Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper th...Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.展开更多
The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is high...The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is highly non-smooth,e.g.,discontinuous.In order to accelerate the convergence,an enriched HBM is developed in this paper where the non-smooth Bernoulli bases are additionally introduced to enrich the conventional Fourier bases.The basic idea behind is that the convergence rate of the HB solution,as a truncated Fourier series,can be improved if the smoothness of the solution becomes finer.Along this line,using non-smooth Bernoulli bases can compensate the highly non-smooth part of the solution and then,the smoothness of the residual part for Fourier approximation is improved so as to achieve accelerated convergence.Numerical examples are conducted on systems with non-smooth restoring and/or external forces.The results confirm that the proposed enriched HBM indeed increases the convergence rate and the increase becomes more significant if more non-smooth bases are used.展开更多
AIM:To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis(LASIK)and LASIK combined with accelerated corneal crosslinking(LASIK Xtra).METHODS:This pr...AIM:To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis(LASIK)and LASIK combined with accelerated corneal crosslinking(LASIK Xtra).METHODS:This prospective study analyzed 52 consecutive myopia patients treated with LASIK Xtra and 45 consecutive myopia patients treated with LASIK.Only the right eyes in the two groups were analyzed.The uncorrected distance visual acuity(UDVA),keratometry values,postoperative central corneal thickness(CCT),corneal demarcation line depth,the corneal compensated intraocular pressure(IOPcc),Goldmann-correlated IOP(IOPg),corneal resistance factor(CRF)and corneal hysteresis(CH)from Ocular Response Analyzer(ORA)were analyzed.Further,the correlation between the demarcation line depth and ORA-related biomechanical parameters were analyzed.RESULTS:No significant differences in UDVA,postoperative CCT,or mean K values were found between the 2 groups at 1 to 12mo postoperative follow-up(all P>0.05).The changes of CRF was significantly lower in the LASIK Xtra group compared to the LASIK group(all P<0.05)at all the postoperative visits.The changes of CH were significantly higher in the LASIK Xtra group(all P<0.05).No significant differences were discovered regarding the changes of IOPcc and IOPg posperatively(all P>0.05).Out of 52 cases in the LASIK Xtra group,the demarcation line was present in 40 eyes(77%).The average depth of the demarcation was 220.73±42.70μm(136 to 288μm).No significant correlation was observed between the depth of the demarcation line and any of the ORA-related biomechanical parameters such as IOPcc,IOPg,CRF and CH at 12mo(all P>0.05).CONCLUSION:Both procedures demonstrate comparable outcomes in terms of visual acuity,refraction and ablation predictability.This study confirms that corneal biomechanical properties of the included patients weakened after both procedures,but the cornea after LASIK Xtra are stiffer than conventional LASIK.展开更多
We study the average rate of change of energy of two accelerated entangled atoms coupled to electromagnetic fields in the presence of a reflecting boundary,which according to the Dalibard,Dupont-Roc and Cohen-Tannoudj...We study the average rate of change of energy of two accelerated entangled atoms coupled to electromagnetic fields in the presence of a reflecting boundary,which according to the Dalibard,Dupont-Roc and Cohen-Tannoudji formalism is only attributed to the contribution of the radiative reaction of atoms.When the boundary is present,this result can be expressed as the sum of the free-space result and the boundary-induced modifications,and it generally depends on the two-atom initial state,the orientations of atomic dipole moments,as well as the relative scales among atom-boundary distance,interatomic separation and the inverse of atomic acceleration.When the two atoms are vertically aligned and one atom is very close to the boundary,we find that the terms only related to the closer atom are zero for the symmetric state but double the free-space counterpart for the antisymmetric state,if the atom is polarizable parallel to the boundary.However,for the atom polarizable vertically to the boundary,these terms vanish for the antisymmetric state but are twice the free-space counterpart for the symmetric state.Moreover,the terms related to the farther atom exhibit obviously oscillatory behavior,and the terms related to both atoms are vanishing unless the dipole moments of two atoms both have their components vertical to the boundary.When the two atoms are aligned parallel to and very close to the boundary,the terms related to one atom are interatomicseparation-independent and only influenced by the atomic dipole moments.The terms related to both atoms are actually consistent with the counterpart in the vertical-alignment case.In addition,when the two atoms are polarizable along the direction parallel to the boundary,the average rate of change of energy of two parallel-aligned and symmetric entangled atoms vanishes as if the two atoms were a closed system.展开更多
Proximal gradient descent and its accelerated version are resultful methods for solving the sum of smooth and non-smooth problems. When the smooth function can be represented as a sum of multiple functions, the stocha...Proximal gradient descent and its accelerated version are resultful methods for solving the sum of smooth and non-smooth problems. When the smooth function can be represented as a sum of multiple functions, the stochastic proximal gradient method performs well. However, research on its accelerated version remains unclear. This paper proposes a proximal stochastic accelerated gradient (PSAG) method to address problems involving a combination of smooth and non-smooth components, where the smooth part corresponds to the average of multiple block sums. Simultaneously, most of convergence analyses hold in expectation. To this end, under some mind conditions, we present an almost sure convergence of unbiased gradient estimation in the non-smooth setting. Moreover, we establish that the minimum of the squared gradient mapping norm arbitrarily converges to zero with probability one.展开更多
The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on...The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization problems.In this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual vari-ables.By satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence rate.This only requires assuming convexity of the objective function.We validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments.展开更多
