The monomer 6-O-vinyladipoyl-D-glucopyranose( VAG)was synthesized by lipase catalyzed trans-esterification of divinyladipate with D-glucopyranose. A novel double hydrophilic glycopolymer poly( diethyleneglycol methacr...The monomer 6-O-vinyladipoyl-D-glucopyranose( VAG)was synthesized by lipase catalyzed trans-esterification of divinyladipate with D-glucopyranose. A novel double hydrophilic glycopolymer poly( diethyleneglycol methacrylate-co-6-Ovinyladipoyl-D-glucopyranose)( P( DEGMA-co-VAG)) with narrow polydispersity( PDI) and thermosensitivity was prepared by reversible addition-fragmentation chain transfer( RAFT)polymerization. P( DEGMA-co-VAG) was characterized by1 H NMR,FTIR and gel permeation chromatography( GPC). The characterization of UV-visible spectroscopy showed that the micelles from glycopolymer P( DEGMA-co-VAG) were thermo-responsive and the low critical solution temperature( LCST) could be controlled by the molar ratio of monomers. When the molar ratio of DEGMA and VAG was 2∶ 1,the LCST of P( DEGMA-co-VAG) was36 ℃ in aqueous solution,which could form nano micelles in the human body environment. It was found that P( DEGMA-co-VAG)was non-toxic at 0. 1-1 mg / m L concentrations when incubated with pig iliac endothelial cells( PIECs) for 24 h. Thus,the synthesized glycopolymers has great potential as drug delivery carriers.展开更多
Polymerization-induced cooperative assembly(PICA)is reported to efficiently access inverse bicontinuous mesophases within particles consisting of amphiphilic block copolymers(BCPs)and solvophobic copolymers.Reversible...Polymerization-induced cooperative assembly(PICA)is reported to efficiently access inverse bicontinuous mesophases within particles consisting of amphiphilic block copolymers(BCPs)and solvophobic copolymers.Reversible addition-fragmentation chain transfer(RAFT)dispersion alternating copolymerization of styrene and pentafluorostyrene is conducted in 2%v/v toluene/ethanol by simultaneously using poly(N,N-dimethylacrylamide)(PDMA29)as a macromolecular chain transfer agent(macro-CTA)and small molecule CTA.展开更多
基金National Natural Science Foundation of China(No.21303014)
文摘The monomer 6-O-vinyladipoyl-D-glucopyranose( VAG)was synthesized by lipase catalyzed trans-esterification of divinyladipate with D-glucopyranose. A novel double hydrophilic glycopolymer poly( diethyleneglycol methacrylate-co-6-Ovinyladipoyl-D-glucopyranose)( P( DEGMA-co-VAG)) with narrow polydispersity( PDI) and thermosensitivity was prepared by reversible addition-fragmentation chain transfer( RAFT)polymerization. P( DEGMA-co-VAG) was characterized by1 H NMR,FTIR and gel permeation chromatography( GPC). The characterization of UV-visible spectroscopy showed that the micelles from glycopolymer P( DEGMA-co-VAG) were thermo-responsive and the low critical solution temperature( LCST) could be controlled by the molar ratio of monomers. When the molar ratio of DEGMA and VAG was 2∶ 1,the LCST of P( DEGMA-co-VAG) was36 ℃ in aqueous solution,which could form nano micelles in the human body environment. It was found that P( DEGMA-co-VAG)was non-toxic at 0. 1-1 mg / m L concentrations when incubated with pig iliac endothelial cells( PIECs) for 24 h. Thus,the synthesized glycopolymers has great potential as drug delivery carriers.
基金support by the National Natural Science Foundation of China(nos.51733003 and 21674059)the Fundamental Research Funds for the Central Universities are thanked.
文摘Polymerization-induced cooperative assembly(PICA)is reported to efficiently access inverse bicontinuous mesophases within particles consisting of amphiphilic block copolymers(BCPs)and solvophobic copolymers.Reversible addition-fragmentation chain transfer(RAFT)dispersion alternating copolymerization of styrene and pentafluorostyrene is conducted in 2%v/v toluene/ethanol by simultaneously using poly(N,N-dimethylacrylamide)(PDMA29)as a macromolecular chain transfer agent(macro-CTA)and small molecule CTA.
