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Infrared Laser Stimulation of Purkinje Cells Primarily Depends on TRP Channel Activation
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作者 Bin-Bin Dong Chen Wang +6 位作者 Wan-Qi Huang Yu-Peng Bian Jun Liu Wei Chen Lin Zhou Ying Shen Luxi Wang 《Neuroscience Bulletin》 2025年第7期1261-1266,共6页
Dear Editor,It is now well established that optogenetic stimulation can achieve precise intervention and modulate the activity of local neurons or neural circuits in the brain.Although this technique holds promise for... Dear Editor,It is now well established that optogenetic stimulation can achieve precise intervention and modulate the activity of local neurons or neural circuits in the brain.Although this technique holds promise for clinical therapy for neurological and psychiatric disorders,it requires the expression of lightsensitive proteins(such as channel rhodopsin)or photoactivatable chemicals(such as caged neurotransmitters)in the targeted brain regions[1]. 展开更多
关键词 channel rhodopsin precise intervention photoactivatable chemicals such optogenetic stimulation Purkinje cells clinical therapy neurological psychiatric modulate activity infrared laser
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Micro-alloying design-enabled surface activity engineering for enhanced anti-poisoning properties of ZrCo-based hydrogen isotope storage materials
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作者 Qianwen Zhou Panpan Zhou +5 位作者 Jiapeng Bi Lingchao Zhang Shunrui Xiao Xuezhang Xiao Xiulin Fan Lixin Chen 《Journal of Energy Chemistry》 2025年第9期254-262,I0008,共10页
ZrCo alloy holds great promise for hydrogen isotope storage,yet its susceptibility to poisoning by impurity gases,especially CO,poses a challenge.This susceptibility arises due to the electron acceptor nature of the s... ZrCo alloy holds great promise for hydrogen isotope storage,yet its susceptibility to poisoning by impurity gases,especially CO,poses a challenge.This susceptibility arises due to the electron acceptor nature of the surface Co element and the formation of the d-πfeedback bond,thereby impeding the surface hydrogen dissociation.Accordingly,we propose a novel local activity modulation strategy,where substituent elements are sacrificed to protect the active Co sites for hydrogen dissociation.Considering CO absorption capacity,solid solubility,and hydrogen affinity,we selected V,Cr,and Mn as microalloying elements and successfully prepared the single-phase ZrCo_(0.97)(VCrMn)_(0.03)alloy.Compared to pristine ZrCo,ZrCo_(0.97)(VCrMn)_(0.03)demonstrates significantly enhanced poisoning resistance.Notably,the hydrogenation kinetics of ZrCo_(0.97)(VCrMn)_(0.03)is 2.4 times higher than that of ZrCo in 4 bar H_(2)+5000 ppm CO.Interestingly,the controllable in situ formation of the Co_(2)C phase shell structure during cycling further safeguards the surface reactivity of ZrCo_(0.97)(VCrMn)_(0.03).Consequently,its capacity retention ratio after 25 cycles has been improved to 74.5%from 55.3%of the ZrCo alloy.These findings suggest that micro-alloying engineering could be a promising strategy for surface activity modulation to enhance the anti-poisoning properties of hydrogen storage materials. 展开更多
关键词 ZrCo-based hydrogen isotope storage alloy Micro-alloying design Surface activity modulation Anti-poisoning properties
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Strong interaction between Fe and Ti compositions for effective CO_(2)hydrogenation to light olefins
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作者 Hao Liang Shunan Zhang +4 位作者 Ruonan Zhang Haozhi Zhou Lin Xia Yuhan Sun Hui Wang 《Chinese Journal of Catalysis》 2025年第4期146-157,共12页
Fe-based catalysts are widely used for CO_(2)hydrogenation to light olefins(C_(2–4)=);however,precise regulation of active phases and the balance between intermediate reactions remain significant challenges.Herein,we... Fe-based catalysts are widely used for CO_(2)hydrogenation to light olefins(C_(2–4)=);however,precise regulation of active phases and the balance between intermediate reactions remain significant challenges.Herein,we find that the addition of moderate amounts of Ti forms a strong interaction with Fe compositions,modulating the Fe_(3)O_(4)and Fe_(5)C_(2)contents.Enhanced interaction leads to an increased Fe_(5)C_(2)/Fe_(3)O_(4)ratio,which in turn enhances the adsorption of reactants and intermediates,promoting CO hydrogenation to unsaturated alkyl groups and facilitating C–C coupling.Furthermore,the strong Fe-Ti interaction induces the preferential growth of Fe_(5)C_(2)into prismatic structures that expose the(020),(–112),and(311)facets,forming compact active interfacial sites with Fe_(3)O_(4)nanoparticles.These facet and interfacial effects significantly promote the synergistic coupling of the reverse water gas shift and Fischer-Tropsch reactions.The optimized 3K/FeTi catalyst with the highest Fe_(5)C_(2)/Fe_(3)O_(4)ratio of 3.6 achieves a 52.2%CO_(2)conversion rate,with 44.5%selectivity for C2–4=and 9.5%for CO,and the highest space-time yield of 412.0 mg gcat^(–1)h^(–1)for C_(2–4)=. 展开更多
