The Accounting Standardization System for Public Administrations （SNC-AP） was approved by Decree-Law No. 192/2015, of September 11 and constituted the new accounting system for public administrations in Portugal...The Accounting Standardization System for Public Administrations （SNC-AP） was approved by Decree-Law No. 192/2015, of September 11 and constituted the new accounting system for public administrations in Portugal, which will take effect from January 1, 2017, although there were pilot entities that are already applying it in the year 2016. The reasons for the approval of these accounting regulations are presented in the approval diploma itself, the existence of a strong fragmentation and outdated accounting standardization for the public sector. This paper intends to analyze the public accounting reform in Portugal based on the SNC-AP and the impacts that it will determine in public institutions in terms of accounting in relation to the previous POC-P regime and sectoral plans as well as the resources involved in the Implementation. Likewise, it is intended to assess whether all public bodies subject to its adoption will proceed to its implementation on January 1, 2017, as planned. For this purpose, the data available on this subject will be used, in particular those of the Directorate-General for the Budget of the Ministry of Finance.展开更多
The Administrative Board of theLianyungang Development Zone isan executive administrative organimplementing unified leadership andmanagement over the development zone onbehalf of the Lianyungang People’sgovernment. A...The Administrative Board of theLianyungang Development Zone isan executive administrative organimplementing unified leadership andmanagement over the development zone onbehalf of the Lianyungang People’sgovernment. According to the State’s lawsand regulations, the administrative board isresponsible for construction planning for thedevelopment zone, the execution of economicdevelopment programmes, the approval ofinvestment projects worth RMB30 millionor less, land use and building design, boostingpublic welfare in education, culture andsanitation, public security in the zone, andprotecting the legal rights of the展开更多
Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese medicine.In order to understand the blood a...Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese medicine.In order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of borneol.Blood samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/kg.Sample preparations were carried out by liquid-liquid extraction with an internal standard solution of octadecane.The pharmacokinetic parameters were calculated by the software of Kinetica.The calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,respectively.The methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic study.The borneol from injection was distributed and metabolized fast without absorption process.The borneol from oral administration was distributed more slowly and had the lowest absolute bioavailability.Nasal administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment.展开更多
Colloidal drug carriers such as liposomes,lipid emulsions,and polymeric nanoparticles have great potential to deliver drugs effectively.Preparation of nano-crystals of API has also received much attention to design do...Colloidal drug carriers such as liposomes,lipid emulsions,and polymeric nanoparticles have great potential to deliver drugs effectively.Preparation of nano-crystals of API has also received much attention to design dosage forms to complete effective drug delivery.A variety of investigations have been carried out toward the design of an optimal particulate system.展开更多
Under the great changes unseen in a century,comprehensive containment and suppression of China in the name of strategic competition has become a crossparty consensus in the United States,with the Republican Trump admi...Under the great changes unseen in a century,comprehensive containment and suppression of China in the name of strategic competition has become a crossparty consensus in the United States,with the Republican Trump administration initiating the process of containing and suppressing China and the Democratic Biden administration continuing and developing such a strategy.In the process of implementing this strategy,there are some diff erences in the goals and means of the two American administrations.The Trump administration was trying to“crush China”with the super strength of the United States,with more extreme and tougher means,being more unilateralist and even going so far as to launch a“new Cold War”against China.The Biden administration,on the other hand,emphasizes long-term competition with China,and focuses on“managing competition”while suppressing China,accustomed to being double-handed and using both carrot and stick.When it comes to addressing global challenges,the Republican Party completely lacks the will to cooperate with China,while the Democratic Party has a certain need for cooperation and action.展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标...《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,...Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,cluster-randomized,crossover trial,we assigned hospitals in Ontario,Canada,to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks.展开更多
Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providin...Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providing researchers,pharmacists,administrators,and educators working within the field of pharmacy worldwide with a platform of communication in the advancement and development in social pharmacy.The journal welcomes original contributions in pharmacy-related research including policies,regulations and laws,administration,monitoring,inspection,surveillance,utilization,formulary analysis,drug manufacturing,drug marketing,drug R&D,pharmacy practice,clinical pharmacy,pharmacoeconomics,and modernization of traditional Chinese medicine.To expedite the dissemination of findings from latest research,the journal receives rapid research report.Rapid research reports can be published within 3 months on submission,which does not preclude publication of full length reports of the research work in other journals.展开更多
State Administration for Market Regulation and National Standardization Administration of China have approved the following 273 national standards and 9 national standards with amendment.
