Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In t...Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In this article, we review recent research based on a mouse model of repeated exposure to autohypoxia. Pre-exposure markedly increases the tolerance to or protection against hypoxic insult, and preserves the cellular structure of the brain. Furthermore, the hippocampal activity amplitude and frequency of electroencephalogram, latency of cortical somatosensory-evoked potential and spinal somatosensory-evoked potential progressively decrease, while spatial learning and memory improve. In the brain, detrimental neurochemicals such as free radicals are down-regulated, while beneficial ones such as adenosine are up-regulated. Also, antihypoxia factor（s） and gene（s） are activated. We propose that the tolerance and protective effects depend on energy conservation and plasticity triggered by exposure to hypoxia via oxygen-sensing transduction pathways and hypoxia-inducible factor-initiated cascades. A potential path for further research is the development of devices and pharma-ceuticals acting on antihypoxia factor（s） and gene（s） for the prevention and treatment of hypoxia and related syndromes.展开更多
The Klein-Cordon equation arises in many scientific areas of quantum mechanics and quantum field theory. In this paper a novel method based on spectral method and Jacobian free Newton method composed by generalized mi...The Klein-Cordon equation arises in many scientific areas of quantum mechanics and quantum field theory. In this paper a novel method based on spectral method and Jacobian free Newton method composed by generalized minimum residual （JFNGMRes） method with adaptive preconditioner will be introduced to solve nonlinear Klein-Gordon equation. In this work the nonlinear Klein-Gordon equation has been converted to a nonlinear system of algebraic equations using collocation method based on Bessel functions without any linearization, discretization and getting help of any other methods. Finally, by using JFNGMRes, solution of the nonlinear algebraic system will be achieved. To illustrate the reliability and efficiency of the proposed method, we solve some examples of the Klein-Gordon equation and compare our results with other methods.展开更多
基金supported by grants from the National Natural Science Foundation of China (3967087, 81060212, and 81160244)the Beijing Natural Science Foundation (7962009)+2 种基金the China Postdoctoral Science Foundation (20080430851)the Science Foundation of Shandong Province, China (ZR2010HM029)the Inner Mongolia Science Foundation (2010BS1104)
文摘Hypoxic preconditioning refers to the exposure of organisms, systems, organs, tissues or cells to moderate hypoxia/ischemia that results in increased resistance to a subsequent episode of severe hypoxia/ischemia. In this article, we review recent research based on a mouse model of repeated exposure to autohypoxia. Pre-exposure markedly increases the tolerance to or protection against hypoxic insult, and preserves the cellular structure of the brain. Furthermore, the hippocampal activity amplitude and frequency of electroencephalogram, latency of cortical somatosensory-evoked potential and spinal somatosensory-evoked potential progressively decrease, while spatial learning and memory improve. In the brain, detrimental neurochemicals such as free radicals are down-regulated, while beneficial ones such as adenosine are up-regulated. Also, antihypoxia factor（s） and gene（s） are activated. We propose that the tolerance and protective effects depend on energy conservation and plasticity triggered by exposure to hypoxia via oxygen-sensing transduction pathways and hypoxia-inducible factor-initiated cascades. A potential path for further research is the development of devices and pharma-ceuticals acting on antihypoxia factor（s） and gene（s） for the prevention and treatment of hypoxia and related syndromes.
文摘The Klein-Cordon equation arises in many scientific areas of quantum mechanics and quantum field theory. In this paper a novel method based on spectral method and Jacobian free Newton method composed by generalized minimum residual （JFNGMRes） method with adaptive preconditioner will be introduced to solve nonlinear Klein-Gordon equation. In this work the nonlinear Klein-Gordon equation has been converted to a nonlinear system of algebraic equations using collocation method based on Bessel functions without any linearization, discretization and getting help of any other methods. Finally, by using JFNGMRes, solution of the nonlinear algebraic system will be achieved. To illustrate the reliability and efficiency of the proposed method, we solve some examples of the Klein-Gordon equation and compare our results with other methods.
