The rapid development of urban rail transit has posed increasing construction and operational challenges for metro tunnels,often leading to structural damage.Grouting technology using cement-based materials is widely ...The rapid development of urban rail transit has posed increasing construction and operational challenges for metro tunnels,often leading to structural damage.Grouting technology using cement-based materials is widely applied to address issues such as seepage,leakage,and alignment correction in shield tunnels.This study investigates the additional stress induced by grouting in silty soil layers,using cement-based grouts with different water-to-cement ratios and polyurethane-modified cement-based materials.Results show that additional stress decreases with depth and is more influenced by horizontal distance from the grouting point.In staged grouting,the first injection phase contributes about 50%of the peak additional stress.A lower water-to-cement ratio(e.g.,0.6)increases additional stress but reduces grout flowability,while a higher ratio improves diffusion but increases the risk of grout loss.(≥1.0)The polyurethane-modified cement-based material enhances stress transfer performance,increasing peak additional stress by approximately 10%.These findings provide theoretical guidance for optimizing material selection and grouting design in metro tunnel repair within silty soil layers.展开更多
The coupling effect of dual-parallel rotor connected stator permanent magnet synchronous motor not only affects the magnetic field in the coupling area, but also generates an additional magnetic field in the uncoupled...The coupling effect of dual-parallel rotor connected stator permanent magnet synchronous motor not only affects the magnetic field in the coupling area, but also generates an additional magnetic field in the uncoupled area.The characteristics of the additional magnetic field and its influence on electromagnetic torque are studied in this paper.The topology and parameters of motor are described briefly.The existence of additional magnetic field is proved by the simulation models under two boundary conditions, and its characteristics and source are analyzed. The analytical model is established, and the influence of key parameters on the additional magnetic field is discussed. On this basis, the influence of the additional magnetic field on the electromagnetic torque of the motor is studied, and the analytical expression of the additional torque is constructed.The fluctuation rule is analyzed, and the additional magnetic field separation model is proposed. The theoretical analysis and simulation results reveal and improve the internal mechanism of reducing motor torque ripple by optimizing the duty angle and coupling distance. Finally, a prototype test platform is built to verify the correctness of the proposed theory and the accuracy of the simulation model.展开更多
Unrelated parallel machine scheduling problem(UPMSP)is a typical scheduling one and UPMSP with various reallife constraints such as additional resources has been widely studied;however,UPMSP with additional resources,...Unrelated parallel machine scheduling problem(UPMSP)is a typical scheduling one and UPMSP with various reallife constraints such as additional resources has been widely studied;however,UPMSP with additional resources,maintenance,and energy-related objectives is seldom investigated.The Artificial Bee Colony(ABC)algorithm has been successfully applied to various production scheduling problems and demonstrates potential search advantages in solving UPMSP with additional resources,among other factors.In this study,an energy-efficient UPMSP with additional resources and maintenance is considered.A dynamical artificial bee colony(DABC)algorithm is presented to minimize makespan and total energy consumption simultaneously.Three heuristics are applied to produce the initial population.Employed bee swarm and onlooker bee swarm are constructed.Computing resources are shifted from the dominated solutions to non-dominated solutions in each swarm when the given condition is met.Dynamical employed bee phase is implemented by computing resource shifting and solution migration.Computing resource shifting and feedback are used to construct dynamical onlooker bee phase.Computational experiments are conducted on 300 instances from the literature and three comparative algorithms and ABC are compared after parameter settings of all algorithms are given.The computational results demonstrate that the new strategies of DABC are effective and that DABC has promising advantages in solving the considered UPMSP.展开更多
An alluvium with a sandy aquifer at the bottom,but lacking an effective impermeable layer between the sandy aquifer and bedrock is referred to as a special alluvial stratum.Impacted by the drainage of the aquifer due ...An alluvium with a sandy aquifer at the bottom,but lacking an effective impermeable layer between the sandy aquifer and bedrock is referred to as a special alluvial stratum.Impacted by the drainage of the aquifer due to mining activities,a shaft wall in this special alluvial stratum will be subject to a downward load by an additional vertical force which must be taken into consideration in the design of the shaft wall.The complexity of interaction between shaft wall and the surrounding walls makes it extremely difficult to determine this additional vertical force.For a particular shaft wall in an extra-thick alluvium and assuming that the friction coefficient between shaft wall and stratum does not change with depth,an analysis of a numerical simulation of the stress within the shaft wall has been carried out.Growth and size of the additional vertical stress have been obtained,based on specific values of the friction coefficient,the modulus of elasticity of the drainage layer and the thickness of the drainage layer.Subsequently, the safety of shaft walls with different structural types was studied and a more suitable structural design,providing an important basis for the design of shaft walls,is promoted.展开更多
