Objective:To observe the effects of acupoint thread-embedding therapy on serum apelin and glucagon-like peptide-1(GLP-1)in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.Methods...Objective:To observe the effects of acupoint thread-embedding therapy on serum apelin and glucagon-like peptide-1(GLP-1)in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.Methods:Sixty-six patients were randomly divided into a control group and an observation group according to the random number table method,with 33 cases in each group.Patients in the control group were treated with exenatide and metformin,while patients in the observation group were treated with additional acupoint thread-embedding.After 12-week treatment,the obesity-related indicators,including body mass index(BMI),waist circumference and body fat rate,the glycometabolism indicators,including fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin,and the lipid metabolism indicators,including total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),as well as serum apelin and GLP-1 levels were observed in patients of the two groups.Results:After treatment,the BMI,waist circumference and body fat rate of patients in the two groups were all reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05);the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of patients in both groups were all decreased(all P<0.05),and were significantly lower in the observation group than in the control group(all P<0.05);the TC level was decreased(P<0.05),while the TG and LDL-C levels did not change significantly in the control group(both P>0.05);the TC,TG and LDL-C levels were all significantly reduced in the observation group(all P<0.05),lower than those in the control group(all P<0.05);the serum apelin level was decreased(P<0.05)and the serum GLP-1 level was increased(P<0.05)in the observation group,statistically different from those in the control group(both P<0.05).Conclusion:Combined with the conventional medication,acupoint thread-embedding therapy can significantly improve the obesity-related indicators,glycometabolism and lipid metabolism in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.This may be achieved by regulating the serum apelin and GLP-1 levels.展开更多
The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the...The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.展开更多
Objective To observe the clinical efficacy of acupoint magnetic therapy for spasmodic torticollis. Methods Twenty patients with spasmodic torticollis were treated by acupoint magnetic therapy at Fengchi （风池 GB 20）...Objective To observe the clinical efficacy of acupoint magnetic therapy for spasmodic torticollis. Methods Twenty patients with spasmodic torticollis were treated by acupoint magnetic therapy at Fengchi （风池 GB 20）, Dazhui （大椎 GV 24） and Shenzhu （身柱 GV 12）. Once a day, ten days as a course of treatment, 24 treatments were given. Results Six cases were cured and 9 cases were markedly effective, 3 cases were effective and 2 cases were ineffective with the cured rate of 30% and the effective rate of 90%. Conclusion Acupoint magnetic therapy has sound effect in the treatment of spasmodic torticollis.展开更多
Objective To explore the clinically indicated diseases of acupoint catgut-embedding therapy, and summarize and analyze the disease spectrum of acupoint catgut-embedding therapy. Methods By literature research and data...Objective To explore the clinically indicated diseases of acupoint catgut-embedding therapy, and summarize and analyze the disease spectrum of acupoint catgut-embedding therapy. Methods By literature research and data mining technique, the clinical study papers relevant to acupoint catgut-embedding therapy published from 1971 to June 2011 were selected, entered and verified, then the effective information were extracted, and finally, the disease spectrum were summarized. Results Acupoint catgut-embedding therapy is indicated for 103 diseases, involving 6 departments, of which there are 50 internal diseases, which is the most, accounting to 48.54%, and 15 surgical diseases, 12 ENT diseases, 11 gynecological diseases and 11 dermatological diseases, and 4 pediatric diseases, which is the least. Meanwhile, according to the rule of ＂Efficacy acupuncture grading disease spectrum＂, the diseases treated with this therapy were graded preliminarily into grade Ⅰ with 26 diseases, grade Ⅱ with 30 diseases, and grade Ⅲ with 8 diseases. Conclusion Acupoint catgut-embedding therapy can be used widely in clinical treatment with much broader disease spectrum, and it is worthy of being spread and applied.展开更多
Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases a...Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.展开更多
Objective： To explore the core acupoints and combination rules of auricular acupoint therapy for simple obesity, and to further analyze the characteristics of the prescription of auricular acupoint therapy for simple...Objective： To explore the core acupoints and combination rules of auricular acupoint therapy for simple obesity, and to further analyze the characteristics of the prescription of auricular acupoint therapy for simple obesity.Methods： Relevant clinical study literature in recent 30 years in PubMed, China Biology Medicine disc（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang Database. VIP Database and TCM Online Database was retrieved, and eligible articles were selected in order to build a prescription database of auricular acupoint therapy for simple obesity. On the basis of complex network techniques, the core acupoints and combination rules of auricular acupoint therapy for simple obesity were analyzed, and the characteristics of auricular acupoint therapy for simple obesity were analyzed comprehensively.Results： There were 46 network nodes of auricular acupoint. The top 16 core acupoints for auricular acupoint therapy for simple obesity included Nèifēnmì（内分泌CO18）, Pí（脾CO13）, Wèi（胃CO4）, Sānjiāo（三焦CO17）, Jīdiǎn（饥点）.Shénmén（神门TF4）. Dàcháng（大肠CO7）. Pízhìxià（皮质下AT4）. Fèi（肺CO14）. Shèn（肾CO10）. Jiāogǎn（交感AH6 a）, Kǒu（口CO1）,Gān（肝CO12）. Xiǎocháng（小肠CO6） and Nǎo（脑）. The combination of auricular acupoints was mainly based on the main indications of acupoints. The analysis of auricular acupoints combination indicated that the combination of CO4 with CO18 was applied most frequently, which was followed by the combinations of CO13 with CO18 and CO13 with C04. According to the analysis of auricular acupoint stimulation methods, ear point taping and pressing with Wángbùliúxíng（王不留行,Semen Vaccariae） seeds was used frequently, which was followed by magnetic beads taping and pressing and pyonex therapy. Auricular acupoint therapy combined with acupuncture for simple obesity was used most commonly, which was followed by auricular acupoint therapy combined with catgut embedment in acupoint and simple auricular acupoint therapy.Conclusion： In this study, the core acupoints and combinations of auricular acupoint therapy for simple obesity were explored effectively, and the pressing materials and major combined intervention methods were summarized and analyzed, thus providing references and treatment thoughts in terms of the point and prescription selection of auricular acupoint therapy for simple obesity.展开更多
Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoin...Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoints Bǎihuì(百会GV20),Shéntíng(神庭GV24),Dàzhuī(大椎GV14),Shēnzhù(身柱GV12),Fèishū(肺俞BL13),and Wèishū(胃俞BL21),and then auricular plaster sticking was applied to the acupoints Yānhòu(咽喉TG3),Fèi(肺CO14),Wèi(胃CO4),Jiāogǎn(交感AH6 a),Pízhìxià(皮质下AT4).Results:After treatment,the Yale Global Tic Severity Scale(YGTSS)scores of the patients were significantly reduced(P<0.05),5 cases were clinically cured,8 cases remarkably effective,12 cases effective,5 cases ineffective,and the total effective rate was 83.33%.Conclusion:Acupoint catgut embedding combined with auricular plaster therapy for vocal tic disorders was effective,being worthy of clinical popularization.展开更多
OBJECTIVE:To assess the efficacy of acupoint therapy combined with spine pinching in patients with menopausal syndrome.METHODS:This is a parallel,randomized,controlled,investigator-blinded trial.A total of 132 partici...OBJECTIVE:To assess the efficacy of acupoint therapy combined with spine pinching in patients with menopausal syndrome.METHODS:This is a parallel,randomized,controlled,investigator-blinded trial.A total of 132 participants were randomly assigned to receive either acupoint therapy combined with spine pinching(intervention group)or tibolone therapy alone(control group).The intervention group received acupoint therapy combined with spine pinching three times per week for 4 weeks.The control group received 2.5 mg of tibolone once daily for 4 weeks.The primary outcome was the improved Kupperman score.The WHO quality of life scale was also used.The secondary aim was to identify those who would benefit from acupoint therapy combined with spine pinching based on the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH).RESULTS:In the intervention group,the improved Kupperman score was significantly decreased after treatment compared with before treatment.However,there were no differences between the intervention and control groups for any outcome.Changes in the physiology score presented negative outcomes in patients with a low FSH level with increasing body mass index(BMI)(P=0.0).In contrast,changes in the physiology score presented positive outcomes in patients with a moderate LH level with increasing BMI(P=0.0).The mean change in the physiology score of patients with a low FSH level and a BMI of≥25.7 kg/m2 was-7.17(range-10.94 to-3.40)after adjustments for age and disease duration.CONCLUSION:Acupoint therapy combined with spine pinching is effective in treating menopausal syndrome,especially in women with a moderate LH level.However,patients with a low FSH level had a negative outcome after acupoint therapy combined with spine pinching.In addition,patients with a BMI of>25.7 kg/m2 had a negative outcome after the intervention,regardless of hormone levels.展开更多
Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the ...Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.展开更多
Prof.Min LI adopted acupoint catgut embedding at Zhōngwǎn(中脘CV12),Tiānshū(天枢ST25),Wèishū(胃俞BL21),Dàchángshū(大肠俞BL25),Zúsānlǐ(足三里ST36),Sānyīnjiāo(三阴交SP6),and Tàichōng...Prof.Min LI adopted acupoint catgut embedding at Zhōngwǎn(中脘CV12),Tiānshū(天枢ST25),Wèishū(胃俞BL21),Dàchángshū(大肠俞BL25),Zúsānlǐ(足三里ST36),Sānyīnjiāo(三阴交SP6),and Tàichōng(太冲LR3),and combined with auricular plaster therapy at Wèi(胃CO4),Dacháng(大肠CO7),Gān(肝CO12),Jiāogǎn(交感AH6 a),Nèifēnmì(内分泌CO18)for the treatment of 18 cases of bulimia nervosa(BN).The result was that 9 cases were clinically cured,6 cases improved,3 case ineffective,and the total effec-tive rate was 83.33%,no obvious adverse reactions.The therapeutic effect of acupoint catgut embedding combined with auricular plaster therapy for BN is good,without side effects.展开更多
Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also ...Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also conducted an initial examination of the underlying molecular mechanisms.Methods:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding treatment.After DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day 8.Mice in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut implantation.Severity was assessed using SCORAD on treatment days 1,10,and 20.On day 18,nine mice per group were euthanized,and the remaining on day 28.Histopathological changes were observed using hematoxylin-eosin and immunohistochemistry staining.TNF-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western blot.Results:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like mice.Significant decreases occurred in serum IL-4,IL-6,IL-13,and TNF-αlevels.Skin analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein levels.Conclusion:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.展开更多
Objective:To systematically evaluate the clinical efficacy and safety of acupoint application in the treatment of stable chronic obstructive pulmonary disease.Methods:A comprehensive search of domestic and internation...Objective:To systematically evaluate the clinical efficacy and safety of acupoint application in the treatment of stable chronic obstructive pulmonary disease.Methods:A comprehensive search of domestic and international databases,the search time is limited to nearly ten years,collecting traditional Chinese medicine acupoint application in the treatment of chronic obstructive pulmonary disease in stable phase of randomized controlled trials.Literature screening,information extraction and literature quality evaluation were carried out independently by two researchers,and Meta analysis was carried out by Revman software.Results:A total of 42 RCTs with a total of 4192 patients were included.The results of Meta analysis showed that:Compared with the routine treatment of western medicine,the addition of acupoint application therapy can significantly increase the effective rate[RR=1.23,95%CI(1.19,1.27),P<0.00001]and FEV1/FVC[MD=4.46,95%CI(3.17,5.76),P<0.00001].Significantly improved BODE index[MD=-0.63,95%CI(-0.87,-0.40),P<0.00001],SGRQ score[MD=-6.77,95%CI(-9.81,-3.72),P<0.00001],CAT score[MD=-3.33,95%CI(-3.87,-2.79),P<0.00001]and TCM syndrome integral[MD=-3.51,95%CI(-3.96,-3.06),P<0.00001].The differences is statistically significant and the safety profile is good.Conclusion:On the basis of routine treatment of COPD western medicine,acupoint application therapy can significantly improve the clinical symptoms of patients with less adverse reactions.However,due to the limitations of the research,high-quality research is still needed to provide further evidence.展开更多