AIM:To observe the effects of femtosecond laserassisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking(FS-LASIK Xtra)on corneal densitometry after correcting for high myopia.METHO...AIM:To observe the effects of femtosecond laserassisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking(FS-LASIK Xtra)on corneal densitometry after correcting for high myopia.METHODS:In this prospectively study,130 patients underwent FS-LASIK or FS-LASIK Xtra for high myopia.Their right eyes were selected for inclusion in the study,of which 65 cases of 65 eyes in the FS-LASIK group,65 patients with 65 eyes in the FS-LASIK Xtra group.Patients were evaluated for corneal densitometry at 1,3,and 6mo postoperatively using Pentacam Scheimpflug imaging.RESULTS:Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant(P>0.05).Layer-by-layer analysis revealed statistically significant differences in the anterior(120μm),central,and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1 and 3mo postoperatively(all P<0.05),the FS-LASIK Xtra group is higher than that of the FS-LASIK group.Analysis of different diameter ranges showed statistically significant differences between the FS-LASIK group and the FS-LASIK Xtra group at 1mo postoperatively in the ranges of 0–2,2–6,and 6–10 mm(both P<0.05);At 3mo postoperatively,the FS-LASIK Xtra group is higher than that of the FS-LASIK group in the ranges of 0–2 and 2–6 mm(P<0.05).At 6mo postoperatively,there were no statistically significant differences in corneal densitometry between the FS-LASIK group and the FS-LASIK Xtra group in different diameter ranges(all P>0.05).CONCLUSION:There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high myopia.However,the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery,with the most significant changes observed in the superficial central zone.展开更多
In this study,the characteristics of heat transfer on an unsteady magnetohydrodynamic(MHD)Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated.The flow was d...In this study,the characteristics of heat transfer on an unsteady magnetohydrodynamic(MHD)Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated.The flow was driven by the combined effects of the magnetic field,heat radiation,heat source/sink and chemical reaction.Copper oxide(CuO)and titanium oxide(TiO2)are acknowledged as nanoparticle materials.The nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form solutions.Graphical representations are provided to analyze how changes in physical parameters,such as the magnetic field,heat radiation,heat source/sink and chemical reaction,affect the velocity,temperature and concentration profiles.The computed values of skin friction,heat and mass transfer rates at the surface were tabulated for various sets of input parameters.It is perceived that there is a drop in temperature due to the rise in the heat source/sink and the Prandtl number.It should be noted that a boost in the thermal radiation parameter prompts an increase in temperature.An increase in the Prandtl number,heat source/sink parameter,time and a decrease in the thermal radiation parameter result in an increase in theNusselt number.The computed values of the skin friction,heat andmass transfer rates at the surface were tabulated for various values of the flow parameters.The present results were compared with those of previously published studies andwere found to be in excellent agreement.This research has practical applications in areas such as drug delivery,thermal medicine and cancer treatment.展开更多
In this work,accelerated sintering of Y_(2)O_(3)dispersion strengthened tungsten alloy with a well-regulated structure was achieved by a novel dissolution-precipitation strategy.As indicated,yttrium oxide was firstly ...In this work,accelerated sintering of Y_(2)O_(3)dispersion strengthened tungsten alloy with a well-regulated structure was achieved by a novel dissolution-precipitation strategy.As indicated,yttrium oxide was firstly dissolved into the lattices of W powder precursor during the thermal plasma synthesis process in a one-step and ultra-fast way,and then homogeneously precipitated out within W grains during sintering.The theoretical calculation reveals that the formation process of Y_(2)O_(3)dispersoids enhanced the driving force of densification by increasing the sintering stress and declining the macroscopic viscosity,resulting in improved diffusion ability for the W skeleton.The microstructural investigation further confirmed the occurrence of mass inter-diffusion at the W-Y_(2)O_(3)interface,which provides a fast diffusion pathway for W atoms,and is responsible for the accelerated densification kinetics.Being sintered at 1600℃ for 1 h,the as-obtained alloy possesses a high relative density of 98.26%,together with a refined grain size of 970 nm for W and 50 nm for intragranular Y_(2)O_(3),respectively.展开更多
OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSMP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated pro...OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSMP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase kinase(MEK)/extracellular regulated protein kinases(ERK) signaling pathway. METHODS: Randomized 70 Sprague-Dawley rats into sham(n = 10) and operation(n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. We randomly divided the operation group rats into the model, ONSMP [including low(L), medium(M), and high(H) dose], and enalapril groups. After the 4-week drug intervention, echocardiography examines the cardiac function and calculates the ratios of the whole/left heart to the rat's body weight. Finally, we observed the degree of myocardial fibrosis by pathological sections, determined myocardium collagen(COL) Ⅰ and COL Ⅲ content by enzyme-linked immunosorbent assay, detected the m RNA levels of COL Ⅰ, COL Ⅲ, α-smooth muscle actin(α-SMA), and c-Fos proto-oncogene(c-Fos) by universal real-time, and detected the protein expression of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ETS-like-1 transcription factor(p-ELK1), p-c-Fos, α-SMA, COL Ⅰ, and COL Ⅲ by Western blot. RESULTS: ONSMP can effectively improve HF rat's cardiac function, decrease cardiac organ coefficient, COL volume fraction, and COL Ⅰ/Ⅲ content, down-regulate the m RNA of COL Ⅰ/Ⅲ, α-SMA and c-Fos, and the protein of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ELK1, c-Fos, COL Ⅰ/Ⅲ, and α-SMA. CONCLUSIONS: ONSMP can effectively reduce myocardial fibrosis in HF rats, and the mechanism may be related to the inhibition of the RAS/RAF/MEK/ERK signaling pathway.展开更多