To analyse a possible way to improve the propulsion performance of ships,the unstructured grid and the Reynolds Average Navier-Stokes equations were used to calculate the performance of a propeller and rudder fitted w...To analyse a possible way to improve the propulsion performance of ships,the unstructured grid and the Reynolds Average Navier-Stokes equations were used to calculate the performance of a propeller and rudder fitted with additional thrust fins in the viscous flow field.The computational fluid dynamics software FLUENT was used to simulate the thrust and torque coefficient as a function of the advance coefficient of propeller and the thrust efficiency of additional thrust fins. The pressure and velocity flow behind the propeller was calculated. The geometrical nodes of the propeller were constituted by FORTRAN program and the NUMBS method was used to create a configuration of the propeller,which was then used by GAMMBIT to generate the calculation model. The thrust efficiency of fins was calculated as a function of the number of additional fins and the attack angles. The results of the calculations agree fairly well with experimental data,which shows that the viscous flow solution we present is useful in simulating the performance of propellers and rudders with additional fins.展开更多
Human epidermal growth factor receptor 2(HER2)-overexpressing breast cancer is an aggressive phenotype with a poor prognosis,and can easily metastasize and recur.Currently,chemotherapy plus HER2-targeted therapy is th...Human epidermal growth factor receptor 2(HER2)-overexpressing breast cancer is an aggressive phenotype with a poor prognosis,and can easily metastasize and recur.Currently,chemotherapy plus HER2-targeted therapy is the standard systemic treatment for most of these patients.Given that neoadjuvant chemotherapy(NAC)has an efficacy equivalent to that of adjuvant chemotherapy and some additional benefits,many patients,especially those with more advanced tumors,prefer NAC and generally will not receive additional chemotherapy after surgery,irrespective of the pathological response.However,achieving pathological complete response to NAC is strongly correlated with prognosis,especially in triple-negative and HER2-overexpressing breast cancer.Therefore,postoperative treatment of these patients with residual diseases should be optimized to achieve favorable outcomes.The CREATE-X study has confirmed that additional chemotherapy can improve the outcomes of patients with HER2-negative residual disease after NAC.In addition,chemotherapy plays an indispensable role in the treatment of patients who receive surgery directly or who have recurrent lesions.Therefore,can additional chemotherapy improve prognosis of patients with HER2-overexpressing residual breast cancer?At present,no studies have compared the efficacy of additional chemotherapy plus trastuzumab with that of anti-HER2 therapy alone in residual cancer.The KATHERINE study revealed that trastuzumab emtansine(T-DM1)can reduce the risk of recurrence or death by 50%compared with trastuzumab in patients with HER2-positive residual invasive breast cancer after neoadjuvant therapy.T-DM1 is an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine,and thus,to an extent,T-DM1 is equivalent to simultaneous application of chemotherapy and targeted therapy.However,high cost and low accessibility limit its use especially in low-and middle-income countries and regions.Hence,we proposed this perspective that additional chemotherapy plus trastuzumab should be given to HER2-overexpressing breast cancer patients with residual disease after NAC to improve their prognosis by discussing that the efficacy of additional chemotherapy plus trastuzumab is superior to that of anti-HER2 therapy alone and not inferior to T-DM1.Additional chemotherapy plus trastuzumab-based HER2-targeted therapy can be used as an alternative regimen to T-DM1 when T-DM1 is unavailable.However,further clinical research on the selection of chemotherapeutic agents is warranted.展开更多
In this study,the tomography of dynamic stress coefficient(TDSC)was established based on a mechanical model of stress wave propagation in bedding planes and a mathematical model of the stress wave attenuation in rock ...In this study,the tomography of dynamic stress coefficient(TDSC)was established based on a mechanical model of stress wave propagation in bedding planes and a mathematical model of the stress wave attenuation in rock masses.The reliability of the TDSC was verified by a linear bedding plane model and field monitoring.Generally,the TDSC in the dynamic stress propagation of bedding planes increases with the following conditions:(1)the increase of the normal stiffness of the bedding plane,(2)the increase of the incident angle of the stress wave,(3)the decrease of the incident frequency of the stress wave,or(4)the growth of three ratios(the ratios of rock densities,elastic moduli,and the Poisson’s ratios)of rocks on either side of bedding planes.The additional stress weakens TDSC linearly and slowly during the stress wave propagation in bedding planes,and the weakening effect increases with the growth of the three ratios.Besides,the TDSC decreases exponentially in the rock mass as propagation distance increases.In a field case,the TDSC decreases significantly as vertical and horizontal distances increase and its wave range increases as vertical distance increases in the sedimentary rock layers.展开更多
A new mechanics model, which reveals additional longitudinal force transmission between the continuously welded rails and the bridges, is established on the fact that the influence of the mutual relative displacement ...A new mechanics model, which reveals additional longitudinal force transmission between the continuously welded rails and the bridges, is established on the fact that the influence of the mutual relative displacement (among) the rail, the sleeper and the beam is taken into account. An example is presented and numerical results are compared. The results show that the additional longitudinal forces calculated with the new model are less than those of the previous, especially in the case of the flexible pier bridges. The new model is also suitable for the analysis of the additional longitudinal force transmission between rails and bridges of ballastless track with small resistance fasteners without taking the sleeper displacement into account, and compared with the ballast bridges, the ballastless bridges have a much stronger additional longitudinal force transmission between the continuously welded rails and the bridges.展开更多