关键词 CO_(2)hydrogenation Light olefins Strong Fe-Ti interaction Fe_(5)C_(2) Active phase modulation
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Intrinsic electrochemical activity modulation of MOF-derived C/N-NiCoMn-LDH/Ag electrode for low temperature hybrid supercapacitors 被引量:1
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作者 Xiaohui Guan Jingyang Chen +4 位作者 Enze Zhu Penggang Yin Liu Yang Xin Guan Guangsheng Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第19期145-158,共14页
Layered double hydroxides(LDHs)are promising electrode candidates for supercapacitors.However,lim-itations like inferior cycling stability and unsatisfactory charge storage capability at low temperatures have exerted ... Layered double hydroxides(LDHs)are promising electrode candidates for supercapacitors.However,lim-itations like inferior cycling stability and unsatisfactory charge storage capability at low temperatures have exerted negative effects on their applications.Herein,a novel synthetic process has been elaborately designed and provided to have the composition and structure of the C/N-NiCoMn-LDH/Ag(C/N-CNMA)delicately regulated.Both the experimental and theoretical researches unveil that the incorporated manganese species and elemental silver could dramatically modulate the bandgap,crystallinity and surface electron structure of the LDH,leading to the remarkable improvement in its conductivity,exposed active sites and intrinsic electrochemical activity,and thus the OH^(*)and O^(*)adsorption free energy could be remarkably optimized,even at low temperatures.In addition,the low crystallinity C/N-CNMA is of great electrochemical compatibility with both the KOH aqueous electrolyte and the isobutyl alcohol(IPA)modulated organohydrogel electrolyte.By means of adjusting the solvation and hydrogen bonding in the electrolytes,the assembled hybrid supercapacitors deliver excellent energy density,power density and cycling stability in the temperature range of-30 to 25℃.Specifically,the gel electrolyte with IPA as the anti-freezing functional additive displays high flexibility and ionic conductivity at low temperatures. 展开更多
关键词 Low crystallinity Intrinsic electrochemical activity modulation IPA modulated organohydrogel electrolyte ANTI-FREEZING Low temperature hybrid supercapacitors
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Multifunctional health-promoting effects of oolong tea and its products 被引量:6
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作者 Shuzhen Wang Ting Zeng +6 位作者 Shuang Zhao Yu Zhu Changchun Feng Jianfeng Zhan Shiming Li Chi-Tang Ho Alexander Gosslau 《Food Science and Human Wellness》 SCIE 2022年第3期512-523,共12页
Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo studies.However,studies on heal... Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo studies.However,studies on health promoting effects of oolong tea and its characteristic compounds are limited.The potential efficacy of bioactives derived from oolong tea and their roles as promising anticancer agents,their cardio-protective benefits during hypoxic conditions,effects in treating allergic disorders,potential prebiotic activities,improvement of blood lipid status in human beings,effectivity as oral hypoglycemic agent in the treatment of type 2 diabetes,and their potentials to reduce the risk of obesity have been discussed in this review.These promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical industries.However,potential health beneficial effects of oolong tea in humans should be further complemented by large-sized,randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications. 展开更多
关键词 Oolong tea Anticancer potential Antioxidative activity Microbiota modulating activities Synergistic effects
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Unlocking high-performance organic cathodes:tailoring active group densities in covalent frameworks for aqueous zinc ion batteries 被引量:1
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作者 Meilin Li Fanbin Zeng +5 位作者 Senlin Li Sanlue Hu Qingming Liu Tengfei Zhang Jun Zhou Cuiping Han 《Energy Materials and Devices》 2023年第1期107-117,106,共12页
Aqueous zinc ion batteries(AZIBs)are a promising energy storage technology due to their cost-effectiveness and safety.Organic materials with sustainable and designable structures are of great interest as AZIBs cath-od... Aqueous zinc ion batteries(AZIBs)are a promising energy storage technology due to their cost-effectiveness and safety.Organic materials with sustainable and designable structures are of great interest as AZIBs cath-odes.However,small molecules in organic cathode materials face dissolution problems and suboptimal cycle life,whereas large molecules suffer from a low theoretical capacity due to their inert carbon skeletons.Here,we designed two covalent organic framework(COF)materials(benzoquinoxaline benzoquinone-based COF(BB-COF)and triquinoxalinylene benzoquinone-based COF(TB-COF))with the same structure and number of energy storage groups to investigate the correlation between the densities of active sites and electrochemi-cal performance.We conclude that the electrochemical behavior of organic conjugate-based energy storage materials lacks a linear correlation with active site quantity.Adjusting active site densities is crucial for mate-rial advancement.BB-COF and TB-COF with dual active sites(C=O and C=N)exhibit distinct characteristics.TB-COF,which has dense active groups,shows a high initial capacity(222 mAh g^(-1)).Conversely,BB-COF,which features a large conjugated ring diameter,presents superior rate performance and enduring cycle stability.It even maintains stable cycling for 2000 cycles at-40℃.In-situ electrochemical quartz crystal mic-robalance tests reveal the energy storage mechanism of BB-COF,in which H+storage is followed by Zn2+storage. 展开更多
