Objective To compare the efficacy of treating obese patients with abnormity of lipids and serum leptin by dilatational wave or continuous wave of electroacupuncture combined with thunder-fire moxibustion in order to p...Objective To compare the efficacy of treating obese patients with abnormity of lipids and serum leptin by dilatational wave or continuous wave of electroacupuncture combined with thunder-fire moxibustion in order to provide a clinical basis for selecting wave types of electroacupuncture for different patterns of obesity. Methods Sixty obese patients with abnormal lipids and serum leptin were randomly divided into a dilatational wave group and a continuous wave group via random number table, with 30 cases in each group. They were divided by TCM differentiation into three types： stomachintestine excessive heat, weakness of the spleen-stomach and spleen-kidney yang deficiency, treated by electroacupuncture on Tianshu （天枢 ST 25）, Daheng （大横 SP 15）, Zusanli （足三里ST 36）, Shangjuxu （上巨虚 ST 37）, Fanglong （丰隆 ST 40）, Yinlingquan （阴陵泉 SP 9）, Quchi （曲池 LI 11）, Zhigou （支沟 TE 6） and Hegu （合谷 LI 4） along with thunder-fire moxibustion. The frequency of electro-acupuncture in the dilatational wave group and the continuous wave group was 2 Hz/100 Hz and 2 Hz, respectively. Patients in the two groups were treated once a day, six times a week. The treatment lasted for 4 weeks with 3-month follow-up. Body mass and body fat percentage before and after the treatment, as well as during the follow-up, were compared. The effectiveness rates in the two groups were compared, and the efficacy statistics of patients with different TCM patterns in the dilatational wave group were also analyzed. Lipid levels of the patients in two groups before and after the treatment were measured with an automatic biochemical analyzer, and serum leptin levels were detected with flow cytometry system. Results After the treatment, the patients＇ blood lipids, serum leptin levels, body mass and body fat percentage were effectively reduced in the two groups; three months＇ follow-up witnessed continuous decline of obesity indicators （P〈0.01 or P〈0.05）, and patients in the dilatat-ional wave group improved more significantly than those in continuous wave group （P〈0.05 or P〈0.01）. The efficacy in the dilatational wave group was superior to that in the continuous wave group （P〈0.01）. The best efficacy could be found among patients with weakness of the spleen and the stomach in the dilatational wave group. Conclusion Efficacy of treating obese patients with abnormity of lipids and serum leptin by electro-acupuncture combined with thunder-fire moxibustion in the dilatational wave group was significantly better than that of the continuous wave group, and efficacy for obese patients with weakness of the spleen and the stomach was superior to that of those with stomach-intestine excessive heat and spleen-kidney yang deficiency.展开更多
Manganese abnormity has been observed in the Holocene sediments of the mud area of Bohai Sea. On the basis of grain size, chemical composition, heavy mineral content and accelerator mass spectrometry （AMS） 14C datin...Manganese abnormity has been observed in the Holocene sediments of the mud area of Bohai Sea. On the basis of grain size, chemical composition, heavy mineral content and accelerator mass spectrometry （AMS） 14C dating of foraminifer, relationships between manganese abnormity and sedimentation rates, material source, hydrodynamic conditions are probed. Manganese abnormity occurred during the Middle Holocene when sea level and sedimentation rates were higher than those at present. Sedimentary hiatus was not observed when material sources and hydrodynamic conditions were quite similar. Compared with the former period, the latter period showed a decrease in reduction environment and an inclination toward oxidation environment with high manganese content, whereas provenance and hydrodynamic conditions showed only a slight change. From the above observations, it can be concluded that correlation among manganese abnormity, material source, and hydrodynamic conditions is not obvious. Redox environment seems to be the key factor for manganese enrichment, which is mainly related to marine authigenic process.展开更多