The model of skaft lining under force is developed on the basis of the special stratum condition led to sbart cracking- The model is broken into 3 sub-questions to solve separately. According to the principle of super...The model of skaft lining under force is developed on the basis of the special stratum condition led to sbart cracking- The model is broken into 3 sub-questions to solve separately. According to the principle of superposition and strain compatibility, a second kind Fredholm integral equation is generated.A theoretical solution to vertical additional force on shaft lining is obtained by numerical method to the integral equation.展开更多
The current research of real-time observation for vehicle roll steer angle and compliance steer angle（both of them comprehensively referred as the additional steer angle in this paper） mainly employs the linear vehi...The current research of real-time observation for vehicle roll steer angle and compliance steer angle（both of them comprehensively referred as the additional steer angle in this paper） mainly employs the linear vehicle dynamic model, in which only the lateral acceleration of vehicle body is considered. The observation accuracy resorting to this method cannot meet the requirements of vehicle real-time stability control, especially under extreme driving conditions. The paper explores the solution resorting to experimental method. Firstly, a multi-body dynamic model of a passenger car is built based on the ADAMS/Car software, whose dynamic accuracy is verified by the same vehicle＇s roadway test data of steady static circular test. Based on this simulation platform, several influencing factors of additional steer angle under different driving conditions are quantitatively analyzed. Then ε-SVR algorithm is employed to build the additional steer angle prediction model, whose input vectors mainly include the sensor information of standard electronic stability control system（ESC）. The method of typical slalom tests and FMVSS 126 tests are adopted to make simulation, train model and test model＇s generalization performance. The test result shows that the influence of lateral acceleration on additional steer angle is maximal （the magnitude up to 1°）, followed by the longitudinal acceleration-deceleration and the road wave amplitude （the magnitude up to 0.3°）. Moreover, both the prediction accuracy and the calculation real-time of the model can meet the control requirements of ESC This research expands the accurate observation methods of the additional steer angle under extreme driving conditions.展开更多
Objective Current clinical evidence on the effects of home blood pressure telemonitoring(HBPT)on improving blood pressure control comes entirely from developed countries.Thus,we performed this randomized controlled tr...Objective Current clinical evidence on the effects of home blood pressure telemonitoring(HBPT)on improving blood pressure control comes entirely from developed countries.Thus,we performed this randomized controlled trial to evaluate whether HBPT plus support(patient education and clinician remote hypertension management)improves blood pressure control more than usual care(UC)in the Chinese population.Methods This single-center,randomized controlled study was conducted in Beijing,China.Patients aged 30-75 years were eligible for enrolment if they had blood pressure[systolic(SBP)≥140 mmHg and/or diastolic(DBP)≥90 mmHg;or SBP≥130 mmHg and/or DBP≥80 mmHg with diabetes].We recruited 190 patients randomized to either the HBPT or the UC groups for 12 weeks.The primary endpoints were blood pressure reduction and the proportion of patients achieving the target blood pressure.Results Totally,172 patients completed the study,the HBPT plus support group(n=84),and the UC group(n=88).Patients in the plus support group showed a greater reduction in mean ambulatory blood pressure than those in the UC group.The plus support group had a significantly higher proportion of patients who achieved the target blood pressure and maintained a dipper blood pressure pattern at the12th week of follow-up.Additionally,the patients in the plus support group showed lower blood pressure variability and higher drug adherence than those in the UC group.Conclusion HBPT plus additional support results in greater blood pressure reduction,better blood pressure control,a higher proportion of dipper blood pressure patterns,lower blood pressure variability,and higher drug adherence than UC.The development of telemedicine may be the cornerstone of hypertension management in primary care.展开更多
Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat treatment.In the supersaturated Al-Tl-S...Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat treatment.In the supersaturated Al-Tl-Si alloy, age hardening occurred after 1 h anneal in the temperature range of 4000~500℃, which seems to be attributed to the precipitation of metastable Ll2- (Al,Si)3Ti phase. However. the microhardness was relatively low because of the low v/o and the insufflcient stability of precipitates. Thus. Cr was added to Al-Ti-Si alloys in order to stabilize the microstructures and to increase the v/o of precipitate5. As a result. the alIoys containing Cr were evaluated to possess the improved properties at the service temperature.展开更多
Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulat...Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulated by specially designed Matlab procedure.Then displacement components of fibers at YZ profile under different negative pressure conditions are extracted and compared.The results show that the fibers of different initial positions gradually converge,and are interlaced for position change in yarn cross-section,caused by the airflow in the condensing zone.Finally,compact-spun yarn with different negative pressure and conventional ring spun yarn are produced and their twists are tested.Both the results of simulation and experiments illustrate the existence of additional twists.Also the relationship between additional twists and negative pressure is verified.展开更多
In this paper, the compatibility between the integral type gauge transformation and the additional symmetry of the constrained KP hierarchy is given. And the string-equation constraint in matrix models is also derived.
