AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patient...AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patients treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012.Seven patients refused to participate.Eventually,60 patients were included,and randomly assigned to three groups(20 in each group):ACNS group(group A),MB group(group B) and non-stained conventional surgical group(group C).In group A,patients received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass.In group B,the main artery of specimen was identified and isolated after the specimen was removed,and 2 mL MB was slowly injected into the isolated,stretched and fixed vessel.In group C,no ACNS and MB were injected.All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue.RESULTS:No difference was observed among the three groups in age,gender,tumor location,tumor diameter,T-stage,degree of differentiation,postoperative complications and peritoneal drainage retention time.The total number of detected lymph nodes was 535,476 and 223 in the three groups,respectively.The mean number of detected lymph nodes per patient was significantly higher in group A than in group C(26.8 ± 8.4 vs 12.2 ± 3.2,P < 0.001).Similarly,there were significantly more lymph nodes detected in group B than in group C(23.8 ± 6.9 vs 12.2 ± 3.2,P < 0.001).However,there was no significant difference between group A and group B.There were 50,46 and 32 metastatic lymph nodes dissected in 13 patients of group A,10 patients of group B and 11 patients of group C,without significant differences among the three groups.Eleven of the 60 patients had insufficient number of detected lymph nodes(< 12).Only one patient with T 4a rectal cancer had 10 lymph nodes detected in group B,the other 10 patients were all from group C.Based on the different diameter categories,the number of detected lymph nodes in groups A and B was significantly higher than in group C.However,there was no statistically significant difference between group A and group B.The metastatic lymph nodes were not significant different among the three groups.Similarly,tumor location,T stage and tumor differentiation did not affect the staining results.Body mass index was a minor influencing factor in the two different staining methods.The stained lymph nodes can easily be identified from the mesenteric adipose tissues,and the staining time for lymph nodes was not significantly different compared with unstained group.None of the patients in groups A and B had drug-related complications.CONCLUSION:Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer.展开更多
The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes,which are used as carriers for delivering docetaxel(DTX)to the metastatic lymph nodes.In this study,w...The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes,which are used as carriers for delivering docetaxel(DTX)to the metastatic lymph nodes.In this study,we first prepared the DTX-loaded activated carbon nanoparticles(DTX-AC-NPs)by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the concentrated nitro-oxide nanocarbon.We then prepared DTX-loaded nanoliposomes(DTX-LPs)by the proliposome method.The physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in vitro.The metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX concentration in metastatic lymph nodes and injection sites.The result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physicochemical properties could be used for in vivo lymph node targeting studies.DTX-AC-NPs significantly increased DTX-AUC_((0-24)) and prolonged DTX-retention in metastatic lymph nodes compared to DTX-LPs and non-modified activate carbon in vivo.This study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes.展开更多
With the development of aquaculture, there is an urgent demand for an alternative antibacterial agent to reduce the drug resistance and environmental pollution caused by the abuse of antibiotics. Recently, silver nano...With the development of aquaculture, there is an urgent demand for an alternative antibacterial agent to reduce the drug resistance and environmental pollution caused by the abuse of antibiotics. Recently, silver nanoparticles（Ag NPs） have been viewed as a novel type of antimicrobial agents due to their unique advantages. In this study,Ag NPs were biosynthesized with the ginger rhizomes extract. The biosynthesized Ag NPs were characterised by UV–visible spectroscopy, transmission electron microscopy, X-ray diffraction and fourier transform infrared spectroscopy. Furthermore, the antimicrobial activities of the Ag NPs were fully analyzed against six typical aquatic pathogens. The results indicated that the components in ginger extract could function as the chemical reductant to synthesize Ag NPs. Moreover, compared with the Ag NPs synthesized by chemical methods, the biosynthesized Ag NPs were smaller, and had higher stability and antibacterial activity. Therefore, the biosynthesized Ag NPs using ginger extract may have prospective applications in aquaculture.展开更多
Biorecycling microbes, which have critical functionalities in natural cycles, are essential to sustain eco-system of the earth. Any alterations in these cycles caused by the mutations of microbes could be a potential ...Biorecycling microbes, which have critical functionalities in natural cycles, are essential to sustain eco-system of the earth. Any alterations in these cycles caused by the mutations of microbes could be a potential threat to life on earth. Antibiotics leached from pharmaceutical waste, animal food and agribusiness prod- ucts are accumulating in the environment. Metal nanoparticles are also accumulating in environment because of their extensive use as biocidal agent in domestic products. Interaction of antibiotics and metal nanoparticles with eco-ffiendly microorganisms has a potential to alter the ecosystem of the earth. In this article, we have studied the antibacterial activities of silver and copper nanoparticles and their for- mulations with antibiotics, tetracycline, and kanamycin against biorecycling microbes, Bacillus subtilis and Pseudomonas fluorescens. Strong synergistic effect of metal nanoparticles on the antimicrobial ac- tivities of commercial antibiotics has been observed. Antimicrobial activity of tetracycline improves by 286%-346% and 0%-28% when being tested in the presence of 250 ppm of silver and copper nanoparticles, respectively. For kanamycin, the improvement is 154%-289% for silver and 3%-20% for copper nanoparticles. Irrespective of the antibiotics and tested organisms, synergy is more prominent for silver nanoparticles even at their minimum active concentration （100 ppm）. This study demonstrates that the combination of metal nanoparticles with antibiotics could be more fatal to ecosystem than either the metal nanoparticles or the antibiotics alone.展开更多
