Physics-informed neural networks(PINNs)are vital for machine learning and exhibit significant advantages when handling complex physical problems.The PINN method can rapidly predict ^(220)Rn progeny concentration and i...Physics-informed neural networks(PINNs)are vital for machine learning and exhibit significant advantages when handling complex physical problems.The PINN method can rapidly predict ^(220)Rn progeny concentration and is very important for regulating and measuring this property.To construct a PINN model,training data are typically preprocessed;however,this approach changes the physical characteristics of the data,with the preprocessed data potentially no longer directly conforming to the original physical equations.As a result,the original physical equations cannot be directly employed in the PINN.Consequently,an effective method for transforming physical equations is crucial for accurately constraining PINNs to model the ^(220)Rn progeny concentration prediction.This study presents an equation adaptation approach for neural networks,which is designed to improve prediction of ^(220)Rn progeny concentration.Five neural network models based on three architectures are established:a classical network,a physics-informed network without equation adaptation,and a physics-informed network with equation adaptation.The transport equation of the ^(220)Rn progeny concentration is transformed via equation adaption and integrated with the PINN model.The compatibility and robustness of the model with equation adaption is then analyzed.The results show that PINNs with equation adaption converge consistently with classical neural networks in terms of the training and validation loss and achieve the same level of prediction accuracy.This outcome indicates that the proposed method can be integrated into the neural network architecture.Moreover,the prediction performance of classical neural networks declines significantly when interference data are encountered,whereas the PINNs with equation adaption exhibit stable prediction accuracy.This performance demonstrates that the proposed method successfully harnesses the constraining power of physical equations,significantly enhancing the robustness of the resultant PINN models.Thus,the use of a physics-informed network with equation adaption can guarantee accurate prediction of ^(220)Rn progeny concentration.展开更多
Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsibl...Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsible for the major quantitative trait locus(QTL)Heading date 2(Hd2)identified in 680 foxtail millets using a genome-wide association study.Overexpression of SiPRR37 in foxtail millet significantly delayed the heading date under both natural long-day and short-day conditions.CRISPR/Cas9-induced Siprr37 mutants exhibited earlier flowering in long-day conditions but later flowering in short-day conditions.The critical day length(CDL)for the reversal of Siprr37’s function was around 14.3 h.Haplotype analysis revealed that accessions with the Tc1-Mariner transposon insertion in SiPRR37(Hap 1)flowered significantly earlier at higher latitudes,and later at lower latitudes,indicating that natural variants of SiPRR37 exert dual functions in flowering regulation according to geographic latitude.The gradual,successive decrease in the frequency of Hap 2 from low to high latitudes,with the concurrent increase of Hap 1,demonstrates that these haplotypes have undergone artificial selection.Further FST analysis demonstrated that SiPRR37 has contributed to the ecological adaption of foxtail millet.Additionally,we reveal that OsPRR37 promotes flowering in rice,while GmPRR37 may only inhibit flowering in soybean.Further diurnal expression and transgenic analyses suggest that the dual function of SiPRR37 might depend on SiHd1.Our study uncovered the distinct functional reversal of SiPRR37 and functional diversification of PRR37 homologs in SD crops.These findings not only enrich knowledge about the regulation of photoperiodic flowering,but also contribute to genetic improvement of crops’regional adaptability.展开更多
This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance ru...This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking accuracy.Moreover, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.展开更多
Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that c...Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.展开更多
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op...In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.展开更多
News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors...News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors such as society, economy and culture. In order to exert its function to gain different social ends, the presentation of news language owns distinguishing features. This article starts from Verschueren's Adaption Theory to have the final conclusion that the adaption to the social, mental and physical world is the key element for the determination of the originality in news language.展开更多
Climate change poses a profound threat to mountain agro-ecosystems,particularly in the Himalayan region of West Bengal,India,by disrupting precipitation patterns,increasing temperature variability,and intensifying ext...Climate change poses a profound threat to mountain agro-ecosystems,particularly in the Himalayan region of West Bengal,India,by disrupting precipitation patterns,increasing temperature variability,and intensifying extreme weather events.Despite growing evidence of climate change impacts,there remains a critical research gap in understanding how socioeconomic factors drive farmers' adaptation strategies to climate change in this vulnerable region.This study examines how farmers in the Himalayan region of West Bengal,India,perceived and responded to the growing impacts of climate change on mountain agro-ecosystems.Drawing on cross-sectional data from 370 farm households selected through multistage sampling,the research employs a combination of analytical tools,including the severity index(SI) to assess farmers' perceptions to climate change,the adaptation index(AI) to evaluate adaptive responses,the Garrett's ranking technique to prioritize constraints,and the ordered logistic regression to identify key socioeconomic drivers of adaptation.Findings reveal a high level of climate awareness among farmers,particularly regarding the increase in weather extremes(SI=74.87%),increase in temperature(SI=72.31%),and irregular rainfall patterns and highly erratic rainfall(SI=62.52%).The most commonly adopted strategies include adopting intercropping and mixed cropping systems(AI=0.613),adoption of the integrated farming system model(AI=0.600),and shift towards non-farm employment(AI=0.608),while the adoption of climate-resilient crop varieties and improved irrigation remains limited.Regression analysis highlights that education(regression coefficient=0.38),average landholding size(regression coefficient=1.21),and access to daily weather forecast information(regression coefficient=1.92) significantly promote adaptive behaviour,whereas age(regression coefficient= –0.09) and gender(regression coefficient= –0.76) are negatively associated.Institutional constraints,particularly unavailability of institutional credit,emerge as primary barriers.The study underscores the urgent need for region-specific,inclusive policy frameworks that enhance climate advisory services,support technology dissemination,and empower marginalized groups in the Himalayan region of West Bengal.By fostering informed,equitable,and resilient agricultural systems,these strategies can significantly strengthen the adaptive capacity of mountain farming communities and contribute to sustainable development under a changing climate.展开更多
