Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California...Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California＇s Proposition 36 Program.Methods Background characteristics and problem severity in multiple key life areas were assessed at intake by using Addiction Severity Index,and drug treatment participation,mental health diagnoses and arrests were based on official records.Results Women demonstrated greater problem severity than men in family relationships,health,psychological health,and sexual and physical abuse history.Men on the other hand had greater criminal history,high rates of attention disorder,and psychotic disorder.More men than women were rearrested during the year after treatment admission.Logistic regression analyses showed that for the combined sample,male,young age,cocaine use（relative to methamphetamine）,drug abuse severity,methadone treatment,arrest history and fewer prior treatment history were associated with higher recidivism at 12‐month follow‐up;lower education,cocaine use,and arrest history were related to women＇s recidivism,while young age,outpatient treatment,and arrest history were predictors of men＇s recidivism.Conclusion Although the specific type of mental disorder did not seem to be predictive of recidivism,the high rates of mental health disorder and arrest of this population is problematic.Intervention strategies taking into consideration gender‐specific problems and needs can improve outcomes for both.展开更多
The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of th...The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.展开更多
Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and...Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.展开更多
Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hin...Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and fire...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.展开更多
Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surve...Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.展开更多
BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiologica...BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.展开更多
The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%fem...The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.展开更多
乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工...乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。展开更多
Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenol...Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.展开更多
As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed supp...As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed support as indicated by a white paper issued by the Obama administration in February. Zhang Monan, an associate research fellow with the State Information Center, said the downfall of Fannie Mae and Freddie Mac is the result of abuses of privileges the two companies have enjoyed since their inception.展开更多
This article reviews the cohort study published in the World Journal of Gastroenterology,which reported low rates of Helicobacter pylori(H.pylori)infection among esophageal cancer(EC)patients,coupled with proton pump ...This article reviews the cohort study published in the World Journal of Gastroenterology,which reported low rates of Helicobacter pylori(H.pylori)infection among esophageal cancer(EC)patients,coupled with proton pump inhibitor(PPI)overuse.These findings suggest a potential protective role of H.pylori against EC and indicate a possible association between PPI use and increased cancer risk.In light of these findings,our article examines the complex relationship between H.pylori and esophageal precancerous lesions,exploring the potential underlying mechanisms.We also address growing concerns regarding PPI overuse,including its potential effects on cancer therapy efficacy and the risk of drug interactions.Ultimately,this article highlights the urgent need for further research to evaluate the safety and efficacy of PPIs in cancer patients and to better understand their broader implications.展开更多
Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and ...Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works.In this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions.Using a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex.Persistent treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol exposure.These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.展开更多
What should academic institutions be doing in order to benefit students,the community at large,and society in the new era?Particularly,as computing is impacting all aspects of human society,it also brings many challen...What should academic institutions be doing in order to benefit students,the community at large,and society in the new era?Particularly,as computing is impacting all aspects of human society,it also brings many challenges and opportunities for the academic departments of computer science.Some of these challenges include the increasing impact of software on society,issues involving privacy and data abuse,and ethical issues concerning AI.Towards addressing these challenges,the Korea Advanced Institute of Science and Technology(KAIST)leverages its position as an educator in order to train the future computing workforce to be more aware of these issues.To achieve this goal,KAIST mainly adopts three strategies:Combining science&technology and humanities together;putting academy and industry together;training software experts while making them understand people and the world.展开更多
