A one-pot method for the synthesis of uniform Eu^(3+)-doped NaBi(MoO_(4))_(2)nanoparticles with an ellipsoidal shape and tetragonal crystal structure functionalized with polyacrylic acid is reported for the first time...A one-pot method for the synthesis of uniform Eu^(3+)-doped NaBi(MoO_(4))_(2)nanoparticles with an ellipsoidal shape and tetragonal crystal structure functionalized with polyacrylic acid is reported for the first time in the literature.The method is based on a homogeneous precipitation reaction from solutions in an ethylene glycol/water medium containing appropriate bismuth,sodium,and molybdate precursors and polyacrylic acid.The luminescence properties(excitation and emission spectra and luminescence lifetime)of such nanoparticles are evaluated for different Eu^(3+)doping levels,finding an intense red emission for all synthesized samples.The X-ray attenuation properties of the nanoparticles have been also analyzed,which were found to be better than those of a commercially computed tomography contrast agent(iohexol).The dispersibility of the nanoparticles in a physiological medium was also analyzed,finding that they could be well dispersed in a 2-N-morpholinoethanesulfonic acid monohydrate medium(pH=6.5).Finally,the cell viability of such a phosphor has been analyzed using MIA-PaCa-2 cells and its in vivo toxicity has been evaluated using the nematode Caenorhabditis elegans model finding no significant toxicity in both cases up to a nanoparticle concentration of 100μg mL-1,which is within the range required for most in vivo applications.The developed Eu^(3+)-doped NaBi(MoO_(4))_(2)nanoparticles are,therefore,excellent candidates for their use as bimodal probes for luminescence imaging and X-ray computed tomography.展开更多
基金the I+D+I Grant RTI2018-094426-B-I00 and funded by MCIN/AEI/10.13039/501100011033 and by“ERDF A way of making Europe”R.M.Calderón-Olvera acknowledges the financial support from the CONACYT-801024 postdoctoral grant+5 种基金support from the FPI program(PRE2019-090170)the grant FPU19/00527 funded by MCIN/AEI/10.13039/501100011033 and by“ESF Investing in your future”the FPU predoctoral contract(FPU19/01311)from Ministerio de Educación Cultura y Deporte(Spain)DGA and Fondos Feder(Bionanosurf E15_17R)and CIBER-Consorcio Centro de Investigación Biomédica en Red(CB16/01/00263)Instituto de Salud Carlos III(Spanish Ministry of Science and Innovation and European Commission,European Regional Development Fund)the European Commission NextGenerationEU(Regulation EU 2020/2094).
文摘A one-pot method for the synthesis of uniform Eu^(3+)-doped NaBi(MoO_(4))_(2)nanoparticles with an ellipsoidal shape and tetragonal crystal structure functionalized with polyacrylic acid is reported for the first time in the literature.The method is based on a homogeneous precipitation reaction from solutions in an ethylene glycol/water medium containing appropriate bismuth,sodium,and molybdate precursors and polyacrylic acid.The luminescence properties(excitation and emission spectra and luminescence lifetime)of such nanoparticles are evaluated for different Eu^(3+)doping levels,finding an intense red emission for all synthesized samples.The X-ray attenuation properties of the nanoparticles have been also analyzed,which were found to be better than those of a commercially computed tomography contrast agent(iohexol).The dispersibility of the nanoparticles in a physiological medium was also analyzed,finding that they could be well dispersed in a 2-N-morpholinoethanesulfonic acid monohydrate medium(pH=6.5).Finally,the cell viability of such a phosphor has been analyzed using MIA-PaCa-2 cells and its in vivo toxicity has been evaluated using the nematode Caenorhabditis elegans model finding no significant toxicity in both cases up to a nanoparticle concentration of 100μg mL-1,which is within the range required for most in vivo applications.The developed Eu^(3+)-doped NaBi(MoO_(4))_(2)nanoparticles are,therefore,excellent candidates for their use as bimodal probes for luminescence imaging and X-ray computed tomography.