1.Introduction The field of exercise science is experiencing a renaissance,with recent research illuminating the molecular,cellular,and systemic effects of physical activity.This is largely due to the now unequivocal ...1.Introduction The field of exercise science is experiencing a renaissance,with recent research illuminating the molecular,cellular,and systemic effects of physical activity.This is largely due to the now unequivocal evidence that a lack of physical activity,not only has direct effects on the prevalence of non-contagious diseases(NCDs)but has profound additive effects of other risk factors for NCD such as obesity and hypertension.1 The articles in this special topic of Journal of Sport and Health Science(JSHS)are dedicated to research on Exercise biochemistry&metabolism.展开更多
It is essential to understand how adaptation needs and options differ among stakeholders in protected areas(PAs)to effectively implement climate change(CC)adaptation strategies.Using the Qiangtang PA in Xizang as a ca...It is essential to understand how adaptation needs and options differ among stakeholders in protected areas(PAs)to effectively implement climate change(CC)adaptation strategies.Using the Qiangtang PA in Xizang as a case study,this research examines CC adaptation needs and options from the perspectives of stakeholders across multiple administrative levels,including provincial,prefectural,county authorities,73 protection stations,and 13364 pastoralists residing within the PA.The findings show that stakeholders at the provincial level,as well as those from the Ali and Naqu prefectures and six counties,place greater emphasis on institutional and resource-related needs than on other categories(attention score:7.0-9.3 vs.5.0-7.0).In contrast,stakeholders from the 73 protection stations prioritize technological and capacity-building needs more strongly than other types(attention score:8.0-9.0 vs.4.0-8.0).The 13364 pastoralists assign the highest importance to social needs relative to other categories(attention score:9.0-9.5 vs.3.0-8.0).Most of the eight existing protection measures were found to indirectly support broader climate adaptation efforts.In particular,protective actions addressing fire,pests,and weather-related disasters can be classified as autonomous adaptation,while other measures generate outcomes that enhance adaptation capacity under specific conditions.Adaptation options,grouped into three main types and 13 subcategories,differ across stakeholder groups,although substantial overlap exists between these options and current protective actions,including ecosystem based adaptation strategies,adaptation-related practices,autonomous adaptation measures,and emergency interventions.Overall,these findings highlight the critical role of all stakeholders-especially staff from the 73 protection stations and the 13364 pastoralists-in the effective implementation of adaptation actions within the PA.展开更多
Dear Editor,This letter deals with the autonomous underwater vehicle(AUV)three dimensional(3D)trajectory tracking control chronically suffering from poor accuracy and efficiency in complex hydrodynamics.A state-of-the...Dear Editor,This letter deals with the autonomous underwater vehicle(AUV)three dimensional(3D)trajectory tracking control chronically suffering from poor accuracy and efficiency in complex hydrodynamics.A state-of-the-art predictive adaptive controller(PAC)is proposed with a distinct dual closed-loop structure.展开更多
This study comprehensively measures the ecological resilience level of seven provinces in the strategic hinterland of Western China during 2013-2023.It constructs an ecological resilience evaluation system covering th...This study comprehensively measures the ecological resilience level of seven provinces in the strategic hinterland of Western China during 2013-2023.It constructs an ecological resilience evaluation system covering the three dimensions of"Resistance-Adaptability-Recovery"and adopts the entropy-weighted TOPSIS method for objective weighting and comprehensive ranking.The results show that:(1)The overall ecological resilience of the strategic hinterlands in Western China presents a steady upward trend,evolving from a low resilience level to a medium resilience range over the decade,with continuous investment in ecological governance and institutional supply gradually transformed into resilience enhancement effects in the long run;(2)Ecological resilience exhibits a typical pattern characterized by"high-level stability of Resistance,continuous improvement of Recovery,and relative lag of Adaptability,"among which Recovery shows the most remarkable growth rate,while Adaptability fluctuates significantly and constitutes a key bottleneck for overall leapfrog development;(3)As core carrying areas,Sichuan and Shaanxi perform outstandingly,and Guizhou demonstrates a remarkable upward momentum,while Qinghai,Ningxia,Gansu and other regions still face constraints such as limited ecological governance capacity and relatively strong structural pressures.Based on the differentiated evolutionary characteristics of the three dimensions,the study proposes enhancement paths including constructing a cross-regional ecological security barrier,breaking through the bottleneck of Adaptability,and driving high-quality resilient growth with Recovery.展开更多
Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise...Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise intervention from gestational Week 17 until birth on key cytokines involved in placental development and function.Secondary aims were to explore:(a)the moderating effects of fetal sex and maternal weight status;and(b)whether gestational weight gain,lifestyle behaviors(diet,sleep patterns,and physical activity),and physical fitness(strength and cardiorespiratory fitness)mediated the effects of exercise on placental cytokines.Methods:Seventy-six pregnant women(33±4 years,mean±SD),divided into exercise(n=40)and control(n=36)groups,participated in this study.The exercise group followed a 60-min,3 days/week(aerobic+resistance)training program of moderate-to-vigorous intensity.Placental cytokines—including granulocyte-macrophage colony-stimulating factor(GM-CSF),granulocyte colony-stimulating factor(G-CSF),plateletderived growth factor AA(PDGF-AA),epidermal growth factor(EGF),monocyte chemoattractant protein-1(MCP-1),fractalkine,interleukin(IL)-8,IL-6,IL-1β,interleukin 1-receptor antagonist(IL-1ra),IL-10,tumor necrosis factor alpha(TNF-a),and interferon gamma(IFN-γ)were analyzed using Luminex multi-analyte profiling(x MAP)technology.Results:The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group(p<0.05).Significant effects of exercise on placental G-CSF and TNF-a(p<0.05)and a trend toward lower IL-6(p=0.08)were observed only in female placentas.Additionally,a reduction in weight gain partially mediated the effects of exercise on G-CSF(p<0.05).Conclusion:Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels.Some exercise-induced effects are observed exclusively in female placentas,including increased G-CSF and lower TNF-a and IL-6 concentrations.Notably,the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.展开更多
Gibbons are small,arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology.However,nearly all species of gibbons are threatened by habitat loss,illegal trade,hunting,and other human activ...Gibbons are small,arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology.However,nearly all species of gibbons are threatened by habitat loss,illegal trade,hunting,and other human activities.Long-term poor understanding of their genetics and evolution undermines effective conservation efforts.In this study,we analyse comparative population genomic data of four Nomascus species.Our results reveal strong genetic differentiation and gene flow among Nomascus species.Additionally,we identify genomic features that are potentially related to natural selection linked to vocalization,fructose metabolism,motor balance,and body size,consistent with the unique phenotype and adaptability of gibbons.Inbreeding,coupled with population declines due to climate change and historical human activities,leads to reduced genetic diversity and the accumulation of deleterious variations that likely affect cardiovascular disease and the reproductive potential of gibbons and further reduce their fitness,highlighting the urgent need for effective conservation strategies.展开更多
Nitric oxide(NO)is a key vasodilator that regulates vascular pressure and blood flow.Tibetans have developed a"blunted"mechanism for regulating NO levels at high altitude,with GTP cyclohydrolase 1(GCH1)ident...Nitric oxide(NO)is a key vasodilator that regulates vascular pressure and blood flow.Tibetans have developed a"blunted"mechanism for regulating NO levels at high altitude,with GTP cyclohydrolase 1(GCH1)identified as a key candidate gene.Here,we present comprehensive genetic and functional analyses of GCH1,which exhibits strong Darwinian positive selection in Tibetans.We show that Tibetan-enriched GCH1 variants down-regulate its expression in the blood of Tibetans.Based on this observation,we generate the heterozygous Gch1 knockout(Gch1^(+/-))mouse model to simulate its downregulation in Tibetans.We find that under prolonged hypoxia,the Gch1^(+/-)mice have relatively higher blood NO and blood oxygen saturation levels compared with the wild-type(WT)controls,providing better oxygen supplies to the cardiovascular and pulmonary systems.Markedly,hypoxia-induced cardiac hypertrophy and pulmonary remodeling are significantly attenuated in the Gch1^(^(+/-))mice compared with the WT controls,likely due to the adaptive changes in molecular regulations related to metabolism,inflammation,circadian rhythm,extracellular matrix,and oxidative stress.This study sheds light on the role of GCH1 in regulating blood NO,contributing to the physiological adaptation of the cardiovascular and pulmonary systems in Tibetans at high altitude.展开更多
Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now av...Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.展开更多
In federated learning,backdoor attacks have become an important research topic with their wide application in processing sensitive datasets.Since federated learning detects or modifies local models through defense mec...In federated learning,backdoor attacks have become an important research topic with their wide application in processing sensitive datasets.Since federated learning detects or modifies local models through defense mechanisms during aggregation,it is difficult to conduct effective backdoor attacks.In addition,existing backdoor attack methods are faced with challenges,such as low backdoor accuracy,poor ability to evade anomaly detection,and unstable model training.To address these challenges,a method called adaptive simulation backdoor attack(ASBA)is proposed.Specifically,ASBA improves the stability of model training by manipulating the local training process and using an adaptive mechanism,the ability of the malicious model to evade anomaly detection by combing large simulation training and clipping,and the backdoor accuracy by introducing a stimulus model to amplify the impact of the backdoor in the global model.Extensive comparative experiments under five advanced defense scenarios show that ASBA can effectively evade anomaly detection and achieve high backdoor accuracy in the global model.Furthermore,it exhibits excellent stability and effectiveness after multiple rounds of attacks,outperforming state-of-the-art backdoor attack methods.展开更多
Objective:International students frequently face psychological adaptation difficulties while studying and living abroad.As an effective psychological resource,positive solitude has been identified as a potential facto...Objective:International students frequently face psychological adaptation difficulties while studying and living abroad.As an effective psychological resource,positive solitude has been identified as a potential factor for improving psychological well-being,but the underlying mechanism linking the two has not been fully explored.The current study aims to explore the relationship between positive solitude and psychological adaptation of international students,with particular emphasis on the intermediary roles of authenticity and loneliness.Methods:A total of 529 international tertiary students(Mage=23.76,SD=5.08;60.68%male)were surveyed using the Positive Solitude Scale(PSS),Authenticity Scale(AS),6-item UCLA Loneliness Scale(ULS-6),and Brief Psychological Adaptation Scale(BPAS).SPSS27.0 was used for descriptive statistical