Additional displacement of the building foundations over old goaf are prone to happen under the addi- tional loads induced by new buildings, weakening-rock mass by mining and seismic actions, which will cause serious ...Additional displacement of the building foundations over old goaf are prone to happen under the addi- tional loads induced by new buildings, weakening-rock mass by mining and seismic actions, which will cause serious damage to the buildings. In order to analyze the safety of the building foundations safety over the old goaf. the structure characteristics of the strata over the old goaf was investigated and the instability conditions of overhanging rocks upon old goaf were also analyzed in this paper. The results indicate that the stability of overhanging rocks is remarkably decreased by the interactions of mining fractures, earthquake force and building load, in addition, the settlement of the foundations over old goal is increased by the instability of overhanging rocks. According to the location of a new power plant in Yima Mine and its ambient conditions, we defined the influence scope of old goal via resistivity tomography. Based on the seismic parameters of the construction site, a numerical FLAC3d model of the building foundation under the seismic actions and building load was developed. The numerical results are obtained as follows： the foundation of the main power house meets the requirement of 6° seismic fortification intensity： however, under 7° seismic fortification intensity, the maximum differential settlement of foundation between the neighboring pillars is close to the maximum allowable value, while the seismic fortification intensity reaches 8°, but the safety requirements will not be satisfied.展开更多
Through adding different additional water use,the compressive strength,splitting tensile strength and fluidity of recycled concrete of three aggregate combination forms were studied by experiment respectively.The expe...Through adding different additional water use,the compressive strength,splitting tensile strength and fluidity of recycled concrete of three aggregate combination forms were studied by experiment respectively.The experimental results show that with the increase of adding additional water use,the compressive strength and splitting tensile strength of recycled coarse aggregate concrete decrease,but that of recycled fine aggregate concrete and recycled all aggregate concrete increase firstly then decrease.When additional water use is added more 15% or 20% than that of basic ordinary concrete,the recycled coarse aggregate concrete and fine one can get pretty good fluidity.When it is added more 30%,the recycled all aggregate concrete has fluidity that is just satisfied.展开更多
BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal...BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal and reasonable rescue option involves early suspicion and identification of patients with inadequate preparation before sedation, additional oral ingestion of a suitable preparation formulation, and same-day colonoscopy.AIM To compare 0.5-L and 1-L polyethylene glycol containing ascorbic acid(PEG +Asc) as additional bowel cleansing methods after a 2-L split-dose PEG + Asc regimen in patients with expected inadequate bowel preparation before colonoscopy.METHODS Individuals with expected inadequate bowel preparation based on last stool form, such as turbid liquid, particulate liquid, or liquid with small amounts of feces, were randomized to either a 0.5-L PEG + Asc group or a 1-L PEG + Asc group. The primary endpoint was bowel preparation as assessed using the Aronchick bowel preparation scale(ABPS) and Boston bowel preparation scale(BBPS) scores. The secondary endpoints were cecal intubation time, withdrawal time, polyp detection rate(PDR), adenoma detection rate(ADR), individual compliance with additional PEG + Asc, and patient satisfaction.RESULTS Initially, 98 patients were included, but 8 were later excluded due to withdrawal of consent to participate in the study. Adequate bowel preparation(as assessed by ABPS) was observed in 80.9%(38/47) of subjects in the 0.5-L group and in88.4%(38/43) of subjects in the 1-L group(P = 0.617). Mean total BBPS was 6.7 points in the 0.5-L group and 7.0 points in the 1-L group(P = 0.458). ADRs and PDRs were similar in the two groups, and cecal intubation and withdrawal times were not significantly different. However, mean patient satisfaction score was significantly higher in the 0.5-L group(P = 0.041).CONCLUSION The bowel cleaning efficacy of additional 0.5-L PEG + Asc was not inferior to that of 1-L PEG + Asc. Additional 0.5-L PEG + Asc is worthwhile when inadequate bowel preparation is expected before colonoscopy.展开更多
To improve the power-extraction performance of the Savonius vertical-axis wind turbine(S-VAWT),additional cylinders,which are used to control the fluid flow around the wind turbine blade,were introduced into the blade...To improve the power-extraction performance of the Savonius vertical-axis wind turbine(S-VAWT),additional cylinders,which are used to control the fluid flow around the wind turbine blade,were introduced into the blade design.In contrast to the traditional numerical method,a mathematical model in the form of a dynamical system was used in this study.A numerical calculation program that could effectively solve the equations of wind-induced rotation of S-VAWT was developed,and combined with the Taguchi experimental method to investigate the influence of additional cylinders on the power-extraction characteristics of the S-VAWT.The results showed that the additional cylinders have a significant impact on the power-extraction performance of the S-VAWT.At 4-m/s wind speed,the average power coefficient of the S-VAWT with additional cylinders is 15%higher than that of the conventional S-VAWT.After construction of the wind turbine prototype and power-extraction tests,the results showed that compared with a conventional S-VAWT,the output power was 29%higher for the S-VAWT with additional cylinders under the same particular conditions.展开更多
A novel car-following model is offered based on the cooperative information transmission delayed effect involving headway and velocity under V2 X environment.The stability conditions and m Kd V equation of the new mod...A novel car-following model is offered based on the cooperative information transmission delayed effect involving headway and velocity under V2 X environment.The stability conditions and m Kd V equation of the new model are obtained via the linear and nonlinear analysis.Through numerical simulation,the variation trend of headway and hysteresis phenomenon are studied.In addition,we investigate the additional energy consumption of the vehicle during acceleration.In brief,theoretical analysis and simulation results confirm that the new car-following model based on the cooperative information transmission delayed effect can improve traffic stability and reduce additional energy consumption.展开更多
基金supported by the National Natural Science Foundation of China(No.42477185)Natural Science Foundation of Zhejiang Province(LQ24A020015)+1 种基金Research Achievement Award Cultivation Project of Zhejiang University of Science and Technology(2023JLYB001)the Postgraduate Course Construction Project of Zhejiang University of Science and Technology(2024yjskj05).