As an achievement of the cooperation with Japan,TOA electromagnetic observation station was established with an 800 m borehole antenna and put into service in 1992 in Dali,Yunnan province,China.Li Wuxian et al.(2003)s...As an achievement of the cooperation with Japan,TOA electromagnetic observation station was established with an 800 m borehole antenna and put into service in 1992 in Dali,Yunnan province,China.Li Wuxian et al.(2003)summarized main anomalous variation characters by analyzing 23 strong earthquakes with magnitudes more than 5.0 recorded in the first ten years.This work mainly presents the electromagnetic changes prior to the last Mojiang MS5.9 earthquake on September 8,2018.First of all,the initial weak signals appeared in two ULF channels out of three observing channels(CH10.01-0.10 Hz,CH20.1-1.0 Hz and CH31-9 kHz)on May 30,2018 at Dali TOA electromagnetic station.The information recorded was characterized by wave-like changes with magnitudes of ACH1≤0.26 mV in CH1 and pulse-like impulses of ACH2≤0.6 mV in CH2,respectively.Then,abnormal information gradually enhanced either in magnitudes or in occurrence frequency.Pulse-like signals were full of lattices of recording paper for CH2 during June24-25 and slopped over the recording paper during June 28-29,with the magnitudes being greater than or equal to 10 mV.At the same time,the clear wave-like signals also appeared in CH1 with a maximum magnitude of^0.6 mV on June 28 and reached its climax.From then on,the information started to decrease from the end of July and only weak signals occasionally occurred till the end of August 2018,when obvious anomaly was recorded again in two ULF channels with maximum magnitudes of ACH1~0.2 mV and ACH2~0.3 mV respectively.Generally,these signals did not appear continuously but group by group and accumulated intensively only in ULF band instead of VLF band during the total period.10 days later,the Mojiang MS5.9 earthquake occurred on September 8,2018,300 km away from Dali TOA station,and a coseismic response was also recorded at this time.Thus,these ULF electromagnetic abnormities could be probably attributed to the Mojiang event.展开更多
A framework that integrates planning,monitoring and replanning techniques is proposed.It can devise the best solution based on the current state according to specific objectives and properly deal with the influence of...A framework that integrates planning,monitoring and replanning techniques is proposed.It can devise the best solution based on the current state according to specific objectives and properly deal with the influence of abnormity on the plan execution.The framework consists of three parts:the hierarchical task network(HTN)planner based on Monte Carlo tree search(MCTS),hybrid plan monitoring based on forward and backward and norm-based replanning method selection.The HTN planner based on MCTS selects the optimal method for HTN compound task through pre-exploration.Based on specific objectives,it can identify the best solution to the current problem.The hybrid plan monitoring has the capability to detect the influence of abnormity on the effect of an executed action and the premise of an unexecuted action,thus trigger the replanning.The norm-based replanning selection method can measure the difference between the expected state and the actual state,and then select the best replanning algorithm.The experimental results reveal that our method can effectively deal with the influence of abnormity on the implementation of the plan and achieve the target task in an optimal way.展开更多
The Sujiatun seismic station is a local professional seismic observation station in the city of Shenyang, Liaoning province. Electromagnetic radiations observation apparatus, of the type EMAOS-L, are used there. In th...The Sujiatun seismic station is a local professional seismic observation station in the city of Shenyang, Liaoning province. Electromagnetic radiations observation apparatus, of the type EMAOS-L, are used there. In this paper, four years observation data and observed earthquakes with M_S≥4.0 were collected in the Sujiatun observation station. The characteristics of electromagnetic radiation abnormities and earthquakes are analyzed from such aspects as capabilities of the apparatus used, tectonic structure, origins of electromagnetic radiations and so on. By analysis, precursor abnormities observed at this observation station are remarkable. The electric and magnetic abnormities are with good synchronism and the abnormities can respond better to the earthquakes with the epicenter distance being less than 20km and taking place in the upper crust. At the same time, for earthquakes with large magnitudes, the variation of precursor abnormities shows a periodic diurnal variation.展开更多
A high-precision automatic state monitoring and abnormity alarm technique is proposed to solve the process improvement issues of fiber-optic coil winding and splicing. Industrial cameras are used to capture optical an...A high-precision automatic state monitoring and abnormity alarm technique is proposed to solve the process improvement issues of fiber-optic coil winding and splicing. Industrial cameras are used to capture optical and hot images during the assembly of optical components of a fiber-optic gyroscope. A line and contour analysis technique is used to detect abnormal winding. By analyzing the intensity distribution of transmitted light, the graph cut model and multivariate Gaussian mixture model are used to detect and segment the splicing defects. The practical applications indicate the correctness and accuracy of our vision-based technique.展开更多
