Adaptable design aims to extend the utilities of design and product. The specific methods are developed for practical applications of adaptable design in the design of mechanical structures, including adaptable platfo...Adaptable design aims to extend the utilities of design and product. The specific methods are developed for practical applications of adaptable design in the design of mechanical structures, including adaptable platform, interface and module designs. Adaptable redesign problems are formulated as adaptable platform design under adaptability bound constraints. Analysis tools are then suggested for the implementation of the redesign of machine tool structures, including variation techniques based sensitivity analysis, similarity-based commonality analysis, performance improvement, and adaptability measures. The specific measure of adaptability for machine tool structures is measured through the quantification of the structural similarity and performance improvement gained from adaptable design. The method provides designers with an approach that brings adaptability into the design process, with considering the cost and benefits of such adaptability. The redesign of CNC spiral bevel gear cutting machine structures has been included to illustrate these concepts and methods.展开更多
A newly emerging design pattern, named as adaptable design （AD）, which aims at developing products that are adaptable from design to post-life cycle, is discussed. AD consists of four main phases： product modeling,...A newly emerging design pattern, named as adaptable design （AD）, which aims at developing products that are adaptable from design to post-life cycle, is discussed. AD consists of four main phases： product modeling, design platform, specific design and product redesign. A new process-based design data model （PDDM） is presented which is organized according to the principles of convenient knowledge extraction, data representation, layout, sharing and reuse. Based on the PDDM, a universal design platform for product family development is established, which has characters of modularity, parameter-driven, variant design, etc. The framework of the platform is also proposed as a conceptual structure and overall logical organization for generating a family of products. AD methodology is successfully applied to develop a family of tunnel boring machine （TBM） for different engineering projects, with the efficiency of our developing team being greatly increased.展开更多
patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayes...patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayesian adaptive two-stage trial,hoping to provide new ideas for the rapid evaluation of the effectiveness of TCM in PPF.An open-label,two-stage,adaptive Bayesian randomized controlled trial will be conducted in China.Based on Bayesian methods,the trial will employ response-adaptive randomization to allocate patients to study groups based on data collected over the course of the trial.The adaptive Bayesian trial design will employ a Bayesian hierarchical model with“stopping”and“continuation”criteria once a predetermined posterior probability of superiority or futility and a decision threshold are reached.The trial can be implemented more efficiently by sharing the master protocol and organizational management mechanisms of the sub-trial we have implemented.The primary patient-reported outcome is a change in the Leicester Cough Questionnaire score,reflecting an improvement in cough-specific quality of life.The adaptive Bayesian trial design may be a promising method to facilitate the rapid clinical evaluation of TCM effectiveness for PPF,and will provide an example for how to evaluate TCM effectiveness in rare and refractory diseases.However,due to the complexity of the trial implementation,sufficient simulation analysis by professional statistical analysts is required to construct a Bayesian response-adaptive randomization procedure for timely response.Moreover,detailed standard operating procedures need to be developed to ensure the feasibility of the trial implementation.展开更多
The core task of tracking control is to make the controlled plant track a desired trajectory.The traditional performance index used in previous studies cannot eliminate completely the tracking error as the number of t...The core task of tracking control is to make the controlled plant track a desired trajectory.The traditional performance index used in previous studies cannot eliminate completely the tracking error as the number of time steps increases.In this paper,a new cost function is introduced to develop the value-iteration-based adaptive critic framework to solve the tracking control problem.Unlike the regulator problem,the iterative value function of tracking control problem cannot be regarded as a Lyapunov function.A novel stability analysis method is developed to guarantee that the tracking error converges to zero.The discounted iterative scheme under the new cost function for the special case of linear systems is elaborated.Finally,the tracking performance of the present scheme is demonstrated by numerical results and compared with those of the traditional approaches.展开更多
To resolve problems of complicated clutter, fast-varying scenes, and low signal-clutterratio （SCR） in application of target detection on sea for space-based radar （SBR）, a target detection approach based on adapti...To resolve problems of complicated clutter, fast-varying scenes, and low signal-clutterratio （SCR） in application of target detection on sea for space-based radar （SBR）, a target detection approach based on adaptive waveform design is proposed in this paper. Firstly, complicated sea clutter is modeled as compound Gaussian process, and a target is modeled as some scatterers with Gaussian reflectivity. Secondly, every dwell duration of radar is divided into several sub-dwells. Regular linear frequency modulated pulses are transmitted at Sub-dwell 1, and the received signal at this sub-dwell is used to estimate clutter covariance matrices and pre-detection. Estimated matrices are updated at every following sub-dwell by multiple particle filtering to cope with fast-varying clutter scenes of SBR. Furthermore, waveform of every following sub-dwell is designed adaptively according to mean square optimization technique. Finally, principal component analysis and generalized likelihood ratio test is used for mitigation of colored interference and property of constant false alarm rate, respectively. Simulation results show that, considering configuration of SBR and condition of complicated clutter, 9 dB is reduced for SCR which reliable detection requires by this target detection approach. Therefore, the work in this paper can markedly improve radar detection performance for weak targets.展开更多
SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target w...SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target was to demonstrate the feasibility of designing,manufacturing and operating in representative environment,instrumented structures.Till now,it represents the major effort carried out within the European Union on the development of adaptive architectures for air systems.Inside that big activity,the realization of an Adaptive Trailing Edge Device(ATED)for wing camber adaptations aimed at compensating the weight reduction following the fuel consumption during cruise was addressed.It made the core of investigations target variable geometry aircraft components together with two other analyses concerning the development of shape-changing winglet and droop nose.ATED activities were conducted by the Italian Aerospace Research Centre(CIRA)in tight cooperation with the University of Napoli,"Federico II",who coordinated a group of 12 different partners from 8 different nations(France,Germany,Greece,the Netherlands,Israel,Spain,Turkey,and Italy).In this paper,an integral synthesis of that work is reported,with a focus on the definition and realization of the components of the presented device.The publication is in fact meant as the first part of a series that is aimed at overviewing the whole adaptive trailing edge development,till wind tunnel tests execution.Such a concise report is a critical and harmonized review of what have been performed by many colleagues spread all over Europe,all of which are duly recalled in the reported bibliography where the reader may access more detailed information and descriptions.In detail,the paper starts with a general introduction of the concept and its aims,to move to the specs definition immediately after.Then,it deals with a short but comprehensive description of the main ATED components:structural skeleton,skin,actuation and sensing systems.It is worth remarking that the paragraph dedicated to the body frame includes some discussion about aeroelastic assessment and manufacture,seen as complementation for a complete assessment of the design constraints.展开更多
Various adaptive designs have been proposed and applied to clinical trials, bio assay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attentio...Various adaptive designs have been proposed and applied to clinical trials, bio assay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attention to these design methods. This paper introduces several broad families of designs, such as the play-the-winner rule, randomized play-the-winner rule and its generalization to the multi-arm case, doubly biased coin adaptive design, Markov chain model.展开更多
The problems of joint adaptive waveform design and baseline range design for bistatic radar to maximize the practical radar resolution were considered.Distinguishing from the conventional ambiguity function(AF)-based ...The problems of joint adaptive waveform design and baseline range design for bistatic radar to maximize the practical radar resolution were considered.Distinguishing from the conventional ambiguity function(AF)-based resolution which is only related with the transmitted waveform and bistatic geometry and could be regarded as the potential resolution of a bistatic radar system,the practical resolution involves the effect of waveform,signal-to-noise ratio(SNR)as well as the measurement model.Thus,it is more practical and will have further significant application in target detection and tracking.The constraint optimization procedure of joint adaptive waveform design and baseline range design for maximizing the practical resolution of bistatic radar system under dynamic target scenario was devised.Simulation results show that the range and velocity resolution are enhanced according to the adaptive waveform and bistatic radar configuration.展开更多
An adaptive robust control algorithm for ship straight path control system in the presence of both modeling uncertainties and the bounded disturbances is proposed. Motivated by the backstepping approach, the algorithm...An adaptive robust control algorithm for ship straight path control system in the presence of both modeling uncertainties and the bounded disturbances is proposed. Motivated by the backstepping approach, the algorithm is developed by using the dissipation theory, such that the resulting dosed-loop system is both strictly dissipative and asymptotically adaptively stable for all admissible uncertainties. Also, it is able to steer an underactuated ship along a prescribed straight path with ultimate bounds under external disturbances induced by wave, wind and ocean current. When there are no disturbances, the straight path control can be implemented in a locally asymptotically stable manner. Simulation results on an ocean-going training ship ‘YULONG＇ are presented to validate the effectiveness of the algorithm.展开更多
Efficient experiment design is of great significance for the validation of simulation model with high nonlinearity and large input space.Excessive validation experiment raises the cost while insufficient test increase...Efficient experiment design is of great significance for the validation of simulation model with high nonlinearity and large input space.Excessive validation experiment raises the cost while insufficient test increases the risks of accepting an invalid model.In this paper,an adaptive sequential experiment design method combining global exploration criterion and local exploitation criterion is proposed.The exploration criterion utilizes discrepancy metric to improve the space-filling property of the design points while the exploitation criterion employs the leave one out error to discover informative points.To avoid the clustering of samples in the local region,an adaptive weight updating approach is provided to maintain the balance between exploration and exploitation.Besides,the credibility distribution function characterizing the relationship between the input and result credibility is introduced to support the model validation experiment design.Finally,six benchmark problems and an engineering case are applied to examine the performance of the proposed method.The experiments indicate that the proposed method achieves satisfactory performance for function approximation in accuracy and convergence.展开更多