关键词 organic electrode materials covalent organic frameworks active group density modulation aqueous zinc ion batteries
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Homo-oligomerization as a common way for Proteins to modulate their activities
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作者 Zengyi Chang Center for Protein Science, School of Life Sciences Peking University 100871 《生物物理学报》 CAS CSCD 北大核心 2009年第S1期88-89,共2页
Although many proteins have been found to exist as homooligomers in nature, the biological significance and mechanism for its occurring is far from clear. We have examined a variety
关键词 Li Zhang Homo-oligomerization as a common way for Proteins to modulate their activities
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《Module 5 Activities》教学设计
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作者 刘淑华 《黑河教育》 2010年第2期36-,共1页
教材内容本节课选自外延版初一下(Unit1《I’m watering the new trees》)教材分析本课是围绕"学生日常活动……如何种树"这个话题展开的,内容紧密结合中学生的日常生活,让学生如何用简单的英语来描素正在做某事的步骤。
关键词 中学生 现在进行时 Module 5 Activities 教学参考 教材分析 教学设计 设计说明
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Active plane modulation of Bi_(2)O_(3)nanosheets via Zn substitution for efficient electrocatalytic CO_(2)reduction to formic acid 被引量:2
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作者 Yumei Liu Tiantian Wu +3 位作者 Hongfei Cheng Jiawen Wu Xiaodong Guo Hong Jin Fan 《Nano Research》 SCIE EI CSCD 2023年第8期10803-10809,共7页
Formic acid is considered one of the most economically viable products for electrocatalytic CO_(2)reduction reaction(CO_(2)RR).However,developing highly active and selective electrocatalysts for effective CO_(2)conver... Formic acid is considered one of the most economically viable products for electrocatalytic CO_(2)reduction reaction(CO_(2)RR).However,developing highly active and selective electrocatalysts for effective CO_(2)conversion remains a grand challenge.Herein,we report that structural modulation of the bismuth oxide nanosheet via Zn^(2+)cooperation has a profound positive effect on exposure of the active plane,thereby contributing to high electrocatalytic CO_(2)RR performance.The obtained Zn-Bi_(2)O_(3)catalyst demonstrates superior selectivity towards formate generation in a wide potential range;a high Faradaic efficiency of 95%and a desirable partial current density of around 20 mA·cm^(-2)are obtained at−0.9 V(vs.reversible hydrogen electrode(RHE)).As proposed by density functional theory calculations,Zn substitution is the most energetically feasible for forming and stabilizing the key OCHO*intermediate among the used metal ions.Moreover,the more negative adsorption energy of OCHO*and the relatively low energy barrier for the desorption of HCOOH*are responsible for the enhanced activity and selectivity. 展开更多
关键词 electrocatalytic CO_(2)reduction Bi_(2)O_(3)catalyst active plane modulation Zn substitution high selectivity
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Optimized kinetic pathways of active hydrogen generation at Cu_(2)O/Cu heterojunction interfaces to enhance nitrate electroreduction to ammonia
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作者 Xi Chen Wei Jin +9 位作者 Xinyu Zhong Hongqiao Lin Junjie Ding Xinyu Liu Hui Wang Fasheng Chen Yan Xiong Changchun Ding Zhong Jin Minghang Jiang 《Chinese Journal of Catalysis》 2025年第12期78-90,共13页
In this paper we report the preparation of nano-dendritic Cu_(2)O/Cu heterojunctions doped with varying concentrations of cobalt through a convenient,energy-consumption-free,and environmentally friendly chemical repla... In this paper we report the preparation of nano-dendritic Cu_(2)O/Cu heterojunctions doped with varying concentrations of cobalt through a convenient,energy-consumption-free,and environmentally friendly chemical replacement method.The analysis results reveal that the incorporation of cobalt in its atomic form enhances the adsorption of nitrate species onto the catalyst surface,whereas doping with metallic cobalt promotes the production of active hydrogen(*H).By adjusting the doping concentration of cobalt,we effectively control its doping form(atomic and metallic states)on the surface of dendritic copper,thereby enabling controllable modulation of the active hydrogen concentration on the catalyst surface.By ensuring sufficient consumption of*H during the NITRR process while avoiding excessively high concentrations that could trigger detrimental hydrogen evolution reaction side reactions,this approach remarkably enhances the selectivity of ammonia synthesis in NITRR.This study offers an effective approach to regulate the*H concentration on the surface of the catalyst through adjusting the metal doping form,thereby improving the performance of ammonia synthesis from NITRR. 展开更多
