval)of the top ADE,febrile neutropenia,was 39.236(33.757–45.604).In addition,we found 121 cases of complications associated with immune-related ADEs.Conclusion The ADRs of atezolizumab reported in the FAERS database were consistent with those mentioned in the instructions for atezolizumab use,suggesting that atezolizumab has an acceptable and controllable drug effect.
文摘The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases.First of all,100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20,2018 to September 18,2018 were selected,and all of them adopted photodynamic therapy.The 100 patients included 40 cases of basal cell carcinoma,14 cases of squamous cell carcinoma,7 cases of proliferative erythema,9 cases of Bowen’s disease and 39 cases of solar keratosis.Among the 100 patients,77 cases had excellent curative effect,18 cases had good effect and 5 cases had poor effect,and the overall effective rate was 95%(95/100).After 6 months of follow-up,5 cases of basal cell carcinoma,2 cases of squamous cell carcinoma,0 cases of proliferative erythra,1 case of Bowen’s disease and 3 cases of solar keratosis recurred,with an overall recurrence rate of 14%(14/100).The adverse reactions of pruritus were 90%(90/100),81%(81/100),90%(90/100)and 3%(3/100).Therefore,the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective,but also safe and not easy to relapse.
文摘Gastrodin(4-hydroxymethylphenyl-β-d-glucopyranoside)is an active ingredient with high content,which is isolated from the rhizome of Gastrodia elata.Gastrodin injections,tablets and capsules are currently the main gastrodin-related preparations in clinical practice,and gastrodin injections are the most widely used.This article will summarize pharmacology and adverse reactions of gastrodin to evaluate its safety,effectiveness and quality control.Gastrodin has pharmacological effects on central nervous system(vertigo,headache,insomnia,neurasthenia,convulsions and epilepsy,etc.),cardiovascular system and other diseases(osteoporosis,osteoarthritis and bone injury,etc.),but we still need to pay attention to its clinical adverse reactions(some patients may have dry mouth and nose,dizziness and stomach discomfort).In addition,further research is needed in other fields,such as health products,food,cosmetics,etc.We also need to further develop and explore the new pharmacological effects of gastrodin and expand its medicinal value.
基金Key Research Project of Scientific and Educational Innovation in the Institute of Educational Science,Chinese Academy of Management Sciences(Grant No:KJCX5406).
文摘Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.
文摘Objective: to summarize the implementation effect of esomeprazole and the effect of effective treatment on the patient's serum index. Methods: in January of 2019 to December of this year, 98 patients coming to our hospital for gastric ulcer were included for investigation and analysis. Patients were divided into two groups according to the actual situation, and 49 patients were included in treatment 1 and 2.The treatment pattern used in treatment group 1 was conventional treatment, and that used in treatment group 2 was esomeprazole. Explore and analyze the excellence and effect of the two treatment options. Results: (1) Through the analysis and statistics of this survey, the treatment composition ratio of 1 treatment group was 79.59%, which was lower than that of 97.96% of 2 treatment group. Therefore, the difference was very significant and with statistical significance and value (P-value <0.05).(2) The composition of adverse reactions in group 1 group was 20.41% and that of 4.08%, with very significant differences and statistical significance and value (P-value <0.05).Conclusion: gastric ulcer is a common disease, and esomeprazole should be the preferred regimen in disease treatment. This regimen can improve the treatment effect and clinical symptoms, which is worthy of clinical application and popularization.
文摘Objective: to analyze the adverse reactions of DPT vaccination in children, and to explore the relevant preventive countermeasures and application effect. Methods: in January 2020, Lianyun District began to actively implement the preventive intervention measures of adverse reactions to pediatric DPT vaccination, Children who have completed the vaccination of prevention countermeasures in Lianyun District before the implementation of this study (January 1,2017 to December 31,2019) and after the implementation (January 1,2020 to December 31,2021). As the routine guidance group (23,921 doses) and the preventive intervention group (11,383 doses), monitoring the adverse reactions and satisfaction with vaccination care in both groups, analyze the effects of the preventive intervention. Results: the general response (0.31%) and total incidence of adverse reaction (0.31%) were significantly lower than the conventional guidance group (0.18%, 0.18%) (P <0.05), and the incidence of abnormal response between the two groups (P> 0.05). Parent satisfaction with vaccination care in the preventive intervention group (99.90%) was significantly higher than that in the conventional guidance group (92.75%) (P <0.05). Conclusion: there are some risks of adverse reactions after vaccination with DPT vaccine, mainly general reactions, which can reduce the risk of adverse reactions and have high application value, which is worth promotion and reference.
