Metabolic reprogramming is a prominent cancer hallmark that enables uncontrolled growth,survival,and dissemination of tumor cells.Among the diverse metabolic alterations,dysregulation of arginine metabolism has garner...Metabolic reprogramming is a prominent cancer hallmark that enables uncontrolled growth,survival,and dissemination of tumor cells.Among the diverse metabolic alterations,dysregulation of arginine metabolism has garnered significant attention due to its profound impact on cancer cells and the tumor microenvironment(TME).Arginine,a semi-essential amino acid,has a central role in various cellular processes,including protein synthesis,nitric oxide(NO)production,and polyamine biosynthesis.In the context of cancer aberrant arginine metabolism fuels tumor cell growth and orchestrates a complex interplay between tumor and immune cells,ultimately facilitating immune evasion and tumor progression.展开更多
基金supported by grants from the National Key R&D Program of China(Grant no.2022YFC3401001)the National Natural Science Foundation of China(Grant nos.82025026,82230091,and 81872144)the Guangdong Basic and Applied Basic Research Foundation(Grant no.2023A1515140033).
文摘Metabolic reprogramming is a prominent cancer hallmark that enables uncontrolled growth,survival,and dissemination of tumor cells.Among the diverse metabolic alterations,dysregulation of arginine metabolism has garnered significant attention due to its profound impact on cancer cells and the tumor microenvironment(TME).Arginine,a semi-essential amino acid,has a central role in various cellular processes,including protein synthesis,nitric oxide(NO)production,and polyamine biosynthesis.In the context of cancer aberrant arginine metabolism fuels tumor cell growth and orchestrates a complex interplay between tumor and immune cells,ultimately facilitating immune evasion and tumor progression.