analysis and Pearson correlation analysis.PROCESS macro(Model 6)was employed to test a serial mediation model,in which authenticity and loneliness function as intermediary variables between positive solitude and psychological adaptation.Results:The correlation analysis indicated significant associations among positive solitude,authenticity,loneliness,and psychological adaptation(r=−0.544~0.511).Positive solitude was directly and positively related to psychological adaptation(β=0.132,t=3.609,p<0.001)and indirectly related to psychological adaptation through two pathways:a single mediation via authenticity(indirect effect=0.089)and a serial mediation through authenticity and loneliness(indirect effect=0.062).Loneliness did not serve as a significant mediator(indirect effect=–0.015,95%CI[–0.049,0.019]).The total indirect effect was 0.136.Conclusions:Interventions targeting international students’capacity for experiencing positive solitude and authenticity can help to reduce loneliness and increase psychological adaptation.The findings derived from this study are conducive to understanding the relationship between positive solitude and psychological adaptation,as well as its underlying mechanisms.In addition,the study offers a new perspective for educational management and psychological counseling services for international students.展开更多
Background:Investigators from low-,middle-,and high-income countries representing 6 continents contributed to the development of the Global Adolescent and Child Physical Activity Questionnaire(GAC-PAQ).The GAC-PAQ is ...Background:Investigators from low-,middle-,and high-income countries representing 6 continents contributed to the development of the Global Adolescent and Child Physical Activity Questionnaire(GAC-PAQ).The GAC-PAQ is designed to assess physical activity(PA)across all key domains(i.e.,school,chores,work/volunteering,transport,free time,outdoor time).It aimed to address multiple gaps in global PA surveillance(e.g.,omission of important PA domains,insufficient cultural adaptation,underrepresentation of rural areas in questionnaire validation studies).The purpose of this study was to assess the content validity of the GAC-PAQ among PA experts,8-to 17-year-olds,and one of their parents/guardians,and to discuss changes made to the questionnaire based on participants'feedback.Methods:Sixty-two experts in PA measurement and/or surveillance from 24 countries completed an online survey that included both closed-and open-ended questions about the content validity of the GAC-PAQ.The proportion of experts who agreed or strongly agreed with the items was calculated.Child-parent/guardian dyads from 15 countries(n=250;10-40 per country)participated in a structured cognitive interview to assess the clarity of the questions and response options,and they were encouraged to provide suggestions to improve clarity and facilitate completion of the questionnaire.Participating countries are:Aotearoa New Zealand,Brazil,Canada,China,Colombia,Czech Republic,India,Malawi,Mexico,Nepal,Nigeria,Spain,Sweden,Thailand,and the United Arab Emirates.Interviews were conducted in 13 different languages and structured by PA domain.Generic images were included to help participants in answering questions about PA intensity.Results:Expert agreement with the items for each domain exceeded 75%,and their qualitative feedback was used to revise the questionnaire before cognitive interviews.In general,participants found the questionnaire to be comprehensive.Adolescents(12-17 years)found it easier than children(8-11 years)to answer the questions.Several children struggled to answer questions about the duration and intensity of activities and/or concepts related to travel modes,active trips,and organized activities.Many parents/guardians were unsure about the frequency,duration,and intensity of their children's or adolescents'PA at school and/or recommended using more culturally relevant and appropriate images.Some participants misunderstood the concept of activities that“make you stronger”(intended to assess resistance activities)and/or struggled to differentiate between work,volunteering,and chores.Conclusion:Participants'feedback was used to develop a revised,simplified,and culturally adapted GAC-PAQ,which will be pilot-tested in all15 countries in an App that will include country-specific images and narration in local languages.Further research is needed to assess the reliability and validity of the revised GAC-PAQ.展开更多
基金supported by the National Natural Science Foundation of China(Nos.12375310,118750356,and 62006110)Graduate Research and Innovation Projects of Hunan Province(CX20230964).
文摘Physics-informed neural networks(PINNs)are vital for machine learning and exhibit significant advantages when handling complex physical problems.The PINN method can rapidly predict ^(220)Rn progeny concentration and is very important for regulating and measuring this property.To construct a PINN model,training data are typically preprocessed;however,this approach changes the physical characteristics of the data,with the preprocessed data potentially no longer directly conforming to the original physical equations.As a result,the original physical equations cannot be directly employed in the PINN.Consequently,an effective method for transforming physical equations is crucial for accurately constraining PINNs to model the ^(220)Rn progeny concentration prediction.This study presents an equation adaptation approach for neural networks,which is designed to improve prediction of ^(220)Rn progeny concentration.Five neural network models based on three architectures are established:a classical network,a physics-informed network without equation adaptation,and a physics-informed network with equation adaptation.The transport equation of the ^(220)Rn progeny concentration is transformed via equation adaption and integrated with the PINN model.The compatibility and robustness of the model with equation adaption is then analyzed.The results show that PINNs with equation adaption converge consistently with classical neural networks in terms of the training and validation loss and achieve the same level of prediction accuracy.This outcome indicates that the proposed method can be integrated into the neural network architecture.Moreover,the prediction performance of classical neural networks declines significantly when interference data are encountered,whereas the PINNs with equation adaption exhibit stable prediction accuracy.This performance demonstrates that the proposed method successfully harnesses the constraining power of physical equations,significantly enhancing the robustness of the resultant PINN models.Thus,the use of a physics-informed network with equation adaption can guarantee accurate prediction of ^(220)Rn progeny concentration.