In order to improve detection and estimation performance of distributed OrthogonalFrequency-Division Multiplexing（OFDM） Multiple-Input Multiple-Output（MIMO） radar system in multi-target scene, we propose a novel a...In order to improve detection and estimation performance of distributed OrthogonalFrequency-Division Multiplexing（OFDM） Multiple-Input Multiple-Output（MIMO） radar system in multi-target scene, we propose a novel approach of Adaptive Waveform Design（AWD） based on a constrained Multi-Objective Optimization（MOO）. The sparse measurement model of this radar system is derived, and the method based on decomposed Dantzig selectors is applied for the sparse recovery according to the block structures of the sparse vector and the system matrix. An AWD approach is proposed, which optimizes two objective functions, namely minimizing the upper bound of the recovery error and maximizing the weakest-target return, by adjusting the complex weights of the emitting waveform amplitudes. Several numerical simulations are provided and their results show that the detection and estimation performance of the radar system is improved significantly when this MOO-based AWD approach is applied to the distributed OFDM MIMO radar system. Especially, we verify the effectiveness of our AWD approach when the available samples are reduced severally and the technique of compressed sensing is introduced.展开更多
It is often important to incorporate covariate information in the design of clinical trials. In literature there are many designs of using stratification and covariate-adaptive randomization to balance certain known c...It is often important to incorporate covariate information in the design of clinical trials. In literature there are many designs of using stratification and covariate-adaptive randomization to balance certain known covariate. Recently, some covariate-adjusted response-adaptive （CARA） designs have been proposed and their asymptotic properties have been studied （Ann. Statist. 2007）. However, these CARA designs usually have high variabilities. In this paper, a new family of covariate-adjusted response-adaptive （CARA） designs is presented. It is shown that the new designs have less variables and therefore are more efficient.展开更多
Today＇s manufacturing cnvironmem forces manufacturing companies to make as many product variations as possible at affordable costs within a short time. Mass customisation is one of most important technologies for com...Today＇s manufacturing cnvironmem forces manufacturing companies to make as many product variations as possible at affordable costs within a short time. Mass customisation is one of most important technologies for companies to achieve their objectives. Efforts to mass customisation should be made on two aspects： （1） To modularize products and make them as less differences as possible; （2） To design manufacturing resources and make them provide as many processes variations as possible. This paper reports our recent work on aspect （2）, i.e. how to design a reconfignrable manufacturing system （RMS） so that it can be competent to accomplish various processes optimally; Reconfignrable robot system （RRS） is taken as an example. RMS design involves architecture design and configuration design, and configuration design is further divided in design analysis and design synthesis. Axiomatic design theory （ADT） is applied to architecture design, the features and issues of RRS configuration design are discussed, automatic modelling method is developed for design analysis, and concurrent design methodology is presented for design synthesis.展开更多
Sample size can be a key design feature that not only affects the probability of a trial＇s success but also determines the duration and feasibility of a trial. If an investigational drug is expected to be effective a...Sample size can be a key design feature that not only affects the probability of a trial＇s success but also determines the duration and feasibility of a trial. If an investigational drug is expected to be effective and address unmet medical needs of an orphan disease, where the accrual period may require many years with a large sample size to detect a minimal clinically relevant treatment effect, a minimum sample size may be set to maintain nominal power. In limited situations such as this, there may be a need for flexibility in the initial and final sample sizes; thus, it is useful to consider the utility of adaptive sample size designs that use sample size re-estimation or group sequential design. In this paper, we propose a new adaptive performance measure to consider the utility of an adaptive sample size design in a trial simulation. Considering that previously proposed sample size re-estimation methods do not take into account errors in estimation based on interim results, we propose Bayesian sample size re-estimation criteria that take into account prior information on treatment effect, and then, we assess its operating characteristics in a simulation study. We also present a review example of sample size re-estimation mainly based on published paper and review report in Pharmaceuticals and Medical Devices Agency （PMDA）.展开更多
This paper proposes a new kind of generalized Friendman's urn model,which with adaptive nonhomogeneous generating matrix.This model may be applied in sequential medical experiment.In this model some limit theorems...This paper proposes a new kind of generalized Friendman's urn model,which with adaptive nonhomogeneous generating matrix.This model may be applied in sequential medical experiment.In this model some limit theorems (strong consistency and asymptot- ical normality) have been obtained.展开更多
In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant...In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant computer system on a single chip of 5000 gate CMOS gate array. The design, fabrication and test of this single chip system will be discussed..展开更多