In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in the treatment of allergic asthma was observed. The results revealed that topical application of drug paste [mixture of ...In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in the treatment of allergic asthma was observed. The results revealed that topical application of drug paste [mixture of powder of Mahuang (Herba Ephedrae), Xixin (Herba Asari), Baijiezi (Semen Sinapis Albae), etc.] at the acupuncture points could improve symptoms and signs of allergic asthma patients, with the total effective rate being 69.57% (16/23) for the short term effect, and 52.17%(12/23) for the long term effect. In medication (Aminophylline) group, of the 25 cases of allergic asthma, 16 (64.0%) were effective after 4 weeks of treatment, while 6 (24.0%) were still effective that was shown by 6 months’ follow up. The therapeutic effect of acupoint application group was significantly better than that of medication group in the long term effect. Results also showed that no obvious interrelation between the short term therapeutic effect and the duration or the severity of the disease. Results also display that acupoint application therapy is an effective, safe and handy method with fewer side effects for asthma.展开更多
In the present paper, the author used acupoint intradermal embedding of ringheaded thumbtack-needle therapy combined with herbal medicine therapy to treat 110 cases of hyperplasia of mammary glands, and compared its t...In the present paper, the author used acupoint intradermal embedding of ringheaded thumbtack-needle therapy combined with herbal medicine therapy to treat 110 cases of hyperplasia of mammary glands, and compared its therapeutic effect with that of herbal therapy alone. The observed indexes of the treatment were pain relief degree, the size of hyperplasic glands and the time of occurrence of marked effect. Following 3 courses of treatment,the results showed the therapeutic effect of the ringheaded thumbtack-needle needle plus herbal medicine therapy was superior to that of herbal medicine therapy alone in the above-mentioned 3 indexes (P ＜ 0.01 ).展开更多
Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, ...Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, thus to offer relevant help for clinical therapies on patients with chronic bronchitis. Methods:120 cases of patients with chronic bronchitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group, 60 cases each. Patients in control group were provided some basic treatments, such as spasmolysis, anti-inflammation, asthma relieving, oxygen inhalation and dissolve phlegm. For therapeutic group on this basis, Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy was provided. Hemorheology, inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment. Results:Differences of hemorheology indexes, inflammatory factors and pulmonary function relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical significance (P>0.05). Compared with prior treatment, hemorheology relevant indexes [whole blood high shear viscosity (WHV), whole blood low shear viscosity (WLV), packed cell volume (PCV), plasma viscosity (PV) and red cell assembling index (RCAI)], inflammatory factors [IL-8 (interleukin-8) and TNF-α(tumor necrosis factor-α)] were significantly decreased and pulmonary function relevant indexes [forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), peak expiratory flow (PEF), maximal voluntary ventilation (MVV) and expiratory flow rate when exhale vital capacity was 0.50], inflammatory factors (IL-4, IL-2) were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments;The differences between the groups showed statistical significance (P<0.05). After combined therapy provided, pulmonary function relevant indexes (FVC, FEV1.0, PEF, MVV and V0.50) and inflammatory factors (IL-4, IL-2) in therapeutic group were significantly higher than control group after basic therapy. Hemorheology relevant indexes (WHV, WLV, PV, PCV and RCAI) and inflammatory factors (IL-8 and TNF-α) in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P<0.05). Conclusions: Combination of Jin-Shui-Liu-Jun-Jian and Acupoint Application significantly improved the levels of hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis. It has a great important clinical significance on therapies for patients with chronic bronchitis.展开更多
BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they o...BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they often fail to fully address the issue of insufficient GI motility.The GI motility therapeutic apparatus promotes dynamic recovery by simulating GI electric waves,whereas acupuncture regulates zang-fu qi movement,both offering effective interventions.However,there are few clinical studies investigating the combined use of GI motility therapy and acupuncture to promote GI function recovery in patients after GI laparoscopic radical surgery.AIM To evaluate the effects of combining GI motility therapy devices with acupuncture on GI function in patients undergoing radical laparoscopic surgery.METHODS This retrospective study included 196 patients who underwent radical GI endoscopic surgery at the Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Medicine,Tongji University,from June 2022 to May 2024.Patients were classified into a normal group(conventional treatment,n=96)and an integrated group(conventional+GI motility therapy device+acupuncture,n=100).The effects on GI function,hormone levels preand post-treatment,GI symptoms,immune function,adverse reactions,and patient satisfaction in both groups were assessed.RESULTS Compared with the normal group,the integrated group demonstrated significantly better overall effectiveness(93.00%vs 84.3%;P<0.05)and shorter durations for first exhaust,feeding,defecation,and hospital stay(P<0.05).Post-treatment,the integrated group had lower gastrin and GI symptom rating scale scores and higher motilin,vasoactive intestinal peptide,and immune marker(CD3+,CD4+,CD4+/CD8+,and natural killer cells)levels(P<0.05).The integrated group,compared to the normal group,also reported fewer adverse reactions(5.00%vs 14.58%)and higher patient satisfaction(97.00%vs 84.38%),both statistically significant(P<0.05).CONCLUSION The combination of a GI motility therapy device and acupuncture promotes GI function recovery after radical gastrectomy,regulates GI hormones and immune function,and is safe and effective.展开更多
Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clini...Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clinical practice.Methods Clinical studies on acupuncture for gallbladder colic,renal colic,and primary dysmenorrhea published between 2006 and 2025 were retrieved from the Chinese National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Wanfang,and PubMed.Bibliometric analysis was performed using IBM SPSS Modeler 18.0,and the Apriori algorithm was applied to evaluate acupoint-use patterns.Results The analysis demonstrated that commonly selected acupoints for these conditions have remained relatively consistent over the past two decades.Frequently used acupoints for gallbladder colic included Yanglingquan(GB 34),Dannang(EX-LE 6),Qiuxu(GB 40),Taichong(LR 3),Danshu(BL 19),Zusanli(ST 36),Qimen(LR 14),Riyue(GB 24),and Ganshu(BL 18).For renal colic,the most frequently reported points were Shenshu(BL 23),Sanyinjiao(SP 6),Zusanli(ST 36),Yinlingquan(SP 9),Jingmen(GB 25),Guanyuan(CV 4),Ashi points,Zhongji(CV 3),and Pangguangshu(BL 28).The main acupoints for primary dysmenorrhea were Sanyinjiao(SP 6),Guanyuan(CV 4),Ciliao(BL 32),Diji(SP 8),Shiqizhui(EX-B 8),Zhongji(CV 3),Zusanli(ST 36),Zigong(EX-CA 1),and Qihai(CV 6).On average,treatment protocols employed 3-4 acupoints per session.Conclusions The most frequently selected acupoints for visceral smooth muscle spasmodic pain were located within the ganglion segment innervation areas,showing close association with the target organs.Furthermore,treatment protocols typically involved a small number of acupoints.These findings highlight the need for further systematic research,particularly randomized controlled trials,to validate and strengthen the evidence base.展开更多