For the first time,Au nanoparticles on graphene oxide（GO-AuNPs） were successfully fabricated without applying any additional reductants,just by the redox reaction between AuCl_4^（-1） and GO.Their structure was cha...For the first time,Au nanoparticles on graphene oxide（GO-AuNPs） were successfully fabricated without applying any additional reductants,just by the redox reaction between AuCl_4^（-1） and GO.Their structure was characterized by transmission electron microscopy and X-ray powder diffraction.The results show that flower-like AuNPs were successfully dispersed on GO surface.Importantly,they showed a high catalytic activity for the Suzuki-Miyaura coupling reaction in an aqueous medium.展开更多
Polysaccharide-based composite materials（beads） containing silver nanoparticles（AgNPs） were successfully prepared.Hydrogel beads acted as an efficient vehicle for Ag＊ delivery.Beads promoted the AgNPs protection ...Polysaccharide-based composite materials（beads） containing silver nanoparticles（AgNPs） were successfully prepared.Hydrogel beads acted as an efficient vehicle for Ag＊ delivery.Beads promoted the AgNPs protection and inhibited their aggregation.Antimicrobial assays showed that the beads/AgNPs concentration can be modulated to deliver an amount of Ag＊ necessary for kill Escherichia coli cells.展开更多
ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basili...ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basilicum）.The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis（between 14 and 27 nm） varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^（2＋）ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.展开更多
Oxygen transfer presents a serious challenge in the application of liquid lead as a nuclear coolant in advanced reactors. To mitigate corrosion by liquid lead in contact with steel, carefully controlling the oxygen co...Oxygen transfer presents a serious challenge in the application of liquid lead as a nuclear coolant in advanced reactors. To mitigate corrosion by liquid lead in contact with steel, carefully controlling the oxygen concentration has been used as an effective way. Oxygen needs to mix in liquid lead uniformly and quickly. To enhance oxygen transport in liquid lead, nanoparticles are added to the liquid metal. In the current study, a lattice Boltzmann method is applied to investigate natural convection of copper/lead and aluminum oxide/lead in two-dimensional simplified container. Two thermal boundary cases are evaluated in order to check the effect of different natural convection flow patterns on oxygen transport. Some useful information are obtained such as improvement in natural convection and reduction in oxygen equilibrium time.展开更多
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditio...Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. The delivery of therapeutic compounds to the target site is a major challenge in the treatment of many diseases. Objective: This study aims to evaluate activated charcoal nanoparticles as a drug delivery system for anticancer agents (Sorafenib and Doxorubicin) in Hepatocellular Cancer Stem Cells. Method: The percent efficiency of entrapment (% EE) of the doxorubicin and sorafenib entrapped onto the activated charcoal was obtained by determining the free doxorubicin and sorafenib concentration in the supernatant-prepared solutions. Then the characterizations of nanoparticles were formed by determination of the particle size distribution, zeta potential, and polydispersity index (PDI). The anticancer activity of activated Charcoal, Doxorubicin-ACNP, sorafenib-ACNP, free doxorubicin, and free sorafenib solutions was measured based on cell viability percentage in HepG2 cell lines (ATCC-CCL 75). In vitro RBC’s toxicity of Doxorubicin/sorafenib loaded charcoal was estimated by hemolysis percentage. Results: The synthesized Doxorubicin-ACNP and Sorafenib-ACNP were evaluated and their physiochemical properties were also examined. Essentially, the percent Efficiency of Entrapment (EE %) was found to be 87.5% and 82.66% for Doxorubicin-ACNP and Sorafenib-ACNP, respectively. The loading capacity was 34.78% and 24.31% for Doxorubicin-ACNP and Sorafenib-ACNP. Using the Dynamic Light scattering [DLS] for the determination of the hydrodynamic size and surface zeta potential, a narrow sample size distribution was obtained of (18, 68, and 190 nm for charcoal, 105, 255, and 712 nm for doxorubicin, and 91, 295, and 955 nm for sorafenib), respectively. A surface charge of −13.2, −15.6 and −17 was obtained for charcoal, doxorubicin/charcoal, and sorafenib/charcoal nanoparticles. The cytotoxic activity of Doxorubicin-ACNP and Sorafenib-ACNP was evaluated in-vitro against HepG2 cell lines and it was observed that Drug loaded ACNP improved anticancer activity when compared to Doxorubicin or Sorafenib alone. Moreover, testing the toxicity potential of DOX-ACNP and Sorafenib-ACNP showed a significant reduction in the hemolysis of red blood cells when compared to Doxorubicin and Sorafenib alone. Conclusion: In conclusion, it is notable to state that this study is regarded as the first to investigate the use of Activated charcoal for the loading of Doxorubicin and Sorafenib for further use in the arena of hepatocellular carcinoma. Doxorubicin-ACNP and Sorafenib-ACNP showed noteworthy anticancer activity along with a reduced potential of RBCs hemolysis rendering it as an efficacious carrier with a low toxicity potential.展开更多