Each place has its own peculiarities,determining that the resilience and adaptation to diverse types of risks will be different,requiring different time and methods for mitigation as well.The coexistence of several ri...Each place has its own peculiarities,determining that the resilience and adaptation to diverse types of risks will be different,requiring different time and methods for mitigation as well.The coexistence of several risks determines further resolution difficulties as commonly,since risks are sudden and unforeseen,there is a tendency to treat the last risk more carefully,neglecting the previous one even if it is just as important.Most of the methodologies used to analyse areas affected by different risks are aimed at focusing in particular on seismic risks without considering those relating to intangible aspects linked to the identity of the places or aspects related to urban health and liveability.And,more in general,in relation to design aspects,urban methodologies do not consider all the results of the analyses,maybe for the difficulty deriving from translating the complexity of collected data in project interventions.Starting from these premises,the objective of the article,elaborated within the SISMI and PRIN 2020 research projects is to propose an original methodology capable of analysing the places affected by multiple risks and planning its resilience attentive to its cultural resources and to its liveability.To this end,the proposed method will be aimed at creating flexible and adaptive places and the case-study of Cittaducale will be illustrated.Criticalities and qualities of this place affected by an earthquake in 2016 will be reported and project interventions to transform its risks into opportunities will be shown.展开更多
Objectives To explore the optimization method of vaccine clinical trial design based on immunological surrogate endpoint to improve the quality and efficiency of vaccine clinical research and development.Methods As to...Objectives To explore the optimization method of vaccine clinical trial design based on immunological surrogate endpoint to improve the quality and efficiency of vaccine clinical research and development.Methods As to the problems in the vaccine clinical research in China,the relevant guidelines and literatures of FDA and WHO were used to analyze and summarize the methods of optimizing the design of vaccine clinical trials.Results and Conclusion The adaptive design guidelines are established to guide clinical trial design,encourage the development and application of immunological surrogate endpoints,establish qualification process for drug development tools and information disclosure procedures to improve vaccine development efficiency.展开更多
Considering the essential and influential role of centrifugal compressors in a wide range of industries makes most of engineers research and study on design and optimization of centrifugal compressors. Centrifugal com...Considering the essential and influential role of centrifugal compressors in a wide range of industries makes most of engineers research and study on design and optimization of centrifugal compressors. Centrifugal compressors are the key to part ofoil, gas and petrochemical industries as well as gas pipeline transports. Since complete 3D design of the compressor consumes a considerable amount of time, most of active companies in the field, are profoundly interested in obtaining a design outline before taking any further steps in designing the entire machine. In this paper, a numerical algorithm, named ACDA （adapted compressor design algorithm） for fast and accurate preliminary design of centrifugal compressor is presented. The design procedure is obtained under real gas behavior, using an appropriate equation of state. Starting from impeller inlet, the procedure is continued on by resulting in numerical calculation for other sections including impeller exit, volute and exit diffuser. Clearly, in any step suitable correction factors are employed in order to conclude in precise numerical results. Finally, the achieved design result is compared with available reference data.展开更多
Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primari...Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primarily focuses on identifying the maximum tolerated dose(MTD),therapies involving targeted and immune agents facilitate the identifica-tion of an optimal biological dose combination(OBDC)by simultaneously evaluating both toxicity and efficacy.Cur-rently,most approaches to determining the OBDC in the literature are model-based and require complex model fittings,making them cumbersome and challenging to implement.To address these challenges,we developed a novel model-as-sisted approach called uTPI-Comb.This approach refines the established utility-based toxicity probability interval design by integrating a strategically devised zone-based local and global candidate set searching strategy,which can effectively optimize the decision-making process for two-agent dose escalation or de-escalation in drug combination trials.Extensive simulation studies demonstrate that the uTPI-Comb design speeds up the dose-searching process and provides substantial improvements over existing model-based methods in determining the optimal biological dose combinations.展开更多
基金National Natural Science Foundation of China(No.50575084,No.50675126)Tianjin Municipal Science Technology Development Key Project,China(No.06YFGZGX00200)National Hi-tech Research Development Program of China(863 Program,No.2006AA04Z107)
文摘Adaptable design aims to extend the utilities of design and product. The specific methods are developed for practical applications of adaptable design in the design of mechanical structures, including adaptable platform, interface and module designs. Adaptable redesign problems are formulated as adaptable platform design under adaptability bound constraints. Analysis tools are then suggested for the implementation of the redesign of machine tool structures, including variation techniques based sensitivity analysis, similarity-based commonality analysis, performance improvement, and adaptability measures. The specific measure of adaptability for machine tool structures is measured through the quantification of the structural similarity and performance improvement gained from adaptable design. The method provides designers with an approach that brings adaptability into the design process, with considering the cost and benefits of such adaptability. The redesign of CNC spiral bevel gear cutting machine structures has been included to illustrate these concepts and methods.
