[1, Theorem 4.4] states that every infinite dimensional Banach space admits a homogenous measure of noncompactness not equivalent to the Hausdorff measure. Howevere, there is a gap in the proof. In fact,we found that ...[1, Theorem 4.4] states that every infinite dimensional Banach space admits a homogenous measure of noncompactness not equivalent to the Hausdorff measure. Howevere, there is a gap in the proof. In fact,we found that [1, Lemma 4.3] is not true. In this erratum, we give a corrected proof of [1, Theorem 4.4].展开更多
Fever of unknown origin(FUO)is recognized as fever with uncertain diagnosis despite three days of hospital admission or three or more outpatient visits.[1]Acute liver fluke infection is characterized by fever,right up...Fever of unknown origin(FUO)is recognized as fever with uncertain diagnosis despite three days of hospital admission or three or more outpatient visits.[1]Acute liver fluke infection is characterized by fever,right upper quadrant pain,hepatomegaly,jaundice,and peripheral blood eosinophilia.By contrast,chronic liver fluke infection is asymptomatic in its early stage,but can easily progress to cirrhosis,cancer,or bile duct cancer initslaterstages.The diagnosis of clonorchiasis is particularly challenging in non-endemic areas.We herein report an unusual case of liver fluke infection in a patient who presented with FUO and eosinophilia.A 38-year-old male was admitted to our hospital with a history of intermittent and recurrent fever for over 10 d and a history of sudden abdominal pain for1 h.He had no other medical history.More than 10d ago,he visited our emergency department because of FUO,with his body temperature reaching 39.7℃,and he had no other symptoms at that time.Laboratory and radiological examinations revealed:white blood cell(WBC)counts,10.9×10^(9)/L;neutrophil percentage,84.5%;eosinophil percentage,3.1%;C-reactive protein(CRP),141 mg/L;liver and kidney function,normal;influenza virus,negative;urine and stool tests,normal;and chest computed tomography(CT)findings,normal.The fever subsided after 1 week of anti-infective treatment with moxifloxacin.Subsequent tests revealed the following results:WBC,15.0×10^(9)/L;neutrophil percentage,70.0%;eosinophil percentage,16.8%;and CRP,122 mg/L.The antimicrobial treatment was then discontinued.展开更多
Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture pr...Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture presents significant risks,including dyspnea,respiratory failure,and potentially fatal airway obstruction,and is often overlooked or diagnosed late in clinical settings.Prompt diagnosis and intervention are prognostically crucial.[1,2]Between January 2013 and December 2023,four children(two male and two female)with bronchial rupture were admitted to the Pediatric Surgical Intensive CareUnit(ICU)at Children’s Hospital,Zhejiang University School of Medicine.Here,we share our experience of patient management.展开更多
BACKGROUND The association between uric acid-albumin ratio(UAR)with different diseases has been evaluated before.However,the association between UAR with spontaneous reperfusion(SR)in patients with ST-segment elevatio...BACKGROUND The association between uric acid-albumin ratio(UAR)with different diseases has been evaluated before.However,the association between UAR with spontaneous reperfusion(SR)in patients with ST-segment elevation myocardial infarction(STEMI)has not been explored.METHODS STEMI patients admitted to our department and underwent primary coronary angiography between 1st November 2018 and 31st December 2020 were retrospectively enrolled.The patients were divided into the SR group and the non-SR group according to the index coronary angiography results.The association between UAR and SR was evaluated by uni-variable and multi-variable logistic analysis.Receiver operating characteristic curve analysis was used to determine the optimum cut-off level of UAR in predicting SR.RESULTS Three hundred and fifty-seven patients were finally enrolled in our study,55 patients were divided into the SR group and 302 patients were divided into the non-SR group.In uni-variable analysis,patients with SR were older(P=0.032),with higher red blood cell distribution width(P<0.001)and red blood cell distribution width-to-platelet ratio(P<0.001),higher level of C-reactive protein(P=0.046),higher level of uric acid(P<0.001)compared with patients without SR.Patients with SR had a lower level of platelets(P=0.008),lower level of on-admission B-type natriuretic peptide(P<0.001).As for the level of UAR,STEMI patients with SR had significantly higher levels of UAR compared with STEMI patients without SR[11.1(8.9–13.4)vs.8.3(6.6–10.0),P<0.001].Further multi-variable logistic analysis reveals that UAR was the independent risk factor of SR in different models after adjusting different variables.Receiver operating characteristic analysis showed that UAR had good predictive value in SR(AUC=0.75,95%CI:0.702–0.794,P<0.01).CONCLUSIONS Our study shows that UAR is an independent risk factor for predicting SR in STEMI patients.展开更多
OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI)...OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are unavailable.Therefore,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with AMI.METHODS In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were enrolled.On admission,ABG,SHR,and GG were assessed and all participants were classified according to their quartiles.Kaplan-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term follow-up.RESULTS During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were recorded.Kaplan-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and GG.After adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term CVM.Additionally,we observed similar associations of these acute glycemic parameters with 30-day CVM.CONCLUSIONS Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.展开更多
BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the as...BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are available.METHODS We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(< 170 mg/L) and those with the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% CI: 0.651–0.754, P< 0.001;sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent results.CONCLUSIONS Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently associated with an increased risk of long-term cardiovascular mortality in STEMI patients.展开更多
We are honored to dedicate this issue to Professor Wenqing Shen to celebrate his 80th birthday,along with his distinguished career,great achievements in nuclear science,and fruitful contributions to science and techno...We are honored to dedicate this issue to Professor Wenqing Shen to celebrate his 80th birthday,along with his distinguished career,great achievements in nuclear science,and fruitful contributions to science and technology management.Professor Wenqing Shen was born in Shanghai on August 21,1945.After graduating from middle school with outstanding grades,he was admitted to the preparatory program of Fudan University;this marked the frst turning point in his life.展开更多
Sepsis is a lethal condition characterized by multiple organ dysfunction due to disrupted host responses to severe infections.[1]Aff ected patients often have a Sequential Organ Failure Assessment(SOFA)score≥2.[2]Pat...Sepsis is a lethal condition characterized by multiple organ dysfunction due to disrupted host responses to severe infections.[1]Aff ected patients often have a Sequential Organ Failure Assessment(SOFA)score≥2.[2]Patients with a SOFA score<2 and at least one of the following were considered as“suspected sepsis”:(1)quick SOFA(qSOFA)score≥2;(2)SOFA score=1;or(3)National Early Warning Score(NEWS)4-6.[3]Compared with studies on fluid resuscitation in sepsis patients,there are few studies on fluid management in patients with suspected sepsis.Therefore,we conducted a retrospective cohort study to evaluate the relationship between fluid management and disease progression in suspected sepsis patients.展开更多
Subdiaphragmatic abscess is uncommon in patients who undergo resection for hepatocellular carcinoma.The identifi cation of pathogens and appropriate treatment can be challenging.[1]Herein,we present a case of subdiaph...Subdiaphragmatic abscess is uncommon in patients who undergo resection for hepatocellular carcinoma.The identifi cation of pathogens and appropriate treatment can be challenging.[1]Herein,we present a case of subdiaphragmatic abscess caused by Cutibacterium modestum.A 66-year-old man was admitted to our hospital with fever,cough,and persistent,dull pain in the right upper quadrant for two days.The patient’s medical history included liver cirrhosis,radical resection of hepatocellular carcinoma three months prior to admission,and type 2 diabetes mellitus.Physical examination revealed tachycardia with small moist rales in the right lower chest.Abdominal examination revealed an L-shaped,well-healed surgical incision in the right upper quadrant without intra-abdominal mass or tenderness.展开更多
A 77-year-old female presented with shortness of breath and tightness of chest was admitted.Her past medical history included hypertension and she has been taking nifedipine regularly.Two years before,she was diagnose...A 77-year-old female presented with shortness of breath and tightness of chest was admitted.Her past medical history included hypertension and she has been taking nifedipine regularly.Two years before,she was diagnosed with pericardial effusion(Figure 1)and had pericardiocentesis drainage.On physical examination,her blood pressure was 151/100 mm-Hg and her pulse rate was 91 beats/min.展开更多
Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of hum...Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.展开更多
Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,follo...Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,followed by contralateral interval percutaneous nephrolithotomy(PCNL).Our case is a 40-year-old male who presented with history of dull aching and dragging sensation in bilateral flanks of 6-month duration.He was admitted and evaluated at other hospital for dizziness,sweating,and loss of consciousness.He was found to have bilateral staghorn calculi and left AML and was referred to our institute for further management after initial stabilization.The proper written and informed consent was taken from the patient for management as well as publication of the report and images,maintaining the patient’s anonymity.展开更多
Dear Editor,We present a case of dacryocystitis and canaliculitis secondary to residual of epidural catheter remaining in lacrimal duct for 25y.A 56-year-old male patient was admitted to our medical center on February...Dear Editor,We present a case of dacryocystitis and canaliculitis secondary to residual of epidural catheter remaining in lacrimal duct for 25y.A 56-year-old male patient was admitted to our medical center on February 16,2023.We obtained the written informed consent from the patient,and this case study was in accordance with the tenets of the Declaration of Helsinki.The main complaint was that the right eye had suffered from persistent tears for more than 25y and discharge for more than 1y.展开更多
Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their recovery.Providing timely and easily accessible psychologica...Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their recovery.Providing timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their illness.Methods In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023.Patients who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support only.VR-CBT consisted of four modules and was delivered at the bedside over a 1-week period.Assessments were done at baseline,immediately after treatment and at 3-month follow-up.The intention-to-treat analysis began in June 2023.The primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control group.The 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire intervention.Cybersickness was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CBT can significantly reduce post-AMI anxiety at the acute stage of the illness;the improvement was maintained at the 3-month follow-up.Trial registration number The trial was registered at www.chictr.org.cn with the identifier:ChiCTR2200066435.展开更多
Deep Underground Science and Engineering(DUSE)launched its first issue in September 2022 as a quarterly journal.So far,it has published 106 articles with nine issues and online early view.The volume of received manusc...Deep Underground Science and Engineering(DUSE)launched its first issue in September 2022 as a quarterly journal.So far,it has published 106 articles with nine issues and online early view.The volume of received manuscripts increases by 50%each year and over 200 manuscripts were received by 28th of November 2024.In the early period,DUSE authorship came from five countries and now reaches 29 countries.DUSE articles have been downloaded over 97000 times by readers from 170 countries/regions.It is indeed encouraging to note that DUSE has been admitted to different indices,including ESCI(August 2024),EI(March 2024),Scopus(July 2023),and DOAJ(May 2023).Its CiteScore in Scopus was 2.2 in 2023 and increased to 5.1 at the mid-November 2024.Its first impact factor from the Web of Science will be available in 2025.DUSE is growing to be a rapidly recognized international journal by readers in deep underground research and practice.展开更多
A 52-year-old female patient was admitted to our department primarily complaining of“palpitations and shortness of breath for one month following physical activity.”Upon admission,the physical examination revealed t...A 52-year-old female patient was admitted to our department primarily complaining of“palpitations and shortness of breath for one month following physical activity.”Upon admission,the physical examination revealed that the cardiac dullness border was expanded to the left,a grade 2/6 systolic murmur at the 2^(nd) to 3^(rd) left intercostal spaces along the left sternal border,and a fixed split second heart sound in the pulmonary valve area.An electrocardiogram revealed sinus rhythm with incomplete right bundle branch block.Echocardiography demonstrated a secundum type atrial septal defect(ASD)with a 16 mm interrup-tion in the atrial septal echo(Figure 1B-1D).展开更多
1.Introducing Professor Wang ProfessorHong-YangWangwas admitted to the MedicalDepartment,Second Military Medical University,in 1973.After graduation,she worked as a physician for the Department of Gastroenterology,Cha...1.Introducing Professor Wang ProfessorHong-YangWangwas admitted to the MedicalDepartment,Second Military Medical University,in 1973.After graduation,she worked as a physician for the Department of Gastroenterology,Changzheng Hospital,Shanghai,while earning herMaster's inGastrointestinal Immunology(awarded in 1984).As a chief physician,ProfessorWang was encouraged by academician Mengchao Wu to pursue a Ph.D.in clinical biochemistry at theMedical School of theUniversity of Ulm,Germany,in 1989.展开更多
At an economy-themed press conference held on the day of the Second Session of the 14th National People's Congress,Minister of Commerce Wang Wentao admitted that the situation of foreign trade situation is still&q...At an economy-themed press conference held on the day of the Second Session of the 14th National People's Congress,Minister of Commerce Wang Wentao admitted that the situation of foreign trade situation is still"very severe"this year.When it comes to the future policies for stabilizing foreign trade,Wang Wentao said that the government will provide better financial services forforeign trade enterprises.展开更多
Lucy Wahome stumbles and struggles to maintain her balance and walk as a nurse rushes to lend her support,soon after she got admitted at the clinic.Wahome,30,initially sought medical treatment at her home clinic in Ki...Lucy Wahome stumbles and struggles to maintain her balance and walk as a nurse rushes to lend her support,soon after she got admitted at the clinic.Wahome,30,initially sought medical treatment at her home clinic in Kiambu County,Kenya,which seemed well organised;but she later realised that constant power outages at the facility seriously compromised the quality of care at the clinic.展开更多
A 23-year-old man was admitted to the hospital after a physical examination revealed a space-occupying lesion in the spleen that had been present for over 2 months.The patient reported no significant symptoms,and labo...A 23-year-old man was admitted to the hospital after a physical examination revealed a space-occupying lesion in the spleen that had been present for over 2 months.The patient reported no significant symptoms,and laboratory tests showed no abnormalities.展开更多
基金supported by National Natural Science Foundation of China(Grant No.11731010)
文摘[1, Theorem 4.4] states that every infinite dimensional Banach space admits a homogenous measure of noncompactness not equivalent to the Hausdorff measure. Howevere, there is a gap in the proof. In fact,we found that [1, Lemma 4.3] is not true. In this erratum, we give a corrected proof of [1, Theorem 4.4].