Numerous wireless networks have emerged that can be used for short communication ranges where the infrastructure-based networks may fail because of their installation and cost.One of them is a sensor network with embe...Numerous wireless networks have emerged that can be used for short communication ranges where the infrastructure-based networks may fail because of their installation and cost.One of them is a sensor network with embedded sensors working as the primary nodes,termed Wireless Sensor Networks(WSNs),in which numerous sensors are connected to at least one Base Station(BS).These sensors gather information from the environment and transmit it to a BS or gathering location.WSNs have several challenges,including throughput,energy usage,and network lifetime concerns.Different strategies have been applied to get over these restrictions.Clustering may,therefore,be thought of as the best way to solve such issues.Consequently,it is crucial to analyze effective Cluster Head(CH)selection to maximize efficiency throughput,extend the network lifetime,and minimize energy consumption.This paper proposed an Accelerated Particle Swarm Optimization(APSO)algorithm based on the Low Energy Adaptive Clustering Hierarchy(LEACH),Neighboring Based Energy Efficient Routing(NBEER),Cooperative Energy Efficient Routing(CEER),and Cooperative Relay Neighboring Based Energy Efficient Routing(CR-NBEER)techniques.With the help of APSO in the implementation of the WSN,the main methodology of this article has taken place.The simulation findings in this study demonstrated that the suggested approach uses less energy,with respective energy consumption ranges of 0.1441 to 0.013 for 5 CH,1.003 to 0.0521 for 10 CH,and 0.1734 to 0.0911 for 15 CH.The sending packets ratio was also raised for all three CH selection scenarios,increasing from 659 to 1730.The number of dead nodes likewise dropped for the given combination,falling between 71 and 66.The network lifetime was deemed to have risen based on the results found.A hybrid with a few valuable parameters can further improve the suggested APSO-based protocol.Similar to underwater,WSN can make use of the proposed protocol.The overall results have been evaluated and compared with the existing approaches of sensor networks.展开更多
Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from M...Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from March 2020 to November 2021 and randomly divided into an observation group and an ACBT (Active Cycle of Breathing Technique) training group. Accelerated recovery care and routine care were respectively used in the perioperative period to compare the nursing effects of the two groups. Results: All perioperative indicators in the observation group were shorter than those in the ACBT training group. The pain scores at different time periods after surgery were lower in the observation group than in the ACBT training group (P 0.05). The improvement in the above indicators was higher in the observation group than in the ACBT training group after nursing care (P Conclusion: Accelerated recovery care during the perioperative period for lung cancer surgery patients showed significant effectiveness.展开更多
Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent...Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.展开更多
Objective: To compare the effectiveness and safety of two surgical methods for lumbar degenerative diseases;the combination of the concept of accelerated rehabilitation with the assistance of Tianji Robotics and the c...Objective: To compare the effectiveness and safety of two surgical methods for lumbar degenerative diseases;the combination of the concept of accelerated rehabilitation with the assistance of Tianji Robotics and the concept of accelerated rehabilitation combined with manual pedicle screw placement assisted by conventional C-arm fluoroscopy. Methods: A retrospective analysis was performed on 70 patients who received the concept of accelerated rehabilitation combined with spinal surgery for lumbar degenerative diseases in Baise People’s Hospital from January 2022 to January 2024. Among them, 35 patients in the robot group received accelerated rehabilitation concept combined with robot-assisted surgery;In the conventional C-arm group, 35 patients received the accelerated rehabilitation concept combined with manual pedicle screw placement assisted by conventional C-arm fluoroscopy. VAS score (preoperative/postoperative), ODI score (preoperative/postoperative), intraoperative bleeding volume, postoperative hospital stay, postoperative complications and the accuracy rate of screw placement were compared between the two groups. Result: There was no statistically significant difference in preoperative VAS scores between the robot group and the conventional C-arm group (6.45 ± 0.82 VS 6.63 ± 0.81, P = 0.6600). The postoperative VAS score of the robot group was better than that of the conventional C-arm group (1.69 ± 0.80 VS 2.45 ± 0.85, P = 0.0000*). There was no statistically significant difference in preoperative ODI scores between the robot group and the conventional C-arm group (32.11 ± 3.18 VS 31.66 ± 2.25, P = 0.4900). The postoperative ODI score of the robot group was better than that of the conventional C-arm group (22.68 ± 1.94 VS 24.57 ± 2.25, P = 0.0000*). The postoperative complications in the robot group were less than those in the conventional C-arm group (2.7778% VS 28.5724%, P = 0.0030*). The intraoperative bleeding in the robot group was lower than that in the conventional C-arm group (320.85 ± 276.28 VS 490.00 ± 395.34, P = 0.0420*). The postoperative hospital stay of the robot group was shorter than that of the conventional C-arm group (10.00 ± 9.32 VS 14.49 ± 7.55, P = 0.0300*). The screw placement inaccuracy score of the robot group was lower than that of the conventional C-arm group (0.17 ± 0.51 VS 1.45 ± 1.46, P = 0.0000*). Conclusion: The combination of the concept of accelerated rehabilitation and Tianji Orthopedic robot-assisted surgery is more effective and safer in posterior lumbar decompression and internal fixation surgery with a screw rod system, and is worthy of promotion and application.展开更多
