A new series of 2-（4-（4-aminophenylsulfonyl） phenylamino）-3-（thiophen-2-ylthio）naphthalene-1,4-dione derivatives （3a-3n） were synthesized and characterized by spectral techniques. To understand the interaction...A new series of 2-（4-（4-aminophenylsulfonyl） phenylamino）-3-（thiophen-2-ylthio）naphthalene-1,4-dione derivatives （3a-3n） were synthesized and characterized by spectral techniques. To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed by the GLIDE program and compound N-（4-（4-（1,4-dioxo-3-（thiophen-2-ylthio）- 1,4- dihydronaphthalen-2-ylamino）phenylsulfonyl）phenyl）-3- methylbenzamide （3b） exhibited good glide and E model scores of-5.89 and -94.90, respectively. Moreover among all the molecules studied including the standards used, namely Sparfloxacin （4.8 μg/mL） and Norfloxacin （no inhibition observed） for their antibacterial property, compound N-（4-（4-（1,4-dioxo-3-（thiophen-2-ylthio）- 1,4- dihydronaphthalen-2-ylamino）phenylsulfonyl）phenyl）-4- nitrobenzamide （3e） exhibited the lowest minimum inhibitory concentration （MIC） value of 1.3 μg/mL against Proteus vulgaris.展开更多
The reduction of diphenyl ditelluride by the Sm/CrCl_3(cat.) system led to atelluride anion. This species reacted with acid chlorides, alkyl halides, and α,β-unsaturatedenoates or α,β-unsaturated ene nitriles to a...The reduction of diphenyl ditelluride by the Sm/CrCl_3(cat.) system led to atelluride anion. This species reacted with acid chlorides, alkyl halides, and α,β-unsaturatedenoates or α,β-unsaturated ene nitriles to afford telluroesters and unsymniet-ricalphenyltellurides, respectively, in moderate to good yields under mild and neutral conditions.展开更多
文摘A new series of 2-（4-（4-aminophenylsulfonyl） phenylamino）-3-（thiophen-2-ylthio）naphthalene-1,4-dione derivatives （3a-3n） were synthesized and characterized by spectral techniques. To understand the interaction of binding sites with bacterial protein receptor, the docking study was performed by the GLIDE program and compound N-（4-（4-（1,4-dioxo-3-（thiophen-2-ylthio）- 1,4- dihydronaphthalen-2-ylamino）phenylsulfonyl）phenyl）-3- methylbenzamide （3b） exhibited good glide and E model scores of-5.89 and -94.90, respectively. Moreover among all the molecules studied including the standards used, namely Sparfloxacin （4.8 μg/mL） and Norfloxacin （no inhibition observed） for their antibacterial property, compound N-（4-（4-（1,4-dioxo-3-（thiophen-2-ylthio）- 1,4- dihydronaphthalen-2-ylamino）phenylsulfonyl）phenyl）-4- nitrobenzamide （3e） exhibited the lowest minimum inhibitory concentration （MIC） value of 1.3 μg/mL against Proteus vulgaris.
基金theNationalNaturalScienceFoundationofChina (No .2 9872 0 10 )theNaturalScienceFoundationofZhejiangProvince China (No .2 980 6 7)
文摘The reduction of diphenyl ditelluride by the Sm/CrCl_3(cat.) system led to atelluride anion. This species reacted with acid chlorides, alkyl halides, and α,β-unsaturatedenoates or α,β-unsaturated ene nitriles to afford telluroesters and unsymniet-ricalphenyltellurides, respectively, in moderate to good yields under mild and neutral conditions.