Objective Sepsis,a life-threatening condition caused by a dysregulated host response to infection,continues to be a major cause of mortality in critical care despite medical advancements.This study aimed to investigat...Objective Sepsis,a life-threatening condition caused by a dysregulated host response to infection,continues to be a major cause of mortality in critical care despite medical advancements.This study aimed to investigate the therapeutic effects and neuroimmune mechanisms of electroacupuncture(EA)at the Shenshu(BL23)acupoint combined with antibiotic therapy in sepsis management.Methods A cecal ligation and puncture(CLP)-induced murine sepsis model was used to evaluate the combined therapy.The study employed enzyme-linked immunosorbent assays(ELISA)and histological analysis to assess systemic inflammation and intestinal damage.Three-dimensional immunolabeling of c-Fos neurons and chemogenetic modulation of hypothalamic paraventricular nucleus(PVN)neurons were performed to investigate neural mechanisms.Additionally,serum catecholamine levels were measured using ultra-performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).Results The combination of EA and antibiotics significantly improved survival rates and reduced sepsis-induced weight loss.The therapy lowered systemic levels of proinflammatory cytokines(TNF-αand IL-6)and mitigated intestinal inflammatory infiltration.EA at BL23 suppressed neuronal activation in the PVN by reducing c-Fos expression.Chemogenetic inhibition of corticotropin-releasing hormone(CRH)neurons replicated the anti-inflammatory effects of the therapy,while their activation diminished therapeutic benefits.Conversely,activation of oxytocin(OXT)neurons reproduced the anti-inflammatory effects,and their inhibition reversed these benefits.The combined therapy also elevated serum catecholamine levels,indicating sympathetic-mediated immunomodulation.Conclusion This study demonstrates that EA at BL23 enhances antibiotic efficacy in sepsis by modulating PVN activity—suppressing CRH neurons and activating OXT neurons—leading to increased catecholamine secretion and systemic inflammation control.These findings reveal a novel neuroimmunological pathway for acupuncture’s therapeutic role in sepsis,supporting its potential as a noninvasive adjunctive therapy in critical care.展开更多
目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上...目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上采用电针腰夹脊穴治疗。观察两组治疗前后视觉模拟评分法(visual analog scale,VAS)、腰椎功能障碍指数(oswestry disability index,ODI)、日本骨科协会(Japanese Orthopaedc Association,JOA)评分的变化,并比较两组治疗前后竖脊肌、多裂肌表面肌电图(surface electromyography,sEMG)中的指标均方根值(root mean square,RMS)和中位频率值(median frequency value,MF)。结果两组治疗2周后VAS、ODI评分低于治疗前,治疗后VAS、ODI评分低于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后VAS、ODI评分低于对照组,差异有统计学意义(P<0.05)。两组治疗2周后JOA评分高于治疗前,治疗后JOA评分高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后JOA评分高于对照组,差异有统计学意义(P<0.05)。对照组竖脊肌、多裂肌双侧RMS值治疗2周后与治疗前比较,差异无统计学意义(P>0.05);治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后竖脊肌、多裂肌双侧RMS值高于治疗前,治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后、治疗后竖脊肌和多裂肌双侧RMS值高于对照组,差异有统计学意义(P<0.05)。两组治疗2周后竖脊肌、多裂肌双侧MF值高于治疗前,治疗后竖脊肌、多裂肌双侧MF值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后竖脊肌、多裂肌双侧MF值高于对照组,差异有统计学意义(P<0.05)。结论电针联合SET训练能更好地减轻患者疼痛,改善椎旁核心肌(多裂肌、竖脊肌)的肌电信号,促进腰椎核心肌群功能恢复。展开更多
Objective To explore the efficacy and safety of acupoint application in treatment of constipation. Methods Sixty-two cases were randomly divided into 2 groups, named acupoint application group （32 cases） and Chinese...Objective To explore the efficacy and safety of acupoint application in treatment of constipation. Methods Sixty-two cases were randomly divided into 2 groups, named acupoint application group （32 cases） and Chinese herb group （30 cases）. In the acupoint application group, Chinese herbal plaster was applied on Tianshu （天枢 ST 25）, Gufnyuan （关元 CV 4） and Qihai （气海 CV 6）. In the Chinese herb group, Congrong Tongbian Koufuye （苁蓉通便口服液） was administered orally. The efficacy was observed after 7 days treatment. Results The total effective rate was 81.3% （26/32） in the acupoint application group and was 60.0% （18/30） in the Chinese herb group, indicating significant statistical difference in comparison （P〈0.05）. The significant difference presented in the time of the first defecation after treatment between two groups （P〈0.05）. The defecation promotion in the acupoint appli- cation group was superior to that in the Chinese herb group. The significant difference resulted in the comparison of clinical symptom integral before and after treatment in two groups （P〈0. 05）. The group comparison did not present significant difference. Conclusion Acupoint application of Chinese herbs has definite efficacy on constipation. It is convenient in operation, no pain and less toxic side effect and good in compliance.展开更多
文摘Objective:To observe the effects of acupoint thread-embedding therapy on serum apelin and glucagon-like peptide-1(GLP-1)in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.Methods:Sixty-six patients were randomly divided into a control group and an observation group according to the random number table method,with 33 cases in each group.Patients in the control group were treated with exenatide and metformin,while patients in the observation group were treated with additional acupoint thread-embedding.After 12-week treatment,the obesity-related indicators,including body mass index(BMI),waist circumference and body fat rate,the glycometabolism indicators,including fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin,and the lipid metabolism indicators,including total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),as well as serum apelin and GLP-1 levels were observed in patients of the two groups.Results:After treatment,the BMI,waist circumference and body fat rate of patients in the two groups were all reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05);the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of patients in both groups were all decreased(all P<0.05),and were significantly lower in the observation group than in the control group(all P<0.05);the TC level was decreased(P<0.05),while the TG and LDL-C levels did not change significantly in the control group(both P>0.05);the TC,TG and LDL-C levels were all significantly reduced in the observation group(all P<0.05),lower than those in the control group(all P<0.05);the serum apelin level was decreased(P<0.05)and the serum GLP-1 level was increased(P<0.05)in the observation group,statistically different from those in the control group(both P<0.05).Conclusion:Combined with the conventional medication,acupoint thread-embedding therapy can significantly improve the obesity-related indicators,glycometabolism and lipid metabolism in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.This may be achieved by regulating the serum apelin and GLP-1 levels.