Objective: Utilizing Mendelian Randomization, this study employs Single Nucleotide Polymorphisms (SNPs) as instrumental variables to explore the causal relationships between bibulosity, smoking, and Primary Open Angle...Objective: Utilizing Mendelian Randomization, this study employs Single Nucleotide Polymorphisms (SNPs) as instrumental variables to explore the causal relationships between bibulosity, smoking, and Primary Open Angle Glaucoma (POAG). Methods: GWAS data for bibulosity, smoking, and POAG were obtained from the Social Science Genetic Association Consortium website and the IEU OpenGWAS Project website, respectively. Using a P-value threshold of −8, a linkage disequilibrium coefficient (r2) of 0.001, and a linkage disequilibrium region width of 10,000 kb, the data were aggregated, resulting in 6 SNPs for bibulosity and 253 SNPs for smoking. Three regression models, MR-Egger, Weighted Median Estimator (WME), and Random-Effects Inverse-Variance Weighted (IVW) were applied to analyze the causal impact of bibulosity and smoking on POAG. Results: The GWAS data for alcohol consumption and smoking were derived from European populations, while the GWAS data for Primary Open-Angle Glaucoma (POAG) were sourced from East Asian populations, with no gender restrictions. Analysis using three different regression models revealed that neither excessive alcohol consumption nor smoking significantly increased the risk of developing POAG. Specifically, the odds ratios with 95% confidence intervals for the alcohol consumption group were 0.854 (0.597 - 1.221) in MR-Egger regression, 0.922 (0.691 - 1.231) in WME regression, and 0.944 (0.711 - 1.252) in IVW regression. For the smoking group, the odds ratios were 1.146 (0.546 - 2.406) in MR-Egger regression, 0.850 (0.653 - 1.111) in WME regression, and 0.939 (0.780 - 1.131) in IVW regression. Given the significant heterogeneity in the SNPs associated with smoking, the focus was primarily on the results from the IVW regression model. Conclusion: Alcohol consumption and smoking are not significant risk factors for the development of POAG.展开更多
Introduction: Gender-based violence is an important public health problem worldwide. The aim of this study was to describe the prevalence, the socio-demographic profile of patients (survivors and perpetrators) and the...Introduction: Gender-based violence is an important public health problem worldwide. The aim of this study was to describe the prevalence, the socio-demographic profile of patients (survivors and perpetrators) and the different types of gender-based violence treated at the Zinder holistic care centre in the Republic of Niger. Method: This was a descriptive cross-sectional study of cases of gender-based violence recorded and managed at the holistic gender-based violence management centre in Zinder (Niger) over the period from 1 January 2022 to 31 December 2023. The data collected were analysed using EPI infos version 7.1 software. Result: During the study period, 515 cases of gender-based violence were recorded. Most of the victims were women and girls (95.15%). Minors accounted for 42.28% of cases. The victims were aged 18 and over in 57.67% (297 cases). Single people accounted for 39.22% of cases. Students accounted for 41.36% of cases. As regards the perpetrators of gender-based violence;men accounted for almost all the cases (95.53%). In 45.44% of cases it was the sexual partner, and in 36.12% of cases, the assault took place in the victim’s home. Five types of gender-based violence were observed: physical violence (121 cases, 23.5%), denial of resources, opportunities or services (148 cases, 28%), rape (117 cases, 22.7%), sexual abuse (64 cases, 12.4%), forced marriage (42 cases, 8%) and psychological/emotional abuse (28 cases, 5.4%). Conclusion: Gender-based violence is common in Niger. The victims were young women, pupils or students, single and unemployed. Efforts still need to be made to increase the reporting of cases of GBV, involve community leaders and provide optimal medical, legal and socio-professional care.展开更多
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), also called ecstasy, is a neurotoxin widely consumed among young people that has increased in recent years because it is a recreational drug, of whi...The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), also called ecstasy, is a neurotoxin widely consumed among young people that has increased in recent years because it is a recreational drug, of which immediate effects are known such as a greater sensation of well-being, extroversion, increased sensory perception. However, its long-term effects have been described very little in the medical literature, including damage to the heart, central nervous system, kidney, etc. One of its little-known effects is hepatotoxicity, of which few cases are known associated with fulminant hepatitis, which is a rapidly deteriorating condition that is generally associated with a syndrome of multiple organ dysfunction and death. Therefore, it is very important to know this type of damage in the short and long term. The following case is of a 39-year-old man who came to our service due to jaundice syndrome and the only history of MDMA consumption, who as the days went by met the criteria for fulminant liver failure, with damage to multiple organs (organ dysfunction syndrome).展开更多
