In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alteration...In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alterations of ocular aberration and crystalline lens biometry during dynamic acoommodative stimuli,we designed an optical coberence tomography with ultra-long penetration depth(UL-OCT)combined with a Shack-Hartmann wavefront sensor(SHWFS).This integrated set up measures human eye's anterior segment as well as mono-chromatie high-order aberrations(HOAs)with 6 um resolution and(1/20)λaccuracy.A total of 10 healthy volunteers without ocular diseases were examined.Upon exposure to accommodative stimuli,the wavefront aberrations became larger.Among the anterior segment biometry,the anterior crystalline lens demonstrated significant curvature during accommodation and was the major cause of high-order aberration.These findings suggest that the front surface of the crys-talline lens can siguificantly affect variation among aberrations,which is a key factor underlying the quality of human vision.展开更多
基金support from the Zhejiang Province Science and Technology Development (Grant No.2013C33170)the Zhejiang Provincial Natural Science Foundation of China (Grant No.Y1110383)the Wenzhou Science and Technology Development (Grant No.Y20100174).
文摘In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alterations of ocular aberration and crystalline lens biometry during dynamic acoommodative stimuli,we designed an optical coberence tomography with ultra-long penetration depth(UL-OCT)combined with a Shack-Hartmann wavefront sensor(SHWFS).This integrated set up measures human eye's anterior segment as well as mono-chromatie high-order aberrations(HOAs)with 6 um resolution and(1/20)λaccuracy.A total of 10 healthy volunteers without ocular diseases were examined.Upon exposure to accommodative stimuli,the wavefront aberrations became larger.Among the anterior segment biometry,the anterior crystalline lens demonstrated significant curvature during accommodation and was the major cause of high-order aberration.These findings suggest that the front surface of the crys-talline lens can siguificantly affect variation among aberrations,which is a key factor underlying the quality of human vision.
