系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以I型干扰素(type I interferon,IFN-I)通路异常激活和病理性自身抗体大量生成为特征的自身免疫性疾病。近年来研究发现,ADP-核糖基化修饰通过调控T淋巴细胞分化、B细胞抗体分...系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以I型干扰素(type I interferon,IFN-I)通路异常激活和病理性自身抗体大量生成为特征的自身免疫性疾病。近年来研究发现,ADP-核糖基化修饰通过调控T淋巴细胞分化、B细胞抗体分泌等免疫过程。多聚ADP-核糖聚合酶家族成员14[poly(adp-ribose)polymerase family member 14,PARP14]作为多功能ADP-核糖基化转移酶,不仅能通过单ADP-核糖基化修饰动态修饰靶蛋白、DNA、RNA等生物大分子,还在DNA损伤修复、炎症调控及免疫稳态维持中发挥关键作用。本文系统综述PARP14通过表观遗传和免疫调节影响SLE发生发展的分子机制。展开更多
Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capa...Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.展开更多
文摘系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以I型干扰素(type I interferon,IFN-I)通路异常激活和病理性自身抗体大量生成为特征的自身免疫性疾病。近年来研究发现,ADP-核糖基化修饰通过调控T淋巴细胞分化、B细胞抗体分泌等免疫过程。多聚ADP-核糖聚合酶家族成员14[poly(adp-ribose)polymerase family member 14,PARP14]作为多功能ADP-核糖基化转移酶,不仅能通过单ADP-核糖基化修饰动态修饰靶蛋白、DNA、RNA等生物大分子,还在DNA损伤修复、炎症调控及免疫稳态维持中发挥关键作用。本文系统综述PARP14通过表观遗传和免疫调节影响SLE发生发展的分子机制。
基金supported in part by funding from BeiGene,Ltd.,USA(Grant No.:KPR081)with additional support from the Alessandra Bono Foundation,Italy.
文摘Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.
