Bacterial infection-induced acute sinusitis is prevalent and can easily progress into chronic sinusitis,which is often difficult to treat due to the challenging nature of the site,increased environmental pollution,and...Bacterial infection-induced acute sinusitis is prevalent and can easily progress into chronic sinusitis,which is often difficult to treat due to the challenging nature of the site,increased environmental pollution,and bacterial drug resistance prevalent nowadays.To address these challenges,a flexible hydrogel(LM@P/S@CP@Hemin)that involves flexible wood-modified logs,photoactive conjugated polymers,an immunomodulator,and an immobilization hydrogel was prepared for nasal cavity treatment.The flexible wood-modified logs providemechanical strength support.In vitro,experiments verified that the hydrogel could efficiently induce the photothermal effect under near-infrared-II laser irradiation after deeply penetrating bone and produce reactive oxygen species(ROS)to initiate the photodynamic effect for synergetically eliminating bacteria.The introduction of hemin endows LM@P/S@CP@Hemin hydrogel with a strong immunomodulatory effect on macrophages to achieve anti-inflammation and cellular ROS clearance abilities,which avoids the excessive oxidative stress in the nasal cavity.The results showed that the hydrogel induced an anti-bacterial effect with a 98.5%inhibition rate against methicillin-resistant Staphylococcus aureus,hadexcellent clearance ability of excessive ROS,and promoted anti-inflammatory M2 macrophage generation to relieve inflammation.Meanwhile,transcriptome sequencing and mRNA level measurements revealed that the hydrogel could regulate inflammatory-related genes.In vivo,bacterial infection-induced acute sinusitis rabbit model experiments and histological analysis further confirmed the great therapeutic effect of LM@P/S@CP@Hemin for acute sinusitis based on photothermal and photodynamic therapy.Therefore,LM@P/S@CP@Hemin is an excellent therapeutic material that can adapt to the nasal environment and treat acute sinusitis.展开更多
Objective:to observe the effect of health education on nursing of acute suppurative sinusitis. Methods: 62 patients with acute suppurative sinusitis were randomly divided into two groups: study group and control group...Objective:to observe the effect of health education on nursing of acute suppurative sinusitis. Methods: 62 patients with acute suppurative sinusitis were randomly divided into two groups: study group and control group. General nursing was used in the control group and health education nursing was used in the study group. The nursing effect and bad mood scores of the two groups were compared. Results: the therapeutic effectiveness of the two groups was significantly higher in the study group than in the control group (P < 0.05). The scores of depression and anxiety in the study group were significantly better than those in the control group (P < 0.05). Conclusion: health education is more effective in the nursing of acute suppurative sinusitis, which can significantly improve the patients' psychological and life quality.展开更多
Objectives:The objective of this study was to study the various outcomes among coronavirus disease 2019(COVID-19)-associated mucormycosis(CAM)in terms of morbidity and mortality.Methods:A prospective study was done on...Objectives:The objective of this study was to study the various outcomes among coronavirus disease 2019(COVID-19)-associated mucormycosis(CAM)in terms of morbidity and mortality.Methods:A prospective study was done on 107 patients(60 male,47 female)in the Department of Otolaryngology and Head and Neck Surgery,Government Medical College,Patiala,India,diagnosed with CAM from April 2021 to August 2021.The patients were managed both medically and surgically.The follow-up was done up to 2 years to assess the various outcomes.Results:Out of 107 patients,short-term(3 months)survival was 68.22%,and longterm(2 years)survival was 52.34%.Overall mortality was 47.66%,with short-term mortality of 31.77%and long-term mortality of 15.89%.Eye loss was seen in 17 patients,residual ophthalmoplegia in 12,palatal loss in 15,depression in 56,cerebrospinal fluid rhinorrhea in two,and recurrence in two patients.Conclusions:In conclusion,despite early management and successful initial outcome,the patients are still haunted by the after-effects of CAM like residual morbidity in terms of eye and palate loss,ophthalmoplegia,and depression.Delayed mortality has also been noticed over 2 years of follow-up.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31470590,82071044,and 32401169)the Jiangsu Provincial Medical Key Discipline Laboratory(ZDXK202243)+1 种基金the Project funded by the China Postdoctoral Science Foundation(No.2022M711586)the Nanjing Health Science and Technology Development Special Foundation(No.YKK22081).