The Financial Technology(FinTech)sector has witnessed rapid growth,resulting in increasingly complex and high-volume digital transactions.Although this expansion improves efficiency and accessibility,it also introduce...The Financial Technology(FinTech)sector has witnessed rapid growth,resulting in increasingly complex and high-volume digital transactions.Although this expansion improves efficiency and accessibility,it also introduces significant vulnerabilities,including fraud,money laundering,and market manipulation.Traditional anomaly detection techniques often fail to capture the relational and dynamic characteristics of financial data.Graph Neural Networks(GNNs),capable of modeling intricate interdependencies among entities,have emerged as a powerful framework for detecting subtle and sophisticated anomalies.However,the high-dimensionality and inherent noise of FinTech datasets demand robust feature selection strategies to improve model scalability,performance,and interpretability.This paper presents a comprehensive survey of GNN-based approaches for anomaly detection in FinTech,with an emphasis on the synergistic role of feature selection.We examine the theoretical foundations of GNNs,review state-of-the-art feature selection techniques,analyze their integration with GNNs,and categorize prevalent anomaly types in FinTech applications.In addition,we discuss practical implementation challenges,highlight representative case studies,and propose future research directions to advance the field of graph-based anomaly detection in financial systems.展开更多
BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifyi...BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifying the prevalence of these abnormalities and understanding their predictors is vital for optimizing pretransplant risk stratification and improving post-transplant outcomes.AIM To determine the prevalence of left ventricular hypertrophy(LVH),left ventricular systolic dysfunction(LVSD),diastolic dysfunction(DD),pulmonary hypertension(PH),and their predictors,and to assess their impact on graft function in pre-transplant candidates.METHODS The study included all successful transplant candidates older than 14 who had a baseline echocardiogram.Binary logistic regression models were constructed to identify factors associated with LVH,LVSD,DD,and PH.RESULTS Out of 259 patients,LVH was present in 64%(166),12%(31)had LVSD,27.5%(71)had DD,and 66(25.5%)had PH.Independent predictors of LVH included male gender[odds ratio(OR):2.51;95%CI:1.17-5.41 P=0.02],PH(OR=2.07;95%CI:1.11-3.86;P=0.02),DD(OR:2.47;95%CI:1.29-4.73;P=0.006),and dyslipidemia(OR=1.94;95%CI:1.07-3.53;P=0.03).Predictors for LVSD included patients with DD(OR=3.3,95%CI:1.41-7.81;P=0.006)and a family history of coronary artery disease(OR=4.50,95%CI:1.33-15.20;P=0.015).Peritoneal dialysis was an independent predictor for DD(OR=10.03;95%CI:1.71-58.94,P=0.011).The presence of LVH(OR=3.32,95%CI:1.05-10.55,P=0.04)and mild to moderate or moderate to severe mitral regurgitation(OR=4.63,95%CI:1.45-14.78,P=0.01)were significant factors associated with PH.These abnormalities had no significant impact on estimated glomerular filtration at discharge,6 months,1 year,or 2 years post-transplant.CONCLUSION Significant echocardiographic abnormalities persist in a potential transplant candidate despite cardiac clearance,although they don’t affect future graft function.Understanding the risk factors associated with these abnormalities may help clinicians address these factors pre-and post-transplant to achieve better outcomes.展开更多
Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 199...Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 1993.TM typically spares the foveal center,is asymptomatic,and is often detected incidentally during routine ophthalmic examinations.Through literature search,we did not identify racial or regional differences in TM.It predominantly affects children,with an estimated prevalence of 2 per 100000 in individuals under 16 ages[3].While previous reports have focused on pediatric and adult populations,this study presents four cases of TM in preterm infants.展开更多
Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nai...Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.展开更多
This study analyzed data from the DEMETER satellite,collected 10 days before the Wenchuan M_(s)8.0 earthquake on May 12,2008.The time-frequency power spectrum of the data indicated a narrow-band radiative destabilizat...This study analyzed data from the DEMETER satellite,collected 10 days before the Wenchuan M_(s)8.0 earthquake on May 12,2008.The time-frequency power spectrum of the data indicated a narrow-band radiative destabilization(below the cut-off frequency)6 days prior to the earthquake.A significant anomaly in the Ez component was observed 3 days before the event.However,similar phenomena were found over aseismic regions,suggesting a link between ionospheric changes and the earthquake generation process.展开更多