文摘The rapid development of urban rail transit has posed increasing construction and operational challenges for metro tunnels,often leading to structural damage.Grouting technology using cement-based materials is widely applied to address issues such as seepage,leakage,and alignment correction in shield tunnels.This study investigates the additional stress induced by grouting in silty soil layers,using cement-based grouts with different water-to-cement ratios and polyurethane-modified cement-based materials.Results show that additional stress decreases with depth and is more influenced by horizontal distance from the grouting point.In staged grouting,the first injection phase contributes about 50%of the peak additional stress.A lower water-to-cement ratio(e.g.,0.6)increases additional stress but reduces grout flowability,while a higher ratio improves diffusion but increases the risk of grout loss.(≥1.0)The polyurethane-modified cement-based material enhances stress transfer performance,increasing peak additional stress by approximately 10%.These findings provide theoretical guidance for optimizing material selection and grouting design in metro tunnel repair within silty soil layers.
基金supported in part by the Natural Science Foundation of Heilongjiang Province under Grant LH2023E084by the National Natural Science Foundation of China under Grant 51777048。
文摘The coupling effect of dual-parallel rotor connected stator permanent magnet synchronous motor not only affects the magnetic field in the coupling area, but also generates an additional magnetic field in the uncoupled area.The characteristics of the additional magnetic field and its influence on electromagnetic torque are studied in this paper.The topology and parameters of motor are described briefly.The existence of additional magnetic field is proved by the simulation models under two boundary conditions, and its characteristics and source are analyzed. The analytical model is established, and the influence of key parameters on the additional magnetic field is discussed. On this basis, the influence of the additional magnetic field on the electromagnetic torque of the motor is studied, and the analytical expression of the additional torque is constructed.The fluctuation rule is analyzed, and the additional magnetic field separation model is proposed. The theoretical analysis and simulation results reveal and improve the internal mechanism of reducing motor torque ripple by optimizing the duty angle and coupling distance. Finally, a prototype test platform is built to verify the correctness of the proposed theory and the accuracy of the simulation model.
基金the National Natural Science Foundation of China(grant number 61573264)。
文摘Unrelated parallel machine scheduling problem(UPMSP)is a typical scheduling one and UPMSP with various reallife constraints such as additional resources has been widely studied;however,UPMSP with additional resources,maintenance,and energy-related objectives is seldom investigated.The Artificial Bee Colony(ABC)algorithm has been successfully applied to various production scheduling problems and demonstrates potential search advantages in solving UPMSP with additional resources,among other factors.In this study,an energy-efficient UPMSP with additional resources and maintenance is considered.A dynamical artificial bee colony(DABC)algorithm is presented to minimize makespan and total energy consumption simultaneously.Three heuristics are applied to produce the initial population.Employed bee swarm and onlooker bee swarm are constructed.Computing resources are shifted from the dominated solutions to non-dominated solutions in each swarm when the given condition is met.Dynamical employed bee phase is implemented by computing resource shifting and solution migration.Computing resource shifting and feedback are used to construct dynamical onlooker bee phase.Computational experiments are conducted on 300 instances from the literature and three comparative algorithms and ABC are compared after parameter settings of all algorithms are given.The computational results demonstrate that the new strategies of DABC are effective and that DABC has promising advantages in solving the considered UPMSP.
文摘An alluvium with a sandy aquifer at the bottom,but lacking an effective impermeable layer between the sandy aquifer and bedrock is referred to as a special alluvial stratum.Impacted by the drainage of the aquifer due to mining activities,a shaft wall in this special alluvial stratum will be subject to a downward load by an additional vertical force which must be taken into consideration in the design of the shaft wall.The complexity of interaction between shaft wall and the surrounding walls makes it extremely difficult to determine this additional vertical force.For a particular shaft wall in an extra-thick alluvium and assuming that the friction coefficient between shaft wall and stratum does not change with depth,an analysis of a numerical simulation of the stress within the shaft wall has been carried out.Growth and size of the additional vertical stress have been obtained,based on specific values of the friction coefficient,the modulus of elasticity of the drainage layer and the thickness of the drainage layer.Subsequently, the safety of shaft walls with different structural types was studied and a more suitable structural design,providing an important basis for the design of shaft walls,is promoted.
文摘To analyse a possible way to improve the propulsion performance of ships,the unstructured grid and the Reynolds Average Navier-Stokes equations were used to calculate the performance of a propeller and rudder fitted with additional thrust fins in the viscous flow field.The computational fluid dynamics software FLUENT was used to simulate the thrust and torque coefficient as a function of the advance coefficient of propeller and the thrust efficiency of additional thrust fins. The pressure and velocity flow behind the propeller was calculated. The geometrical nodes of the propeller were constituted by FORTRAN program and the NUMBS method was used to create a configuration of the propeller,which was then used by GAMMBIT to generate the calculation model. The thrust efficiency of fins was calculated as a function of the number of additional fins and the attack angles. The results of the calculations agree fairly well with experimental data,which shows that the viscous flow solution we present is useful in simulating the performance of propellers and rudders with additional fins.