文摘The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.
文摘Objective To observe the clinical efficacy of acupoint magnetic therapy for spasmodic torticollis. Methods Twenty patients with spasmodic torticollis were treated by acupoint magnetic therapy at Fengchi （风池 GB 20）, Dazhui （大椎 GV 24） and Shenzhu （身柱 GV 12）. Once a day, ten days as a course of treatment, 24 treatments were given. Results Six cases were cured and 9 cases were markedly effective, 3 cases were effective and 2 cases were ineffective with the cured rate of 30% and the effective rate of 90%. Conclusion Acupoint magnetic therapy has sound effect in the treatment of spasmodic torticollis.
基金Supported by Na onal Natural Science Founda on:81072883, 81173342University Student Innova on Instruc on Project of Hebei Medical University:2010
文摘Objective To explore the clinically indicated diseases of acupoint catgut-embedding therapy, and summarize and analyze the disease spectrum of acupoint catgut-embedding therapy. Methods By literature research and data mining technique, the clinical study papers relevant to acupoint catgut-embedding therapy published from 1971 to June 2011 were selected, entered and verified, then the effective information were extracted, and finally, the disease spectrum were summarized. Results Acupoint catgut-embedding therapy is indicated for 103 diseases, involving 6 departments, of which there are 50 internal diseases, which is the most, accounting to 48.54%, and 15 surgical diseases, 12 ENT diseases, 11 gynecological diseases and 11 dermatological diseases, and 4 pediatric diseases, which is the least. Meanwhile, according to the rule of ＂Efficacy acupuncture grading disease spectrum＂, the diseases treated with this therapy were graded preliminarily into grade Ⅰ with 26 diseases, grade Ⅱ with 30 diseases, and grade Ⅲ with 8 diseases. Conclusion Acupoint catgut-embedding therapy can be used widely in clinical treatment with much broader disease spectrum, and it is worthy of being spread and applied.
基金Supported by China Academy of Chinese Medical Sciences:ZZ0908019
文摘Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.
基金Supported by special program of scientific research in Traditional Chinese Medicine in 2015(201507003)National Natural Science Foundation of China(81674081)~~
文摘Objective： To explore the core acupoints and combination rules of auricular acupoint therapy for simple obesity, and to further analyze the characteristics of the prescription of auricular acupoint therapy for simple obesity.Methods： Relevant clinical study literature in recent 30 years in PubMed, China Biology Medicine disc（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang Database. VIP Database and TCM Online Database was retrieved, and eligible articles were selected in order to build a prescription database of auricular acupoint therapy for simple obesity. On the basis of complex network techniques, the core acupoints and combination rules of auricular acupoint therapy for simple obesity were analyzed, and the characteristics of auricular acupoint therapy for simple obesity were analyzed comprehensively.Results： There were 46 network nodes of auricular acupoint. The top 16 core acupoints for auricular acupoint therapy for simple obesity included Nèifēnmì（内分泌CO18）, Pí（脾CO13）, Wèi（胃CO4）, Sānjiāo（三焦CO17）, Jīdiǎn（饥点）.Shénmén（神门TF4）. Dàcháng（大肠CO7）. Pízhìxià（皮质下AT4）. Fèi（肺CO14）. Shèn（肾CO10）. Jiāogǎn（交感AH6 a）, Kǒu（口CO1）,Gān（肝CO12）. Xiǎocháng（小肠CO6） and Nǎo（脑）. The combination of auricular acupoints was mainly based on the main indications of acupoints. The analysis of auricular acupoints combination indicated that the combination of CO4 with CO18 was applied most frequently, which was followed by the combinations of CO13 with CO18 and CO13 with C04. According to the analysis of auricular acupoint stimulation methods, ear point taping and pressing with Wángbùliúxíng（王不留行,Semen Vaccariae） seeds was used frequently, which was followed by magnetic beads taping and pressing and pyonex therapy. Auricular acupoint therapy combined with acupuncture for simple obesity was used most commonly, which was followed by auricular acupoint therapy combined with catgut embedment in acupoint and simple auricular acupoint therapy.Conclusion： In this study, the core acupoints and combinations of auricular acupoint therapy for simple obesity were explored effectively, and the pressing materials and major combined intervention methods were summarized and analyzed, thus providing references and treatment thoughts in terms of the point and prescription selection of auricular acupoint therapy for simple obesity.