The increased incidence ofNHL(non-Hodgkin's lymphoma),along with its high mortality rate and pronounced resistance to therapy pose an enormous challenge.Both traditional therapeutic strategies and recently develop...The increased incidence ofNHL(non-Hodgkin's lymphoma),along with its high mortality rate and pronounced resistance to therapy pose an enormous challenge.Both traditional therapeutic strategies and recently developed therapeutic strategies against NHL such as chemoimmunotherapy and targeted therapy have drawbacks.Therefore,novel therapeutic approaches for NHL are urgently needed.Maytansine-loaded PLA-TPGS(polyethylene glycol 1000 succinate-polylactide)nanoparticles were synthesized.And then,rituximab targeting NHL was conjugated together by using EDC(1-ethyl-3-(3-dimethylaminopropyl)carbodiimide)as a coupling agent.The in vitro/vivo antitumor activity was evaluated by Raji cell proliferation inhibition and nude mice xenograft tumor models for NHL.Both the rituximab-conjugated and maytansine-loaded PLA-TPGS nanoparticles(maytansine-NPs(Nanoparticles)-rituximab)and maytansine-loaded PLA-TPGS nanoparticles(maytansine-NPs)presented significant inhibition effect on Raji cell proliferation in a concentration-dependent manner.Compared with conventional maytansine and maytansine-NPs,maytansine-NPs-rituximab showed significantly enhanced cytotoxicity and increased cell apoptosis in Raji cells.The maytansine-NPs-rituximab described in this paper might be a potential formulation for targeting chemotherapy and immunotherapy to CD20+B cell malignancies.展开更多
Here,Ag2S nanoparticles on reduced graphene oxide（Ag2S NPs/RGO） nanocomposites with relatively good distribution are synthesized for the first time by conversing Ag NPs/RGO to Ag2S NPs/RGO via a facile hydrothermal ...Here,Ag2S nanoparticles on reduced graphene oxide（Ag2S NPs/RGO） nanocomposites with relatively good distribution are synthesized for the first time by conversing Ag NPs/RGO to Ag2S NPs/RGO via a facile hydrothermal sulfurization method.As an noval catalyst for the reduction of 4-nitrophenol（4-NP）,it only takes 5 min for Ag2S NPs/RGO to reduce 98% of 4-NP,and the rate constant of the composites is almost 13 times higher than that of Ag NPs/RGO composites.The high catalytic activity of Ag2S NPs/RGO can be attributed to the following three reasons：（1） Like metal complex catalysts,the Ag2S NPs is also rich with metal center Ag（δ^＋）,with pendant base S（δ） close to it,and thus the Ag and basic S function as the electron-acceptor and proton-acceptor centers,respectively,which facilitates the catalyst reaction;（2）RGO features the high adsorption ability toward 4-NP which provides a high concentration of 4-NP near the Ag2S NPs;and（3） electron transfer from RGO to Ag2S NPs,facilitating the uptake of electrons by 4-NP molecules.展开更多
The chemical structure of newly synthesized cationic surfactants based on Schiff base was confirmed using Fourier transform infrared spectroscopy,proton nuclear magnetic resonance spectroscopy,and mass spectroscopy.Th...The chemical structure of newly synthesized cationic surfactants based on Schiff base was confirmed using Fourier transform infrared spectroscopy,proton nuclear magnetic resonance spectroscopy,and mass spectroscopy.The synthesized surfactants were used in the synthesis of silver nanoparticles by a simple one-step method.The silver nanoparticle（AgNPs） formation was confirmed using transmission electron microscopy（TEM）,electron diffraction（SAED）,dynamic light scattering（DLS）,and energy dispersive X-ray spectroscopy（EDX）.The structure of the surfactant played an important role in the synthesis process.Increasing the hydrophobic chain length,the stability,and the amount of surfactant increased the quantity of AgNPs formed.The surface activity of the synthesized cationic surfactants was determined using surface tension measurements at three different temperatures.The synthesized surfactants showed a high tendency toward adsorption and micellization.Increasing the hydrophobic chain length of the synthesized surfactant increased its adsorption.Screening the synthesized cationic surfactants and their nano-form against bacteria and fungi showed that they are highly effective.The silver nanoparticles enhanced the biological activity of the synthesized cationic surfactants.展开更多
The studies on the human toxicity of nanoparticles（NPs） are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. Ho...The studies on the human toxicity of nanoparticles（NPs） are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs（C_（60） NPs） have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C_（60） NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C_（60） NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C_（60） NPs, of greater hydrophobicity and hydrogen bond（HB） donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive inhibitors.Molecular docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C_（60） NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C_（60） NPs relevant to their anticoagulation effect.展开更多
The study aims to identify the potential acute effects of suspended aluminum nitride（Al N）nanoparticles（NPs） on soluble microbial products（SMP） of activated sludge.Cultured activated sludge loaded with 1,10,50,1...The study aims to identify the potential acute effects of suspended aluminum nitride（Al N）nanoparticles（NPs） on soluble microbial products（SMP） of activated sludge.Cultured activated sludge loaded with 1,10,50,100,150 and 200 mg/L of Al N NPs were carried out in this study.As results showed,Al N NPs had a highly inverse proportionality to bacterial dehydrogenase and OUR,indicating its direct toxicity to the activated sludge viability.The toxicity of Al N NPs was mainly due to the nano-scale of Al N NPs.In SMP,Al N NPs led to the decrease of polysaccharide and humic compounds,but had slight effects on protein.The decrease of tryptophan-like substances in SMP indicated the inhibition of Al N NPs on the bacterial metabolism.Additionally,Al N NPs reduced obviously the molecular weight of SMP,which might be due to the nano-scale of Al N.展开更多
The effects of graphene nanoplates(GNPs)on the microstructures and mechanical properties of nanoparticlesstrengthening activating tungsten inert gas arc welding(NSA-TIG)welded AZ31magnesium alloy joints were investiga...The effects of graphene nanoplates(GNPs)on the microstructures and mechanical properties of nanoparticlesstrengthening activating tungsten inert gas arc welding(NSA-TIG)welded AZ31magnesium alloy joints were investigated.It wasfound that compared with those of activating TIG(A-TIG),and obvious refinement ofα-Mg grains was achieved and the finestα-Mggrains of fusion zone of NSA-TIG joints were obtained in the welded joints with TiO2+GNPs flux coating.In addition,thepenetrations of joints coated by TiO2+GNPs flux were similar to those coated by the TiO2+SiCp flux.However,the welded jointswith TiO2+GNPs flux coating showed better mechanical properties(i.e.,ultimate tensile strength and microhardness)than those withTiO2+SiCp flux coating.Moreover,the generation of necking only occurred in the welded joints with TiO2+GNPs flux.展开更多