文摘Human epidermal growth factor receptor 2(HER2)-overexpressing breast cancer is an aggressive phenotype with a poor prognosis,and can easily metastasize and recur.Currently,chemotherapy plus HER2-targeted therapy is the standard systemic treatment for most of these patients.Given that neoadjuvant chemotherapy(NAC)has an efficacy equivalent to that of adjuvant chemotherapy and some additional benefits,many patients,especially those with more advanced tumors,prefer NAC and generally will not receive additional chemotherapy after surgery,irrespective of the pathological response.However,achieving pathological complete response to NAC is strongly correlated with prognosis,especially in triple-negative and HER2-overexpressing breast cancer.Therefore,postoperative treatment of these patients with residual diseases should be optimized to achieve favorable outcomes.The CREATE-X study has confirmed that additional chemotherapy can improve the outcomes of patients with HER2-negative residual disease after NAC.In addition,chemotherapy plays an indispensable role in the treatment of patients who receive surgery directly or who have recurrent lesions.Therefore,can additional chemotherapy improve prognosis of patients with HER2-overexpressing residual breast cancer?At present,no studies have compared the efficacy of additional chemotherapy plus trastuzumab with that of anti-HER2 therapy alone in residual cancer.The KATHERINE study revealed that trastuzumab emtansine(T-DM1)can reduce the risk of recurrence or death by 50%compared with trastuzumab in patients with HER2-positive residual invasive breast cancer after neoadjuvant therapy.T-DM1 is an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine,and thus,to an extent,T-DM1 is equivalent to simultaneous application of chemotherapy and targeted therapy.However,high cost and low accessibility limit its use especially in low-and middle-income countries and regions.Hence,we proposed this perspective that additional chemotherapy plus trastuzumab should be given to HER2-overexpressing breast cancer patients with residual disease after NAC to improve their prognosis by discussing that the efficacy of additional chemotherapy plus trastuzumab is superior to that of anti-HER2 therapy alone and not inferior to T-DM1.Additional chemotherapy plus trastuzumab-based HER2-targeted therapy can be used as an alternative regimen to T-DM1 when T-DM1 is unavailable.However,further clinical research on the selection of chemotherapeutic agents is warranted.
基金This work is supported by the National Natural Science Foundation of China(Nos.51804099 and U1704129)the Focus Research and Special Development for Scientific and Technological Project of Henan Province(No.202102310542)+1 种基金the Fundamental Research Funds for the Central Universities(No.2018ZDPY02ZDPY02)the research fund of State Key Laboratory of Coal Resources and Safe Mining,CUMT(SKLCRSM19KF011).
文摘In this study,the tomography of dynamic stress coefficient(TDSC)was established based on a mechanical model of stress wave propagation in bedding planes and a mathematical model of the stress wave attenuation in rock masses.The reliability of the TDSC was verified by a linear bedding plane model and field monitoring.Generally,the TDSC in the dynamic stress propagation of bedding planes increases with the following conditions:(1)the increase of the normal stiffness of the bedding plane,(2)the increase of the incident angle of the stress wave,(3)the decrease of the incident frequency of the stress wave,or(4)the growth of three ratios(the ratios of rock densities,elastic moduli,and the Poisson’s ratios)of rocks on either side of bedding planes.The additional stress weakens TDSC linearly and slowly during the stress wave propagation in bedding planes,and the weakening effect increases with the growth of the three ratios.Besides,the TDSC decreases exponentially in the rock mass as propagation distance increases.In a field case,the TDSC decreases significantly as vertical and horizontal distances increase and its wave range increases as vertical distance increases in the sedimentary rock layers.
文摘A new mechanics model, which reveals additional longitudinal force transmission between the continuously welded rails and the bridges, is established on the fact that the influence of the mutual relative displacement (among) the rail, the sleeper and the beam is taken into account. An example is presented and numerical results are compared. The results show that the additional longitudinal forces calculated with the new model are less than those of the previous, especially in the case of the flexible pier bridges. The new model is also suitable for the analysis of the additional longitudinal force transmission between rails and bridges of ballastless track with small resistance fasteners without taking the sleeper displacement into account, and compared with the ballast bridges, the ballastless bridges have a much stronger additional longitudinal force transmission between the continuously welded rails and the bridges.
文摘The model of skaft lining under force is developed on the basis of the special stratum condition led to sbart cracking- The model is broken into 3 sub-questions to solve separately. According to the principle of superposition and strain compatibility, a second kind Fredholm integral equation is generated.A theoretical solution to vertical additional force on shaft lining is obtained by numerical method to the integral equation.