基金supported by the National Natural Science Foundation of China(32101759,32241042)the National Key Research and Development Program of China(2023YFD1200700 and 2023YFD1200704).
文摘Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsible for the major quantitative trait locus(QTL)Heading date 2(Hd2)identified in 680 foxtail millets using a genome-wide association study.Overexpression of SiPRR37 in foxtail millet significantly delayed the heading date under both natural long-day and short-day conditions.CRISPR/Cas9-induced Siprr37 mutants exhibited earlier flowering in long-day conditions but later flowering in short-day conditions.The critical day length(CDL)for the reversal of Siprr37’s function was around 14.3 h.Haplotype analysis revealed that accessions with the Tc1-Mariner transposon insertion in SiPRR37(Hap 1)flowered significantly earlier at higher latitudes,and later at lower latitudes,indicating that natural variants of SiPRR37 exert dual functions in flowering regulation according to geographic latitude.The gradual,successive decrease in the frequency of Hap 2 from low to high latitudes,with the concurrent increase of Hap 1,demonstrates that these haplotypes have undergone artificial selection.Further FST analysis demonstrated that SiPRR37 has contributed to the ecological adaption of foxtail millet.Additionally,we reveal that OsPRR37 promotes flowering in rice,while GmPRR37 may only inhibit flowering in soybean.Further diurnal expression and transgenic analyses suggest that the dual function of SiPRR37 might depend on SiHd1.Our study uncovered the distinct functional reversal of SiPRR37 and functional diversification of PRR37 homologs in SD crops.These findings not only enrich knowledge about the regulation of photoperiodic flowering,but also contribute to genetic improvement of crops’regional adaptability.
基金supported in part by the National Natural Science Foundation of China(62303117,T2325018,92367109)the Xiangjiang Scholar Program(XJ2023018)+2 种基金the Key Laboratory of System Control and Information Processing(Scip20240108)the Aeronautical Science Foundation of China(20230001144001)Fujian Provincial Natural Science Foundation(2024J01130098)
文摘This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking accuracy.Moreover, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.
基金supported by the Financial Special Fund,grant number XZ202401JD0027National Barley Industry Technology System(CARS-05-01A-08)+3 种基金the Xizang Agri-Tech Innovation Project(XZNKY-2025-CXGC-T01)the Joint Funds of the National Natural Science Foundation of China(No.U20A2026)the Financial Special Fund,grant number(32401784,2017CZZX001/2,XZNKY-2018-C-021 and NYSTC202401)the China Agriculture Research System of Barley(CARS-05).
文摘Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.
基金Supported by the National Natural Science Foundation of China(12071133)Natural Science Foundation of Henan Province(252300421993)Key Scientific Research Project of Higher Education Institutions in Henan Province(25B110005)。
文摘In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.
文摘News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors such as society, economy and culture. In order to exert its function to gain different social ends, the presentation of news language owns distinguishing features. This article starts from Verschueren's Adaption Theory to have the final conclusion that the adaption to the social, mental and physical world is the key element for the determination of the originality in news language.
文摘Climate change poses a profound threat to mountain agro-ecosystems,particularly in the Himalayan region of West Bengal,India,by disrupting precipitation patterns,increasing temperature variability,and intensifying extreme weather events.Despite growing evidence of climate change impacts,there remains a critical research gap in understanding how socioeconomic factors drive farmers' adaptation strategies to climate change in this vulnerable region.This study examines how farmers in the Himalayan region of West Bengal,India,perceived and responded to the growing impacts of climate change on mountain agro-ecosystems.Drawing on cross-sectional data from 370 farm households selected through multistage sampling,the research employs a combination of analytical tools,including the severity index(SI) to assess farmers' perceptions to climate change,the adaptation index(AI) to evaluate adaptive responses,the Garrett's ranking technique to prioritize constraints,and the ordered logistic regression to identify key socioeconomic drivers of adaptation.Findings reveal a high level of climate awareness among farmers,particularly regarding the increase in weather extremes(SI=74.87%),increase in temperature(SI=72.31%),and irregular rainfall patterns and highly erratic rainfall(SI=62.52%).The most commonly adopted strategies include adopting intercropping and mixed cropping systems(AI=0.613),adoption of the integrated farming system model(AI=0.600),and shift towards non-farm employment(AI=0.608),while the adoption of climate-resilient crop varieties and improved irrigation remains limited.Regression analysis highlights that education(regression coefficient=0.38),average landholding size(regression coefficient=1.21),and access to daily weather forecast information(regression coefficient=1.92) significantly promote adaptive behaviour,whereas age(regression coefficient= –0.09) and gender(regression coefficient= –0.76) are negatively associated.Institutional constraints,particularly unavailability of institutional credit,emerge as primary barriers.The study underscores the urgent need for region-specific,inclusive policy frameworks that enhance climate advisory services,support technology dissemination,and empower marginalized groups in the Himalayan region of West Bengal.By fostering informed,equitable,and resilient agricultural systems,these strategies can significantly strengthen the adaptive capacity of mountain farming communities and contribute to sustainable development under a changing climate.
