Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influenci...Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influencing consumer preference.These VOCs are mainly derived from amino acids,fatty acids,and terpenoid pathways(Chen et al.,2023).Esters contribute to fruity and sweet notes,whereas terpenes and C_(9) aldehydes/alcohols impart floral and melon-like aromas,respectively(Mayobre et al.,2024).展开更多
Biotin(vitamin H or B7)is a sulfur-containing intermediate of fatty acids,and functions as an indispensable co-enzyme across the three domains of life.In general,biotin synthesis occurs in bac-teria,fungi and plants,r...Biotin(vitamin H or B7)is a sulfur-containing intermediate of fatty acids,and functions as an indispensable co-enzyme across the three domains of life.In general,biotin synthesis occurs in bac-teria,fungi and plants,rather than mammals and birds.In certain bacterial pathogens like the tuberculosis-causing agent,Mycobac-terium[1]and the life-threatening causative,Francisella[2],it also acts as a nutritional restriction factor having a critical role in bac-terial pathogenesis.Apart from hypervirulence of the two recalci-trant ESKAPE members,Klebsiella pneumoniae[3]and Pseudomonas aeruginosa[4,5],biotin biosynthesis was recently demonstrated to determine Acinetobacter baumannii polymyxin resistance[6].As an energetically-expansive molecule whose de novo biosynthesis requires 15-20 ATP equivalents,a number of diversified bacteria have evolved different regulated mechanisms for biotin production(perhaps salvage).The bifunctional enzyme BirA of E.coli is a paradigm regulator of biotin synthesis[7].In addition,two distinct regulatory mechanisms are functionally defined.Namely,they include the BioR repressor restricted to a-proteobacte ria[8],and the BioQ regulator found in Corynebac-terium glutamicum and Mycobacterium smegmatis[9].展开更多
基金supported by Project of Renovation Capacity Building for the Young Sci-Tech Talents Sponsored by Xinjiang Academy of Agricultural Sciences(Grant No.xjnkq-2021011)Key Research and Development Program of Hainan Province(Grant No.ZDYF2025XDNY089)+2 种基金Project of Fund for Stable Support to Agricultural Sci-Tech Renovation(Grant No.xjnkywdzc-2023001-35)Guangxi Agricultural Science and Technology Project,China Agriculture Research System of MOF and MORA(CARS-25)the Fundamental Research Funds for the Central Universities(Grant No.2662024JC004)。
文摘Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influencing consumer preference.These VOCs are mainly derived from amino acids,fatty acids,and terpenoid pathways(Chen et al.,2023).Esters contribute to fruity and sweet notes,whereas terpenes and C_(9) aldehydes/alcohols impart floral and melon-like aromas,respectively(Mayobre et al.,2024).
基金supported by the National Key R&D Program of China(2023YFC2308403)the National Science Fund for Distin-guished Young Scholars(32125003)the National Natural Science Foundation of China(32141001).
文摘Biotin(vitamin H or B7)is a sulfur-containing intermediate of fatty acids,and functions as an indispensable co-enzyme across the three domains of life.In general,biotin synthesis occurs in bac-teria,fungi and plants,rather than mammals and birds.In certain bacterial pathogens like the tuberculosis-causing agent,Mycobac-terium[1]and the life-threatening causative,Francisella[2],it also acts as a nutritional restriction factor having a critical role in bac-terial pathogenesis.Apart from hypervirulence of the two recalci-trant ESKAPE members,Klebsiella pneumoniae[3]and Pseudomonas aeruginosa[4,5],biotin biosynthesis was recently demonstrated to determine Acinetobacter baumannii polymyxin resistance[6].As an energetically-expansive molecule whose de novo biosynthesis requires 15-20 ATP equivalents,a number of diversified bacteria have evolved different regulated mechanisms for biotin production(perhaps salvage).The bifunctional enzyme BirA of E.coli is a paradigm regulator of biotin synthesis[7].In addition,two distinct regulatory mechanisms are functionally defined.Namely,they include the BioR repressor restricted to a-proteobacte ria[8],and the BioQ regulator found in Corynebac-terium glutamicum and Mycobacterium smegmatis[9].
