Objective: To study the mechanism of acupuncture in treating simple obesity. Methods: Central nerve push-pull perfusion and biochemical technique were used to observe the effect of acupuncture on the obese parameters,...Objective: To study the mechanism of acupuncture in treating simple obesity. Methods: Central nerve push-pull perfusion and biochemical technique were used to observe the effect of acupuncture on the obese parameters, changes of monoamine transmitters and activity of ATPase in the lateral hypothalamic area (LHA) of obese rats. Results: Noradrenaline (NA) level in LHA of obese rats was higher but serotonin (5-HT) level and ATPase activity were lower than those in normal rats. After acupuncture treatment, in the same time of reducing body weight, NA level in LHA of rats was reduced, and 5-HT level and ATPase activity in it were increased.(P<0.05 and P<0.01). Conclusion:The effective regulation on LHA of obese rats is possibly one of the key factors in anti-obesity effect of acupuncture.展开更多
Over the past decade,considerable scientific attention has been given to adapting cobalt bis(dicarbollide)as innovative agent with various biomedical applications.Although the studied compounds show great potential in...Over the past decade,considerable scientific attention has been given to adapting cobalt bis(dicarbollide)as innovative agent with various biomedical applications.Although the studied compounds show great potential in this field,only a few reports have explored broad,well-thought-out libraries of derivatives to correlate their structure with biological activity.In this study,we investigate a panel of[CoSAN]^(−)derivatives substituted with fluorine,chlorine,bromine and iodine in order to elucidate the impact of the halogen presence on antimicrobial action and selectivity over mammalian cells.We present the first evidence that increasing the atomic mass of a substituent improves the biological activity of a derivative.Our results demonstrate that the addition of a single iodine atom to the[CoSAN]^(−)core results in the most selective antibacterial outcome,especially toward Staphylococcus aureus ATCC 6538.The described correlation between the lipophilicity and the activity of the compounds toward both bacteria and human cell lines highlights the importance of a conscious design method to obtain the most desirable[CoSAN]^(−)-based derivatives.展开更多
文摘Objective: To study the mechanism of acupuncture in treating simple obesity. Methods: Central nerve push-pull perfusion and biochemical technique were used to observe the effect of acupuncture on the obese parameters, changes of monoamine transmitters and activity of ATPase in the lateral hypothalamic area (LHA) of obese rats. Results: Noradrenaline (NA) level in LHA of obese rats was higher but serotonin (5-HT) level and ATPase activity were lower than those in normal rats. After acupuncture treatment, in the same time of reducing body weight, NA level in LHA of rats was reduced, and 5-HT level and ATPase activity in it were increased.(P<0.05 and P<0.01). Conclusion:The effective regulation on LHA of obese rats is possibly one of the key factors in anti-obesity effect of acupuncture.
文摘Over the past decade,considerable scientific attention has been given to adapting cobalt bis(dicarbollide)as innovative agent with various biomedical applications.Although the studied compounds show great potential in this field,only a few reports have explored broad,well-thought-out libraries of derivatives to correlate their structure with biological activity.In this study,we investigate a panel of[CoSAN]^(−)derivatives substituted with fluorine,chlorine,bromine and iodine in order to elucidate the impact of the halogen presence on antimicrobial action and selectivity over mammalian cells.We present the first evidence that increasing the atomic mass of a substituent improves the biological activity of a derivative.Our results demonstrate that the addition of a single iodine atom to the[CoSAN]^(−)core results in the most selective antibacterial outcome,especially toward Staphylococcus aureus ATCC 6538.The described correlation between the lipophilicity and the activity of the compounds toward both bacteria and human cell lines highlights the importance of a conscious design method to obtain the most desirable[CoSAN]^(−)-based derivatives.
