A 1-butyl-3-methylimidazolium chloride-salt aqueous two-phase system was studied on extraction of abused drugs. The effects of sorts of salts, temperature, concentration of salt and drugs on system were investigated s...A 1-butyl-3-methylimidazolium chloride-salt aqueous two-phase system was studied on extraction of abused drugs. The effects of sorts of salts, temperature, concentration of salt and drugs on system were investigated systematically. A satisfactory extraction efficiency of 93% was obtained for papaverine while that of morphine was 65%. The extraction mechanism was primarily discussed.展开更多
I. Introduction This paper discusses child protection in the United States. I will discuss four general topics. The first topic is United States laws on the protection of children from child abuse and neglect. The se...I. Introduction This paper discusses child protection in the United States. I will discuss four general topics. The first topic is United States laws on the protection of children from child abuse and neglect. The second topic is providing care for children who must be removed from their homes. The third is the role of courts in child protection in the United States.展开更多
Background: Prenatal exposure to fentanyl may lead to Neonatal Abstinence Syndrome (NAS), a constellation of symptoms observed when newborns begin withdrawing from addictive substances such as opioids. The use of umbi...Background: Prenatal exposure to fentanyl may lead to Neonatal Abstinence Syndrome (NAS), a constellation of symptoms observed when newborns begin withdrawing from addictive substances such as opioids. The use of umbilical cord tissue segments (UC) for newborn toxicology has been increasing due to its apparent long detection window, sensitivity, and ease of collection. However, very little has been reported in the literature concerning the prevalence of in utero exposure to fentanyl and co-exposure with other commonly abused substances. Specific aim: The specific aims of this retrospective study are twofold. We will report prevalence of neonatal exposure to fentanyl for a nationwide high-risk population using UC submitted to a national reference laboratory for routine forensic toxicology analysis and the co-exposure patterns observed for these fentanyl-exposed neonates. Methods: A secondary analysis was performed using historical data for UC received between January 1, 2020 and December 31, 2020 for routine forensic toxicology analysis. Results: During the study period, our laboratory received 23,104 UC for analysis and 9667 (41.8%) of those UC were positive for at least one drug. The prevalence of fentanyl detection was 1.9% (n = 429). Of these 429 specimens there were 407 UC where both fentanyl and norfentanyl were detected. There were 14 UC where only fentanyl was detected and 8 UC where only norfentanyl was detected. When detected, the median concentrations of fentanyl and norfentanyl were 4029 pg/g (IQR: 1696, 9230 pg/g) and 10,756 pg/mg (IQR: 3925, 25,288 pg/g), respectively. Of the 429 positive fentanyl and/or norfentanyl UC, 33 (7.7%) were only positive for fentanyl and/or norfentanyl. Of the 396 polypositive UC, morphine was the highest co-exposure with 243 UC (56.6%) being positive for both fentanyls and morphine. The second most prevalent co-exposure observed was methamphetamine/amphetamine (n = 173;40.3%) followed by cannabinoids (n = 113;26.3%) and benzoylecgonine (cocaine metabolite;n = 106;24.7%). Conclusions: Nonmedical use of fentanyl is an alarming trend in this country including this maternal demographic reported here. Fentanyl was typically found with other commonly abused substances.展开更多
This study aims to identify details of the psychosocial characteristics of fathers who have abused children as they appear to public health nurses (PHNs). In this study a qualitative descriptive design was applied to ...This study aims to identify details of the psychosocial characteristics of fathers who have abused children as they appear to public health nurses (PHNs). In this study a qualitative descriptive design was applied to the data analysis. Interviewees were 10 public health nurses (PHNs), in charge of maternal and child health services for 5 or more years at public health centers. The study analyzed 13 cases reported in the PHNs interviews. The characteristics of the fathers who had abused children as seen by the PHNs were the psycho-social characteristics of ‘weak suppression and control of impulsiveness’, ‘cognitive dissonance in the fatherhood role’, ‘poor social sensitivity’, ‘unbalanced relationship with other members of the family’ and ‘weak relationships with people around the father’. The father’s impulsiveness and cognitive dissonances in the fatherhood role are associated with weaknesses in the family relationships and social adaptation. Conversely, the weakness in the strength of family relationships and social adaptation affects the father’s ability to control impulsiveness and give rise to the cognitive dissonance in the fatherhood role. These in turn interact to create a negative downward spiral, a steadily worsening situation. The findings of this study suggest the necessity for PHNs to focus on the background to the cognitive dissonance in the fatherhood role and to work to educate and guide the fathers.展开更多