文摘Fever of unknown origin(FUO)is recognized as fever with uncertain diagnosis despite three days of hospital admission or three or more outpatient visits.[1]Acute liver fluke infection is characterized by fever,right upper quadrant pain,hepatomegaly,jaundice,and peripheral blood eosinophilia.By contrast,chronic liver fluke infection is asymptomatic in its early stage,but can easily progress to cirrhosis,cancer,or bile duct cancer initslaterstages.The diagnosis of clonorchiasis is particularly challenging in non-endemic areas.We herein report an unusual case of liver fluke infection in a patient who presented with FUO and eosinophilia.A 38-year-old male was admitted to our hospital with a history of intermittent and recurrent fever for over 10 d and a history of sudden abdominal pain for1 h.He had no other medical history.More than 10d ago,he visited our emergency department because of FUO,with his body temperature reaching 39.7℃,and he had no other symptoms at that time.Laboratory and radiological examinations revealed:white blood cell(WBC)counts,10.9×10^(9)/L;neutrophil percentage,84.5%;eosinophil percentage,3.1%;C-reactive protein(CRP),141 mg/L;liver and kidney function,normal;influenza virus,negative;urine and stool tests,normal;and chest computed tomography(CT)findings,normal.The fever subsided after 1 week of anti-infective treatment with moxifloxacin.Subsequent tests revealed the following results:WBC,15.0×10^(9)/L;neutrophil percentage,70.0%;eosinophil percentage,16.8%;and CRP,122 mg/L.The antimicrobial treatment was then discontinued.
文摘Bronchial rupture from penetrating,perforating,or compressive cervical or thoracic injuries can lead to complete tracheal,mainstem bronchial,or lobar bronchial detachment.Although rare in children,bronchial rupture presents significant risks,including dyspnea,respiratory failure,and potentially fatal airway obstruction,and is often overlooked or diagnosed late in clinical settings.Prompt diagnosis and intervention are prognostically crucial.[1,2]Between January 2013 and December 2023,four children(two male and two female)with bronchial rupture were admitted to the Pediatric Surgical Intensive CareUnit(ICU)at Children’s Hospital,Zhejiang University School of Medicine.Here,we share our experience of patient management.
文摘BACKGROUND The association between uric acid-albumin ratio(UAR)with different diseases has been evaluated before.However,the association between UAR with spontaneous reperfusion(SR)in patients with ST-segment elevation myocardial infarction(STEMI)has not been explored.METHODS STEMI patients admitted to our department and underwent primary coronary angiography between 1st November 2018 and 31st December 2020 were retrospectively enrolled.The patients were divided into the SR group and the non-SR group according to the index coronary angiography results.The association between UAR and SR was evaluated by uni-variable and multi-variable logistic analysis.Receiver operating characteristic curve analysis was used to determine the optimum cut-off level of UAR in predicting SR.RESULTS Three hundred and fifty-seven patients were finally enrolled in our study,55 patients were divided into the SR group and 302 patients were divided into the non-SR group.In uni-variable analysis,patients with SR were older(P=0.032),with higher red blood cell distribution width(P<0.001)and red blood cell distribution width-to-platelet ratio(P<0.001),higher level of C-reactive protein(P=0.046),higher level of uric acid(P<0.001)compared with patients without SR.Patients with SR had a lower level of platelets(P=0.008),lower level of on-admission B-type natriuretic peptide(P<0.001).As for the level of UAR,STEMI patients with SR had significantly higher levels of UAR compared with STEMI patients without SR[11.1(8.9–13.4)vs.8.3(6.6–10.0),P<0.001].Further multi-variable logistic analysis reveals that UAR was the independent risk factor of SR in different models after adjusting different variables.Receiver operating characteristic analysis showed that UAR had good predictive value in SR(AUC=0.75,95%CI:0.702–0.794,P<0.01).CONCLUSIONS Our study shows that UAR is an independent risk factor for predicting SR in STEMI patients.