文摘Objective: to study the adverse reactions of roxithromycin and azithromycin. Methods: among the patients investigated in our hospital, 200 cases were selected for the study. In terms of drug use, roxithromycin and azithromycin were respectively used in the two groups. Patients were selected in April 2019 and April 2020 to observe the adverse reactions. Results: the overall adverse reactions of azithromycin and roxithromycin were analyzed in 200 patients. Adverse reactions occurred in 10 patients after intravenous administration, compared with 6 patients after oral administration. Adverse reactions included nervous system, digestive system and gastrointestinal tract reactions. Digestive system reaction was the majority of adverse reactions, with a total of 7 cases and an incidence of 43.75%. In addition, all patients had more adverse reactions within 30 minutes of drug use. There were 11 persons, accounting for 68.75% of the total population. After a few days of drug use, the adverse reactions gradually decreased. After the adverse reactions occurred in the patients, 4 patients stopped taking drugs, 6 patients cooperated with antiallergic drugs, and 6 patients cooperated with antipyretic drugs. In terms of drug types, gastrointestinal reactions were more common in patients treated with azithromycin. Conclusion: in clinical practice, the incidence of adverse reactions of roxithromycin and azithromycin is not high, but according to the different types of drugs, different ways will lead to adverse reactions in patients, therefore, it is necessary to supervise the use method and dose of roxithromycin and azithromycin, to rational drug use.
文摘Objective: to observe the effect of intravenous infusion speed on adverse reactions in the treatment of azithromycin. Methods: 100 patients treated with azithromycin in our hospital were selected for the experiment, and the patient time was 2020.5-2021.5. According to the method of drawing lots, the patients were divided into routine group and analysis group. The number of patients between the groups was 50, which were administered by intravenous infusion. The infusion speed of the routine group was the standard value, and the infusion speed of the analysis group was lower than the standard value. The adverse reactions between the groups were observed and analyzed. Results: through observation and statistics, it can be determined that there were fewer adverse reactions in the analysis group, that is, the incidence of adverse reactions was lower than that in the routine group (P < 0.05). Among the 21 patients with adverse drug reactions, 61.80% had adverse gastrointestinal reactions, 19.05% had local reactions, 9.52% had skin reactions and 4.76% had other adverse reactions. Conclusion: when azithromycin is provided to patients through intravenous infusion, the infusion speed should be strictly controlled, and the changes of physical signs should be observed. This can reduce the incidence of adverse reactions and improve the safety of medication.
文摘Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded picmice.The pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality control.Hirudin has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female infertility.However,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).
文摘Objective: diabetes belongs to one of the higher clinical incidence of endocrine diseases, the identity of diabetes patients for long-term hyperglycemia. At the same time, diabetes patients in the early disease have no obvious clinical symptoms. Therefore, early diabetes patients usually do not realize the existence of the disease, and until the condition is serious, affect the normal life to medical patients was found. Clinical usually use oral hypoglycemic treatment of patients, but patients in the process of taking hypoglycemic drugs easily a variety of adverse reactions, and different drugs to the patient body adverse reactions. This article will be based on the type of oral hypoglycemic drugs to its adverse reactions, analyze its research progress, to provide reference for clinical treatment of diabetes patients.
文摘Objective: to analyze the causes of adverse reactions after unpaid blood donation. Methods: the data of 24114 unpaid blood donors were analyzed retrospectively, and the number of adverse reactions was counted. Single factor and multifactor logistic regression analysis was used to identify the causes of adverse reactions. Results: among 24114 blood donors who donated blood free of charge from June 2020 to June 2021 in this station, 178 had adverse reactions according to statistics, with the incidence rate of 0.74%. Class A, B, C and D accounted for 45.51%, 30.90%, 12.36% and 11.24% respectively. The final analysis results showed that the weight of the blood donors, the time and season of blood donation, as well as the food status, sleep quality, anxiety and social support level before blood donation were the main causes of adverse reactions to blood donation (P0.05). Conclusion: low personal weight, inappropriate time or season of blood donation, blood donation on an empty stomach and poor physical and mental status of unpaid blood donors are important reasons for adverse reactions.
文摘AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinical data were collected from cases that presented with serious adverse reactions to telbivudine. We analyzed general information and medicine status, clinical features, results of examination, and misdiagnosis. RESULTS: Out of 105 patients who were treated with telbivudine for hepatitis B in an outpatient department from January, 2007 to January, 2008, five presented with serious adverse drug reactions. Most of these five patients had used other nucleoside analogues in the past. Four were treated with a combination of telbivudine and interferon or another nucleoside analogue, while the other received an increased dose of telbivudine. The main adverse reactions were myalgia and general weakness. This was accompanied by cardiac arrhythmia in one patient, and nervous symptoms in three. Serum creatine kinase was elevated. The rate of misdiagnosis was high. CONCLUSION: The adverse reactions were related to telbivudine, but the biological mechanism of the reactions is not yet clear. Combination therapy with interferon or another nucleoside analogue and a high dose may increase the risk of adverse reactions.
