Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California...Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California＇s Proposition 36 Program.Methods Background characteristics and problem severity in multiple key life areas were assessed at intake by using Addiction Severity Index,and drug treatment participation,mental health diagnoses and arrests were based on official records.Results Women demonstrated greater problem severity than men in family relationships,health,psychological health,and sexual and physical abuse history.Men on the other hand had greater criminal history,high rates of attention disorder,and psychotic disorder.More men than women were rearrested during the year after treatment admission.Logistic regression analyses showed that for the combined sample,male,young age,cocaine use（relative to methamphetamine）,drug abuse severity,methadone treatment,arrest history and fewer prior treatment history were associated with higher recidivism at 12‐month follow‐up;lower education,cocaine use,and arrest history were related to women＇s recidivism,while young age,outpatient treatment,and arrest history were predictors of men＇s recidivism.Conclusion Although the specific type of mental disorder did not seem to be predictive of recidivism,the high rates of mental health disorder and arrest of this population is problematic.Intervention strategies taking into consideration gender‐specific problems and needs can improve outcomes for both.展开更多
As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed supp...As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed support as indicated by a white paper issued by the Obama administration in February. Zhang Monan, an associate research fellow with the State Information Center, said the downfall of Fannie Mae and Freddie Mac is the result of abuses of privileges the two companies have enjoyed since their inception.展开更多
The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of th...The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.展开更多
Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and...Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.展开更多
Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hin...Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and fire...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.展开更多
BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiologica...BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.展开更多
Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surve...Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.展开更多
The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%fem...The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.展开更多
乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工...乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。展开更多
Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such condit...Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such conditions may go unrecognized This case illustrated severe complications from chronic metformin abuse in a young female with suspected anorexia nervosa,highlighting the need for integrated medical and psychiatric care.To the best of our knowledge,this is only the second case report of multiple organ dysfunction syndrome(MODS)due to metformin toxicity.CASE SUMMARY Here,we reported a rare case of MODS involving four organs due to metformin abuse.A 22-year-old female located in Syria with a history suspicious of anorexia nervosa presented with dehydration,diarrhea,and altered consciousness.Labs revealed mixed high and normal anion gap metabolic acidosis from starvation ketosis and bicarbonate loss.She recovered with supportive care but returned 3 months later in shock with severe acidemia,kidney injury,pancreatitis,and liver dysfunction,consistent with MODS.Further history revealed chronic metformin abuse(up to 3000 mg/day)for weight loss.She recovered fully and began cognitive behavioral therapy.This case underscored the dangers of metformin misuse in eating disorders.CONCLUSION This case highlighted the potentially life-threatening consequences of surreptitious metformin abuse in the context of an underlying eating disorder.Early recognition,thorough history-taking,and multidisciplinary management,including psychiatric support,are essential for recovery and prevention of recurrence.展开更多
Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenol...Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.展开更多
The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been conf...The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been confirmed; the processing methods to analyse spectrum data automatically have been found; It is simple,quick,sensitive and reliable,and can take place of manual operation,It is very useful to screen the familiar toxicants in unkown sample.展开更多
上期的第二个话题“跳槽”是目前普遍存在的现象,对此人们看法不一。有些人认为这在国外并非什么新鲜事,中国人也开始这样做说明人们的思想解放了.打破了过去那种在一个单位干一辈子的传统观念.这是社会的进步。也有人把“跳槽”看做是...上期的第二个话题“跳槽”是目前普遍存在的现象,对此人们看法不一。有些人认为这在国外并非什么新鲜事,中国人也开始这样做说明人们的思想解放了.打破了过去那种在一个单位干一辈子的传统观念.这是社会的进步。也有人把“跳槽”看做是人的私欲膨胀,是对金钱和物质利益的过分追求,不利于一个企业或部门的发展,不应提倡。考生如同意后一种观点就可以说:“I don’t think it is reasonable for aperson to change his(her)job frequently.A展开更多
基金supported by the NIDA(Grants R01DA15431and P30DA016383)National Key Clinical Disciplines at Shanghai Mental Health Center(Office of Medical Affairs,Ministry of Health,2011-873)
文摘Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California＇s Proposition 36 Program.Methods Background characteristics and problem severity in multiple key life areas were assessed at intake by using Addiction Severity Index,and drug treatment participation,mental health diagnoses and arrests were based on official records.Results Women demonstrated greater problem severity than men in family relationships,health,psychological health,and sexual and physical abuse history.Men on the other hand had greater criminal history,high rates of attention disorder,and psychotic disorder.More men than women were rearrested during the year after treatment admission.Logistic regression analyses showed that for the combined sample,male,young age,cocaine use（relative to methamphetamine）,drug abuse severity,methadone treatment,arrest history and fewer prior treatment history were associated with higher recidivism at 12‐month follow‐up;lower education,cocaine use,and arrest history were related to women＇s recidivism,while young age,outpatient treatment,and arrest history were predictors of men＇s recidivism.Conclusion Although the specific type of mental disorder did not seem to be predictive of recidivism,the high rates of mental health disorder and arrest of this population is problematic.Intervention strategies taking into consideration gender‐specific problems and needs can improve outcomes for both.