The main aim of the paper is to present (and at the same time offer) a differ-ent perspective for the analysis of the accelerated expansion of the Universe. A perspective that can surely be considered as being “in pa...The main aim of the paper is to present (and at the same time offer) a differ-ent perspective for the analysis of the accelerated expansion of the Universe. A perspective that can surely be considered as being “in parallel” to the tradition-al ones, such as those based, for example, on the hypotheses of “Dark Matter” and “Dark Energy”, or better as a “com-possible” perspective, because it is not understood as being “exclusive”. In fact, it is an approach that, when con-firmed by experimental results, always keeps its validity from an “operative” point of view. This is because, in analogy to the traditional perspectives, on the basis of Popper’s Falsification Principle the corresponding “Generative” Logic on which it is based has not the property of the perfect induction. The basic difference then only consists in the fact that the Evolution of the Universe is now modeled by considering the Universe as a Self-Organizing System, which is thus analyzed in the light of the Maximum Ordinality Principle.展开更多
Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing spee...Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization effects.OCT technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data size.Despite the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data processing.Additionally,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further analysis.Firstly,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact noises.Then,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data visualization.Furthermore,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic information.Moreover,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like network.OCTA imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network formation.Therefore,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.展开更多
In this paper, we obtain the optimum plan by discussing a constant-stress accelerated life test (ALT) satisfying the condition (3.3) at k stresses under an exponential distribution.
To design an accelerated method to evaluate thymopentin release from PLGA microspheres in vitro. Microspheres were prepared by double emulsion technique, using poly（lactide-co-glycolide） （PLGA） as carrier. At high...To design an accelerated method to evaluate thymopentin release from PLGA microspheres in vitro. Microspheres were prepared by double emulsion technique, using poly（lactide-co-glycolide） （PLGA） as carrier. At higher medium temperature （45℃, 50℃ and 55℃）, an accelerated release testing in short time was studied and correlated with the conventional release （37℃） in vitro. The release in vitro of thymopentin from PLGA microspheres at 45 ℃, 50℃ and 55℃ was significantly accelerated （P 〈 0.05）. In particular, at 50℃, an accelerated release （30 h） of the hydrophilic peptide from the PLGA matrix was achieved and correlated well with the conventional release （30 d）. An accelerated release testing in vitro at higher temperature could be used to monitor thymopentin release from PLGA microspheres.展开更多
The image reconstruction of electrical impedance tomography(EIT)is a nonlinear and ill-posed inverse problem and the imaging results are easily affected by measurement noise,which needs to be solved by using regulariz...The image reconstruction of electrical impedance tomography(EIT)is a nonlinear and ill-posed inverse problem and the imaging results are easily affected by measurement noise,which needs to be solved by using regularization methods.The iterative regularization method has become a focus of the research due to its ease of implementation.To deal with the ill-posed and ill-conditional problems in image reconstruction,the inexact Newton-Landweber iterative method is considered and the Nesterov’s acceleration strategy is introduced.One Nesterov-type accelerated version of the inexact Newton-Landweber iteration is presented to determine the conductivity distributions inside an object from electrical measurements made on the surface.In order to further optimize the acceleration,both the steepest descent step-length and the minimal error step-length are exploited during the iterative image reconstruction process.Landweber iteration and its accelerated version are also implemented for comparison.All algorithms are terminated by the discrepancy principle.Finally,the performance is tested by reporting numerical simulations to verify the remarkable acceleration efficiency of the proposed method.展开更多
Through different dose-rate switching evaluation methods,the radiation-response rules of operational amplifiers are studied when the irradiation dose rate is switched from high to low under different radiation tempera...Through different dose-rate switching evaluation methods,the radiation-response rules of operational amplifiers are studied when the irradiation dose rate is switched from high to low under different radiation temperatures and total doses. The experimental results indicate that the response characteristics could be affected by the switching total doses, irradiation temperatures,and dose rates individually or together. Accelerated evaluation on the ELDRS can be realized by adopting a proper dose-rate switching method. Meanwhile, the irradiation time can also be reduced. Finally, the mechanisms of the difference between various radiation responses are analyzed.展开更多
基金supported by the National Natural Science Foundation of China(82071143,82371000,82270361)Key Research and Development Program of Jiangsu Province(BE2022795)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_1801)the Jiangsu Province Capability Improvement Project through the Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4)Jiangsu Provincial Medical Innovation Center(CXZX202227).
文摘Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.
基金supported by the National Natural Science Foundation of China (Grant No. 12372028)the National Key Research and Development Program of China (Grant No. 2020YFC2201101)the Guangdong Basic and Applied Basic Research Foundation (Grant No.2022A1515011809)。
文摘The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is highly non-smooth,e.g.,discontinuous.In order to accelerate the convergence,an enriched HBM is developed in this paper where the non-smooth Bernoulli bases are additionally introduced to enrich the conventional Fourier bases.The basic idea behind is that the convergence rate of the HB solution,as a truncated Fourier series,can be improved if the smoothness of the solution becomes finer.Along this line,using non-smooth Bernoulli bases can compensate the highly non-smooth part of the solution and then,the smoothness of the residual part for Fourier approximation is improved so as to achieve accelerated convergence.Numerical examples are conducted on systems with non-smooth restoring and/or external forces.The results confirm that the proposed enriched HBM indeed increases the convergence rate and the increase becomes more significant if more non-smooth bases are used.