As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven si...As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven size distribution.Through electron backscattered diffraction(EBSD),the forged microstructure at various locations of as-forged WSTi6421 titanium alloy billet was analyzed,revealing that the strength of theβphase cubic texture generated by forging significantly influences the grain size afterβannealing.Heat treatment experiments were conducted within the temperature range from T_(β)−50°C to T_(β)+10°C to observe the macro-and micro-morphologies.Results show that the cubic texture ofβphase caused by forging impacts the texture of the secondaryαphase,which subsequently influences theβphase formed during the post-βannealing process.Moreover,the pinning effect of the residual primaryαphase plays a crucial role in the growth ofβgrains during theβannealing process.EBSD analysis results suggest that the strength ofβphase with cubic texture formed during forging process impacts the orientation distribution differences ofβgrains afterβannealing.Additionally,the development of grains with large orientations within the cubic texture shows a certain degree of selectivity duringβannealing,which is affected by various factors,including the pinning effect of the primaryαphase,the strength of the matrix cubic texture,and the orientation relationship betweenβgrain and matrix.Comprehensively,the stronger the texture in a certain region,the less likely the large misoriented grains suffering secondary growth,thereby aggregating the difference in microstructure and grain orientation distribution across different regions afterβannealing.展开更多
Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella(MMAF).Distinct projections encircling the central microtubules of the spermatozoal axoneme play p...Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella(MMAF).Distinct projections encircling the central microtubules of the spermatozoal axoneme play pivotal roles in flagellar bending and spermatozoal movement.Mammalian sperm-associated antigen 17(SPAG17)encodes a conserved axonemal protein of cilia and flagella,forming part of the C1a projection of the central apparatus,with functions related to ciliary/flagellar motility,skeletal growth,and male fertility.This study investigated two novel homozygous SPAG17 mutations(M1:NM_206996.2,c.829+1G>T,p.Asp212_Glu276del;and M2:c.2120del,p.Leu707*)identified in four infertile patients from two consanguineous Pakistani families.These patients displayed the MMAF phenotype confirmed by Papanicolaou staining and scanning electron microscopy assays of spermatozoa.Quantitative real-time polymerase chain reaction(PCR)of patients’spermatozoa also revealed a significant decrease in SPAG17 mRNA expression,and immunofluorescence staining showed the absence of SPAG17 protein signals along the flagella.However,no apparent ciliary-related symptoms or skeletal malformations were observed in the chest X-rays of any of the patients.Transmission electron microscopy of axoneme cross-sections from the patients showed incomplete C1a projection and a higher frequency of missing microtubule doublets 1 and 9 compared with those from fertile controls.Immunofluorescence staining and Western blot analyses of spermatogenesis-associated protein 17(SPATA17),a component of the C1a projection,and sperm-associated antigen 6(SPAG6),a marker of the spring layer,revealed disrupted expression of both proteins in the patients’spermatozoa.Altogether,these findings demonstrated that SPAG17 maintains the integrity of spermatozoal flagellar axoneme,expanding the phenotypic spectrum of SPAG17 mutations in humans.展开更多
Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate p...Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate prediction of the state of charge(SOC)of lithium-ion batteries is of great importance in reducing the probability of abnormal accidents and ensuring flight safety.展开更多
1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出...1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。展开更多
The rapid integration of Internet of Things(IoT)technologies is reshaping the global energy landscape by deploying smart meters that enable high-resolution consumption monitoring,two-way communication,and advanced met...The rapid integration of Internet of Things(IoT)technologies is reshaping the global energy landscape by deploying smart meters that enable high-resolution consumption monitoring,two-way communication,and advanced metering infrastructure services.However,this digital transformation also exposes power system to evolving threats,ranging from cyber intrusions and electricity theft to device malfunctions,and the unpredictable nature of these anomalies,coupled with the scarcity of labeled fault data,makes realtime detection exceptionally challenging.To address these difficulties,a real-time decision support framework is presented for smart meter anomality detection that leverages rolling time windows and two self-supervised contrastive learning modules.The first module synthesizes diverse negative samples to overcome the lack of labeled anomalies,while the second captures intrinsic temporal patterns for enhanced contextual discrimination.The end-to-end framework continuously updates its model with rolling updated meter data to deliver timely identification of emerging abnormal behaviors in evolving grids.Extensive evaluations on eight publicly available smart meter datasets over seven diverse abnormal patterns testing demonstrate the effectiveness of the proposed full framework,achieving average recall and F1 score of more than 0.85.展开更多
BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary arteries.AIM To report the presence and implications of incidental congenital coronary a...BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary arteries.AIM To report the presence and implications of incidental congenital coronary artery anomalies that had been misinterpreted as coronary artery abnormalities(CAAs)on 2DE.METHODS Records of children diagnosed with KD,who underwent computed tomography coronary angiography(CTCA)at our center between 2013-2023 were reviewed.We identified 3 children with congenital coronary artery anomalies in this cohort on CTCA.Findings of CTCA and 2DE were compared in these 3 children.RESULTS Of the 241 patients with KD who underwent CTCA,3(1.24%)had congenital coronary artery anomalies on CTCA detected incidentally.In all 3 patients,baseline 2DE had identified CAAs.CTCA was then performed for detailed evaluation as per our unit protocol.One(11-year-boy)amongst the 3 patients had complete KD,while the other two(3.3-year-boy;4-month-girl)had incomplete KD.CTCA revealed separate origins of left anterior descending artery and left circumflex from left sinus[misinterpreted as dilated left main coronary artery(LCA)on 2DE],single coronary artery(interpreted as dilated LCA on 2DE)and dilated right coronary artery on 2DE in case of anomalous origin of LCA from the main pulmonary artery.The latter one was subsequently operated upon.CONCLUSION CTCA is essential for detailed assessment of coronary arteries in children with KD especially in cases where there is suspicion of congenital coronary artery anomalies.Relying solely on 2DE may not be sufficient in such cases,and findings from CTCA can significantly impact therapeutic decision-making.展开更多
BACKGROUND:This study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.METHODS:This retrospective single-cente...BACKGROUND:This study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.METHODS:This retrospective single-center study collected data from patients meeting the clinical criteria for systemic inflammatory response syndrome(SIRS) with a confirmed infection source.Patients with coagulation disorders or on medications affecting coagulation were excluded.Patients were divided into sepsis and non-sepsis groups based on a Sequential Organ Failure Assessment(SOFA) score of ≥2.Univariate and multivariate logistic regression identified indicators from routine coagulation tests that predict sepsis.Prognostic roles of coagulation indicators were analyzed within the sepsis group.RESULTS:A total of 512 patients were included,with 396 in the sepsis group and 116 in the non-sepsis group.The predictive factors in the sepsis prediction model encompass fibrin degradation products(FDP),D-dimer,lactate,procalcitonin(PCT) levels and the utilization of mechanical ventilation.Early elevation of FDP and D-dimer levels predicted sepsis onset.The model exhibited an area under the curve(AUC) of 0.943(95% CI:0.923–0.963).In the sepsis group,Cox regression analysis revealed an association between prothrombin time(PT) and in-hospital mortality.CONCLUSION:Abnormal high FDP and D-dimer levels in the early stages of sepsis provide a supplementary method for predicting sepsis.As the disease progresses,prolonged PT in the early stages of sepsis suggests a poor prognosis.展开更多
The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also e...The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also expands the attack surface,introducing critical security vulnerabilities.To address these challenges,this article proposes a hybrid intrusion detection scheme for securing ICPSs that combines system state anomaly and network traffic anomaly detection.Specifically,an improved variation-Bayesian-based noise covariance-adaptive nonlinear Kalman filtering(IVB-NCA-NLKF)method is developed to model nonlinear system dynamics,enabling optimal state estimation in multi-sensor ICPS environments.Intrusions within the physical sensing system are identified by analyzing residual discrepancies between predicted and observed system states.Simultaneously,an adaptive network traffic anomaly detection mechanism is introduced,leveraging learned traffic patterns to detect node-and network-level anomalies through pattern matching.Extensive experiments on a simulated network control system demonstrate that the proposed framework achieves higher detection accuracy(92.14%)with a reduced false alarm rate(0.81%).Moreover,it not only detects known attacks and vulnerabilities but also uncovers stealthy attacks that induce system state deviations,providing a robust and comprehensive security solution for the safety protection of ICPS.展开更多