Background: The use of drugs for purposes other than those for which they are meant to be used or in excess amounts. Psychoactive drugs are some of the drugs more commonly abused, also, antibiotics and other medicatio...Background: The use of drugs for purposes other than those for which they are meant to be used or in excess amounts. Psychoactive drugs are some of the drugs more commonly abused, also, antibiotics and other medications too can be misused. Drug abuse and misuse can lead to serious social, medical and emotional harm to the patients, and antibiotic resistance that makes treatment harder are also likely complications. Method: Patients in both male and female wards of the Orthoepaedics Department of ATBUTH, Bauchi were interviewed using a structured questionnaire and their responses were recorded and data were analyzed using the SPSS version 29. Results: A total of 112 patients were interviewed, 76 males and 36 females. Thirty-two (28.6%) patients had taken various kinds of unprescribed medications while on admission: 9 patients had taken unprescribed tramadol, 4 patients had taken codeine, 6 Ampiclox, 5 flagyl and about 8 patients had taken different kinds of traditional medications while on admission. Among the 32 patients, 23 (72%) are aged less than 30 years, 5 (16%) are aged between 30 and 50 years and 4 (12%) are aged above 50 years. Sixteen (50%) had such medications brought to them by relatives or friends, 10 (30%) were given by other patients on admission, 5 (15%) brought or bought the drugs by themselves while 1 (5%) were given by a non-clinical staff of the hospital. Conclusion: Drug misuse and abuse is a very serious, deleterious practice with destructive consequences in its wake, such consequences as drug dependency with all its antecedent effects, antibiotic resistance and difficulties in controlling/managing infections are but a few. So, it’s very important to both educate patients about these terrible practices and cope with the spread of them in our wards and hospitals.展开更多
Social media platforms like Instagram have increasingly become venues for online abuse and offensive comments. This study aimed to enhance user security to create a safe online environment by eliminating hate speech a...Social media platforms like Instagram have increasingly become venues for online abuse and offensive comments. This study aimed to enhance user security to create a safe online environment by eliminating hate speech and abusive language. The proposed system employed a multifaceted approach to comment filtering, incorporating the multi-level filter theory. This involved developing a comprehensive list of words representing various types of offensive language, from slang to explicit abuse. Machine learning models were trained to identify abusive messages through sentiment analysis and contextual understanding. The system categorized comments as positive, negative, or abusive using sentiment analysis algorithms. Employing AI technology, it created a dynamic filtering mechanism that adapted to evolving online language and abusive behavior. Integrated with Instagram while adhering to ethical data collection principles, the platform sought to promote a clean and positive user experience, encouraging users to focus on non-abusive communication. Our machine-learned models, trained on a cleaned Arabic language dataset, demonstrated promising accuracy (75.8%) in classifying Arabic comments, potentially reducing abusive content significantly. This advancement aimed to provide users with a clean and positive online experience.展开更多
基金supported by the NIDA(Grants R01DA15431and P30DA016383)National Key Clinical Disciplines at Shanghai Mental Health Center(Office of Medical Affairs,Ministry of Health,2011-873)
文摘Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California＇s Proposition 36 Program.Methods Background characteristics and problem severity in multiple key life areas were assessed at intake by using Addiction Severity Index,and drug treatment participation,mental health diagnoses and arrests were based on official records.Results Women demonstrated greater problem severity than men in family relationships,health,psychological health,and sexual and physical abuse history.Men on the other hand had greater criminal history,high rates of attention disorder,and psychotic disorder.More men than women were rearrested during the year after treatment admission.Logistic regression analyses showed that for the combined sample,male,young age,cocaine use（relative to methamphetamine）,drug abuse severity,methadone treatment,arrest history and fewer prior treatment history were associated with higher recidivism at 12‐month follow‐up;lower education,cocaine use,and arrest history were related to women＇s recidivism,while young age,outpatient treatment,and arrest history were predictors of men＇s recidivism.Conclusion Although the specific type of mental disorder did not seem to be predictive of recidivism,the high rates of mental health disorder and arrest of this population is problematic.Intervention strategies taking into consideration gender‐specific problems and needs can improve outcomes for both.
文摘The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.
基金funded by a Grant-in-Aid for Scientific Research(JP19K19762,JP 23K10258)from the Japan Society for the Promotion of Science,Japan.
文摘Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.
文摘Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.
文摘Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.
文摘BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.
文摘The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.
文摘乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。
基金supported by Key Research and Development Program of Hubei Province(2022BBA0072)Applied Fundamental Frontier Project of Wuhan Science and Technology Bureau(2020020601012271)。
文摘Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.
文摘As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed support as indicated by a white paper issued by the Obama administration in February. Zhang Monan, an associate research fellow with the State Information Center, said the downfall of Fannie Mae and Freddie Mac is the result of abuses of privileges the two companies have enjoyed since their inception.