基金supported by National Natural Science Foundation of China(Grant No.51105001)State Key Laboratory of Automotive Safety and Energy,Tsinghua University,China(Grant No.KF14022)
文摘The current research of real-time observation for vehicle roll steer angle and compliance steer angle（both of them comprehensively referred as the additional steer angle in this paper） mainly employs the linear vehicle dynamic model, in which only the lateral acceleration of vehicle body is considered. The observation accuracy resorting to this method cannot meet the requirements of vehicle real-time stability control, especially under extreme driving conditions. The paper explores the solution resorting to experimental method. Firstly, a multi-body dynamic model of a passenger car is built based on the ADAMS/Car software, whose dynamic accuracy is verified by the same vehicle＇s roadway test data of steady static circular test. Based on this simulation platform, several influencing factors of additional steer angle under different driving conditions are quantitatively analyzed. Then ε-SVR algorithm is employed to build the additional steer angle prediction model, whose input vectors mainly include the sensor information of standard electronic stability control system（ESC）. The method of typical slalom tests and FMVSS 126 tests are adopted to make simulation, train model and test model＇s generalization performance. The test result shows that the influence of lateral acceleration on additional steer angle is maximal （the magnitude up to 1°）, followed by the longitudinal acceleration-deceleration and the road wave amplitude （the magnitude up to 0.3°）. Moreover, both the prediction accuracy and the calculation real-time of the model can meet the control requirements of ESC This research expands the accurate observation methods of the additional steer angle under extreme driving conditions.
基金The Project of the National Ministry of Industry and Information Technology[2020-0103-3-1-1]The Project of Beijing Science and technology“capital characteristics”[Z181100001718007]。
文摘Objective Current clinical evidence on the effects of home blood pressure telemonitoring(HBPT)on improving blood pressure control comes entirely from developed countries.Thus,we performed this randomized controlled trial to evaluate whether HBPT plus support(patient education and clinician remote hypertension management)improves blood pressure control more than usual care(UC)in the Chinese population.Methods This single-center,randomized controlled study was conducted in Beijing,China.Patients aged 30-75 years were eligible for enrolment if they had blood pressure[systolic(SBP)≥140 mmHg and/or diastolic(DBP)≥90 mmHg;or SBP≥130 mmHg and/or DBP≥80 mmHg with diabetes].We recruited 190 patients randomized to either the HBPT or the UC groups for 12 weeks.The primary endpoints were blood pressure reduction and the proportion of patients achieving the target blood pressure.Results Totally,172 patients completed the study,the HBPT plus support group(n=84),and the UC group(n=88).Patients in the plus support group showed a greater reduction in mean ambulatory blood pressure than those in the UC group.The plus support group had a significantly higher proportion of patients who achieved the target blood pressure and maintained a dipper blood pressure pattern at the12th week of follow-up.Additionally,the patients in the plus support group showed lower blood pressure variability and higher drug adherence than those in the UC group.Conclusion HBPT plus additional support results in greater blood pressure reduction,better blood pressure control,a higher proportion of dipper blood pressure patterns,lower blood pressure variability,and higher drug adherence than UC.The development of telemedicine may be the cornerstone of hypertension management in primary care.
文摘Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat treatment.In the supersaturated Al-Tl-Si alloy, age hardening occurred after 1 h anneal in the temperature range of 4000~500℃, which seems to be attributed to the precipitation of metastable Ll2- (Al,Si)3Ti phase. However. the microhardness was relatively low because of the low v/o and the insufflcient stability of precipitates. Thus. Cr was added to Al-Ti-Si alloys in order to stabilize the microstructures and to increase the v/o of precipitate5. As a result. the alIoys containing Cr were evaluated to possess the improved properties at the service temperature.
文摘Based on the flow simulation in the condensing zone of compact spinning with lattice apron and a bead-elastic rod dynamic model of the flexible fiber,trajectories of fibers with different negative pressure are simulated by specially designed Matlab procedure.Then displacement components of fibers at YZ profile under different negative pressure conditions are extracted and compared.The results show that the fibers of different initial positions gradually converge,and are interlaced for position change in yarn cross-section,caused by the airflow in the condensing zone.Finally,compact-spun yarn with different negative pressure and conventional ring spun yarn are produced and their twists are tested.Both the results of simulation and experiments illustrate the existence of additional twists.Also the relationship between additional twists and negative pressure is verified.
基金supported by the Fundamental Research Funds for the Central Universities(2015QNA43)
文摘In this paper, the compatibility between the integral type gauge transformation and the additional symmetry of the constrained KP hierarchy is given. And the string-equation constraint in matrix models is also derived.
基金the Funds of the State Key Development Program for Basic Research of China (Nos. 2013CB227900, 2010CB226800)the National Natural Science Foundation of China (Nos. 51108161, 51374201)+2 种基金the Open Laboratory Foundation for Deep Mine Construction of Henan Province of China (No. 2011KF-09)the Doctor Foundation in Henan Polytechnic University of China (No. Q2013-065)the Key Program for Science and Technology Research of Henan Province of China (Nos. 14A560002, 14B560021).