This study aimed to differentiate between the therapeutic and purely cosmetic aspects of keratopigmentation by examining the results of previous studies.Corneal opacity,corneal leukoma,and iris abnormalities represent...This study aimed to differentiate between the therapeutic and purely cosmetic aspects of keratopigmentation by examining the results of previous studies.Corneal opacity,corneal leukoma,and iris abnormalities represent the primary reasons for keratopigmentation in therapeutic settings.In therapeutic contexts,the most commonly reported adverse effects included inflammation,foreign body sensation,light sensitivity,reduced intraocular pressure,and neovascularization.The side effects most frequently noted in purely cosmetic applications were photophobia and ectasia.In therapeutic scenarios,patients who experience pre-operative vision impairment often report not only the absence of visual loss post-procedure but also an enhancement in visual acuity,accompanied by alleviation of symptoms such as glare.In purely cosmetic procedures,visual acuity tends to remain stable.Research indicates that dissatisfaction with keratopigmentation results is more prevalent in studies aimed at therapeutic interventions compared to cosmetic enhancements.Furthermore,instances of discoloration and fading are more frequently observed in therapeutic cases than in cosmetic ones,including the need for retouching.The use of keratopigmentation in both therapeutic and cosmetic settings produces positive and acceptable results,especially in cosmetic applications.Nevertheless,complications are more commonly observed in therapeutic situations,which underscores the importance of candidate selection for keratopigmentation procedures.展开更多
基金Supported by Guangxi Natural Science Foundation Project:2010 GXNSFA 013210
文摘Objective To compare the efficacy of treating obese patients with abnormity of lipids and serum leptin by dilatational wave or continuous wave of electroacupuncture combined with thunder-fire moxibustion in order to provide a clinical basis for selecting wave types of electroacupuncture for different patterns of obesity. Methods Sixty obese patients with abnormal lipids and serum leptin were randomly divided into a dilatational wave group and a continuous wave group via random number table, with 30 cases in each group. They were divided by TCM differentiation into three types： stomachintestine excessive heat, weakness of the spleen-stomach and spleen-kidney yang deficiency, treated by electroacupuncture on Tianshu （天枢 ST 25）, Daheng （大横 SP 15）, Zusanli （足三里ST 36）, Shangjuxu （上巨虚 ST 37）, Fanglong （丰隆 ST 40）, Yinlingquan （阴陵泉 SP 9）, Quchi （曲池 LI 11）, Zhigou （支沟 TE 6） and Hegu （合谷 LI 4） along with thunder-fire moxibustion. The frequency of electro-acupuncture in the dilatational wave group and the continuous wave group was 2 Hz/100 Hz and 2 Hz, respectively. Patients in the two groups were treated once a day, six times a week. The treatment lasted for 4 weeks with 3-month follow-up. Body mass and body fat percentage before and after the treatment, as well as during the follow-up, were compared. The effectiveness rates in the two groups were compared, and the efficacy statistics of patients with different TCM patterns in the dilatational wave group were also analyzed. Lipid levels of the patients in two groups before and after the treatment were measured with an automatic biochemical analyzer, and serum leptin levels were detected with flow cytometry system. Results After the treatment, the patients＇ blood lipids, serum leptin levels, body mass and body fat percentage were effectively reduced in the two groups; three months＇ follow-up witnessed continuous decline of obesity indicators （P〈0.01 or P〈0.05）, and patients in the dilatat-ional wave group improved more significantly than those in continuous wave group （P〈0.05 or P〈0.01）. The efficacy in the dilatational wave group was superior to that in the continuous wave group （P〈0.01）. The best efficacy could be found among patients with weakness of the spleen and the stomach in the dilatational wave group. Conclusion Efficacy of treating obese patients with abnormity of lipids and serum leptin by electro-acupuncture combined with thunder-fire moxibustion in the dilatational wave group was significantly better than that of the continuous wave group, and efficacy for obese patients with weakness of the spleen and the stomach was superior to that of those with stomach-intestine excessive heat and spleen-kidney yang deficiency.
基金This paper is supported by the National Natural Science Foundation of China (No. 40576032).
