Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer dr...Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer drugs and reduce the side effects in remote tissue. In the present study, two prodrugs-glycosylated aromatic nitrogen mustard derivatives were synthesized. Glucose and lactose were converted into glycosyl donors-trichloroacetimidate; the obtained glycosyl donors were glycosylated with p-nitrophenol （ glycosyl donors） to form β-glucosyl p-nitrobenzene and β-lactosyl p-nitrobenzene that were protected by acetyl in a stereoselective manner; the two products were reduced by zinc dust and then treated with ethylene oxide, afforded two glycosylated nitrogen mustard derivatives that were protected by acetyl; the last step was to deacetylate and then afforded the two target compounds that could be used as prodrugs of ADEPT for further Anti-tumor research.展开更多
本文探讨“亚历山大数字地球典型”(以下简称ADEPF,原文全称为Alexandria Digital Earth ProtoType)在教育评估中的研究设计。作为与地理学科相关资料库的数字图书馆,ADEPT现正在洛杉矾和圣.巴巴拉加利福尼亚大学本科生课堂上进行实例...本文探讨“亚历山大数字地球典型”(以下简称ADEPF,原文全称为Alexandria Digital Earth ProtoType)在教育评估中的研究设计。作为与地理学科相关资料库的数字图书馆,ADEPT现正在洛杉矾和圣.巴巴拉加利福尼亚大学本科生课堂上进行实例研究。本文介绍了数字图书馆在学校中的配置、信息技术在开发学生科学思维能力上的作用及对数字图书馆的总体评价,给出了全方位的研究设计,以及最新发展动向等。展开更多
Drug targeting to specific organs and tissues has become one of the critical endeavors of the century since the use of free drugs in conventional dosage forms generally involves difficulties in achieving the target si...Drug targeting to specific organs and tissues has become one of the critical endeavors of the century since the use of free drugs in conventional dosage forms generally involves difficulties in achieving the target site at the appropriate dose after or during a proper time period. Consequently, the search for new drug delivery approaches and new modes of action represent one of the frontier research areas. New drug delivery systems include lipidic, proteic and polymeric technologies to provide new sustained drug delivery with better body distribution, drug protection from harsh external environment and avoidance of drug clearance. Many of these technologies have reached the market therefore proving the benefits of these new carriers. This review covers the generalities of those new carriers and their new advances in drug delivery.展开更多
Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-t...Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-term experience of the ADEPT metal-on-metal system which has both modular and non-modular hip options. Methods: Functional assessment, blood metal ion quantification, and radiographic analysis were performed for the modular and non-modular ADEPT variants. Fifty implants were implanted with a mean follow up time of 28 months. Unpaired t-tests were used to compare modular and resurfacing groups, standardised hip scores were used to compare function to conventional total hip arthroplasty. Results: Metal ion levels were significantly higher in modular prostheses compared to resurfacing implants, but not at “harmful” levels (as determined by a previous metal-on-metal implant recall). Functional outcomes were excellent and revision rates were lower than expected. Conclusions: At our institution we have good outcomes with the ADEPT hip prosthesis. Though patient selection and implant position are crucial, poor performance of metal-on-metal hip replacements is implant specific.展开更多
案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技...案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技术和流程。但是在南非,航空和工程业规模不大,能获得的补助也非常有限。因此,ADEPT的运营预算颇为紧张。展开更多
基金Supported by the National Natural Science Foundation of China(No20030708)the Natural Science Foundation of JinlinProrince, P R China(No20050702-4)
文摘Antibody-directed enzyme prodrug therapy（ADEPT） is a new strategy for the treatment of cancer that has arisen in recent twenty years, the main merits of which are that it can improve the selectivity of anticancer drugs and reduce the side effects in remote tissue. In the present study, two prodrugs-glycosylated aromatic nitrogen mustard derivatives were synthesized. Glucose and lactose were converted into glycosyl donors-trichloroacetimidate; the obtained glycosyl donors were glycosylated with p-nitrophenol （ glycosyl donors） to form β-glucosyl p-nitrobenzene and β-lactosyl p-nitrobenzene that were protected by acetyl in a stereoselective manner; the two products were reduced by zinc dust and then treated with ethylene oxide, afforded two glycosylated nitrogen mustard derivatives that were protected by acetyl; the last step was to deacetylate and then afforded the two target compounds that could be used as prodrugs of ADEPT for further Anti-tumor research.
文摘本文探讨“亚历山大数字地球典型”(以下简称ADEPF,原文全称为Alexandria Digital Earth ProtoType)在教育评估中的研究设计。作为与地理学科相关资料库的数字图书馆,ADEPT现正在洛杉矾和圣.巴巴拉加利福尼亚大学本科生课堂上进行实例研究。本文介绍了数字图书馆在学校中的配置、信息技术在开发学生科学思维能力上的作用及对数字图书馆的总体评价,给出了全方位的研究设计,以及最新发展动向等。
文摘Drug targeting to specific organs and tissues has become one of the critical endeavors of the century since the use of free drugs in conventional dosage forms generally involves difficulties in achieving the target site at the appropriate dose after or during a proper time period. Consequently, the search for new drug delivery approaches and new modes of action represent one of the frontier research areas. New drug delivery systems include lipidic, proteic and polymeric technologies to provide new sustained drug delivery with better body distribution, drug protection from harsh external environment and avoidance of drug clearance. Many of these technologies have reached the market therefore proving the benefits of these new carriers. This review covers the generalities of those new carriers and their new advances in drug delivery.
文摘Background: There is much interest regarding metal-on-metal implants in medical and general media. Much of this has been regarding failure of specific implant systems and metal ion toxicity. We present our early mid-term experience of the ADEPT metal-on-metal system which has both modular and non-modular hip options. Methods: Functional assessment, blood metal ion quantification, and radiographic analysis were performed for the modular and non-modular ADEPT variants. Fifty implants were implanted with a mean follow up time of 28 months. Unpaired t-tests were used to compare modular and resurfacing groups, standardised hip scores were used to compare function to conventional total hip arthroplasty. Results: Metal ion levels were significantly higher in modular prostheses compared to resurfacing implants, but not at “harmful” levels (as determined by a previous metal-on-metal implant recall). Functional outcomes were excellent and revision rates were lower than expected. Conclusions: At our institution we have good outcomes with the ADEPT hip prosthesis. Though patient selection and implant position are crucial, poor performance of metal-on-metal hip replacements is implant specific.
文摘案例客户:ADEPT案例相关行业:航空航天案例相关产品:Autodesk Inventor项目挑战位于南飞的ADEPT Air motive(ADEPT)成立四年后就明确了自己的目标:开发通用航空引擎,获得绝对竞争力。为了实现这一目标,ADEPT决定采用业内最先进的技术和流程。但是在南非,航空和工程业规模不大,能获得的补助也非常有限。因此,ADEPT的运营预算颇为紧张。