基金Supported by Wu Jieping Medical Foundation(No.320.6750.2021-04-15).
文摘AIM:To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis(LASIK)and LASIK combined with accelerated corneal crosslinking(LASIK Xtra).METHODS:This prospective study analyzed 52 consecutive myopia patients treated with LASIK Xtra and 45 consecutive myopia patients treated with LASIK.Only the right eyes in the two groups were analyzed.The uncorrected distance visual acuity(UDVA),keratometry values,postoperative central corneal thickness(CCT),corneal demarcation line depth,the corneal compensated intraocular pressure(IOPcc),Goldmann-correlated IOP(IOPg),corneal resistance factor(CRF)and corneal hysteresis(CH)from Ocular Response Analyzer(ORA)were analyzed.Further,the correlation between the demarcation line depth and ORA-related biomechanical parameters were analyzed.RESULTS:No significant differences in UDVA,postoperative CCT,or mean K values were found between the 2 groups at 1 to 12mo postoperative follow-up(all P>0.05).The changes of CRF was significantly lower in the LASIK Xtra group compared to the LASIK group(all P<0.05)at all the postoperative visits.The changes of CH were significantly higher in the LASIK Xtra group(all P<0.05).No significant differences were discovered regarding the changes of IOPcc and IOPg posperatively(all P>0.05).Out of 52 cases in the LASIK Xtra group,the demarcation line was present in 40 eyes(77%).The average depth of the demarcation was 220.73±42.70μm(136 to 288μm).No significant correlation was observed between the depth of the demarcation line and any of the ORA-related biomechanical parameters such as IOPcc,IOPg,CRF and CH at 12mo(all P>0.05).CONCLUSION:Both procedures demonstrate comparable outcomes in terms of visual acuity,refraction and ablation predictability.This study confirms that corneal biomechanical properties of the included patients weakened after both procedures,but the cornea after LASIK Xtra are stiffer than conventional LASIK.
基金supported in part by the NSFC under Grant Nos.12047551 and 12105061the Graduate Innovation Project of Shanxi Normal University under Grant No.2023XSY041。
文摘We study the average rate of change of energy of two accelerated entangled atoms coupled to electromagnetic fields in the presence of a reflecting boundary,which according to the Dalibard,Dupont-Roc and Cohen-Tannoudji formalism is only attributed to the contribution of the radiative reaction of atoms.When the boundary is present,this result can be expressed as the sum of the free-space result and the boundary-induced modifications,and it generally depends on the two-atom initial state,the orientations of atomic dipole moments,as well as the relative scales among atom-boundary distance,interatomic separation and the inverse of atomic acceleration.When the two atoms are vertically aligned and one atom is very close to the boundary,we find that the terms only related to the closer atom are zero for the symmetric state but double the free-space counterpart for the antisymmetric state,if the atom is polarizable parallel to the boundary.However,for the atom polarizable vertically to the boundary,these terms vanish for the antisymmetric state but are twice the free-space counterpart for the symmetric state.Moreover,the terms related to the farther atom exhibit obviously oscillatory behavior,and the terms related to both atoms are vanishing unless the dipole moments of two atoms both have their components vertical to the boundary.When the two atoms are aligned parallel to and very close to the boundary,the terms related to one atom are interatomicseparation-independent and only influenced by the atomic dipole moments.The terms related to both atoms are actually consistent with the counterpart in the vertical-alignment case.In addition,when the two atoms are polarizable along the direction parallel to the boundary,the average rate of change of energy of two parallel-aligned and symmetric entangled atoms vanishes as if the two atoms were a closed system.
文摘Proximal gradient descent and its accelerated version are resultful methods for solving the sum of smooth and non-smooth problems. When the smooth function can be represented as a sum of multiple functions, the stochastic proximal gradient method performs well. However, research on its accelerated version remains unclear. This paper proposes a proximal stochastic accelerated gradient (PSAG) method to address problems involving a combination of smooth and non-smooth components, where the smooth part corresponds to the average of multiple block sums. Simultaneously, most of convergence analyses hold in expectation. To this end, under some mind conditions, we present an almost sure convergence of unbiased gradient estimation in the non-smooth setting. Moreover, we establish that the minimum of the squared gradient mapping norm arbitrarily converges to zero with probability one.
基金supported by the National Natural Science Foundation of China(62176218,62176027)the Fundamental Research Funds for the Central Universities(XDJK2020TY003)the Funds for Chongqing Talent Plan(cstc2024ycjh-bgzxm0082)。
文摘The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization problems.In this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual vari-ables.By satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence rate.This only requires assuming convexity of the objective function.We validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments.
基金Supported by Shandong Province Medical Staff Science and Technology Innovation Program Project(No.SDYWZGKCJH2022021).