Accumulating evidence suggests that the flavone glycoside baicalin has immunomodulatory effects and antitumor potential. However, its weak stability in solution, poor absorption, and low bioavailability limit its clin...Accumulating evidence suggests that the flavone glycoside baicalin has immunomodulatory effects and antitumor potential. However, its weak stability in solution, poor absorption, and low bioavailability limit its clinical application. To overcome these disadvantages, we developed baicalin-loaded poly（lactic-co-glycolic acid） nanoparticles （PLGA-B） of small size. Next, we evaluated the dual function of immunotherapy and chemotherapy for PLGA-B using immune-related cells and tumor cells. Results showed that PLGA-B were spherical, with a particle size -120 nm and narrow size distribution with an excellent polydispersity index of 0.103. In vitro experiments revealed that baicalin and PLGA-B could activate dendritic cells （DCs） to have higher expression of surface marker molecules and costimulatory molecules than those of control cells. Baicalin and PLGA-B could trigger apoptosis in melanoma （B16） cells via cell-cycle arrest at the G2/M phase. These data suggest that PLGA-B have important roles in activating DCs and killing melanoma cells. Our study could lay a foundation for melanoma treatment through a combined strategy of immunotherapy and chemotherapy.展开更多
The potentials of activated carbon nanoparticles(ACNP)as anticancer drug carriers were studied.ACNP were prepared with a top-down method.ACNP-based drug delivery system of docetaxel(ACNP-DOC)was prepared with a simple...The potentials of activated carbon nanoparticles(ACNP)as anticancer drug carriers were studied.ACNP were prepared with a top-down method.ACNP-based drug delivery system of docetaxel(ACNP-DOC)was prepared with a simple absorption method and its effects were studied primarily with methyl thiazolyl tetrazolium(MTT)assay,light microscope(LM),atomic force microscope(AFM)and transmission electron microscope(TEM).The prepared ACNP were approximately globular in shape with an average size of 233 nm,which had a saturate adsorption of 195.69 mg/g at mass ratio of ACNP:DOC=5:1.The drug delivery system prepared by adsorbing of ACNP for DOC had excellent releasing profile in the simulated in vivo environment.LM observation showed that ACNP can accumulate around the cells and on the surface of cells and TEM revealed that ACNP can enter cells and nuclears.MTT test demonstrated that ACNP-DOC had inhibitive effects on the growth of A549 cells,with an IC50 of 0.79μg/ml,significantly smaller than that of 20μg/ml of free DOC,indicating ACNP-DOC had stronger effects than free DOC.The imaging of AFM showed that both DOC and ACNP-DOC caused significant pathological changes of the cell membrane,including rough surfaces,large grains and holes,but these pathological changes were more obvious in ACNP-DOC treated cells than those free DOC treated ones.In all of the experiments,ACNP themselves had no significant influences on A549 cells.It was concluded that ACNP could serve as a good nanocarrier for anti-cancer drug delivery to target cells and have a great potential application in antitumor chemotherapy.展开更多
TiO2-loaded activated carbon fibers （ACF） were prepared by a hydrothermal method. The samples were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, Fourier transform infrared （FTIR...TiO2-loaded activated carbon fibers （ACF） were prepared by a hydrothermal method. The samples were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, Fourier transform infrared （FTIR） spectrometry and UV-vis diffuse reflectance spectra （DRS）. SEM images showed that the TiO2 nanoparticles were deposited on the surface of ACF, and the particle size and loading amount of TiO2 were varied by changing the initial concentration of tetrabutyl titanate （TBOT）. The results of an ash experiment showed that the loading amounts of TiO2 were 18.4%, 43.3%, 52.5%, 75.1%, and 91.1% for initial concentrations of TBOT of 0.07,014, 0.21,0.28, and 0.35 tool/L, respectively, Physical interactions played an important role in the formation of TiO2/ACF composite fibers that absorb UV and visible light. Compared with those of ACF, improved adsorption and photocatalytic activity toward Rhodamine B （RhB） were observed for TiO2/ACF composite fiber. The Rhodamine B could be removed efficiently by TiO2/ACF composite fibers, and the TiO2 loading amount had a significant effect on the photocatalytic activity of TiO2/ACF composite fibers.展开更多
Radiofrequency ablation(RFA)is a promising tumor treatment in clinics,but its use is limited given the high post-RFA recurrence rate.To overcome tumor relapse,RFA needs to be used in combination with a long-lasting tr...Radiofrequency ablation(RFA)is a promising tumor treatment in clinics,but its use is limited given the high post-RFA recurrence rate.To overcome tumor relapse,RFA needs to be used in combination with a long-lasting treatment.Obviously,the focal injection of antitumor drugs is capable of increasing the effective treatment period.Nano drug delivery systems(NDDS),which allow for a controlled and slow release of drugs,provide a promising strategy to overcome post-RFA tumor recurrence.Our results showed a clear transit area,between the non-ablation tumor area and the ablation necrotic area,indicative of apparent histopathological partition.Focal injection of the NDDS in combination with focally-injected carbomicin(CBMC)is an effective assistant treatment for RFA,as it increases efficiency and inhibits tumor relapse.Focally injected CBMC is a novel strategy which overcomes the disadvantages of RFA and may even cure it.展开更多