文摘A newly emerging design pattern, named as adaptable design （AD）, which aims at developing products that are adaptable from design to post-life cycle, is discussed. AD consists of four main phases： product modeling, design platform, specific design and product redesign. A new process-based design data model （PDDM） is presented which is organized according to the principles of convenient knowledge extraction, data representation, layout, sharing and reuse. Based on the PDDM, a universal design platform for product family development is established, which has characters of modularity, parameter-driven, variant design, etc. The framework of the platform is also proposed as a conceptual structure and overall logical organization for generating a family of products. AD methodology is successfully applied to develop a family of tunnel boring machine （TBM） for different engineering projects, with the efficiency of our developing team being greatly increased.
基金supported by National Natural Science Foundation of China(No.81973713)。
文摘patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayesian adaptive two-stage trial,hoping to provide new ideas for the rapid evaluation of the effectiveness of TCM in PPF.An open-label,two-stage,adaptive Bayesian randomized controlled trial will be conducted in China.Based on Bayesian methods,the trial will employ response-adaptive randomization to allocate patients to study groups based on data collected over the course of the trial.The adaptive Bayesian trial design will employ a Bayesian hierarchical model with“stopping”and“continuation”criteria once a predetermined posterior probability of superiority or futility and a decision threshold are reached.The trial can be implemented more efficiently by sharing the master protocol and organizational management mechanisms of the sub-trial we have implemented.The primary patient-reported outcome is a change in the Leicester Cough Questionnaire score,reflecting an improvement in cough-specific quality of life.The adaptive Bayesian trial design may be a promising method to facilitate the rapid clinical evaluation of TCM effectiveness for PPF,and will provide an example for how to evaluate TCM effectiveness in rare and refractory diseases.However,due to the complexity of the trial implementation,sufficient simulation analysis by professional statistical analysts is required to construct a Bayesian response-adaptive randomization procedure for timely response.Moreover,detailed standard operating procedures need to be developed to ensure the feasibility of the trial implementation.
基金This work was supported in part by Beijing Natural Science Foundation(JQ19013)the National Key Research and Development Program of China(2021ZD0112302)the National Natural Science Foundation of China(61773373).
文摘The core task of tracking control is to make the controlled plant track a desired trajectory.The traditional performance index used in previous studies cannot eliminate completely the tracking error as the number of time steps increases.In this paper,a new cost function is introduced to develop the value-iteration-based adaptive critic framework to solve the tracking control problem.Unlike the regulator problem,the iterative value function of tracking control problem cannot be regarded as a Lyapunov function.A novel stability analysis method is developed to guarantee that the tracking error converges to zero.The discounted iterative scheme under the new cost function for the special case of linear systems is elaborated.Finally,the tracking performance of the present scheme is demonstrated by numerical results and compared with those of the traditional approaches.
