The tricarboxylic acid(TCA)cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions.Although tumor metabolic reprogramming places aerobic glycolysis in a dominant posit...The tricarboxylic acid(TCA)cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions.Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position,the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of glucose,lipids,and certain amino acids.TCA intermediates such as citrate,α-ketoglutarate,succinate,and fumarate are altered in tumors,and they regulate the tumor metabolism,signal transduction,and immune environment to affect tumorigenesis and tumor progression.This article provides a comprehensive review of the modifications occurring in tumor cells in relation to the intermediates of the TCA cycle,which affects tumor pathogenesis and current therapeutic strategy for therapy through targeting TCA cycle in cancer cells.展开更多
基金supported by grant nos.82073458,82173424,81974476,and 82221002 from the National Natural Science Foundationby grant from The Scientific Research Program of FuRong Laboratory(no.2023SK2103)+1 种基金by the Science and Technology Innovation Program of Hunan Province(2021RC4013)as well as the key project in Hunan province(2024JJ3052).
文摘The tricarboxylic acid(TCA)cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions.Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position,the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of glucose,lipids,and certain amino acids.TCA intermediates such as citrate,α-ketoglutarate,succinate,and fumarate are altered in tumors,and they regulate the tumor metabolism,signal transduction,and immune environment to affect tumorigenesis and tumor progression.This article provides a comprehensive review of the modifications occurring in tumor cells in relation to the intermediates of the TCA cycle,which affects tumor pathogenesis and current therapeutic strategy for therapy through targeting TCA cycle in cancer cells.