文摘AIM:To observe the effects of femtosecond laserassisted excimer laser in situ keratomileusis combined with accelerated corneal cross-linking(FS-LASIK Xtra)on corneal densitometry after correcting for high myopia.METHODS:In this prospectively study,130 patients underwent FS-LASIK or FS-LASIK Xtra for high myopia.Their right eyes were selected for inclusion in the study,of which 65 cases of 65 eyes in the FS-LASIK group,65 patients with 65 eyes in the FS-LASIK Xtra group.Patients were evaluated for corneal densitometry at 1,3,and 6mo postoperatively using Pentacam Scheimpflug imaging.RESULTS:Preoperative differences in corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups in different ranges were not statistically significant(P>0.05).Layer-by-layer analysis revealed statistically significant differences in the anterior(120μm),central,and total layer corneal densitometry between the FS-LASIK and FS-LASIK Xtra groups at 1 and 3mo postoperatively(all P<0.05),the FS-LASIK Xtra group is higher than that of the FS-LASIK group.Analysis of different diameter ranges showed statistically significant differences between the FS-LASIK group and the FS-LASIK Xtra group at 1mo postoperatively in the ranges of 0–2,2–6,and 6–10 mm(both P<0.05);At 3mo postoperatively,the FS-LASIK Xtra group is higher than that of the FS-LASIK group in the ranges of 0–2 and 2–6 mm(P<0.05).At 6mo postoperatively,there were no statistically significant differences in corneal densitometry between the FS-LASIK group and the FS-LASIK Xtra group in different diameter ranges(all P>0.05).CONCLUSION:There is an increase in internal corneal densitometry during the early postoperative period after FS-LASIK Xtra for correction of high myopia.However,the densitometry values decreased to the level of conventional FS-LASIK at 6mo after surgery,with the most significant changes observed in the superficial central zone.
文摘In this study,the characteristics of heat transfer on an unsteady magnetohydrodynamic(MHD)Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated.The flow was driven by the combined effects of the magnetic field,heat radiation,heat source/sink and chemical reaction.Copper oxide(CuO)and titanium oxide(TiO2)are acknowledged as nanoparticle materials.The nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form solutions.Graphical representations are provided to analyze how changes in physical parameters,such as the magnetic field,heat radiation,heat source/sink and chemical reaction,affect the velocity,temperature and concentration profiles.The computed values of skin friction,heat and mass transfer rates at the surface were tabulated for various sets of input parameters.It is perceived that there is a drop in temperature due to the rise in the heat source/sink and the Prandtl number.It should be noted that a boost in the thermal radiation parameter prompts an increase in temperature.An increase in the Prandtl number,heat source/sink parameter,time and a decrease in the thermal radiation parameter result in an increase in theNusselt number.The computed values of the skin friction,heat andmass transfer rates at the surface were tabulated for various values of the flow parameters.The present results were compared with those of previously published studies andwere found to be in excellent agreement.This research has practical applications in areas such as drug delivery,thermal medicine and cancer treatment.
基金supported by the National Natural Science Foundation of China(Nos.52130407,52174342)Beijing Natural Science Foundation(No.2232044).
文摘In this work,accelerated sintering of Y_(2)O_(3)dispersion strengthened tungsten alloy with a well-regulated structure was achieved by a novel dissolution-precipitation strategy.As indicated,yttrium oxide was firstly dissolved into the lattices of W powder precursor during the thermal plasma synthesis process in a one-step and ultra-fast way,and then homogeneously precipitated out within W grains during sintering.The theoretical calculation reveals that the formation process of Y_(2)O_(3)dispersoids enhanced the driving force of densification by increasing the sintering stress and declining the macroscopic viscosity,resulting in improved diffusion ability for the W skeleton.The microstructural investigation further confirmed the occurrence of mass inter-diffusion at the W-Y_(2)O_(3)interface,which provides a fast diffusion pathway for W atoms,and is responsible for the accelerated densification kinetics.Being sintered at 1600℃ for 1 h,the as-obtained alloy possesses a high relative density of 98.26%,together with a refined grain size of 970 nm for W and 50 nm for intragranular Y_(2)O_(3),respectively.
基金Innovation Team Development Program of the Ministry of Education:Research on the Prevention and Treatment of Cardiovascular Diseases with Traditional Chinese Medicine (IRT-16R54)。
文摘OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSMP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase kinase(MEK)/extracellular regulated protein kinases(ERK) signaling pathway. METHODS: Randomized 70 Sprague-Dawley rats into sham(n = 10) and operation(n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. We randomly divided the operation group rats into the model, ONSMP [including low(L), medium(M), and high(H) dose], and enalapril groups. After the 4-week drug intervention, echocardiography examines the cardiac function and calculates the ratios of the whole/left heart to the rat's body weight. Finally, we observed the degree of myocardial fibrosis by pathological sections, determined myocardium collagen(COL) Ⅰ and COL Ⅲ content by enzyme-linked immunosorbent assay, detected the m RNA levels of COL Ⅰ, COL Ⅲ, α-smooth muscle actin(α-SMA), and c-Fos proto-oncogene(c-Fos) by universal real-time, and detected the protein expression of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ETS-like-1 transcription factor(p-ELK1), p-c-Fos, α-SMA, COL Ⅰ, and COL Ⅲ by Western blot. RESULTS: ONSMP can effectively improve HF rat's cardiac function, decrease cardiac organ coefficient, COL volume fraction, and COL Ⅰ/Ⅲ content, down-regulate the m RNA of COL Ⅰ/Ⅲ, α-SMA and c-Fos, and the protein of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ELK1, c-Fos, COL Ⅰ/Ⅲ, and α-SMA. CONCLUSIONS: ONSMP can effectively reduce myocardial fibrosis in HF rats, and the mechanism may be related to the inhibition of the RAS/RAF/MEK/ERK signaling pathway.