文摘Bacterial infection-induced acute sinusitis is prevalent and can easily progress into chronic sinusitis,which is often difficult to treat due to the challenging nature of the site,increased environmental pollution,and bacterial drug resistance prevalent nowadays.To address these challenges,a flexible hydrogel(LM@P/S@CP@Hemin)that involves flexible wood-modified logs,photoactive conjugated polymers,an immunomodulator,and an immobilization hydrogel was prepared for nasal cavity treatment.The flexible wood-modified logs providemechanical strength support.In vitro,experiments verified that the hydrogel could efficiently induce the photothermal effect under near-infrared-II laser irradiation after deeply penetrating bone and produce reactive oxygen species(ROS)to initiate the photodynamic effect for synergetically eliminating bacteria.The introduction of hemin endows LM@P/S@CP@Hemin hydrogel with a strong immunomodulatory effect on macrophages to achieve anti-inflammation and cellular ROS clearance abilities,which avoids the excessive oxidative stress in the nasal cavity.The results showed that the hydrogel induced an anti-bacterial effect with a 98.5%inhibition rate against methicillin-resistant Staphylococcus aureus,hadexcellent clearance ability of excessive ROS,and promoted anti-inflammatory M2 macrophage generation to relieve inflammation.Meanwhile,transcriptome sequencing and mRNA level measurements revealed that the hydrogel could regulate inflammatory-related genes.In vivo,bacterial infection-induced acute sinusitis rabbit model experiments and histological analysis further confirmed the great therapeutic effect of LM@P/S@CP@Hemin for acute sinusitis based on photothermal and photodynamic therapy.Therefore,LM@P/S@CP@Hemin is an excellent therapeutic material that can adapt to the nasal environment and treat acute sinusitis.
文摘Objective:to observe the effect of health education on nursing of acute suppurative sinusitis. Methods: 62 patients with acute suppurative sinusitis were randomly divided into two groups: study group and control group. General nursing was used in the control group and health education nursing was used in the study group. The nursing effect and bad mood scores of the two groups were compared. Results: the therapeutic effectiveness of the two groups was significantly higher in the study group than in the control group (P < 0.05). The scores of depression and anxiety in the study group were significantly better than those in the control group (P < 0.05). Conclusion: health education is more effective in the nursing of acute suppurative sinusitis, which can significantly improve the patients' psychological and life quality.
文摘Objectives:The objective of this study was to study the various outcomes among coronavirus disease 2019(COVID-19)-associated mucormycosis(CAM)in terms of morbidity and mortality.Methods:A prospective study was done on 107 patients(60 male,47 female)in the Department of Otolaryngology and Head and Neck Surgery,Government Medical College,Patiala,India,diagnosed with CAM from April 2021 to August 2021.The patients were managed both medically and surgically.The follow-up was done up to 2 years to assess the various outcomes.Results:Out of 107 patients,short-term(3 months)survival was 68.22%,and longterm(2 years)survival was 52.34%.Overall mortality was 47.66%,with short-term mortality of 31.77%and long-term mortality of 15.89%.Eye loss was seen in 17 patients,residual ophthalmoplegia in 12,palatal loss in 15,depression in 56,cerebrospinal fluid rhinorrhea in two,and recurrence in two patients.Conclusions:In conclusion,despite early management and successful initial outcome,the patients are still haunted by the after-effects of CAM like residual morbidity in terms of eye and palate loss,ophthalmoplegia,and depression.Delayed mortality has also been noticed over 2 years of follow-up.