基金Guangdong Province Graduate Education Innovation Project:No.2017SFKC13。
文摘Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoints Bǎihuì(百会GV20),Shéntíng(神庭GV24),Dàzhuī(大椎GV14),Shēnzhù(身柱GV12),Fèishū(肺俞BL13),and Wèishū(胃俞BL21),and then auricular plaster sticking was applied to the acupoints Yānhòu(咽喉TG3),Fèi(肺CO14),Wèi(胃CO4),Jiāogǎn(交感AH6 a),Pízhìxià(皮质下AT4).Results:After treatment,the Yale Global Tic Severity Scale(YGTSS)scores of the patients were significantly reduced(P<0.05),5 cases were clinically cured,8 cases remarkably effective,12 cases effective,5 cases ineffective,and the total effective rate was 83.33%.Conclusion:Acupoint catgut embedding combined with auricular plaster therapy for vocal tic disorders was effective,being worthy of clinical popularization.
基金Supported by the Special Project for Scientific Research and Construction of a National Traditional Chinese Medicine Clinical Research Base of the China State Administration of Traditional Chinese Medicine(No.JD2X2012019)
文摘OBJECTIVE:To assess the efficacy of acupoint therapy combined with spine pinching in patients with menopausal syndrome.METHODS:This is a parallel,randomized,controlled,investigator-blinded trial.A total of 132 participants were randomly assigned to receive either acupoint therapy combined with spine pinching(intervention group)or tibolone therapy alone(control group).The intervention group received acupoint therapy combined with spine pinching three times per week for 4 weeks.The control group received 2.5 mg of tibolone once daily for 4 weeks.The primary outcome was the improved Kupperman score.The WHO quality of life scale was also used.The secondary aim was to identify those who would benefit from acupoint therapy combined with spine pinching based on the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH).RESULTS:In the intervention group,the improved Kupperman score was significantly decreased after treatment compared with before treatment.However,there were no differences between the intervention and control groups for any outcome.Changes in the physiology score presented negative outcomes in patients with a low FSH level with increasing body mass index(BMI)(P=0.0).In contrast,changes in the physiology score presented positive outcomes in patients with a moderate LH level with increasing BMI(P=0.0).The mean change in the physiology score of patients with a low FSH level and a BMI of≥25.7 kg/m2 was-7.17(range-10.94 to-3.40)after adjustments for age and disease duration.CONCLUSION:Acupoint therapy combined with spine pinching is effective in treating menopausal syndrome,especially in women with a moderate LH level.However,patients with a low FSH level had a negative outcome after acupoint therapy combined with spine pinching.In addition,patients with a BMI of>25.7 kg/m2 had a negative outcome after the intervention,regardless of hormone levels.
文摘Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.
基金Supported by Guangdong Graduate Education Innovation Program:2017SFKC13。
文摘Prof.Min LI adopted acupoint catgut embedding at Zhōngwǎn(中脘CV12),Tiānshū(天枢ST25),Wèishū(胃俞BL21),Dàchángshū(大肠俞BL25),Zúsānlǐ(足三里ST36),Sānyīnjiāo(三阴交SP6),and Tàichōng(太冲LR3),and combined with auricular plaster therapy at Wèi(胃CO4),Dacháng(大肠CO7),Gān(肝CO12),Jiāogǎn(交感AH6 a),Nèifēnmì(内分泌CO18)for the treatment of 18 cases of bulimia nervosa(BN).The result was that 9 cases were clinically cured,6 cases improved,3 case ineffective,and the total effec-tive rate was 83.33%,no obvious adverse reactions.The therapeutic effect of acupoint catgut embedding combined with auricular plaster therapy for BN is good,without side effects.
基金supported by grants from the National Natural Science Foundation of China(Grant No.82260940)the Yunnan Provincial(Traditional Chinese Medicine)Clinical Dermatology Center,12th Five-year Key Construction Discipline of State Administration of Traditional Chinese Medicine“Dai Pharmacy”+1 种基金Open Project of Yunnan Key Laboratory of Dai and Yi Medicines(No.30971101100)Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan Minzu University.
文摘Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also conducted an initial examination of the underlying molecular mechanisms.Methods:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding treatment.After DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day 8.Mice in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut implantation.Severity was assessed using SCORAD on treatment days 1,10,and 20.On day 18,nine mice per group were euthanized,and the remaining on day 28.Histopathological changes were observed using hematoxylin-eosin and immunohistochemistry staining.TNF-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western blot.Results:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like mice.Significant decreases occurred in serum IL-4,IL-6,IL-13,and TNF-αlevels.Skin analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein levels.Conclusion:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.
基金Traditional Chinese Medicine Research Project of Hubei Provincial Administration of Traditional Chinese Medicine from 2023 to 2024 (ZY2023F138)the Construction Project of the"National Famous Traditional Chinese Medicine Inheritance Studio"of the National Administration of Traditional Chinese Medicine[Guozhong Pharmaceutical Renjiao Fa (2022)No.5]。
文摘Objective:To systematically evaluate the clinical efficacy and safety of acupoint application in the treatment of stable chronic obstructive pulmonary disease.Methods:A comprehensive search of domestic and international databases,the search time is limited to nearly ten years,collecting traditional Chinese medicine acupoint application in the treatment of chronic obstructive pulmonary disease in stable phase of randomized controlled trials.Literature screening,information extraction and literature quality evaluation were carried out independently by two researchers,and Meta analysis was carried out by Revman software.Results:A total of 42 RCTs with a total of 4192 patients were included.The results of Meta analysis showed that:Compared with the routine treatment of western medicine,the addition of acupoint application therapy can significantly increase the effective rate[RR=1.23,95%CI(1.19,1.27),P<0.00001]and FEV1/FVC[MD=4.46,95%CI(3.17,5.76),P<0.00001].Significantly improved BODE index[MD=-0.63,95%CI(-0.87,-0.40),P<0.00001],SGRQ score[MD=-6.77,95%CI(-9.81,-3.72),P<0.00001],CAT score[MD=-3.33,95%CI(-3.87,-2.79),P<0.00001]and TCM syndrome integral[MD=-3.51,95%CI(-3.96,-3.06),P<0.00001].The differences is statistically significant and the safety profile is good.Conclusion:On the basis of routine treatment of COPD western medicine,acupoint application therapy can significantly improve the clinical symptoms of patients with less adverse reactions.However,due to the limitations of the research,high-quality research is still needed to provide further evidence.