This study aims to identify the support to provide to fathers who have abused children as reported by public health nurses (PHNs). In this study, a qualitative descriptive design was applied to the data analysis. Inte...This study aims to identify the support to provide to fathers who have abused children as reported by public health nurses (PHNs). In this study, a qualitative descriptive design was applied to the data analysis. Interviewees were 10 public health nurses (PHNs) in charge of child abuse services for at least 5 years at public health centers. The study analyzed 13 cases reported in the interviews. Measures to support fathers who abuse their children as suggested by PHNs were classified into direct support to the father, support to other family members, and support to be provided by others involved including related organizations. The direct support to the father includes “gaining an in-depth understanding of the abusive situation and psychological states of those involved”, “refraining from involvement in areas where it is difficult to understand the personality of the father”, and others. Support of other family members includes “understanding the marital relationship and assessing the qualities of the relationship”, “refraining from matters that will involve divorce”, and others. Support to be provided by others including related organizations includes “understanding the value of social exchange and assessment of the ability to create and maintain interpersonal relationships”, “establishing support arrangements to enable intervention when necessary”, and others. The interviews report that PHNs arrange support measures that enable intervention as it becomes required, and that this enables learning about child-abuse preventing activities.展开更多
Today,facial recognition technology is being used in many public places.Recently,China Pharmaceutical University,which is based in Nanjing,east China’s Jiangsu Province,instal ed a facial recognition system in some c...Today,facial recognition technology is being used in many public places.Recently,China Pharmaceutical University,which is based in Nanjing,east China’s Jiangsu Province,instal ed a facial recognition system in some classrooms as a trial run to prevent students from skipping class or asking others to take their place so that they would get the required attendance.展开更多
This study investigated the presence of 11 abused drugs and their metabolites, including amphetamine, methamphetamine (METH), ketamine, ephedrine (EPH), cocaine, benzoylecgonine, methadone, morphine, heroin, codeine, ...This study investigated the presence of 11 abused drugs and their metabolites, including amphetamine, methamphetamine (METH), ketamine, ephedrine (EPH), cocaine, benzoylecgonine, methadone, morphine, heroin, codeine, and methcathinone in the surface water and sediment samples of Beiyunhe River, a typical urban river flowing through Beijing, Tianjin, and Hebei provinces in North China. An analytical method of determining these abused drugs and their metabolites in water and sediment was developed and validated prior to sample collection in the study area. Results showed that METH and EPH were predominant in water and sediment samples. The total drug concentrations ranged from 26.6 to 183.0 ng/L in water and from 2.6 to 32.4 ng/g dry weight in sediment, and the drugs mainly originated from hospitals and sewage treatment plants. The average field-based sediment water distribution coefficients of abused drugs were calculated between 149.3 and 1214.0 L/kg and corrected by organic carbon. Quotient method was used to assess the risks. The findings revealed that these drugs and their metabolites at determined concentrations in water samples will not impair the aquatic ecosystem biologically, but their potential harmful effect on the function of the ecosystem and human health should not be overlooked.展开更多
The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of th...The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.展开更多
Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and...Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.展开更多
Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hin...Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.展开更多
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and fire...BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.展开更多
Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surve...Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.展开更多
BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiologica...BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.展开更多
The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%fem...The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.展开更多
乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工...乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。展开更多
Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such condit...Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such conditions may go unrecognized This case illustrated severe complications from chronic metformin abuse in a young female with suspected anorexia nervosa,highlighting the need for integrated medical and psychiatric care.To the best of our knowledge,this is only the second case report of multiple organ dysfunction syndrome(MODS)due to metformin toxicity.CASE SUMMARY Here,we reported a rare case of MODS involving four organs due to metformin abuse.A 22-year-old female located in Syria with a history suspicious of anorexia nervosa presented with dehydration,diarrhea,and altered consciousness.Labs revealed mixed high and normal anion gap metabolic acidosis from starvation ketosis and bicarbonate loss.She recovered with supportive care but returned 3 months later in shock with severe acidemia,kidney injury,pancreatitis,and liver dysfunction,consistent with MODS.Further history revealed chronic metformin abuse(up to 3000 mg/day)for weight loss.She recovered fully and began cognitive behavioral therapy.This case underscored the dangers of metformin misuse in eating disorders.CONCLUSION This case highlighted the potentially life-threatening consequences of surreptitious metformin abuse in the context of an underlying eating disorder.Early recognition,thorough history-taking,and multidisciplinary management,including psychiatric support,are essential for recovery and prevention of recurrence.展开更多
Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenol...Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.展开更多
The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been conf...The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been confirmed; the processing methods to analyse spectrum data automatically have been found; It is simple,quick,sensitive and reliable,and can take place of manual operation,It is very useful to screen the familiar toxicants in unkown sample.展开更多
基金This study was jointly supported by the National Natural Science Foundation of China(20275003 and 20335010).