文摘1.Introduction The field of exercise science is experiencing a renaissance,with recent research illuminating the molecular,cellular,and systemic effects of physical activity.This is largely due to the now unequivocal evidence that a lack of physical activity,not only has direct effects on the prevalence of non-contagious diseases(NCDs)but has profound additive effects of other risk factors for NCD such as obesity and hypertension.1 The articles in this special topic of Journal of Sport and Health Science(JSHS)are dedicated to research on Exercise biochemistry&metabolism.
基金supported by the National Key Research and Development Project[Grand No.2022YFF0802304]Key Research and Development and Transformation Project of the Xizang Autonomous Region[Grand No.XZ202501ZY0119].
文摘It is essential to understand how adaptation needs and options differ among stakeholders in protected areas(PAs)to effectively implement climate change(CC)adaptation strategies.Using the Qiangtang PA in Xizang as a case study,this research examines CC adaptation needs and options from the perspectives of stakeholders across multiple administrative levels,including provincial,prefectural,county authorities,73 protection stations,and 13364 pastoralists residing within the PA.The findings show that stakeholders at the provincial level,as well as those from the Ali and Naqu prefectures and six counties,place greater emphasis on institutional and resource-related needs than on other categories(attention score:7.0-9.3 vs.5.0-7.0).In contrast,stakeholders from the 73 protection stations prioritize technological and capacity-building needs more strongly than other types(attention score:8.0-9.0 vs.4.0-8.0).The 13364 pastoralists assign the highest importance to social needs relative to other categories(attention score:9.0-9.5 vs.3.0-8.0).Most of the eight existing protection measures were found to indirectly support broader climate adaptation efforts.In particular,protective actions addressing fire,pests,and weather-related disasters can be classified as autonomous adaptation,while other measures generate outcomes that enhance adaptation capacity under specific conditions.Adaptation options,grouped into three main types and 13 subcategories,differ across stakeholder groups,although substantial overlap exists between these options and current protective actions,including ecosystem based adaptation strategies,adaptation-related practices,autonomous adaptation measures,and emergency interventions.Overall,these findings highlight the critical role of all stakeholders-especially staff from the 73 protection stations and the 13364 pastoralists-in the effective implementation of adaptation actions within the PA.
基金supported by the National Natural Science Foundation of China(U24B20183)the Pioneer Leading Goose+X Science and Technology Program of Zhejiang Province(2025C02018)。
文摘Dear Editor,This letter deals with the autonomous underwater vehicle(AUV)three dimensional(3D)trajectory tracking control chronically suffering from poor accuracy and efficiency in complex hydrodynamics.A state-of-the-art predictive adaptive controller(PAC)is proposed with a distinct dual closed-loop structure.
文摘This study comprehensively measures the ecological resilience level of seven provinces in the strategic hinterland of Western China during 2013-2023.It constructs an ecological resilience evaluation system covering the three dimensions of"Resistance-Adaptability-Recovery"and adopts the entropy-weighted TOPSIS method for objective weighting and comprehensive ranking.The results show that:(1)The overall ecological resilience of the strategic hinterlands in Western China presents a steady upward trend,evolving from a low resilience level to a medium resilience range over the decade,with continuous investment in ecological governance and institutional supply gradually transformed into resilience enhancement effects in the long run;(2)Ecological resilience exhibits a typical pattern characterized by"high-level stability of Resistance,continuous improvement of Recovery,and relative lag of Adaptability,"among which Recovery shows the most remarkable growth rate,while Adaptability fluctuates significantly and constitutes a key bottleneck for overall leapfrog development;(3)As core carrying areas,Sichuan and Shaanxi perform outstandingly,and Guizhou demonstrates a remarkable upward momentum,while Qinghai,Ningxia,Gansu and other regions still face constraints such as limited ecological governance capacity and relatively strong structural pressures.Based on the differentiated evolutionary characteristics of the three dimensions,the study proposes enhancement paths including constructing a cross-regional ecological security barrier,breaking through the bottleneck of Adaptability,and driving high-quality resilient growth with Recovery.
基金funded by the Regional Ministry of Health of the Junta de Andalucıa(PI-0395-2016)the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement(No.101027215)+1 种基金supported by the PLACENTRAINING project,funded through the FEDER-UGR23 funding call(European Regional Development Fund University of Granada programGrant No.C-EXP-336UGR23)。
文摘Background:The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood.The objective of the current study was to ascertain the influence of a supervised concurrent exercise intervention from gestational Week 17 until birth on key cytokines involved in placental development and function.Secondary aims were to explore:(a)the moderating effects of fetal sex and maternal weight status;and(b)whether gestational weight gain,lifestyle behaviors(diet,sleep patterns,and physical activity),and physical fitness(strength and cardiorespiratory fitness)mediated the effects of exercise on placental cytokines.Methods:Seventy-six pregnant women(33±4 years,mean±SD),divided into exercise(n=40)and control(n=36)groups,participated in this study.The exercise group followed a 60-min,3 days/week(aerobic+resistance)training program of moderate-to-vigorous intensity.Placental cytokines—including granulocyte-macrophage colony-stimulating factor(GM-CSF),granulocyte colony-stimulating factor(G-CSF),plateletderived growth factor AA(PDGF-AA),epidermal growth factor(EGF),monocyte chemoattractant protein-1(MCP-1),fractalkine,interleukin(IL)-8,IL-6,IL-1β,interleukin 1-receptor antagonist(IL-1ra),IL-10,tumor necrosis factor alpha(TNF-a),and interferon gamma(IFN-γ)were analyzed using Luminex multi-analyte profiling(x MAP)technology.Results:The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group(p<0.05).Significant effects of exercise on placental G-CSF and TNF-a(p<0.05)and a trend toward lower IL-6(p=0.08)were observed only in female placentas.Additionally,a reduction in weight gain partially mediated the effects of exercise on G-CSF(p<0.05).Conclusion:Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels.Some exercise-induced effects are observed exclusively in female placentas,including increased G-CSF and lower TNF-a and IL-6 concentrations.Notably,the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.