In recent years,the operational landscape of companies within the digital economy has experienced significant transformations.Embracing cutting-edge ideologies and digital innovations has not only created diverse aven...In recent years,the operational landscape of companies within the digital economy has experienced significant transformations.Embracing cutting-edge ideologies and digital innovations has not only created diverse avenues for growth but also led to substantial progress in certain areas while phasing out and optimizing several business models.Against this backdrop,employing effective and rational strategies to enhance corporate management standards is crucial.This is particularly important given the imperfections in current management systems,the shortage of specialized talent,and the need for digital capability improvements,all of which are vital for ensuring the long-term stability and success of enterprises.With this in mind,this paper explores corporate administration models and proposes several practical solutions to address challenges faced in business management under the digital economy,aiming to serve as a valuable resource for professionals and decision-makers alike.展开更多
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory...Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.展开更多
State Administration for Market Regulation and National Standardization Administration of China have approved the following 26 mandatory national standards and 1 mandatory national standard with amendment.
State Administration for Market Regulation and National Standardization Administration of China have approved the following 416 voluntary national standards and 3 voluntary national standards with amendment.
State Administration for Market Regulation and National Standardization Administration of China have approved the following 278 voluntary national standards and 3 voluntary national standards with amendment.
Xizang has been an integral part of Chinese territory since ancient times.During the Qing Dynasty,the central government further strengthened its governance over Xizang,with management measures in local administration...Xizang has been an integral part of Chinese territory since ancient times.During the Qing Dynasty,the central government further strengthened its governance over Xizang,with management measures in local administration,military,religion,economy,and culture gradually being perfected and implemented.展开更多
文摘The Accounting Standardization System for Public Administrations （SNC-AP） was approved by Decree-Law No. 192/2015, of September 11 and constituted the new accounting system for public administrations in Portugal, which will take effect from January 1, 2017, although there were pilot entities that are already applying it in the year 2016. The reasons for the approval of these accounting regulations are presented in the approval diploma itself, the existence of a strong fragmentation and outdated accounting standardization for the public sector. This paper intends to analyze the public accounting reform in Portugal based on the SNC-AP and the impacts that it will determine in public institutions in terms of accounting in relation to the previous POC-P regime and sectoral plans as well as the resources involved in the Implementation. Likewise, it is intended to assess whether all public bodies subject to its adoption will proceed to its implementation on January 1, 2017, as planned. For this purpose, the data available on this subject will be used, in particular those of the Directorate-General for the Budget of the Ministry of Finance.
文摘The Administrative Board of theLianyungang Development Zone isan executive administrative organimplementing unified leadership andmanagement over the development zone onbehalf of the Lianyungang People’sgovernment. According to the State’s lawsand regulations, the administrative board isresponsible for construction planning for thedevelopment zone, the execution of economicdevelopment programmes, the approval ofinvestment projects worth RMB30 millionor less, land use and building design, boostingpublic welfare in education, culture andsanitation, public security in the zone, andprotecting the legal rights of the
基金Project supported by the Key New Drug Creation and Development Programme of China (No. 2009ZX09502-008)the National Natural Science Foundation of China (No. 81073057)the Innovation Team Development Program of Beijing University of Chinese Medicine (No. 2011-CXTD-13)
文摘Borneol,a monoterpenoid alcohol,is used widely,particularly in combined formulas for preventing and curing cardiovascular and cerebrovascular diseases in traditional Chinese medicine.In order to understand the blood and brain pharmacokinetics after intravenous,intranasal,or oral administration and to investigate the superiority and feasibility of intranasal administration,a simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the quantification of borneol.Blood samples and brain were collected from mice at 1,3,5,10,20,30,60,90,and 120 min after intravenous,intranasal,or oral administration of borneol at a dosage of 30.0 mg/kg.Sample preparations were carried out by liquid-liquid extraction with an internal standard solution of octadecane.The pharmacokinetic parameters were calculated by the software of Kinetica.The calibration curves were linear in the range of 0.11-84.24 μg/ml and 0.16-63.18 μg/g for borneol in plasma and brain,respectively.The methodological and extraction recoveries were both in the range of 85%-115%.The intra-day and inter-day variabilities for plasma and brain samples were ≤5.00% relative standard deviation (RSD).The absolute bioavailabilities F of intranasal and oral administrations were 90.68% and 42.99%.The relative brain targeted coefficients Re of intranasal and oral administrations were 68.37% and 38.40%.The GC-FID method developed could be applied to determination and pharmacokinetic study.The borneol from injection was distributed and metabolized fast without absorption process.The borneol from oral administration was distributed more slowly and had the lowest absolute bioavailability.Nasal administration of borneol was quickly absorbed into the blood and brain,was easy to use and had a greater safety than infection,which makes it worthy of further development as an administration route for encephalopathy treatment.