基金supported by the National Defense Pre-Research Foundation of China
文摘To resolve problems of complicated clutter, fast-varying scenes, and low signal-clutterratio （SCR） in application of target detection on sea for space-based radar （SBR）, a target detection approach based on adaptive waveform design is proposed in this paper. Firstly, complicated sea clutter is modeled as compound Gaussian process, and a target is modeled as some scatterers with Gaussian reflectivity. Secondly, every dwell duration of radar is divided into several sub-dwells. Regular linear frequency modulated pulses are transmitted at Sub-dwell 1, and the received signal at this sub-dwell is used to estimate clutter covariance matrices and pre-detection. Estimated matrices are updated at every following sub-dwell by multiple particle filtering to cope with fast-varying clutter scenes of SBR. Furthermore, waveform of every following sub-dwell is designed adaptively according to mean square optimization technique. Finally, principal component analysis and generalized likelihood ratio test is used for mitigation of colored interference and property of constant false alarm rate, respectively. Simulation results show that, considering configuration of SBR and condition of complicated clutter, 9 dB is reduced for SCR which reliable detection requires by this target detection approach. Therefore, the work in this paper can markedly improve radar detection performance for weak targets.
基金The research herein reported did gratefully receive funding from Seventh Framework Programme of the European Union(FP7/2007-2013)under Grant Agreement N.284562,SARISTUThe project was prodigiously and effectively coordinated by Piet Christof Woelcken(Airbus)with the support of Michael Papadopoulos(EASN–European Aeronautic Science Network).
文摘SARISTU was a big cooperation project granted by the European Commission,7th Framework Programme,carried out between 2011 and 2015.It dealt with smart aeronautic structures,both morphing and sensored;its main target was to demonstrate the feasibility of designing,manufacturing and operating in representative environment,instrumented structures.Till now,it represents the major effort carried out within the European Union on the development of adaptive architectures for air systems.Inside that big activity,the realization of an Adaptive Trailing Edge Device(ATED)for wing camber adaptations aimed at compensating the weight reduction following the fuel consumption during cruise was addressed.It made the core of investigations target variable geometry aircraft components together with two other analyses concerning the development of shape-changing winglet and droop nose.ATED activities were conducted by the Italian Aerospace Research Centre(CIRA)in tight cooperation with the University of Napoli,"Federico II",who coordinated a group of 12 different partners from 8 different nations(France,Germany,Greece,the Netherlands,Israel,Spain,Turkey,and Italy).In this paper,an integral synthesis of that work is reported,with a focus on the definition and realization of the components of the presented device.The publication is in fact meant as the first part of a series that is aimed at overviewing the whole adaptive trailing edge development,till wind tunnel tests execution.Such a concise report is a critical and harmonized review of what have been performed by many colleagues spread all over Europe,all of which are duly recalled in the reported bibliography where the reader may access more detailed information and descriptions.In detail,the paper starts with a general introduction of the concept and its aims,to move to the specs definition immediately after.Then,it deals with a short but comprehensive description of the main ATED components:structural skeleton,skin,actuation and sensing systems.It is worth remarking that the paragraph dedicated to the body frame includes some discussion about aeroelastic assessment and manufacture,seen as complementation for a complete assessment of the design constraints.
文摘Various adaptive designs have been proposed and applied to clinical trials, bio assay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attention to these design methods. This paper introduces several broad families of designs, such as the play-the-winner rule, randomized play-the-winner rule and its generalization to the multi-arm case, doubly biased coin adaptive design, Markov chain model.
基金Project supported by the Program for New Century Excellent Talents in University,ChinaProject(61171133)supported by the National Natural Science Foundation of China+2 种基金Project(11JJ1010)supported by the Natural Science Fund for Distinguished Young Scholars of Hunan Province,ChinaProject(61101182)supported by the National Natural Science Foundation for Young Scientists of ChinaProject(20124307110013)supported by the Doctoral Program of Higher Education of China
文摘The problems of joint adaptive waveform design and baseline range design for bistatic radar to maximize the practical radar resolution were considered.Distinguishing from the conventional ambiguity function(AF)-based resolution which is only related with the transmitted waveform and bistatic geometry and could be regarded as the potential resolution of a bistatic radar system,the practical resolution involves the effect of waveform,signal-to-noise ratio(SNR)as well as the measurement model.Thus,it is more practical and will have further significant application in target detection and tracking.The constraint optimization procedure of joint adaptive waveform design and baseline range design for maximizing the practical resolution of bistatic radar system under dynamic target scenario was devised.Simulation results show that the range and velocity resolution are enhanced according to the adaptive waveform and bistatic radar configuration.