文摘AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patients treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012.Seven patients refused to participate.Eventually,60 patients were included,and randomly assigned to three groups(20 in each group):ACNS group(group A),MB group(group B) and non-stained conventional surgical group(group C).In group A,patients received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass.In group B,the main artery of specimen was identified and isolated after the specimen was removed,and 2 mL MB was slowly injected into the isolated,stretched and fixed vessel.In group C,no ACNS and MB were injected.All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue.RESULTS:No difference was observed among the three groups in age,gender,tumor location,tumor diameter,T-stage,degree of differentiation,postoperative complications and peritoneal drainage retention time.The total number of detected lymph nodes was 535,476 and 223 in the three groups,respectively.The mean number of detected lymph nodes per patient was significantly higher in group A than in group C(26.8 ± 8.4 vs 12.2 ± 3.2,P < 0.001).Similarly,there were significantly more lymph nodes detected in group B than in group C(23.8 ± 6.9 vs 12.2 ± 3.2,P < 0.001).However,there was no significant difference between group A and group B.There were 50,46 and 32 metastatic lymph nodes dissected in 13 patients of group A,10 patients of group B and 11 patients of group C,without significant differences among the three groups.Eleven of the 60 patients had insufficient number of detected lymph nodes(< 12).Only one patient with T 4a rectal cancer had 10 lymph nodes detected in group B,the other 10 patients were all from group C.Based on the different diameter categories,the number of detected lymph nodes in groups A and B was significantly higher than in group C.However,there was no statistically significant difference between group A and group B.The metastatic lymph nodes were not significant different among the three groups.Similarly,tumor location,T stage and tumor differentiation did not affect the staining results.Body mass index was a minor influencing factor in the two different staining methods.The stained lymph nodes can easily be identified from the mesenteric adipose tissues,and the staining time for lymph nodes was not significantly different compared with unstained group.None of the patients in groups A and B had drug-related complications.CONCLUSION:Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer.
基金the support of Pharmacy Laboratory Centre and Animal Centre of Shenyang Pharmaceutical Universitysupported by the State Key Laboratory(Long-acting and Targeting Drug Delivery System)the Special Construction Project(Taishan ScholarePharmacy Specially Recruited Experts).
文摘The objective of this study is to compare the targeting ability of activated carbon nanoparticles and nanoliposomes,which are used as carriers for delivering docetaxel(DTX)to the metastatic lymph nodes.In this study,we first prepared the DTX-loaded activated carbon nanoparticles(DTX-AC-NPs)by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the concentrated nitro-oxide nanocarbon.We then prepared DTX-loaded nanoliposomes(DTX-LPs)by the proliposome method.The physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in vitro.The metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX concentration in metastatic lymph nodes and injection sites.The result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physicochemical properties could be used for in vivo lymph node targeting studies.DTX-AC-NPs significantly increased DTX-AUC_((0-24)) and prolonged DTX-retention in metastatic lymph nodes compared to DTX-LPs and non-modified activate carbon in vivo.This study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes.
基金The Scientific Research Projects of Shandong University under contract No.J15LE03the Key Research and Development Program of Shandong Province under contract No.2016GNC111016the Key Research and Developement Program of Yantai under contract No.2016ZH059
文摘With the development of aquaculture, there is an urgent demand for an alternative antibacterial agent to reduce the drug resistance and environmental pollution caused by the abuse of antibiotics. Recently, silver nanoparticles（Ag NPs） have been viewed as a novel type of antimicrobial agents due to their unique advantages. In this study,Ag NPs were biosynthesized with the ginger rhizomes extract. The biosynthesized Ag NPs were characterised by UV–visible spectroscopy, transmission electron microscopy, X-ray diffraction and fourier transform infrared spectroscopy. Furthermore, the antimicrobial activities of the Ag NPs were fully analyzed against six typical aquatic pathogens. The results indicated that the components in ginger extract could function as the chemical reductant to synthesize Ag NPs. Moreover, compared with the Ag NPs synthesized by chemical methods, the biosynthesized Ag NPs were smaller, and had higher stability and antibacterial activity. Therefore, the biosynthesized Ag NPs using ginger extract may have prospective applications in aquaculture.
基金financially supported by the University Grants Commission,New Delhi(scheme No.F.No.42-850/2013(SR))
文摘Biorecycling microbes, which have critical functionalities in natural cycles, are essential to sustain eco-system of the earth. Any alterations in these cycles caused by the mutations of microbes could be a potential threat to life on earth. Antibiotics leached from pharmaceutical waste, animal food and agribusiness prod- ucts are accumulating in the environment. Metal nanoparticles are also accumulating in environment because of their extensive use as biocidal agent in domestic products. Interaction of antibiotics and metal nanoparticles with eco-ffiendly microorganisms has a potential to alter the ecosystem of the earth. In this article, we have studied the antibacterial activities of silver and copper nanoparticles and their for- mulations with antibiotics, tetracycline, and kanamycin against biorecycling microbes, Bacillus subtilis and Pseudomonas fluorescens. Strong synergistic effect of metal nanoparticles on the antimicrobial ac- tivities of commercial antibiotics has been observed. Antimicrobial activity of tetracycline improves by 286%-346% and 0%-28% when being tested in the presence of 250 ppm of silver and copper nanoparticles, respectively. For kanamycin, the improvement is 154%-289% for silver and 3%-20% for copper nanoparticles. Irrespective of the antibiotics and tested organisms, synergy is more prominent for silver nanoparticles even at their minimum active concentration （100 ppm）. This study demonstrates that the combination of metal nanoparticles with antibiotics could be more fatal to ecosystem than either the metal nanoparticles or the antibiotics alone.