文摘A 1-butyl-3-methylimidazolium chloride-salt aqueous two-phase system was studied on extraction of abused drugs. The effects of sorts of salts, temperature, concentration of salt and drugs on system were investigated systematically. A satisfactory extraction efficiency of 93% was obtained for papaverine while that of morphine was 65%. The extraction mechanism was primarily discussed.
文摘I. Introduction This paper discusses child protection in the United States. I will discuss four general topics. The first topic is United States laws on the protection of children from child abuse and neglect. The second topic is providing care for children who must be removed from their homes. The third is the role of courts in child protection in the United States.
文摘Background: Prenatal exposure to fentanyl may lead to Neonatal Abstinence Syndrome (NAS), a constellation of symptoms observed when newborns begin withdrawing from addictive substances such as opioids. The use of umbilical cord tissue segments (UC) for newborn toxicology has been increasing due to its apparent long detection window, sensitivity, and ease of collection. However, very little has been reported in the literature concerning the prevalence of in utero exposure to fentanyl and co-exposure with other commonly abused substances. Specific aim: The specific aims of this retrospective study are twofold. We will report prevalence of neonatal exposure to fentanyl for a nationwide high-risk population using UC submitted to a national reference laboratory for routine forensic toxicology analysis and the co-exposure patterns observed for these fentanyl-exposed neonates. Methods: A secondary analysis was performed using historical data for UC received between January 1, 2020 and December 31, 2020 for routine forensic toxicology analysis. Results: During the study period, our laboratory received 23,104 UC for analysis and 9667 (41.8%) of those UC were positive for at least one drug. The prevalence of fentanyl detection was 1.9% (n = 429). Of these 429 specimens there were 407 UC where both fentanyl and norfentanyl were detected. There were 14 UC where only fentanyl was detected and 8 UC where only norfentanyl was detected. When detected, the median concentrations of fentanyl and norfentanyl were 4029 pg/g (IQR: 1696, 9230 pg/g) and 10,756 pg/mg (IQR: 3925, 25,288 pg/g), respectively. Of the 429 positive fentanyl and/or norfentanyl UC, 33 (7.7%) were only positive for fentanyl and/or norfentanyl. Of the 396 polypositive UC, morphine was the highest co-exposure with 243 UC (56.6%) being positive for both fentanyls and morphine. The second most prevalent co-exposure observed was methamphetamine/amphetamine (n = 173;40.3%) followed by cannabinoids (n = 113;26.3%) and benzoylecgonine (cocaine metabolite;n = 106;24.7%). Conclusions: Nonmedical use of fentanyl is an alarming trend in this country including this maternal demographic reported here. Fentanyl was typically found with other commonly abused substances.
