<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current...<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current neurochips,such as microelectrode array and field effect transistor array can be settled easily.Based on the theoretical analysis of the interface between cells and LAPS,spontaneously discharges of hippocampal neurons induced by Mg~ 2+)-free media treatment were recorded by LAPS.The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.展开更多
The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface fo...The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells.The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor device.The LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also paramount.This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level.Both characteristics of active recording array areas and cell culture conditions are measured.展开更多
In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industr...In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.30270387,No.30570492)the Project of State Key Laboratory of Transducer Technology of China(Grant No.SKT0403)the Foundation for the Bureau of Zhejiang Province of China(Grant No.20040197).
文摘<正>A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed.Using its light addressable characteristic.The problems of the limitations of restricted discrete active sites of current neurochips,such as microelectrode array and field effect transistor array can be settled easily.Based on the theoretical analysis of the interface between cells and LAPS,spontaneously discharges of hippocampal neurons induced by Mg~ 2+)-free media treatment were recorded by LAPS.The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 30270387, No. 30570492）；the Project of State Key Laboratory of Transducer Technology of China （Grant No. SKT0403）；the Foundation for the Bureau of Zhejiang Province of China （Grant No. 20040197）.
文摘The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells.The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor device.The LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also paramount.This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level.Both characteristics of active recording array areas and cell culture conditions are measured.
基金supported by the National Natural Science Foundation of China (Nos. 61834005, 61602377, 61772417, 61802304, 61874087)the Shaanxi International Science and Technology Cooperation Program No. 2018KW-006+1 种基金Shaanxi Provincial Key R&D Plan under Grant No. 2017GY-060Shaanxi Province Co-ordination Innovation Project of Science and Technology under Grant No. 2016KTZDGY02-04-02
文摘In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.