文摘Numerous wireless networks have emerged that can be used for short communication ranges where the infrastructure-based networks may fail because of their installation and cost.One of them is a sensor network with embedded sensors working as the primary nodes,termed Wireless Sensor Networks(WSNs),in which numerous sensors are connected to at least one Base Station(BS).These sensors gather information from the environment and transmit it to a BS or gathering location.WSNs have several challenges,including throughput,energy usage,and network lifetime concerns.Different strategies have been applied to get over these restrictions.Clustering may,therefore,be thought of as the best way to solve such issues.Consequently,it is crucial to analyze effective Cluster Head(CH)selection to maximize efficiency throughput,extend the network lifetime,and minimize energy consumption.This paper proposed an Accelerated Particle Swarm Optimization(APSO)algorithm based on the Low Energy Adaptive Clustering Hierarchy(LEACH),Neighboring Based Energy Efficient Routing(NBEER),Cooperative Energy Efficient Routing(CEER),and Cooperative Relay Neighboring Based Energy Efficient Routing(CR-NBEER)techniques.With the help of APSO in the implementation of the WSN,the main methodology of this article has taken place.The simulation findings in this study demonstrated that the suggested approach uses less energy,with respective energy consumption ranges of 0.1441 to 0.013 for 5 CH,1.003 to 0.0521 for 10 CH,and 0.1734 to 0.0911 for 15 CH.The sending packets ratio was also raised for all three CH selection scenarios,increasing from 659 to 1730.The number of dead nodes likewise dropped for the given combination,falling between 71 and 66.The network lifetime was deemed to have risen based on the results found.A hybrid with a few valuable parameters can further improve the suggested APSO-based protocol.Similar to underwater,WSN can make use of the proposed protocol.The overall results have been evaluated and compared with the existing approaches of sensor networks.
文摘Aim: To study the clinical value of accelerated recovery care in pulmonary rehabilitation of perioperative lung cancer patients. Methods: 98 lung cancer patients undergoing surgery were admitted to our hospital from March 2020 to November 2021 and randomly divided into an observation group and an ACBT (Active Cycle of Breathing Technique) training group. Accelerated recovery care and routine care were respectively used in the perioperative period to compare the nursing effects of the two groups. Results: All perioperative indicators in the observation group were shorter than those in the ACBT training group. The pain scores at different time periods after surgery were lower in the observation group than in the ACBT training group (P 0.05). The improvement in the above indicators was higher in the observation group than in the ACBT training group after nursing care (P Conclusion: Accelerated recovery care during the perioperative period for lung cancer surgery patients showed significant effectiveness.
文摘Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.
文摘Objective: To compare the effectiveness and safety of two surgical methods for lumbar degenerative diseases;the combination of the concept of accelerated rehabilitation with the assistance of Tianji Robotics and the concept of accelerated rehabilitation combined with manual pedicle screw placement assisted by conventional C-arm fluoroscopy. Methods: A retrospective analysis was performed on 70 patients who received the concept of accelerated rehabilitation combined with spinal surgery for lumbar degenerative diseases in Baise People’s Hospital from January 2022 to January 2024. Among them, 35 patients in the robot group received accelerated rehabilitation concept combined with robot-assisted surgery;In the conventional C-arm group, 35 patients received the accelerated rehabilitation concept combined with manual pedicle screw placement assisted by conventional C-arm fluoroscopy. VAS score (preoperative/postoperative), ODI score (preoperative/postoperative), intraoperative bleeding volume, postoperative hospital stay, postoperative complications and the accuracy rate of screw placement were compared between the two groups. Result: There was no statistically significant difference in preoperative VAS scores between the robot group and the conventional C-arm group (6.45 ± 0.82 VS 6.63 ± 0.81, P = 0.6600). The postoperative VAS score of the robot group was better than that of the conventional C-arm group (1.69 ± 0.80 VS 2.45 ± 0.85, P = 0.0000*). There was no statistically significant difference in preoperative ODI scores between the robot group and the conventional C-arm group (32.11 ± 3.18 VS 31.66 ± 2.25, P = 0.4900). The postoperative ODI score of the robot group was better than that of the conventional C-arm group (22.68 ± 1.94 VS 24.57 ± 2.25, P = 0.0000*). The postoperative complications in the robot group were less than those in the conventional C-arm group (2.7778% VS 28.5724%, P = 0.0030*). The intraoperative bleeding in the robot group was lower than that in the conventional C-arm group (320.85 ± 276.28 VS 490.00 ± 395.34, P = 0.0420*). The postoperative hospital stay of the robot group was shorter than that of the conventional C-arm group (10.00 ± 9.32 VS 14.49 ± 7.55, P = 0.0300*). The screw placement inaccuracy score of the robot group was lower than that of the conventional C-arm group (0.17 ± 0.51 VS 1.45 ± 1.46, P = 0.0000*). Conclusion: The combination of the concept of accelerated rehabilitation and Tianji Orthopedic robot-assisted surgery is more effective and safer in posterior lumbar decompression and internal fixation surgery with a screw rod system, and is worthy of promotion and application.