文摘In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in the treatment of allergic asthma was observed. The results revealed that topical application of drug paste [mixture of powder of Mahuang (Herba Ephedrae), Xixin (Herba Asari), Baijiezi (Semen Sinapis Albae), etc.] at the acupuncture points could improve symptoms and signs of allergic asthma patients, with the total effective rate being 69.57% (16/23) for the short term effect, and 52.17%(12/23) for the long term effect. In medication (Aminophylline) group, of the 25 cases of allergic asthma, 16 (64.0%) were effective after 4 weeks of treatment, while 6 (24.0%) were still effective that was shown by 6 months’ follow up. The therapeutic effect of acupoint application group was significantly better than that of medication group in the long term effect. Results also showed that no obvious interrelation between the short term therapeutic effect and the duration or the severity of the disease. Results also display that acupoint application therapy is an effective, safe and handy method with fewer side effects for asthma.
文摘In the present paper, the author used acupoint intradermal embedding of ringheaded thumbtack-needle therapy combined with herbal medicine therapy to treat 110 cases of hyperplasia of mammary glands, and compared its therapeutic effect with that of herbal therapy alone. The observed indexes of the treatment were pain relief degree, the size of hyperplasic glands and the time of occurrence of marked effect. Following 3 courses of treatment,the results showed the therapeutic effect of the ringheaded thumbtack-needle needle plus herbal medicine therapy was superior to that of herbal medicine therapy alone in the above-mentioned 3 indexes (P ＜ 0.01 ).
文摘Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, thus to offer relevant help for clinical therapies on patients with chronic bronchitis. Methods:120 cases of patients with chronic bronchitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group, 60 cases each. Patients in control group were provided some basic treatments, such as spasmolysis, anti-inflammation, asthma relieving, oxygen inhalation and dissolve phlegm. For therapeutic group on this basis, Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy was provided. Hemorheology, inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment. Results:Differences of hemorheology indexes, inflammatory factors and pulmonary function relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical significance (P>0.05). Compared with prior treatment, hemorheology relevant indexes [whole blood high shear viscosity (WHV), whole blood low shear viscosity (WLV), packed cell volume (PCV), plasma viscosity (PV) and red cell assembling index (RCAI)], inflammatory factors [IL-8 (interleukin-8) and TNF-α(tumor necrosis factor-α)] were significantly decreased and pulmonary function relevant indexes [forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), peak expiratory flow (PEF), maximal voluntary ventilation (MVV) and expiratory flow rate when exhale vital capacity was 0.50], inflammatory factors (IL-4, IL-2) were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments;The differences between the groups showed statistical significance (P<0.05). After combined therapy provided, pulmonary function relevant indexes (FVC, FEV1.0, PEF, MVV and V0.50) and inflammatory factors (IL-4, IL-2) in therapeutic group were significantly higher than control group after basic therapy. Hemorheology relevant indexes (WHV, WLV, PV, PCV and RCAI) and inflammatory factors (IL-8 and TNF-α) in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P<0.05). Conclusions: Combination of Jin-Shui-Liu-Jun-Jian and Acupoint Application significantly improved the levels of hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis. It has a great important clinical significance on therapies for patients with chronic bronchitis.
基金Supported by Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),Key Project within the Hospital,No.2024CRZD007Shanghai Municipal Health Commission,2024-2025 Traditional Chinese Medicine Research Project,No.2024QN063.
文摘BACKGROUND Gastrointestinal(GI)dysfunction is common after laparoscopic radical gastrectomy for gastric cancer and affects rehabilitation.While conventional treatments can alleviate symptoms to a certain extent,they often fail to fully address the issue of insufficient GI motility.The GI motility therapeutic apparatus promotes dynamic recovery by simulating GI electric waves,whereas acupuncture regulates zang-fu qi movement,both offering effective interventions.However,there are few clinical studies investigating the combined use of GI motility therapy and acupuncture to promote GI function recovery in patients after GI laparoscopic radical surgery.AIM To evaluate the effects of combining GI motility therapy devices with acupuncture on GI function in patients undergoing radical laparoscopic surgery.METHODS This retrospective study included 196 patients who underwent radical GI endoscopic surgery at the Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Medicine,Tongji University,from June 2022 to May 2024.Patients were classified into a normal group(conventional treatment,n=96)and an integrated group(conventional+GI motility therapy device+acupuncture,n=100).The effects on GI function,hormone levels preand post-treatment,GI symptoms,immune function,adverse reactions,and patient satisfaction in both groups were assessed.RESULTS Compared with the normal group,the integrated group demonstrated significantly better overall effectiveness(93.00%vs 84.3%;P<0.05)and shorter durations for first exhaust,feeding,defecation,and hospital stay(P<0.05).Post-treatment,the integrated group had lower gastrin and GI symptom rating scale scores and higher motilin,vasoactive intestinal peptide,and immune marker(CD3+,CD4+,CD4+/CD8+,and natural killer cells)levels(P<0.05).The integrated group,compared to the normal group,also reported fewer adverse reactions(5.00%vs 14.58%)and higher patient satisfaction(97.00%vs 84.38%),both statistically significant(P<0.05).CONCLUSION The combination of a GI motility therapy device and acupuncture promotes GI function recovery after radical gastrectomy,regulates GI hormones and immune function,and is safe and effective.
基金supported by the Research and Innovation Fund of Shandong University of Traditional Chinese Medicine(2018-220315).
