Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc...Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc sulfate(ZnSO_(4))to be oyster peptide-zinc chelates(OPZs)that offer potential as a valuable zinc supplement.The complexation of zinc with oyster peptides induces conformational changes in the peptides,altering their overall spatial arrangement.This could potentially impact their functions and properties.OPZs have demonstrated enhanced physical and gastrointestinal stability,as they are resistant to digestion by pepsin and trypsin.The research has shown that OPZs can modulate the expression of key proteins involved in zinc binding(MT1),peptide transport(PePT1),and zinc transport(ZIP4 and ZnT1)in enterocytes.By regulating the proteins expression,OPZs have the potential to affect zinc absorption and homeostasis.Furthermore,OPZs have been found to enhance zinc absorption through dual pathways compared to the single pathway of inorganic zinc.Additionally,they have the potential to improve zinc bioaccessibility and bioavailability,meaning they can make zinc more easily absorbed by the body and readily available for use.展开更多
A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and el...A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion（ADME）,展开更多
基金supported by the National Natural Science Foundation of China(32130085)the National Natural Science Foundation Youth Fund Project of China(32202021).
文摘Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc sulfate(ZnSO_(4))to be oyster peptide-zinc chelates(OPZs)that offer potential as a valuable zinc supplement.The complexation of zinc with oyster peptides induces conformational changes in the peptides,altering their overall spatial arrangement.This could potentially impact their functions and properties.OPZs have demonstrated enhanced physical and gastrointestinal stability,as they are resistant to digestion by pepsin and trypsin.The research has shown that OPZs can modulate the expression of key proteins involved in zinc binding(MT1),peptide transport(PePT1),and zinc transport(ZIP4 and ZnT1)in enterocytes.By regulating the proteins expression,OPZs have the potential to affect zinc absorption and homeostasis.Furthermore,OPZs have been found to enhance zinc absorption through dual pathways compared to the single pathway of inorganic zinc.Additionally,they have the potential to improve zinc bioaccessibility and bioavailability,meaning they can make zinc more easily absorbed by the body and readily available for use.
基金supported by the Natural Science Foundation ofChina(Nos.30873159 and 31271405)
文摘A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion（ADME）,