文摘The main aim of the paper is to present (and at the same time offer) a differ-ent perspective for the analysis of the accelerated expansion of the Universe. A perspective that can surely be considered as being “in parallel” to the tradition-al ones, such as those based, for example, on the hypotheses of “Dark Matter” and “Dark Energy”, or better as a “com-possible” perspective, because it is not understood as being “exclusive”. In fact, it is an approach that, when con-firmed by experimental results, always keeps its validity from an “operative” point of view. This is because, in analogy to the traditional perspectives, on the basis of Popper’s Falsification Principle the corresponding “Generative” Logic on which it is based has not the property of the perfect induction. The basic difference then only consists in the fact that the Evolution of the Universe is now modeled by considering the Universe as a Self-Organizing System, which is thus analyzed in the light of the Maximum Ordinality Principle.
基金supported by the National Key Research and Development Program of China(Nos.2022YFA1104600 and 2022YFA1200208)National Natural Science Foundation of China(No.31927801)Key Research and Development Foundation of Zhejiang Province(No.2022C01123).
文摘Optical coherence tomography(OCT)imaging technology has significant advantages in in situ and noninvasive monitoring of biological tissues.However,it still faces the following challenges:including data processing speed,image quality,and improvements in three-dimensional(3D)visualization effects.OCT technology,especially functional imaging techniques like optical coherence tomography angiography(OCTA),requires a long acquisition time and a large data size.Despite the substantial increase in the acquisition speed of swept source optical coherence tomography(SS-OCT),it still poses significant challenges for data processing.Additionally,during in situ acquisition,image artifacts resulting from interface reflections or strong reflections from biological tissues and culturing containers present obstacles to data visualization and further analysis.Firstly,a customized frequency domainfilter with anti-banding suppression parameters was designed to suppress artifact noises.Then,this study proposed a graphics processing unit(GPU)-based real-time data processing pipeline for SS-OCT,achieving a measured line-process rate of 800 kHz for 3D fast and high-quality data visualization.Furthermore,a GPU-based realtime data processing for CC-OCTA was integrated to acquire dynamic information.Moreover,a vascular-like network chip was prepared using extrusion-based 3D printing and sacrificial materials,with sacrificial material being printed at the desired vascular network locations and then removed to form the vascular-like network.OCTA imaging technology was used to monitor the progression of sacrificial material removal and vascular-like network formation.Therefore,GPU-based OCT enables real-time processing and visualization with artifact suppression,making it particularly suitable for in situ noninvasive longitudinal monitoring of 3D bioprinting tissue and vascular-like networks in microfluidic chips.
文摘In this paper, we obtain the optimum plan by discussing a constant-stress accelerated life test (ALT) satisfying the condition (3.3) at k stresses under an exponential distribution.
文摘To design an accelerated method to evaluate thymopentin release from PLGA microspheres in vitro. Microspheres were prepared by double emulsion technique, using poly（lactide-co-glycolide） （PLGA） as carrier. At higher medium temperature （45℃, 50℃ and 55℃）, an accelerated release testing in short time was studied and correlated with the conventional release （37℃） in vitro. The release in vitro of thymopentin from PLGA microspheres at 45 ℃, 50℃ and 55℃ was significantly accelerated （P 〈 0.05）. In particular, at 50℃, an accelerated release （30 h） of the hydrophilic peptide from the PLGA matrix was achieved and correlated well with the conventional release （30 d）. An accelerated release testing in vitro at higher temperature could be used to monitor thymopentin release from PLGA microspheres.
基金National Natural Science Foundation of China(12101204,12261021)Heilongjiang Provincial Natural Science Foundation of China(LH2023A018)Modern Numerical Method Course for Research Program on Teaching Reform of Degree and Postgraduate Education of Heilongjiang University(2024)。
文摘The image reconstruction of electrical impedance tomography(EIT)is a nonlinear and ill-posed inverse problem and the imaging results are easily affected by measurement noise,which needs to be solved by using regularization methods.The iterative regularization method has become a focus of the research due to its ease of implementation.To deal with the ill-posed and ill-conditional problems in image reconstruction,the inexact Newton-Landweber iterative method is considered and the Nesterov’s acceleration strategy is introduced.One Nesterov-type accelerated version of the inexact Newton-Landweber iteration is presented to determine the conductivity distributions inside an object from electrical measurements made on the surface.In order to further optimize the acceleration,both the steepest descent step-length and the minimal error step-length are exploited during the iterative image reconstruction process.Landweber iteration and its accelerated version are also implemented for comparison.All algorithms are terminated by the discrepancy principle.Finally,the performance is tested by reporting numerical simulations to verify the remarkable acceleration efficiency of the proposed method.
文摘Through different dose-rate switching evaluation methods,the radiation-response rules of operational amplifiers are studied when the irradiation dose rate is switched from high to low under different radiation temperatures and total doses. The experimental results indicate that the response characteristics could be affected by the switching total doses, irradiation temperatures,and dose rates individually or together. Accelerated evaluation on the ELDRS can be realized by adopting a proper dose-rate switching method. Meanwhile, the irradiation time can also be reduced. Finally, the mechanisms of the difference between various radiation responses are analyzed.