文摘This study aims to identify details of the psychosocial characteristics of fathers who have abused children as they appear to public health nurses (PHNs). In this study a qualitative descriptive design was applied to the data analysis. Interviewees were 10 public health nurses (PHNs), in charge of maternal and child health services for 5 or more years at public health centers. The study analyzed 13 cases reported in the PHNs interviews. The characteristics of the fathers who had abused children as seen by the PHNs were the psycho-social characteristics of ‘weak suppression and control of impulsiveness’, ‘cognitive dissonance in the fatherhood role’, ‘poor social sensitivity’, ‘unbalanced relationship with other members of the family’ and ‘weak relationships with people around the father’. The father’s impulsiveness and cognitive dissonances in the fatherhood role are associated with weaknesses in the family relationships and social adaptation. Conversely, the weakness in the strength of family relationships and social adaptation affects the father’s ability to control impulsiveness and give rise to the cognitive dissonance in the fatherhood role. These in turn interact to create a negative downward spiral, a steadily worsening situation. The findings of this study suggest the necessity for PHNs to focus on the background to the cognitive dissonance in the fatherhood role and to work to educate and guide the fathers.
文摘This study aims to identify the support to provide to fathers who have abused children as reported by public health nurses (PHNs). In this study, a qualitative descriptive design was applied to the data analysis. Interviewees were 10 public health nurses (PHNs) in charge of child abuse services for at least 5 years at public health centers. The study analyzed 13 cases reported in the interviews. Measures to support fathers who abuse their children as suggested by PHNs were classified into direct support to the father, support to other family members, and support to be provided by others involved including related organizations. The direct support to the father includes “gaining an in-depth understanding of the abusive situation and psychological states of those involved”, “refraining from involvement in areas where it is difficult to understand the personality of the father”, and others. Support of other family members includes “understanding the marital relationship and assessing the qualities of the relationship”, “refraining from matters that will involve divorce”, and others. Support to be provided by others including related organizations includes “understanding the value of social exchange and assessment of the ability to create and maintain interpersonal relationships”, “establishing support arrangements to enable intervention when necessary”, and others. The interviews report that PHNs arrange support measures that enable intervention as it becomes required, and that this enables learning about child-abuse preventing activities.
文摘Today,facial recognition technology is being used in many public places.Recently,China Pharmaceutical University,which is based in Nanjing,east China’s Jiangsu Province,instal ed a facial recognition system in some classrooms as a trial run to prevent students from skipping class or asking others to take their place so that they would get the required attendance.
基金funded by the Major Science and Technology Program for Water Pollution Control and Treatment (No. 2017ZX07302001)National Natural Science Foundation of China (Grant No. 41673120).
文摘This study investigated the presence of 11 abused drugs and their metabolites, including amphetamine, methamphetamine (METH), ketamine, ephedrine (EPH), cocaine, benzoylecgonine, methadone, morphine, heroin, codeine, and methcathinone in the surface water and sediment samples of Beiyunhe River, a typical urban river flowing through Beijing, Tianjin, and Hebei provinces in North China. An analytical method of determining these abused drugs and their metabolites in water and sediment was developed and validated prior to sample collection in the study area. Results showed that METH and EPH were predominant in water and sediment samples. The total drug concentrations ranged from 26.6 to 183.0 ng/L in water and from 2.6 to 32.4 ng/g dry weight in sediment, and the drugs mainly originated from hospitals and sewage treatment plants. The average field-based sediment water distribution coefficients of abused drugs were calculated between 149.3 and 1214.0 L/kg and corrected by organic carbon. Quotient method was used to assess the risks. The findings revealed that these drugs and their metabolites at determined concentrations in water samples will not impair the aquatic ecosystem biologically, but their potential harmful effect on the function of the ecosystem and human health should not be overlooked.
文摘The article seeks to present spiritual abuse and the untold harm it causes.While cognisant of the fact that this kind of abuse can occur within any faith context,the focus of this study is the possible existence of the phenomenon within certain Christian religious groups,such as lay associations and movements,although it can take place within other more formal ecclesial structures such as dioceses,parishes,and institutes of consecrated life,too.The features of spiritual abuse are outlined,together with the urgency concerning an increased awareness about it.The Catholic Church,at a universal level,is in the process of delving more deeply into the phenomenon as it seeks to prepare useful guidelines with the aim of safeguarding the vulnerable who may be potential victims of this kind of abuse.The subtlety of the latter is coupled with the fact that it may be conveniently disguised under the cover of spiritual input,practices and prayer,as well as personal and communal spiritual relationships.
基金funded by a Grant-in-Aid for Scientific Research(JP19K19762,JP 23K10258)from the Japan Society for the Promotion of Science,Japan.
