The study of aging,particularly in the context of the gut,is a rapidly advancing field with significant implications for understanding the mechanisms underlying age-related diseases.The gut,as a major digestive and im...The study of aging,particularly in the context of the gut,is a rapidly advancing field with significant implications for understanding the mechanisms underlying age-related diseases.The gut,as a major digestive and immune organ,undergoes notable functional and structural changes with age.These changes include impaired nutrient absorption,altered gut microbiota,increased permeability,and heightened inflammation.Such disruptions can contribute to various age-associated pathologies,including metabolic disorders and inflammatory diseases(Calleja-Conde et al.2021).Investigating the molecular and genetic underpinnings of gut aging is crucial for identifying potential therapeutic targets that could ameliorate age-related declines in gut function and overall health.The study by Sun et al.(2024)contributes to this understanding by examining the role of Lipase H(Liph)and its Drosophila ortholog,CG6295,in gut aging,revealing novel insights into how lipid metabolism influences intestinal health and lifespan.展开更多
基金the National Key R&D Program of China(2023YFC3603300)the National Natural Science Foundation of China(82171558)+1 种基金Yunnan Fundamental Research Projects(202305AH340006,202201AS070038)the Pioneer Hundred Talents Program of the Chinese Academy of Sciences and the Yunnan Revitalization Talent Support Program Young Talent Project.
文摘The study of aging,particularly in the context of the gut,is a rapidly advancing field with significant implications for understanding the mechanisms underlying age-related diseases.The gut,as a major digestive and immune organ,undergoes notable functional and structural changes with age.These changes include impaired nutrient absorption,altered gut microbiota,increased permeability,and heightened inflammation.Such disruptions can contribute to various age-associated pathologies,including metabolic disorders and inflammatory diseases(Calleja-Conde et al.2021).Investigating the molecular and genetic underpinnings of gut aging is crucial for identifying potential therapeutic targets that could ameliorate age-related declines in gut function and overall health.The study by Sun et al.(2024)contributes to this understanding by examining the role of Lipase H(Liph)and its Drosophila ortholog,CG6295,in gut aging,revealing novel insights into how lipid metabolism influences intestinal health and lifespan.