基金supported by Science and Technology Program from the Forestry Administration of Guangdong Province(2024KJQT0012)the Guangdong Provincial Key R&D Program(2022B1111040001)+2 种基金the National Forestry Administration rare and endangered species field rescue and breeding project(Gui lin hu yu O10)the National Natural Science Foundation of China(32200337)a fellowship from the China Postdoctoral Science Foundation(2022M712003).
文摘Gibbons are small,arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology.However,nearly all species of gibbons are threatened by habitat loss,illegal trade,hunting,and other human activities.Long-term poor understanding of their genetics and evolution undermines effective conservation efforts.In this study,we analyse comparative population genomic data of four Nomascus species.Our results reveal strong genetic differentiation and gene flow among Nomascus species.Additionally,we identify genomic features that are potentially related to natural selection linked to vocalization,fructose metabolism,motor balance,and body size,consistent with the unique phenotype and adaptability of gibbons.Inbreeding,coupled with population declines due to climate change and historical human activities,leads to reduced genetic diversity and the accumulation of deleterious variations that likely affect cardiovascular disease and the reproductive potential of gibbons and further reduce their fitness,highlighting the urgent need for effective conservation strategies.
基金funded by grants from the National Natural Science Foundation of China(32288101 and 91631306 to B.S32170632 and 32000390 to Y.H.32400503 to Y.G.)Major Scientific Project of Yunnan Province(202305AH340007 to B.S.)+4 种基金Yunnan Revitalization Talent Support Program Science&Technology Champion Project(202005AB160004 to B.S.)Yunnan Revitalization Talent Support Program Innovation Team(202405AS350008)Yunnan Scientist Workshops(to B.S.)the Youth Innovation Promotion Association of CAS(to Y.H.),the Science and Technology General Program of Yunnan Province(202301AW070010 and 202001AT070110 to Y.H.)and the Provincial Key Research,Development,and Translational Program(XZ202101ZY0009G to Baima.).
文摘Nitric oxide(NO)is a key vasodilator that regulates vascular pressure and blood flow.Tibetans have developed a"blunted"mechanism for regulating NO levels at high altitude,with GTP cyclohydrolase 1(GCH1)identified as a key candidate gene.Here,we present comprehensive genetic and functional analyses of GCH1,which exhibits strong Darwinian positive selection in Tibetans.We show that Tibetan-enriched GCH1 variants down-regulate its expression in the blood of Tibetans.Based on this observation,we generate the heterozygous Gch1 knockout(Gch1^(+/-))mouse model to simulate its downregulation in Tibetans.We find that under prolonged hypoxia,the Gch1^(+/-)mice have relatively higher blood NO and blood oxygen saturation levels compared with the wild-type(WT)controls,providing better oxygen supplies to the cardiovascular and pulmonary systems.Markedly,hypoxia-induced cardiac hypertrophy and pulmonary remodeling are significantly attenuated in the Gch1^(^(+/-))mice compared with the WT controls,likely due to the adaptive changes in molecular regulations related to metabolism,inflammation,circadian rhythm,extracellular matrix,and oxidative stress.This study sheds light on the role of GCH1 in regulating blood NO,contributing to the physiological adaptation of the cardiovascular and pulmonary systems in Tibetans at high altitude.
文摘Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.
文摘In federated learning,backdoor attacks have become an important research topic with their wide application in processing sensitive datasets.Since federated learning detects or modifies local models through defense mechanisms during aggregation,it is difficult to conduct effective backdoor attacks.In addition,existing backdoor attack methods are faced with challenges,such as low backdoor accuracy,poor ability to evade anomaly detection,and unstable model training.To address these challenges,a method called adaptive simulation backdoor attack(ASBA)is proposed.Specifically,ASBA improves the stability of model training by manipulating the local training process and using an adaptive mechanism,the ability of the malicious model to evade anomaly detection by combing large simulation training and clipping,and the backdoor accuracy by introducing a stimulus model to amplify the impact of the backdoor in the global model.Extensive comparative experiments under five advanced defense scenarios show that ASBA can effectively evade anomaly detection and achieve high backdoor accuracy in the global model.Furthermore,it exhibits excellent stability and effectiveness after multiple rounds of attacks,outperforming state-of-the-art backdoor attack methods.
基金supported by the 2024 Zhejiang Provincial Women’s Federation&Women’s Studies Association Research Project(202450).