文摘Objectives:To evaluate the occurrence of depression and its related factors among public health nurses(PHNs)engaged in child neglect-related abuse cases.Methods:A cross-sectional study of PHNs involved in maternal and child health or child and family welfare,and engaged in cases of child neglect-related abuse was conducted from January to March 2023 in all municipalities of 13 prefectures selected from Japan's seven regions,considering geographic diversity and major urban areas.The Patient Health Questionnaire-2 was used to screen for depression.Statistical analyses included the Chi-square test,Mann-Whitney U test,and logistic regression analysis.Results:A total of 359 provided valid responses.Among them,11.4%screened positive for depression.Significant individual factors related depression were management-stage nurses(OR=6.27,95%CI:1.63-24.18),no disability welfare experience(OR=3.49,95%CI:1.05-11.55),being assignment of highrisk cases within the past year(OR=8.28,95%CI:2.07-33.08),and lower work control(OR=0.53,95%CI:0.32-0.86).Workplace environment factors were lower perceptions and relationships within the workplace(OR=0.43,95%CI:0.29-0.65)and perceiving manpower as not secured(OR=9.07,95%CI:1.17-70.40),Conclusions:Mental health measures for PHNs should include workload management and reduced burdens through workforce enhancement,attention to burdens on managerial PHNs,promoting communication and mutual support,and opportunities to engage in disability welfare work.
文摘Heart failure(HF)is a growing public health concern,with an increasing inci-dence among younger populations.Traditionally,HF was considered a condition primarily affecting the elderly,but of late,emerging evidence hints at a rapidly rising HF incidence in youth in the past 2 decades.HF in youth has been linked to a complex interaction between emerging risk factors,such as metabolic syndrome,environmental exposures,genetic predispositions,and lifestyle behaviors.This review examines these evolving determinants,including substance abuse,autoim-mune diseases,and the long-term cardiovascular effects of coronavirus disease 2019,which disproportionately affect younger individuals.Through a compre-hensive analysis,the study highlights the importance of early detection,targeted prevention strategies,and multidisciplinary management approaches to address this alarming trend.Promoting awareness and integrating age-specific interven-tions could significantly reduce the burden of HF and improve long-term out-comes among younger populations.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm injury.Our under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is limited.AIM To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ transplantation.METHODS Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research database.Crude rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing database.RESULTS Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm injury.AAPC in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm injury.There was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of death.COVID-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two causes.CONCLUSION Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.
文摘Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.
文摘BACKGROUND Several conditions may present with acute neurological symptoms,thus mimicking the presentation of stroke.Although the underlying disorder can be diagnosed after careful medical,neurological,and radiological examinations,a few conditions,such as Wernicke encephalopathy(WE),may present a particular diagnostic difficulty.WE is a neurological disorder caused by deficiency of thiamine(B1 vitamin),most often resulting from alcoholism,malnutrition,hyperemesis gravidarum or bariatric surgery.The diagnosis of WE in a certain historical,clinical setting is easily suggested,but in a few cases presenting with acute neurological deficits,it can be particularly challenging.CASE SUMMARY We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities,dizziness and a confusional state,which had lasted for approximately 30 minutes.The patient had a similar episode of a confusional state approximately two months earlier;at that time,a transient ischemic attack was suspected and he was started on aspirin.The initial clinical evaluation and imaging findings were unremarkable for stroke,but the patient’s symptoms,history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE.Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.CONCLUSION Through this case report,we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke,especially when the presentation is atypical or when risk factors for thiamine deficiency are present.Since intravenous thiamine significantly improves outcomes,delayed recognition and treatment in some cases might be deleterious.
文摘The study examined work engagement and coping strategies in the relationship between abusive supervision and helping behaviors among hospitality employees.Participants were 386 frontline hospitality employees(50.8%females;38.9%with 1–5 years of experience;78.3%in the 18–40 age range).They self-reported coping strategies,abusive supervision,work engagement,and helping behaviors.Structural equation model results showed that abusive supervision to be associated with lower employee helping behaviors.Work engagement was higher with employees’helping behaviors.Engaged employees would unleash helping behaviors.Work engagement mediated the relationship between abusive supervision and helping behaviors,lowering the abusive supervision risk.Finally,avoidance of contact exacerbated the moderated abusive supervision–work engagement relationship for lower work engagement,while support-seeking and reframing exerted no moderation role.Findings suggest that avoiding an immediate supervisor exacerbates abusive supervision.Hence,applying behavior-based interviews when hiring supervisors would be of strategic advantage to employees’productivity.