文摘Colloidal drug carriers such as liposomes,lipid emulsions,and polymeric nanoparticles have great potential to deliver drugs effectively.Preparation of nano-crystals of API has also received much attention to design dosage forms to complete effective drug delivery.A variety of investigations have been carried out toward the design of an optimal particulate system.
文摘Under the great changes unseen in a century,comprehensive containment and suppression of China in the name of strategic competition has become a crossparty consensus in the United States,with the Republican Trump administration initiating the process of containing and suppressing China and the Democratic Biden administration continuing and developing such a strategy.In the process of implementing this strategy,there are some diff erences in the goals and means of the two American administrations.The Trump administration was trying to“crush China”with the super strength of the United States,with more extreme and tougher means,being more unilateralist and even going so far as to launch a“new Cold War”against China.The Biden administration,on the other hand,emphasizes long-term competition with China,and focuses on“managing competition”while suppressing China,accustomed to being double-handed and using both carrot and stick.When it comes to addressing global challenges,the Republican Party completely lacks the will to cooperate with China,while the Democratic Party has a certain need for cooperation and action.
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,cluster-randomized,crossover trial,we assigned hospitals in Ontario,Canada,to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks.
文摘Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providing researchers,pharmacists,administrators,and educators working within the field of pharmacy worldwide with a platform of communication in the advancement and development in social pharmacy.The journal welcomes original contributions in pharmacy-related research including policies,regulations and laws,administration,monitoring,inspection,surveillance,utilization,formulary analysis,drug manufacturing,drug marketing,drug R&D,pharmacy practice,clinical pharmacy,pharmacoeconomics,and modernization of traditional Chinese medicine.To expedite the dissemination of findings from latest research,the journal receives rapid research report.Rapid research reports can be published within 3 months on submission,which does not preclude publication of full length reports of the research work in other journals.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 273 national standards and 9 national standards with amendment.
文摘In recent years,the operational landscape of companies within the digital economy has experienced significant transformations.Embracing cutting-edge ideologies and digital innovations has not only created diverse avenues for growth but also led to substantial progress in certain areas while phasing out and optimizing several business models.Against this backdrop,employing effective and rational strategies to enhance corporate management standards is crucial.This is particularly important given the imperfections in current management systems,the shortage of specialized talent,and the need for digital capability improvements,all of which are vital for ensuring the long-term stability and success of enterprises.With this in mind,this paper explores corporate administration models and proposes several practical solutions to address challenges faced in business management under the digital economy,aiming to serve as a valuable resource for professionals and decision-makers alike.
基金supported by the National Natural Science Foundation of China (32471188,32170984,82301787)。
文摘Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 26 mandatory national standards and 1 mandatory national standard with amendment.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 416 voluntary national standards and 3 voluntary national standards with amendment.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 278 voluntary national standards and 3 voluntary national standards with amendment.
文摘Xizang has been an integral part of Chinese territory since ancient times.During the Qing Dynasty,the central government further strengthened its governance over Xizang,with management measures in local administration,military,religion,economy,and culture gradually being perfected and implemented.