文摘This article reviews the cohort study published in the World Journal of Gastroenterology,which reported low rates of Helicobacter pylori(H.pylori)infection among esophageal cancer(EC)patients,coupled with proton pump inhibitor(PPI)overuse.These findings suggest a potential protective role of H.pylori against EC and indicate a possible association between PPI use and increased cancer risk.In light of these findings,our article examines the complex relationship between H.pylori and esophageal precancerous lesions,exploring the potential underlying mechanisms.We also address growing concerns regarding PPI overuse,including its potential effects on cancer therapy efficacy and the risk of drug interactions.Ultimately,this article highlights the urgent need for further research to evaluate the safety and efficacy of PPIs in cancer patients and to better understand their broader implications.
基金STI2030-Major Projects(2022ZD0207600)National Key Research and Development Program of China(2020YFA0113600)+2 种基金National Natural Science Foundation of China(U22A20301,32070955)Key Research and Development Plan of Ningxia(2022BEG01004)Guangdong Basic and Applied Basic Research Foundation(2023B1515040015).
文摘Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works.In this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions.Using a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex.Persistent treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol exposure.These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.
文摘What should academic institutions be doing in order to benefit students,the community at large,and society in the new era?Particularly,as computing is impacting all aspects of human society,it also brings many challenges and opportunities for the academic departments of computer science.Some of these challenges include the increasing impact of software on society,issues involving privacy and data abuse,and ethical issues concerning AI.Towards addressing these challenges,the Korea Advanced Institute of Science and Technology(KAIST)leverages its position as an educator in order to train the future computing workforce to be more aware of these issues.To achieve this goal,KAIST mainly adopts three strategies:Combining science&technology and humanities together;putting academy and industry together;training software experts while making them understand people and the world.
文摘Objective: Utilizing Mendelian Randomization, this study employs Single Nucleotide Polymorphisms (SNPs) as instrumental variables to explore the causal relationships between bibulosity, smoking, and Primary Open Angle Glaucoma (POAG). Methods: GWAS data for bibulosity, smoking, and POAG were obtained from the Social Science Genetic Association Consortium website and the IEU OpenGWAS Project website, respectively. Using a P-value threshold of −8, a linkage disequilibrium coefficient (r2) of 0.001, and a linkage disequilibrium region width of 10,000 kb, the data were aggregated, resulting in 6 SNPs for bibulosity and 253 SNPs for smoking. Three regression models, MR-Egger, Weighted Median Estimator (WME), and Random-Effects Inverse-Variance Weighted (IVW) were applied to analyze the causal impact of bibulosity and smoking on POAG. Results: The GWAS data for alcohol consumption and smoking were derived from European populations, while the GWAS data for Primary Open-Angle Glaucoma (POAG) were sourced from East Asian populations, with no gender restrictions. Analysis using three different regression models revealed that neither excessive alcohol consumption nor smoking significantly increased the risk of developing POAG. Specifically, the odds ratios with 95% confidence intervals for the alcohol consumption group were 0.854 (0.597 - 1.221) in MR-Egger regression, 0.922 (0.691 - 1.231) in WME regression, and 0.944 (0.711 - 1.252) in IVW regression. For the smoking group, the odds ratios were 1.146 (0.546 - 2.406) in MR-Egger regression, 0.850 (0.653 - 1.111) in WME regression, and 0.939 (0.780 - 1.131) in IVW regression. Given the significant heterogeneity in the SNPs associated with smoking, the focus was primarily on the results from the IVW regression model. Conclusion: Alcohol consumption and smoking are not significant risk factors for the development of POAG.