基金supported by the Capital Health Development Fund[201614035],the CAMS Innovation Fund for Medical Sciences[2021-I2M-1-008]the National High-level Hospital Clinical Research Funding[2023-GSP-RC-09,2023-GSP-QN-8].
文摘OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are unavailable.Therefore,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with AMI.METHODS In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were enrolled.On admission,ABG,SHR,and GG were assessed and all participants were classified according to their quartiles.Kaplan-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term follow-up.RESULTS During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were recorded.Kaplan-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and GG.After adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term CVM.Additionally,we observed similar associations of these acute glycemic parameters with 30-day CVM.CONCLUSIONS Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.
文摘BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are available.METHODS We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(< 170 mg/L) and those with the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% CI: 0.651–0.754, P< 0.001;sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent results.CONCLUSIONS Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently associated with an increased risk of long-term cardiovascular mortality in STEMI patients.
文摘We are honored to dedicate this issue to Professor Wenqing Shen to celebrate his 80th birthday,along with his distinguished career,great achievements in nuclear science,and fruitful contributions to science and technology management.Professor Wenqing Shen was born in Shanghai on August 21,1945.After graduating from middle school with outstanding grades,he was admitted to the preparatory program of Fudan University;this marked the frst turning point in his life.
文摘Sepsis is a lethal condition characterized by multiple organ dysfunction due to disrupted host responses to severe infections.[1]Aff ected patients often have a Sequential Organ Failure Assessment(SOFA)score≥2.[2]Patients with a SOFA score<2 and at least one of the following were considered as“suspected sepsis”:(1)quick SOFA(qSOFA)score≥2;(2)SOFA score=1;or(3)National Early Warning Score(NEWS)4-6.[3]Compared with studies on fluid resuscitation in sepsis patients,there are few studies on fluid management in patients with suspected sepsis.Therefore,we conducted a retrospective cohort study to evaluate the relationship between fluid management and disease progression in suspected sepsis patients.
基金This research did not receive any specific grant from funding agencies in the publiccommercialor not-for-profit sectors
文摘Subdiaphragmatic abscess is uncommon in patients who undergo resection for hepatocellular carcinoma.The identifi cation of pathogens and appropriate treatment can be challenging.[1]Herein,we present a case of subdiaphragmatic abscess caused by Cutibacterium modestum.A 66-year-old man was admitted to our hospital with fever,cough,and persistent,dull pain in the right upper quadrant for two days.The patient’s medical history included liver cirrhosis,radical resection of hepatocellular carcinoma three months prior to admission,and type 2 diabetes mellitus.Physical examination revealed tachycardia with small moist rales in the right lower chest.Abdominal examination revealed an L-shaped,well-healed surgical incision in the right upper quadrant without intra-abdominal mass or tenderness.
基金funded by the Tianjin Natural Science Foundation (No. 21JCYBJC01740 and 21JCYBJC01460)the Tianjin Key Medical Discipline (Specialty) Construction Project+1 种基金the Tianjin Key Medical Discipline (Specialty) Construction Project(TJYXZDXK-029A)Science Foundation of The Tianjin Education Commission (No.2023ZD007)
文摘A 77-year-old female presented with shortness of breath and tightness of chest was admitted.Her past medical history included hypertension and she has been taking nifedipine regularly.Two years before,she was diagnosed with pericardial effusion(Figure 1)and had pericardiocentesis drainage.On physical examination,her blood pressure was 151/100 mm-Hg and her pulse rate was 91 beats/min.
文摘Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.
文摘Dear Editor,We present a case of ruptured renal angiomyolipoma(AML)and bilateral renal staghorn calculi.We discuss about the management of this patient by angioembolization,partial nephrectomy,and pyelolithotomy,followed by contralateral interval percutaneous nephrolithotomy(PCNL).Our case is a 40-year-old male who presented with history of dull aching and dragging sensation in bilateral flanks of 6-month duration.He was admitted and evaluated at other hospital for dizziness,sweating,and loss of consciousness.He was found to have bilateral staghorn calculi and left AML and was referred to our institute for further management after initial stabilization.The proper written and informed consent was taken from the patient for management as well as publication of the report and images,maintaining the patient’s anonymity.