基金supported by the National Science Foundation of China(No.21074089)Tianjin Municipal Science and Technology Commission,China(No.09JCZDJC23300)
文摘For the first time,Au nanoparticles on graphene oxide（GO-AuNPs） were successfully fabricated without applying any additional reductants,just by the redox reaction between AuCl_4^（-1） and GO.Their structure was characterized by transmission electron microscopy and X-ray powder diffraction.The results show that flower-like AuNPs were successfully dispersed on GO surface.Importantly,they showed a high catalytic activity for the Suzuki-Miyaura coupling reaction in an aqueous medium.
基金the financial support (Nos.481424/2010-5 and 308337/2013-1)
文摘Polysaccharide-based composite materials（beads） containing silver nanoparticles（AgNPs） were successfully prepared.Hydrogel beads acted as an efficient vehicle for Ag＊ delivery.Beads promoted the AgNPs protection and inhibited their aggregation.Antimicrobial assays showed that the beads/AgNPs concentration can be modulated to deliver an amount of Ag＊ necessary for kill Escherichia coli cells.
基金supported by the Romanian Ministry of Education and Research within the Nucleu Programme(Project PN 09-44)
文摘ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basilicum）.The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis（between 14 and 27 nm） varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^（2＋）ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.
基金the financial support from the office of Vice-President for Research at University of Nevada-Las Vegas
文摘Oxygen transfer presents a serious challenge in the application of liquid lead as a nuclear coolant in advanced reactors. To mitigate corrosion by liquid lead in contact with steel, carefully controlling the oxygen concentration has been used as an effective way. Oxygen needs to mix in liquid lead uniformly and quickly. To enhance oxygen transport in liquid lead, nanoparticles are added to the liquid metal. In the current study, a lattice Boltzmann method is applied to investigate natural convection of copper/lead and aluminum oxide/lead in two-dimensional simplified container. Two thermal boundary cases are evaluated in order to check the effect of different natural convection flow patterns on oxygen transport. Some useful information are obtained such as improvement in natural convection and reduction in oxygen equilibrium time.
文摘Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the leading causes of cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, and traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. The delivery of therapeutic compounds to the target site is a major challenge in the treatment of many diseases. Objective: This study aims to evaluate activated charcoal nanoparticles as a drug delivery system for anticancer agents (Sorafenib and Doxorubicin) in Hepatocellular Cancer Stem Cells. Method: The percent efficiency of entrapment (% EE) of the doxorubicin and sorafenib entrapped onto the activated charcoal was obtained by determining the free doxorubicin and sorafenib concentration in the supernatant-prepared solutions. Then the characterizations of nanoparticles were formed by determination of the particle size distribution, zeta potential, and polydispersity index (PDI). The anticancer activity of activated Charcoal, Doxorubicin-ACNP, sorafenib-ACNP, free doxorubicin, and free sorafenib solutions was measured based on cell viability percentage in HepG2 cell lines (ATCC-CCL 75). In vitro RBC’s toxicity of Doxorubicin/sorafenib loaded charcoal was estimated by hemolysis percentage. Results: The synthesized Doxorubicin-ACNP and Sorafenib-ACNP were evaluated and their physiochemical properties were also examined. Essentially, the percent Efficiency of Entrapment (EE %) was found to be 87.5% and 82.66% for Doxorubicin-ACNP and Sorafenib-ACNP, respectively. The loading capacity was 34.78% and 24.31% for Doxorubicin-ACNP and Sorafenib-ACNP. Using the Dynamic Light scattering [DLS] for the determination of the hydrodynamic size and surface zeta potential, a narrow sample size distribution was obtained of (18, 68, and 190 nm for charcoal, 105, 255, and 712 nm for doxorubicin, and 91, 295, and 955 nm for sorafenib), respectively. A surface charge of −13.2, −15.6 and −17 was obtained for charcoal, doxorubicin/charcoal, and sorafenib/charcoal nanoparticles. The cytotoxic activity of Doxorubicin-ACNP and Sorafenib-ACNP was evaluated in-vitro against HepG2 cell lines and it was observed that Drug loaded ACNP improved anticancer activity when compared to Doxorubicin or Sorafenib alone. Moreover, testing the toxicity potential of DOX-ACNP and Sorafenib-ACNP showed a significant reduction in the hemolysis of red blood cells when compared to Doxorubicin and Sorafenib alone. Conclusion: In conclusion, it is notable to state that this study is regarded as the first to investigate the use of Activated charcoal for the loading of Doxorubicin and Sorafenib for further use in the arena of hepatocellular carcinoma. Doxorubicin-ACNP and Sorafenib-ACNP showed noteworthy anticancer activity along with a reduced potential of RBCs hemolysis rendering it as an efficacious carrier with a low toxicity potential.