文摘Introduction: Gender-based violence is an important public health problem worldwide. The aim of this study was to describe the prevalence, the socio-demographic profile of patients (survivors and perpetrators) and the different types of gender-based violence treated at the Zinder holistic care centre in the Republic of Niger. Method: This was a descriptive cross-sectional study of cases of gender-based violence recorded and managed at the holistic gender-based violence management centre in Zinder (Niger) over the period from 1 January 2022 to 31 December 2023. The data collected were analysed using EPI infos version 7.1 software. Result: During the study period, 515 cases of gender-based violence were recorded. Most of the victims were women and girls (95.15%). Minors accounted for 42.28% of cases. The victims were aged 18 and over in 57.67% (297 cases). Single people accounted for 39.22% of cases. Students accounted for 41.36% of cases. As regards the perpetrators of gender-based violence;men accounted for almost all the cases (95.53%). In 45.44% of cases it was the sexual partner, and in 36.12% of cases, the assault took place in the victim’s home. Five types of gender-based violence were observed: physical violence (121 cases, 23.5%), denial of resources, opportunities or services (148 cases, 28%), rape (117 cases, 22.7%), sexual abuse (64 cases, 12.4%), forced marriage (42 cases, 8%) and psychological/emotional abuse (28 cases, 5.4%). Conclusion: Gender-based violence is common in Niger. The victims were young women, pupils or students, single and unemployed. Efforts still need to be made to increase the reporting of cases of GBV, involve community leaders and provide optimal medical, legal and socio-professional care.
文摘The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA), also called ecstasy, is a neurotoxin widely consumed among young people that has increased in recent years because it is a recreational drug, of which immediate effects are known such as a greater sensation of well-being, extroversion, increased sensory perception. However, its long-term effects have been described very little in the medical literature, including damage to the heart, central nervous system, kidney, etc. One of its little-known effects is hepatotoxicity, of which few cases are known associated with fulminant hepatitis, which is a rapidly deteriorating condition that is generally associated with a syndrome of multiple organ dysfunction and death. Therefore, it is very important to know this type of damage in the short and long term. The following case is of a 39-year-old man who came to our service due to jaundice syndrome and the only history of MDMA consumption, who as the days went by met the criteria for fulminant liver failure, with damage to multiple organs (organ dysfunction syndrome).
文摘Background: The use of drugs for purposes other than those for which they are meant to be used or in excess amounts. Psychoactive drugs are some of the drugs more commonly abused, also, antibiotics and other medications too can be misused. Drug abuse and misuse can lead to serious social, medical and emotional harm to the patients, and antibiotic resistance that makes treatment harder are also likely complications. Method: Patients in both male and female wards of the Orthoepaedics Department of ATBUTH, Bauchi were interviewed using a structured questionnaire and their responses were recorded and data were analyzed using the SPSS version 29. Results: A total of 112 patients were interviewed, 76 males and 36 females. Thirty-two (28.6%) patients had taken various kinds of unprescribed medications while on admission: 9 patients had taken unprescribed tramadol, 4 patients had taken codeine, 6 Ampiclox, 5 flagyl and about 8 patients had taken different kinds of traditional medications while on admission. Among the 32 patients, 23 (72%) are aged less than 30 years, 5 (16%) are aged between 30 and 50 years and 4 (12%) are aged above 50 years. Sixteen (50%) had such medications brought to them by relatives or friends, 10 (30%) were given by other patients on admission, 5 (15%) brought or bought the drugs by themselves while 1 (5%) were given by a non-clinical staff of the hospital. Conclusion: Drug misuse and abuse is a very serious, deleterious practice with destructive consequences in its wake, such consequences as drug dependency with all its antecedent effects, antibiotic resistance and difficulties in controlling/managing infections are but a few. So, it’s very important to both educate patients about these terrible practices and cope with the spread of them in our wards and hospitals.
文摘Social media platforms like Instagram have increasingly become venues for online abuse and offensive comments. This study aimed to enhance user security to create a safe online environment by eliminating hate speech and abusive language. The proposed system employed a multifaceted approach to comment filtering, incorporating the multi-level filter theory. This involved developing a comprehensive list of words representing various types of offensive language, from slang to explicit abuse. Machine learning models were trained to identify abusive messages through sentiment analysis and contextual understanding. The system categorized comments as positive, negative, or abusive using sentiment analysis algorithms. Employing AI technology, it created a dynamic filtering mechanism that adapted to evolving online language and abusive behavior. Integrated with Instagram while adhering to ethical data collection principles, the platform sought to promote a clean and positive user experience, encouraging users to focus on non-abusive communication. Our machine-learned models, trained on a cleaned Arabic language dataset, demonstrated promising accuracy (75.8%) in classifying Arabic comments, potentially reducing abusive content significantly. This advancement aimed to provide users with a clean and positive online experience.