文摘As U.S. mortgage finance giants-Fannie Mae and Freddie Mac-try to sell their huge backlog of foreclosed homes, they face foreclosures themselves as the U.S. Government contemplates cutting their government-backed support as indicated by a white paper issued by the Obama administration in February. Zhang Monan, an associate research fellow with the State Information Center, said the downfall of Fannie Mae and Freddie Mac is the result of abuses of privileges the two companies have enjoyed since their inception.
文摘The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.
基金funded by a Grant-in-Aid for Scientific Research(JP19K19762,JP 23K10258)from the Japan Society for the Promotion of Science,Japan.
文摘Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.
文摘Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.
文摘BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.
文摘Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.
文摘The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.
文摘乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。
文摘Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such conditions may go unrecognized This case illustrated severe complications from chronic metformin abuse in a young female with suspected anorexia nervosa,highlighting the need for integrated medical and psychiatric care.To the best of our knowledge,this is only the second case report of multiple organ dysfunction syndrome(MODS)due to metformin toxicity.CASE SUMMARY Here,we reported a rare case of MODS involving four organs due to metformin abuse.A 22-year-old female located in Syria with a history suspicious of anorexia nervosa presented with dehydration,diarrhea,and altered consciousness.Labs revealed mixed high and normal anion gap metabolic acidosis from starvation ketosis and bicarbonate loss.She recovered with supportive care but returned 3 months later in shock with severe acidemia,kidney injury,pancreatitis,and liver dysfunction,consistent with MODS.Further history revealed chronic metformin abuse(up to 3000 mg/day)for weight loss.She recovered fully and began cognitive behavioral therapy.This case underscored the dangers of metformin misuse in eating disorders.CONCLUSION This case highlighted the potentially life-threatening consequences of surreptitious metformin abuse in the context of an underlying eating disorder.Early recognition,thorough history-taking,and multidisciplinary management,including psychiatric support,are essential for recovery and prevention of recurrence.
基金supported by Key Research and Development Program of Hubei Province(2022BBA0072)Applied Fundamental Frontier Project of Wuhan Science and Technology Bureau(2020020601012271)。
文摘Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.
文摘The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been confirmed; the processing methods to analyse spectrum data automatically have been found; It is simple,quick,sensitive and reliable,and can take place of manual operation,It is very useful to screen the familiar toxicants in unkown sample.
文摘上期的第二个话题“跳槽”是目前普遍存在的现象,对此人们看法不一。有些人认为这在国外并非什么新鲜事,中国人也开始这样做说明人们的思想解放了.打破了过去那种在一个单位干一辈子的传统观念.这是社会的进步。也有人把“跳槽”看做是人的私欲膨胀,是对金钱和物质利益的过分追求,不利于一个企业或部门的发展,不应提倡。考生如同意后一种观点就可以说:“I don’t think it is reasonable for aperson to change his(her)job frequently.A