文摘The increased incidence ofNHL(non-Hodgkin's lymphoma),along with its high mortality rate and pronounced resistance to therapy pose an enormous challenge.Both traditional therapeutic strategies and recently developed therapeutic strategies against NHL such as chemoimmunotherapy and targeted therapy have drawbacks.Therefore,novel therapeutic approaches for NHL are urgently needed.Maytansine-loaded PLA-TPGS(polyethylene glycol 1000 succinate-polylactide)nanoparticles were synthesized.And then,rituximab targeting NHL was conjugated together by using EDC(1-ethyl-3-(3-dimethylaminopropyl)carbodiimide)as a coupling agent.The in vitro/vivo antitumor activity was evaluated by Raji cell proliferation inhibition and nude mice xenograft tumor models for NHL.Both the rituximab-conjugated and maytansine-loaded PLA-TPGS nanoparticles(maytansine-NPs(Nanoparticles)-rituximab)and maytansine-loaded PLA-TPGS nanoparticles(maytansine-NPs)presented significant inhibition effect on Raji cell proliferation in a concentration-dependent manner.Compared with conventional maytansine and maytansine-NPs,maytansine-NPs-rituximab showed significantly enhanced cytotoxicity and increased cell apoptosis in Raji cells.The maytansine-NPs-rituximab described in this paper might be a potential formulation for targeting chemotherapy and immunotherapy to CD20+B cell malignancies.
文摘Here,Ag2S nanoparticles on reduced graphene oxide（Ag2S NPs/RGO） nanocomposites with relatively good distribution are synthesized for the first time by conversing Ag NPs/RGO to Ag2S NPs/RGO via a facile hydrothermal sulfurization method.As an noval catalyst for the reduction of 4-nitrophenol（4-NP）,it only takes 5 min for Ag2S NPs/RGO to reduce 98% of 4-NP,and the rate constant of the composites is almost 13 times higher than that of Ag NPs/RGO composites.The high catalytic activity of Ag2S NPs/RGO can be attributed to the following three reasons：（1） Like metal complex catalysts,the Ag2S NPs is also rich with metal center Ag（δ^＋）,with pendant base S（δ） close to it,and thus the Ag and basic S function as the electron-acceptor and proton-acceptor centers,respectively,which facilitates the catalyst reaction;（2）RGO features the high adsorption ability toward 4-NP which provides a high concentration of 4-NP near the Ag2S NPs;and（3） electron transfer from RGO to Ag2S NPs,facilitating the uptake of electrons by 4-NP molecules.
文摘The chemical structure of newly synthesized cationic surfactants based on Schiff base was confirmed using Fourier transform infrared spectroscopy,proton nuclear magnetic resonance spectroscopy,and mass spectroscopy.The synthesized surfactants were used in the synthesis of silver nanoparticles by a simple one-step method.The silver nanoparticle（AgNPs） formation was confirmed using transmission electron microscopy（TEM）,electron diffraction（SAED）,dynamic light scattering（DLS）,and energy dispersive X-ray spectroscopy（EDX）.The structure of the surfactant played an important role in the synthesis process.Increasing the hydrophobic chain length,the stability,and the amount of surfactant increased the quantity of AgNPs formed.The surface activity of the synthesized cationic surfactants was determined using surface tension measurements at three different temperatures.The synthesized surfactants showed a high tendency toward adsorption and micellization.Increasing the hydrophobic chain length of the synthesized surfactant increased its adsorption.Screening the synthesized cationic surfactants and their nano-form against bacteria and fungi showed that they are highly effective.The silver nanoparticles enhanced the biological activity of the synthesized cationic surfactants.
基金supported by Chinese Academy of Sciences(XDB14030501)the National Natural Science Foundation(21277164,21177146,21621064)
文摘The studies on the human toxicity of nanoparticles（NPs） are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs（C_（60） NPs） have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C_（60） NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C_（60） NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C_（60） NPs, of greater hydrophobicity and hydrogen bond（HB） donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive inhibitors.Molecular docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C_（60） NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C_（60） NPs relevant to their anticoagulation effect.
基金supported by the National Natural Science Foundation of China(No.51378368)the Foundation of State Key Laboratory of Pollution Control and Resource Reuse(Tongji University),China(No.PCRRT16003)Shenzhen Science and Technology Research Fund(No.CXZZ20150330151321966)
文摘The study aims to identify the potential acute effects of suspended aluminum nitride（Al N）nanoparticles（NPs） on soluble microbial products（SMP） of activated sludge.Cultured activated sludge loaded with 1,10,50,100,150 and 200 mg/L of Al N NPs were carried out in this study.As results showed,Al N NPs had a highly inverse proportionality to bacterial dehydrogenase and OUR,indicating its direct toxicity to the activated sludge viability.The toxicity of Al N NPs was mainly due to the nano-scale of Al N NPs.In SMP,Al N NPs led to the decrease of polysaccharide and humic compounds,but had slight effects on protein.The decrease of tryptophan-like substances in SMP indicated the inhibition of Al N NPs on the bacterial metabolism.Additionally,Al N NPs reduced obviously the molecular weight of SMP,which might be due to the nano-scale of Al N.
基金Project(51375511) supported by the National Natural Science Foundation of ChinaProject(cstc2016jcyj A0167) supported by the Research Program of Basic Research and Frontier Technology of Chongqing of China+1 种基金Project(SF201602) supported by the Science and Technology Project in the Field of Social Development of Shapingba District of Chongqing of ChinaProject(XJ201608) supported by the Key Industry Technology Innovation Funds of Science and Technology Development Board of Xiangcheng District of Suzhou of China
文摘The effects of graphene nanoplates(GNPs)on the microstructures and mechanical properties of nanoparticlesstrengthening activating tungsten inert gas arc welding(NSA-TIG)welded AZ31magnesium alloy joints were investigated.It wasfound that compared with those of activating TIG(A-TIG),and obvious refinement ofα-Mg grains was achieved and the finestα-Mggrains of fusion zone of NSA-TIG joints were obtained in the welded joints with TiO2+GNPs flux coating.In addition,thepenetrations of joints coated by TiO2+GNPs flux were similar to those coated by the TiO2+SiCp flux.However,the welded jointswith TiO2+GNPs flux coating showed better mechanical properties(i.e.,ultimate tensile strength and microhardness)than those withTiO2+SiCp flux coating.Moreover,the generation of necking only occurred in the welded joints with TiO2+GNPs flux.