文摘Additional displacement of the building foundations over old goaf are prone to happen under the addi- tional loads induced by new buildings, weakening-rock mass by mining and seismic actions, which will cause serious damage to the buildings. In order to analyze the safety of the building foundations safety over the old goaf. the structure characteristics of the strata over the old goaf was investigated and the instability conditions of overhanging rocks upon old goaf were also analyzed in this paper. The results indicate that the stability of overhanging rocks is remarkably decreased by the interactions of mining fractures, earthquake force and building load, in addition, the settlement of the foundations over old goal is increased by the instability of overhanging rocks. According to the location of a new power plant in Yima Mine and its ambient conditions, we defined the influence scope of old goal via resistivity tomography. Based on the seismic parameters of the construction site, a numerical FLAC3d model of the building foundation under the seismic actions and building load was developed. The numerical results are obtained as follows： the foundation of the main power house meets the requirement of 6° seismic fortification intensity： however, under 7° seismic fortification intensity, the maximum differential settlement of foundation between the neighboring pillars is close to the maximum allowable value, while the seismic fortification intensity reaches 8°, but the safety requirements will not be satisfied.
基金Project(Xiangjianke(2007)No.425) supported by Scientific Research Fund of Hunan Provincial Construction DepartmentProject supported by the Youth Framework Teacher Fund of Xiangtan University(2006)
文摘Through adding different additional water use,the compressive strength,splitting tensile strength and fluidity of recycled concrete of three aggregate combination forms were studied by experiment respectively.The experimental results show that with the increase of adding additional water use,the compressive strength and splitting tensile strength of recycled coarse aggregate concrete decrease,but that of recycled fine aggregate concrete and recycled all aggregate concrete increase firstly then decrease.When additional water use is added more 15% or 20% than that of basic ordinary concrete,the recycled coarse aggregate concrete and fine one can get pretty good fluidity.When it is added more 30%,the recycled all aggregate concrete has fluidity that is just satisfied.
文摘BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal and reasonable rescue option involves early suspicion and identification of patients with inadequate preparation before sedation, additional oral ingestion of a suitable preparation formulation, and same-day colonoscopy.AIM To compare 0.5-L and 1-L polyethylene glycol containing ascorbic acid(PEG +Asc) as additional bowel cleansing methods after a 2-L split-dose PEG + Asc regimen in patients with expected inadequate bowel preparation before colonoscopy.METHODS Individuals with expected inadequate bowel preparation based on last stool form, such as turbid liquid, particulate liquid, or liquid with small amounts of feces, were randomized to either a 0.5-L PEG + Asc group or a 1-L PEG + Asc group. The primary endpoint was bowel preparation as assessed using the Aronchick bowel preparation scale(ABPS) and Boston bowel preparation scale(BBPS) scores. The secondary endpoints were cecal intubation time, withdrawal time, polyp detection rate(PDR), adenoma detection rate(ADR), individual compliance with additional PEG + Asc, and patient satisfaction.RESULTS Initially, 98 patients were included, but 8 were later excluded due to withdrawal of consent to participate in the study. Adequate bowel preparation(as assessed by ABPS) was observed in 80.9%(38/47) of subjects in the 0.5-L group and in88.4%(38/43) of subjects in the 1-L group(P = 0.617). Mean total BBPS was 6.7 points in the 0.5-L group and 7.0 points in the 1-L group(P = 0.458). ADRs and PDRs were similar in the two groups, and cecal intubation and withdrawal times were not significantly different. However, mean patient satisfaction score was significantly higher in the 0.5-L group(P = 0.041).CONCLUSION The bowel cleaning efficacy of additional 0.5-L PEG + Asc was not inferior to that of 1-L PEG + Asc. Additional 0.5-L PEG + Asc is worthwhile when inadequate bowel preparation is expected before colonoscopy.
基金This work is supported by the National Natural Science Foundation of China(No.51975429).
文摘To improve the power-extraction performance of the Savonius vertical-axis wind turbine(S-VAWT),additional cylinders,which are used to control the fluid flow around the wind turbine blade,were introduced into the blade design.In contrast to the traditional numerical method,a mathematical model in the form of a dynamical system was used in this study.A numerical calculation program that could effectively solve the equations of wind-induced rotation of S-VAWT was developed,and combined with the Taguchi experimental method to investigate the influence of additional cylinders on the power-extraction characteristics of the S-VAWT.The results showed that the additional cylinders have a significant impact on the power-extraction performance of the S-VAWT.At 4-m/s wind speed,the average power coefficient of the S-VAWT with additional cylinders is 15%higher than that of the conventional S-VAWT.After construction of the wind turbine prototype and power-extraction tests,the results showed that compared with a conventional S-VAWT,the output power was 29%higher for the S-VAWT with additional cylinders under the same particular conditions.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61963008,61673168,1176200412047567)+2 种基金the Guangxi Natural Science Foundation,China(Grant Nos.2022GXNSFDA035080 and 2018GXNSFAA281274)the Guangxi Innovation-Driven Development Special Fund Project,China(Grant No.GUIKEAA19254034-3)the Zhenjiang Science and Technology Project,China(Grant No.GY2020019)。
文摘A novel car-following model is offered based on the cooperative information transmission delayed effect involving headway and velocity under V2 X environment.The stability conditions and m Kd V equation of the new model are obtained via the linear and nonlinear analysis.Through numerical simulation,the variation trend of headway and hysteresis phenomenon are studied.In addition,we investigate the additional energy consumption of the vehicle during acceleration.In brief,theoretical analysis and simulation results confirm that the new car-following model based on the cooperative information transmission delayed effect can improve traffic stability and reduce additional energy consumption.