文摘An adaptive robust control algorithm for ship straight path control system in the presence of both modeling uncertainties and the bounded disturbances is proposed. Motivated by the backstepping approach, the algorithm is developed by using the dissipation theory, such that the resulting dosed-loop system is both strictly dissipative and asymptotically adaptively stable for all admissible uncertainties. Also, it is able to steer an underactuated ship along a prescribed straight path with ultimate bounds under external disturbances induced by wave, wind and ocean current. When there are no disturbances, the straight path control can be implemented in a locally asymptotically stable manner. Simulation results on an ocean-going training ship ‘YULONG＇ are presented to validate the effectiveness of the algorithm.
基金supported by the National Natural Science Foundation of China(No.61627810)。
文摘Efficient experiment design is of great significance for the validation of simulation model with high nonlinearity and large input space.Excessive validation experiment raises the cost while insufficient test increases the risks of accepting an invalid model.In this paper,an adaptive sequential experiment design method combining global exploration criterion and local exploitation criterion is proposed.The exploration criterion utilizes discrepancy metric to improve the space-filling property of the design points while the exploitation criterion employs the leave one out error to discover informative points.To avoid the clustering of samples in the local region,an adaptive weight updating approach is provided to maintain the balance between exploration and exploitation.Besides,the credibility distribution function characterizing the relationship between the input and result credibility is introduced to support the model validation experiment design.Finally,six benchmark problems and an engineering case are applied to examine the performance of the proposed method.The experiments indicate that the proposed method achieves satisfactory performance for function approximation in accuracy and convergence.
基金supported by the National Basic Research Program of China(No.613205212)
文摘In order to improve detection and estimation performance of distributed OrthogonalFrequency-Division Multiplexing（OFDM） Multiple-Input Multiple-Output（MIMO） radar system in multi-target scene, we propose a novel approach of Adaptive Waveform Design（AWD） based on a constrained Multi-Objective Optimization（MOO）. The sparse measurement model of this radar system is derived, and the method based on decomposed Dantzig selectors is applied for the sparse recovery according to the block structures of the sparse vector and the system matrix. An AWD approach is proposed, which optimizes two objective functions, namely minimizing the upper bound of the recovery error and maximizing the weakest-target return, by adjusting the complex weights of the emitting waveform amplitudes. Several numerical simulations are provided and their results show that the detection and estimation performance of the radar system is improved significantly when this MOO-based AWD approach is applied to the distributed OFDM MIMO radar system. Especially, we verify the effectiveness of our AWD approach when the available samples are reduced severally and the technique of compressed sensing is introduced.
基金Partially supported by the National Natural Science Foundation of China (10771192)NSF Awards DMS-0349048 of USA
文摘It is often important to incorporate covariate information in the design of clinical trials. In literature there are many designs of using stratification and covariate-adaptive randomization to balance certain known covariate. Recently, some covariate-adjusted response-adaptive （CARA） designs have been proposed and their asymptotic properties have been studied （Ann. Statist. 2007）. However, these CARA designs usually have high variabilities. In this paper, a new family of covariate-adjusted response-adaptive （CARA） designs is presented. It is shown that the new designs have less variables and therefore are more efficient.
文摘Today＇s manufacturing cnvironmem forces manufacturing companies to make as many product variations as possible at affordable costs within a short time. Mass customisation is one of most important technologies for companies to achieve their objectives. Efforts to mass customisation should be made on two aspects： （1） To modularize products and make them as less differences as possible; （2） To design manufacturing resources and make them provide as many processes variations as possible. This paper reports our recent work on aspect （2）, i.e. how to design a reconfignrable manufacturing system （RMS） so that it can be competent to accomplish various processes optimally; Reconfignrable robot system （RRS） is taken as an example. RMS design involves architecture design and configuration design, and configuration design is further divided in design analysis and design synthesis. Axiomatic design theory （ADT） is applied to architecture design, the features and issues of RRS configuration design are discussed, automatic modelling method is developed for design analysis, and concurrent design methodology is presented for design synthesis.
文摘Sample size can be a key design feature that not only affects the probability of a trial＇s success but also determines the duration and feasibility of a trial. If an investigational drug is expected to be effective and address unmet medical needs of an orphan disease, where the accrual period may require many years with a large sample size to detect a minimal clinically relevant treatment effect, a minimum sample size may be set to maintain nominal power. In limited situations such as this, there may be a need for flexibility in the initial and final sample sizes; thus, it is useful to consider the utility of adaptive sample size designs that use sample size re-estimation or group sequential design. In this paper, we propose a new adaptive performance measure to consider the utility of an adaptive sample size design in a trial simulation. Considering that previously proposed sample size re-estimation methods do not take into account errors in estimation based on interim results, we propose Bayesian sample size re-estimation criteria that take into account prior information on treatment effect, and then, we assess its operating characteristics in a simulation study. We also present a review example of sample size re-estimation mainly based on published paper and review report in Pharmaceuticals and Medical Devices Agency （PMDA）.