关键词 modulation of the active hydrogen concentration Adjusting the Co doping form Electrocatalytic nitrate reduction reaction Electrocatalytic ammonia synthesis
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Co-regulated Protein Functional Modules with Varying Activities in Dynamic PPI Networks 被引量:2
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作者 Yuan Zhang Nan Du +2 位作者 Kang L Kebin Jia Aidong Zhang 《Tsinghua Science and Technology》 SCIE EI CAS 2013年第5期530-540,共11页
Current methods for the detection of differential gene expression focus on finding individual genes that may be responsible for certain diseases or external irritants. However, for common genetic diseases, multiple ge... Current methods for the detection of differential gene expression focus on finding individual genes that may be responsible for certain diseases or external irritants. However, for common genetic diseases, multiple genes and their interactions should be understood and treated together during the exploration of disease causes and possible drug design. The present study focuses on analyzing the dynamic patterns of co-regulated modules during biological progression and determining those having remarkably varying activities, using the yeast cell cycle as a case study. We first constructed dynamic active protein-protein interaction networks by modeling the activity of proteins and assembling the dynamic co-regulation protein network at each time point. The dynamic active modules were detected using a method based on the Bayesian graphical model and then the modules with the most varied dispersion of clustering coefficients, which could be responsible for the dynamic mechanism of the cell cycle, were identified. Comparison of results from our functional module detection with the state-of-art functional module detection methods and validation of the ranking of activities of functional modules using GO annotations demonstrate the efficacy of our method for narrowing the scope of possible essential responding modules that could provide multiple targets for biologists to further experimentally validate. 展开更多
关键词 dynamic protein-protein interaction networks dynamic active modules varying activities Bayesian graphical mode
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All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking 被引量:1
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作者 JIHWAN KIM JOONHOI KOO JU HAN LEE 《Photonics Research》 SCIE EI 2017年第5期391-395,共5页
An all-fiber acousto-optic modulator(AOM), which features a compact structure and a low-driving voltage, is experimentally demonstrated for the active mode-locking of a fiber laser. The proposed AOM is based on the sh... An all-fiber acousto-optic modulator(AOM), which features a compact structure and a low-driving voltage, is experimentally demonstrated for the active mode-locking of a fiber laser. The proposed AOM is based on the short length of the cladding-etched fiber, the ends of which are fixed on a slide glass. On top of the cladding-etched fiber, a piezoelectric transducer was overlaid. A chemical wet-etching technique, which is based on a mixed solution of NH_4F and (NH_4)2SO_4, is used to reduce the fiber diameter down to ~25 μm, and the length of the etched section is only 0.5 cm. The fabricated device exhibited a modulation depth of 73.10% at an acoustic frequency of 918.9 kHz and a peak-to-peak electrical voltage of 10 V, while a laser beam was coupled at 1560 nm.By using the prepared AOM within an erbium-doped-fiber ring cavity, the mode-locked pulses with a temporalwidth of 2.66 ps were readily obtained at a repetition rate of 1.838 MHz. 展开更多
关键词 All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking
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A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules
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作者 Tomoaki Yoshida Hideaki Kimura +2 位作者 Shuichiro Asakawa Akira Ohki Kiyomi Kumozaki 《光学学报》 EI CAS CSCD 北大核心 2003年第S1期321-322,共2页
A simplified simulation method based on the FDTD technique that can handle active devices is proposed. This method well suits the electrical crosstalk analysis of multi-channel integrated, opto-electronic mixed module... A simplified simulation method based on the FDTD technique that can handle active devices is proposed. This method well suits the electrical crosstalk analysis of multi-channel integrated, opto-electronic mixed modules. We apply this method to an 8-channel integrated super-compact high-sensitivity optical module. The results show good agreement between simulations and measurements. 展开更多
关键词 口口 of In FDTD as BE by for A Simplified Numerical Simulation Method Considering Active Devices for Opto-Electronic Mixed Modules
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