文摘Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clinical practice.Methods Clinical studies on acupuncture for gallbladder colic,renal colic,and primary dysmenorrhea published between 2006 and 2025 were retrieved from the Chinese National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Wanfang,and PubMed.Bibliometric analysis was performed using IBM SPSS Modeler 18.0,and the Apriori algorithm was applied to evaluate acupoint-use patterns.Results The analysis demonstrated that commonly selected acupoints for these conditions have remained relatively consistent over the past two decades.Frequently used acupoints for gallbladder colic included Yanglingquan(GB 34),Dannang(EX-LE 6),Qiuxu(GB 40),Taichong(LR 3),Danshu(BL 19),Zusanli(ST 36),Qimen(LR 14),Riyue(GB 24),and Ganshu(BL 18).For renal colic,the most frequently reported points were Shenshu(BL 23),Sanyinjiao(SP 6),Zusanli(ST 36),Yinlingquan(SP 9),Jingmen(GB 25),Guanyuan(CV 4),Ashi points,Zhongji(CV 3),and Pangguangshu(BL 28).The main acupoints for primary dysmenorrhea were Sanyinjiao(SP 6),Guanyuan(CV 4),Ciliao(BL 32),Diji(SP 8),Shiqizhui(EX-B 8),Zhongji(CV 3),Zusanli(ST 36),Zigong(EX-CA 1),and Qihai(CV 6).On average,treatment protocols employed 3-4 acupoints per session.Conclusions The most frequently selected acupoints for visceral smooth muscle spasmodic pain were located within the ganglion segment innervation areas,showing close association with the target organs.Furthermore,treatment protocols typically involved a small number of acupoints.These findings highlight the need for further systematic research,particularly randomized controlled trials,to validate and strengthen the evidence base.
基金the National Key Research and Development Program of China(2022YFC3500704).
文摘Objective Sepsis,a life-threatening condition caused by a dysregulated host response to infection,continues to be a major cause of mortality in critical care despite medical advancements.This study aimed to investigate the therapeutic effects and neuroimmune mechanisms of electroacupuncture(EA)at the Shenshu(BL23)acupoint combined with antibiotic therapy in sepsis management.Methods A cecal ligation and puncture(CLP)-induced murine sepsis model was used to evaluate the combined therapy.The study employed enzyme-linked immunosorbent assays(ELISA)and histological analysis to assess systemic inflammation and intestinal damage.Three-dimensional immunolabeling of c-Fos neurons and chemogenetic modulation of hypothalamic paraventricular nucleus(PVN)neurons were performed to investigate neural mechanisms.Additionally,serum catecholamine levels were measured using ultra-performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).Results The combination of EA and antibiotics significantly improved survival rates and reduced sepsis-induced weight loss.The therapy lowered systemic levels of proinflammatory cytokines(TNF-αand IL-6)and mitigated intestinal inflammatory infiltration.EA at BL23 suppressed neuronal activation in the PVN by reducing c-Fos expression.Chemogenetic inhibition of corticotropin-releasing hormone(CRH)neurons replicated the anti-inflammatory effects of the therapy,while their activation diminished therapeutic benefits.Conversely,activation of oxytocin(OXT)neurons reproduced the anti-inflammatory effects,and their inhibition reversed these benefits.The combined therapy also elevated serum catecholamine levels,indicating sympathetic-mediated immunomodulation.Conclusion This study demonstrates that EA at BL23 enhances antibiotic efficacy in sepsis by modulating PVN activity—suppressing CRH neurons and activating OXT neurons—leading to increased catecholamine secretion and systemic inflammation control.These findings reveal a novel neuroimmunological pathway for acupuncture’s therapeutic role in sepsis,supporting its potential as a noninvasive adjunctive therapy in critical care.
文摘目的观察电针联合悬吊训练(sling exercise therapy,SET)治疗慢性非特异性下腰痛(chronic nonspecific low back pain,CNLBP)的临床疗效。方法将72例CNLBP患者随机分为观察组和对照组,每组36例。对照组行SET治疗,观察组在对照组基础上采用电针腰夹脊穴治疗。观察两组治疗前后视觉模拟评分法(visual analog scale,VAS)、腰椎功能障碍指数(oswestry disability index,ODI)、日本骨科协会(Japanese Orthopaedc Association,JOA)评分的变化,并比较两组治疗前后竖脊肌、多裂肌表面肌电图(surface electromyography,sEMG)中的指标均方根值(root mean square,RMS)和中位频率值(median frequency value,MF)。结果两组治疗2周后VAS、ODI评分低于治疗前,治疗后VAS、ODI评分低于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后VAS、ODI评分低于对照组,差异有统计学意义(P<0.05)。两组治疗2周后JOA评分高于治疗前,治疗后JOA评分高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后JOA评分高于对照组,差异有统计学意义(P<0.05)。对照组竖脊肌、多裂肌双侧RMS值治疗2周后与治疗前比较,差异无统计学意义(P>0.05);治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后竖脊肌、多裂肌双侧RMS值高于治疗前,治疗后竖脊肌、多裂肌双侧RMS值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后、治疗后竖脊肌和多裂肌双侧RMS值高于对照组,差异有统计学意义(P<0.05)。两组治疗2周后竖脊肌、多裂肌双侧MF值高于治疗前,治疗后竖脊肌、多裂肌双侧MF值高于治疗2周后和治疗前,差异有统计学意义(P<0.05);观察组治疗2周后和治疗后竖脊肌、多裂肌双侧MF值高于对照组,差异有统计学意义(P<0.05)。结论电针联合SET训练能更好地减轻患者疼痛,改善椎旁核心肌(多裂肌、竖脊肌)的肌电信号,促进腰椎核心肌群功能恢复。
文摘Objective To explore the efficacy and safety of acupoint application in treatment of constipation. Methods Sixty-two cases were randomly divided into 2 groups, named acupoint application group （32 cases） and Chinese herb group （30 cases）. In the acupoint application group, Chinese herbal plaster was applied on Tianshu （天枢 ST 25）, Gufnyuan （关元 CV 4） and Qihai （气海 CV 6）. In the Chinese herb group, Congrong Tongbian Koufuye （苁蓉通便口服液） was administered orally. The efficacy was observed after 7 days treatment. Results The total effective rate was 81.3% （26/32） in the acupoint application group and was 60.0% （18/30） in the Chinese herb group, indicating significant statistical difference in comparison （P〈0.05）. The significant difference presented in the time of the first defecation after treatment between two groups （P〈0.05）. The defecation promotion in the acupoint appli- cation group was superior to that in the Chinese herb group. The significant difference resulted in the comparison of clinical symptom integral before and after treatment in two groups （P〈0. 05）. The group comparison did not present significant difference. Conclusion Acupoint application of Chinese herbs has definite efficacy on constipation. It is convenient in operation, no pain and less toxic side effect and good in compliance.