基金This work was supported financially by the National Science and Technology Major Project of China （2014ZX09102045- 008）, National Science Foundation of China （21476243 and 81274101）, Fundamental Research Funds for the Central Universities （DL13EA03-03 and 2572016EAJ1）, Natural Science Foundation of Heilongjiang Province （C2015051） and 973 Program （2013CB531500）.
文摘Accumulating evidence suggests that the flavone glycoside baicalin has immunomodulatory effects and antitumor potential. However, its weak stability in solution, poor absorption, and low bioavailability limit its clinical application. To overcome these disadvantages, we developed baicalin-loaded poly（lactic-co-glycolic acid） nanoparticles （PLGA-B） of small size. Next, we evaluated the dual function of immunotherapy and chemotherapy for PLGA-B using immune-related cells and tumor cells. Results showed that PLGA-B were spherical, with a particle size -120 nm and narrow size distribution with an excellent polydispersity index of 0.103. In vitro experiments revealed that baicalin and PLGA-B could activate dendritic cells （DCs） to have higher expression of surface marker molecules and costimulatory molecules than those of control cells. Baicalin and PLGA-B could trigger apoptosis in melanoma （B16） cells via cell-cycle arrest at the G2/M phase. These data suggest that PLGA-B have important roles in activating DCs and killing melanoma cells. Our study could lay a foundation for melanoma treatment through a combined strategy of immunotherapy and chemotherapy.
基金supported by the budget of China 973 project(2010CB933904)State Project for Essential Drug Research and Development of China(2011ZX09102-001-15).
文摘The potentials of activated carbon nanoparticles(ACNP)as anticancer drug carriers were studied.ACNP were prepared with a top-down method.ACNP-based drug delivery system of docetaxel(ACNP-DOC)was prepared with a simple absorption method and its effects were studied primarily with methyl thiazolyl tetrazolium(MTT)assay,light microscope(LM),atomic force microscope(AFM)and transmission electron microscope(TEM).The prepared ACNP were approximately globular in shape with an average size of 233 nm,which had a saturate adsorption of 195.69 mg/g at mass ratio of ACNP:DOC=5:1.The drug delivery system prepared by adsorbing of ACNP for DOC had excellent releasing profile in the simulated in vivo environment.LM observation showed that ACNP can accumulate around the cells and on the surface of cells and TEM revealed that ACNP can enter cells and nuclears.MTT test demonstrated that ACNP-DOC had inhibitive effects on the growth of A549 cells,with an IC50 of 0.79μg/ml,significantly smaller than that of 20μg/ml of free DOC,indicating ACNP-DOC had stronger effects than free DOC.The imaging of AFM showed that both DOC and ACNP-DOC caused significant pathological changes of the cell membrane,including rough surfaces,large grains and holes,but these pathological changes were more obvious in ACNP-DOC treated cells than those free DOC treated ones.In all of the experiments,ACNP themselves had no significant influences on A549 cells.It was concluded that ACNP could serve as a good nanocarrier for anti-cancer drug delivery to target cells and have a great potential application in antitumor chemotherapy.
基金financial support of the National Natural Science Foundation of China(No.21103017No.51104042)the Fundamental Research Funds for the Central Universities(No.110405007)
文摘TiO2-loaded activated carbon fibers （ACF） were prepared by a hydrothermal method. The samples were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, Fourier transform infrared （FTIR） spectrometry and UV-vis diffuse reflectance spectra （DRS）. SEM images showed that the TiO2 nanoparticles were deposited on the surface of ACF, and the particle size and loading amount of TiO2 were varied by changing the initial concentration of tetrabutyl titanate （TBOT）. The results of an ash experiment showed that the loading amounts of TiO2 were 18.4%, 43.3%, 52.5%, 75.1%, and 91.1% for initial concentrations of TBOT of 0.07,014, 0.21,0.28, and 0.35 tool/L, respectively, Physical interactions played an important role in the formation of TiO2/ACF composite fibers that absorb UV and visible light. Compared with those of ACF, improved adsorption and photocatalytic activity toward Rhodamine B （RhB） were observed for TiO2/ACF composite fiber. The Rhodamine B could be removed efficiently by TiO2/ACF composite fibers, and the TiO2 loading amount had a significant effect on the photocatalytic activity of TiO2/ACF composite fibers.
基金supported by the National Key Basic Research Program(973 Project)(No.2010CB933904)the Foundation of General Logistics Department of PLA(DWS16J007)a Military Medical Scientific and Technological Project for the“Twelfth Five-year Plan”(AWS15J007).
文摘Radiofrequency ablation(RFA)is a promising tumor treatment in clinics,but its use is limited given the high post-RFA recurrence rate.To overcome tumor relapse,RFA needs to be used in combination with a long-lasting treatment.Obviously,the focal injection of antitumor drugs is capable of increasing the effective treatment period.Nano drug delivery systems(NDDS),which allow for a controlled and slow release of drugs,provide a promising strategy to overcome post-RFA tumor recurrence.Our results showed a clear transit area,between the non-ablation tumor area and the ablation necrotic area,indicative of apparent histopathological partition.Focal injection of the NDDS in combination with focally-injected carbomicin(CBMC)is an effective assistant treatment for RFA,as it increases efficiency and inhibits tumor relapse.Focally injected CBMC is a novel strategy which overcomes the disadvantages of RFA and may even cure it.