文摘Objective:International students frequently face psychological adaptation difficulties while studying and living abroad.As an effective psychological resource,positive solitude has been identified as a potential factor for improving psychological well-being,but the underlying mechanism linking the two has not been fully explored.The current study aims to explore the relationship between positive solitude and psychological adaptation of international students,with particular emphasis on the intermediary roles of authenticity and loneliness.Methods:A total of 529 international tertiary students(Mage=23.76,SD=5.08;60.68%male)were surveyed using the Positive Solitude Scale(PSS),Authenticity Scale(AS),6-item UCLA Loneliness Scale(ULS-6),and Brief Psychological Adaptation Scale(BPAS).SPSS27.0 was used for descriptive statistical analysis and Pearson correlation analysis.PROCESS macro(Model 6)was employed to test a serial mediation model,in which authenticity and loneliness function as intermediary variables between positive solitude and psychological adaptation.Results:The correlation analysis indicated significant associations among positive solitude,authenticity,loneliness,and psychological adaptation(r=−0.544~0.511).Positive solitude was directly and positively related to psychological adaptation(β=0.132,t=3.609,p<0.001)and indirectly related to psychological adaptation through two pathways:a single mediation via authenticity(indirect effect=0.089)and a serial mediation through authenticity and loneliness(indirect effect=0.062).Loneliness did not serve as a significant mediator(indirect effect=–0.015,95%CI[–0.049,0.019]).The total indirect effect was 0.136.Conclusions:Interventions targeting international students’capacity for experiencing positive solitude and authenticity can help to reduce loneliness and increase psychological adaptation.The findings derived from this study are conducive to understanding the relationship between positive solitude and psychological adaptation,as well as its underlying mechanisms.In addition,the study offers a new perspective for educational management and psychological counseling services for international students.
基金supported by a Project Grant(Grant No.PJT183705)an Early Career Investigator Prize(Grant No.ECP 184184)from the Canadian Institutes of Health Research+7 种基金a Prentice Institute Research Affiliate Fund Grant from the Prentice Institute for Global Population and Economy(Grant No.G00004116)a Te Herenga Waka Victoria University of Wellington Division of Science Health Engineering Architecture and Design Innovation Faculty Strategic Research Grant(Grant No.FSRG-SHEADI-10724)The Thailand Physical Activity Knowledge Development Centre(TPAK)/Thai Health Promotion Foundation provided funding for the cognitive interviews and pilot study in Thailand(Grant No.66-P1-0473)The University Pablo de Olavide provided a scholarship for 2 undergraduate students working on the project(codes PPI2207 and PPI2308)In the Czech Republicthe study was supported by Palacky University IGA(Grant No.IGA_FTK_2023_017)supported by the Division of Intramural Research at the National Institute on Minority Health and Health Disparities of the National Institutes of Healthsupported by the Key Project of the National Philosophy and Social Science Foundation of China(23&ZD197)。
文摘Background:Investigators from low-,middle-,and high-income countries representing 6 continents contributed to the development of the Global Adolescent and Child Physical Activity Questionnaire(GAC-PAQ).The GAC-PAQ is designed to assess physical activity(PA)across all key domains(i.e.,school,chores,work/volunteering,transport,free time,outdoor time).It aimed to address multiple gaps in global PA surveillance(e.g.,omission of important PA domains,insufficient cultural adaptation,underrepresentation of rural areas in questionnaire validation studies).The purpose of this study was to assess the content validity of the GAC-PAQ among PA experts,8-to 17-year-olds,and one of their parents/guardians,and to discuss changes made to the questionnaire based on participants'feedback.Methods:Sixty-two experts in PA measurement and/or surveillance from 24 countries completed an online survey that included both closed-and open-ended questions about the content validity of the GAC-PAQ.The proportion of experts who agreed or strongly agreed with the items was calculated.Child-parent/guardian dyads from 15 countries(n=250;10-40 per country)participated in a structured cognitive interview to assess the clarity of the questions and response options,and they were encouraged to provide suggestions to improve clarity and facilitate completion of the questionnaire.Participating countries are:Aotearoa New Zealand,Brazil,Canada,China,Colombia,Czech Republic,India,Malawi,Mexico,Nepal,Nigeria,Spain,Sweden,Thailand,and the United Arab Emirates.Interviews were conducted in 13 different languages and structured by PA domain.Generic images were included to help participants in answering questions about PA intensity.Results:Expert agreement with the items for each domain exceeded 75%,and their qualitative feedback was used to revise the questionnaire before cognitive interviews.In general,participants found the questionnaire to be comprehensive.Adolescents(12-17 years)found it easier than children(8-11 years)to answer the questions.Several children struggled to answer questions about the duration and intensity of activities and/or concepts related to travel modes,active trips,and organized activities.Many parents/guardians were unsure about the frequency,duration,and intensity of their children's or adolescents'PA at school and/or recommended using more culturally relevant and appropriate images.Some participants misunderstood the concept of activities that“make you stronger”(intended to assess resistance activities)and/or struggled to differentiate between work,volunteering,and chores.Conclusion:Participants'feedback was used to develop a revised,simplified,and culturally adapted GAC-PAQ,which will be pilot-tested in all15 countries in an App that will include country-specific images and narration in local languages.Further research is needed to assess the reliability and validity of the revised GAC-PAQ.