文摘Dear Editor,We present a case of dacryocystitis and canaliculitis secondary to residual of epidural catheter remaining in lacrimal duct for 25y.A 56-year-old male patient was admitted to our medical center on February 16,2023.We obtained the written informed consent from the patient,and this case study was in accordance with the tenets of the Declaration of Helsinki.The main complaint was that the right eye had suffered from persistent tears for more than 25y and discharge for more than 1y.
基金The study was supported by the Transverse Project of Zhongshan Hospital and Hangzhou Xinjing Science and Technology(XH,H2022-009)National Key Research and Development Program of China(XH,2023YFC2506200)Shanghai Clinical Research Center for Interventional Medicine(JBG,19MC1910300).
文摘Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their recovery.Providing timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their illness.Methods In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023.Patients who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support only.VR-CBT consisted of four modules and was delivered at the bedside over a 1-week period.Assessments were done at baseline,immediately after treatment and at 3-month follow-up.The intention-to-treat analysis began in June 2023.The primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control group.The 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire intervention.Cybersickness was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CBT can significantly reduce post-AMI anxiety at the acute stage of the illness;the improvement was maintained at the 3-month follow-up.Trial registration number The trial was registered at www.chictr.org.cn with the identifier:ChiCTR2200066435.
文摘Deep Underground Science and Engineering(DUSE)launched its first issue in September 2022 as a quarterly journal.So far,it has published 106 articles with nine issues and online early view.The volume of received manuscripts increases by 50%each year and over 200 manuscripts were received by 28th of November 2024.In the early period,DUSE authorship came from five countries and now reaches 29 countries.DUSE articles have been downloaded over 97000 times by readers from 170 countries/regions.It is indeed encouraging to note that DUSE has been admitted to different indices,including ESCI(August 2024),EI(March 2024),Scopus(July 2023),and DOAJ(May 2023).Its CiteScore in Scopus was 2.2 in 2023 and increased to 5.1 at the mid-November 2024.Its first impact factor from the Web of Science will be available in 2025.DUSE is growing to be a rapidly recognized international journal by readers in deep underground research and practice.
文摘A 52-year-old female patient was admitted to our department primarily complaining of“palpitations and shortness of breath for one month following physical activity.”Upon admission,the physical examination revealed that the cardiac dullness border was expanded to the left,a grade 2/6 systolic murmur at the 2^(nd) to 3^(rd) left intercostal spaces along the left sternal border,and a fixed split second heart sound in the pulmonary valve area.An electrocardiogram revealed sinus rhythm with incomplete right bundle branch block.Echocardiography demonstrated a secundum type atrial septal defect(ASD)with a 16 mm interrup-tion in the atrial septal echo(Figure 1B-1D).
文摘1.Introducing Professor Wang ProfessorHong-YangWangwas admitted to the MedicalDepartment,Second Military Medical University,in 1973.After graduation,she worked as a physician for the Department of Gastroenterology,Changzheng Hospital,Shanghai,while earning herMaster's inGastrointestinal Immunology(awarded in 1984).As a chief physician,ProfessorWang was encouraged by academician Mengchao Wu to pursue a Ph.D.in clinical biochemistry at theMedical School of theUniversity of Ulm,Germany,in 1989.
文摘At an economy-themed press conference held on the day of the Second Session of the 14th National People's Congress,Minister of Commerce Wang Wentao admitted that the situation of foreign trade situation is still"very severe"this year.When it comes to the future policies for stabilizing foreign trade,Wang Wentao said that the government will provide better financial services forforeign trade enterprises.
文摘Lucy Wahome stumbles and struggles to maintain her balance and walk as a nurse rushes to lend her support,soon after she got admitted at the clinic.Wahome,30,initially sought medical treatment at her home clinic in Kiambu County,Kenya,which seemed well organised;but she later realised that constant power outages at the facility seriously compromised the quality of care at the clinic.
文摘A 23-year-old man was admitted to the hospital after a physical examination revealed a space-occupying lesion in the spleen that had been present for over 2 months.The patient reported no significant symptoms,and laboratory tests showed no abnormalities.