基金This work is supported by a grant of National University of Singapore(RP 3972712)by partially National Science Foundation of
文摘This paper proposes a new kind of generalized Friendman's urn model,which with adaptive nonhomogeneous generating matrix.This model may be applied in sequential medical experiment.In this model some limit theorems (strong consistency and asymptot- ical normality) have been obtained.
文摘In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant computer system on a single chip of 5000 gate CMOS gate array. The design, fabrication and test of this single chip system will be discussed..
基金the Italian Ministry of University and Research(MUR)in the framework of the Project PRIN2020#20209F3A37 is gratefully acknowledged.
文摘Each place has its own peculiarities,determining that the resilience and adaptation to diverse types of risks will be different,requiring different time and methods for mitigation as well.The coexistence of several risks determines further resolution difficulties as commonly,since risks are sudden and unforeseen,there is a tendency to treat the last risk more carefully,neglecting the previous one even if it is just as important.Most of the methodologies used to analyse areas affected by different risks are aimed at focusing in particular on seismic risks without considering those relating to intangible aspects linked to the identity of the places or aspects related to urban health and liveability.And,more in general,in relation to design aspects,urban methodologies do not consider all the results of the analyses,maybe for the difficulty deriving from translating the complexity of collected data in project interventions.Starting from these premises,the objective of the article,elaborated within the SISMI and PRIN 2020 research projects is to propose an original methodology capable of analysing the places affected by multiple risks and planning its resilience attentive to its cultural resources and to its liveability.To this end,the proposed method will be aimed at creating flexible and adaptive places and the case-study of Cittaducale will be illustrated.Criticalities and qualities of this place affected by an earthquake in 2016 will be reported and project interventions to transform its risks into opportunities will be shown.
文摘Objectives To explore the optimization method of vaccine clinical trial design based on immunological surrogate endpoint to improve the quality and efficiency of vaccine clinical research and development.Methods As to the problems in the vaccine clinical research in China,the relevant guidelines and literatures of FDA and WHO were used to analyze and summarize the methods of optimizing the design of vaccine clinical trials.Results and Conclusion The adaptive design guidelines are established to guide clinical trial design,encourage the development and application of immunological surrogate endpoints,establish qualification process for drug development tools and information disclosure procedures to improve vaccine development efficiency.
文摘Considering the essential and influential role of centrifugal compressors in a wide range of industries makes most of engineers research and study on design and optimization of centrifugal compressors. Centrifugal compressors are the key to part ofoil, gas and petrochemical industries as well as gas pipeline transports. Since complete 3D design of the compressor consumes a considerable amount of time, most of active companies in the field, are profoundly interested in obtaining a design outline before taking any further steps in designing the entire machine. In this paper, a numerical algorithm, named ACDA （adapted compressor design algorithm） for fast and accurate preliminary design of centrifugal compressor is presented. The design procedure is obtained under real gas behavior, using an appropriate equation of state. Starting from impeller inlet, the procedure is continued on by resulting in numerical calculation for other sections including impeller exit, volute and exit diffuser. Clearly, in any step suitable correction factors are employed in order to conclude in precise numerical results. Finally, the achieved design result is compared with available reference data.
基金This work was supported by the Natural Science Foundation of Anhui Province(2022AH050703)the National Natural Science Foundation of China(11671375).
文摘Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primarily focuses on identifying the maximum tolerated dose(MTD),therapies involving targeted and immune agents facilitate the identifica-tion of an optimal biological dose combination(OBDC)by simultaneously evaluating both toxicity and efficacy.Cur-rently,most approaches to determining the OBDC in the literature are model-based and require complex model fittings,making them cumbersome and challenging to implement.To address these challenges,we developed a novel model-as-sisted approach called uTPI-Comb.This approach refines the established utility-based toxicity probability interval design by integrating a strategically devised zone-based local and global candidate set searching strategy,which can effectively optimize the decision-making process for two-agent dose escalation or de-escalation in drug combination trials.Extensive simulation studies demonstrate that the uTPI-Comb design speeds up the dose-searching process and provides substantial improvements over existing model-based methods in determining the optimal biological dose combinations.