文摘乳腺健康对于女性来说至关重要,它不仅关系到女性的生理健康,还直接影响到女性的生活质量。近年来,随着医疗技术的不断进步,自动乳腺容积超声成像技术(Automated Breast Ultra Sound,简称ABUS)以其独特的优势,成为守护乳腺健康的重要工具。本文将详细介绍乳腺的重要性、乳腺疾病的常见类型、传统乳腺超声技术的局限性以及ABUS技术的原理、优势和应用,旨在提高公众对乳腺健康的重视,并了解如何通过先进的超声技术来守护乳腺健康。
文摘Metformin is generally safe but can cause lactic acidosis and rarely organ dysfunction during overdose.Misuse for weight loss,especially in undiagnosed eating disorder,is concerning.In stigmatized settings such conditions may go unrecognized This case illustrated severe complications from chronic metformin abuse in a young female with suspected anorexia nervosa,highlighting the need for integrated medical and psychiatric care.To the best of our knowledge,this is only the second case report of multiple organ dysfunction syndrome(MODS)due to metformin toxicity.CASE SUMMARY Here,we reported a rare case of MODS involving four organs due to metformin abuse.A 22-year-old female located in Syria with a history suspicious of anorexia nervosa presented with dehydration,diarrhea,and altered consciousness.Labs revealed mixed high and normal anion gap metabolic acidosis from starvation ketosis and bicarbonate loss.She recovered with supportive care but returned 3 months later in shock with severe acidemia,kidney injury,pancreatitis,and liver dysfunction,consistent with MODS.Further history revealed chronic metformin abuse(up to 3000 mg/day)for weight loss.She recovered fully and began cognitive behavioral therapy.This case underscored the dangers of metformin misuse in eating disorders.CONCLUSION This case highlighted the potentially life-threatening consequences of surreptitious metformin abuse in the context of an underlying eating disorder.Early recognition,thorough history-taking,and multidisciplinary management,including psychiatric support,are essential for recovery and prevention of recurrence.
基金supported by Key Research and Development Program of Hubei Province(2022BBA0072)Applied Fundamental Frontier Project of Wuhan Science and Technology Bureau(2020020601012271)。
文摘Rape bee pollen has attracted increasing interests for its excellent protective effect against chemicalinduced liver injury owing to its abundant polyphenols.This study aims to analyze the types and contents of phenolamides(seldom concerned)in rape bee pollen and their protective mechanism on alcoholic liver disease(ALD).Different from the previous finding that flavonoids are dominant polyphenols in bee pollen polyphenolic extract,our results demonstrated that there are only three flavonoids but 24 phenolamides in the as-prepared rape bee pollen phenolic extract(PPE).In addition,PPE was found to significantly improve the viability(from 54.9%to 84.1%,89.2%,and 94.0%)of alcohol-induced AML12 cells and alleviate alcoholinduced cell apoptosis(from 28.5%to 22.89%,22.0%,and 17.4%).To dissect the underlying mechanism for the protective effect of PPE against ALD,the molecular pathway was identified by RNA-Seq analysis.Transcriptome data revealed that PPE may protect against ALD by decreasing inflammation,cholesterol,and fatty acid synthesis(P<0.05).The National Institute on Alcohol Abuse and Alcoholism(NIAAA)model was used to further evaluate the hepatoprotective effect of PPE in vivo,and the results validated that PPE could alleviate liver injury and hepatic steatosis(from 22.7%to 11.5%and 10.9%)induced by alcohol.As the dominant polyphenols in PPE,phenolamides can be a class of valuable polyphenolic compounds in bee pollen with the potential to alleviate ALD.
文摘The spectrum user’s librarys containing 1533 familiar toxicants have been built; A method with high separability and sensitivity has been found,The RT and the detection limit of 210 familiar abuse drugs has been confirmed; the processing methods to analyse spectrum data automatically have been found; It is simple,quick,sensitive and reliable,and can take place of manual operation,It is very useful to screen the familiar toxicants in unkown sample.
