Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Me...Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Medical University were randomly divided into three groups： normal group （A）, sleep deprivation group （B） and treatment group （C）. Volunteers in group B and C received 48 h sleep deprivation （SD）, and in the mean time volunteers in group C were treated by garlic paste at Shenque （神阙 CV8）, while those in group A had no any treatment. The body temperature of all the volunteers was detected at 6：00 am, 12：00 am, 6：00 pm and 0：00 am, respectively, after the treatment. Results The mean body temperature values in group A and C both were highest at 6： 00 pm and lowest at 6： 00 am which had a significant difference in each group （P〈0.01）; in group B, the mean body temperature was highest at 0：00 am and lowestat 6：00 am, no significant difference was found between them （P〉0.05）. Results of cosine analysis showed that in subjects of group B the circadian rhythm of body temperature still kept going well after SD, but the peak amplitude and amplitude of vibration were higher than those of group A, and the acrophase of group B was obviously lower than that of group C and A. The 3 indexes of group C were similar to those of group A, denoting that garlic paste application of Shenque （神阙 CV8） could prevent disorders of circadian rhythm of the body temperature. Conclusion The garlic paste application at Shenque （神阙 CV8） can adjust circadian rhythm and accelerate the recovery processes of circadian rhythm in SD young students.展开更多
Objective:To explore the effects of natural moxibustion on inhibition of airway remodeling in bronchial asthmatic rats.Materials and Methods:Sprague Dawley rats were treated with ovalbumin to establish an asthma model...Objective:To explore the effects of natural moxibustion on inhibition of airway remodeling in bronchial asthmatic rats.Materials and Methods:Sprague Dawley rats were treated with ovalbumin to establish an asthma model.The ancient prescription of natural moxibustion,named Bai-Jie-Zi pulvis,was applied by pasting acupoints in combination with budesonide suspension inhalation to treat the asthmatic models for a consecutive period of 14 days.Histopathological changes were then observed and assessed.The cytokines involved in airway remodeling progression,namely matrix metalloproteinase 9(MMP-9)and transforming growth factor beta-1(TGF-β1)in lung tissue,were measured using immunohistochemistry and western blotting.The positive control group received treatment solely by inhalation of budesonide.Results:Combination therapy with budesonide suspension inhalation and natural moxibustion demonstrated significant improvements in inflammatory cell infiltration,bronchial mucus plug secretion,terminal bronchial obstruction,and edema in the lung tissue compared with the model(MOD)group(P<0.01,P<0.05,P<0.01,respectively).In addition,an enhanced effect in relieving branchial mucous plug secretion was observed in the BUD+BJZ group(P<0.01).Both MMP-9 and TGF-β1 expression were downregulated compared to the group treated solely with budesonide suspension inhalation(P<0.05,P<0.01,respectively).Conclusions:The combination therapy of natural moxibustion and budesonide inhalation demonstrated a synergistic effect in asthmatic rats,effectively inhibiting the airway remodeling process.This traditional external therapy exhibited efficacy in asthmatic rats and may potentially serve as a complementary approach in the treatment of asthma.展开更多
文摘Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Medical University were randomly divided into three groups： normal group （A）, sleep deprivation group （B） and treatment group （C）. Volunteers in group B and C received 48 h sleep deprivation （SD）, and in the mean time volunteers in group C were treated by garlic paste at Shenque （神阙 CV8）, while those in group A had no any treatment. The body temperature of all the volunteers was detected at 6：00 am, 12：00 am, 6：00 pm and 0：00 am, respectively, after the treatment. Results The mean body temperature values in group A and C both were highest at 6： 00 pm and lowest at 6： 00 am which had a significant difference in each group （P〈0.01）; in group B, the mean body temperature was highest at 0：00 am and lowestat 6：00 am, no significant difference was found between them （P〉0.05）. Results of cosine analysis showed that in subjects of group B the circadian rhythm of body temperature still kept going well after SD, but the peak amplitude and amplitude of vibration were higher than those of group A, and the acrophase of group B was obviously lower than that of group C and A. The 3 indexes of group C were similar to those of group A, denoting that garlic paste application of Shenque （神阙 CV8） could prevent disorders of circadian rhythm of the body temperature. Conclusion The garlic paste application at Shenque （神阙 CV8） can adjust circadian rhythm and accelerate the recovery processes of circadian rhythm in SD young students.
基金supported by the National Natural Science Foundation of China(grant number:81874489)the Science and Technology Innovation Project of the Shanxi Provincial Education Department(grant number:2020 L0451)。
文摘Objective:To explore the effects of natural moxibustion on inhibition of airway remodeling in bronchial asthmatic rats.Materials and Methods:Sprague Dawley rats were treated with ovalbumin to establish an asthma model.The ancient prescription of natural moxibustion,named Bai-Jie-Zi pulvis,was applied by pasting acupoints in combination with budesonide suspension inhalation to treat the asthmatic models for a consecutive period of 14 days.Histopathological changes were then observed and assessed.The cytokines involved in airway remodeling progression,namely matrix metalloproteinase 9(MMP-9)and transforming growth factor beta-1(TGF-β1)in lung tissue,were measured using immunohistochemistry and western blotting.The positive control group received treatment solely by inhalation of budesonide.Results:Combination therapy with budesonide suspension inhalation and natural moxibustion demonstrated significant improvements in inflammatory cell infiltration,bronchial mucus plug secretion,terminal bronchial obstruction,and edema in the lung tissue compared with the model(MOD)group(P<0.01,P<0.05,P<0.01,respectively).In addition,an enhanced effect in relieving branchial mucous plug secretion was observed in the BUD+BJZ group(P<0.01).Both MMP-9 and TGF-β1 expression were downregulated compared to the group treated solely with budesonide suspension inhalation(P<0.05,P<0.01,respectively).Conclusions:The combination therapy of natural moxibustion and budesonide inhalation demonstrated a synergistic effect in asthmatic rats,effectively inhibiting the airway remodeling process.This traditional external therapy exhibited efficacy in asthmatic rats and may potentially serve as a complementary approach in the treatment of asthma.