文摘Manganese abnormity has been observed in the Holocene sediments of the mud area of Bohai Sea. On the basis of grain size, chemical composition, heavy mineral content and accelerator mass spectrometry （AMS） 14C dating of foraminifer, relationships between manganese abnormity and sedimentation rates, material source, hydrodynamic conditions are probed. Manganese abnormity occurred during the Middle Holocene when sea level and sedimentation rates were higher than those at present. Sedimentary hiatus was not observed when material sources and hydrodynamic conditions were quite similar. Compared with the former period, the latter period showed a decrease in reduction environment and an inclination toward oxidation environment with high manganese content, whereas provenance and hydrodynamic conditions showed only a slight change. From the above observations, it can be concluded that correlation among manganese abnormity, material source, and hydrodynamic conditions is not obvious. Redox environment seems to be the key factor for manganese enrichment, which is mainly related to marine authigenic process.
基金the National Natural Science Foundation of China(41774084)
文摘As an achievement of the cooperation with Japan,TOA electromagnetic observation station was established with an 800 m borehole antenna and put into service in 1992 in Dali,Yunnan province,China.Li Wuxian et al.(2003)summarized main anomalous variation characters by analyzing 23 strong earthquakes with magnitudes more than 5.0 recorded in the first ten years.This work mainly presents the electromagnetic changes prior to the last Mojiang MS5.9 earthquake on September 8,2018.First of all,the initial weak signals appeared in two ULF channels out of three observing channels(CH10.01-0.10 Hz,CH20.1-1.0 Hz and CH31-9 kHz)on May 30,2018 at Dali TOA electromagnetic station.The information recorded was characterized by wave-like changes with magnitudes of ACH1≤0.26 mV in CH1 and pulse-like impulses of ACH2≤0.6 mV in CH2,respectively.Then,abnormal information gradually enhanced either in magnitudes or in occurrence frequency.Pulse-like signals were full of lattices of recording paper for CH2 during June24-25 and slopped over the recording paper during June 28-29,with the magnitudes being greater than or equal to 10 mV.At the same time,the clear wave-like signals also appeared in CH1 with a maximum magnitude of^0.6 mV on June 28 and reached its climax.From then on,the information started to decrease from the end of July and only weak signals occasionally occurred till the end of August 2018,when obvious anomaly was recorded again in two ULF channels with maximum magnitudes of ACH1~0.2 mV and ACH2~0.3 mV respectively.Generally,these signals did not appear continuously but group by group and accumulated intensively only in ULF band instead of VLF band during the total period.10 days later,the Mojiang MS5.9 earthquake occurred on September 8,2018,300 km away from Dali TOA station,and a coseismic response was also recorded at this time.Thus,these ULF electromagnetic abnormities could be probably attributed to the Mojiang event.
基金supported by the National Natural Science Foundation of China(61806221).
文摘A framework that integrates planning,monitoring and replanning techniques is proposed.It can devise the best solution based on the current state according to specific objectives and properly deal with the influence of abnormity on the plan execution.The framework consists of three parts:the hierarchical task network(HTN)planner based on Monte Carlo tree search(MCTS),hybrid plan monitoring based on forward and backward and norm-based replanning method selection.The HTN planner based on MCTS selects the optimal method for HTN compound task through pre-exploration.Based on specific objectives,it can identify the best solution to the current problem.The hybrid plan monitoring has the capability to detect the influence of abnormity on the effect of an executed action and the premise of an unexecuted action,thus trigger the replanning.The norm-based replanning selection method can measure the difference between the expected state and the actual state,and then select the best replanning algorithm.The experimental results reveal that our method can effectively deal with the influence of abnormity on the implementation of the plan and achieve the target task in an optimal way.
基金The project was sponsored by the National Science and Technology Basic Program(2004DEA71000-62050303-1) .
文摘The Sujiatun seismic station is a local professional seismic observation station in the city of Shenyang, Liaoning province. Electromagnetic radiations observation apparatus, of the type EMAOS-L, are used there. In this paper, four years observation data and observed earthquakes with M_S≥4.0 were collected in the Sujiatun observation station. The characteristics of electromagnetic radiation abnormities and earthquakes are analyzed from such aspects as capabilities of the apparatus used, tectonic structure, origins of electromagnetic radiations and so on. By analysis, precursor abnormities observed at this observation station are remarkable. The electric and magnetic abnormities are with good synchronism and the abnormities can respond better to the earthquakes with the epicenter distance being less than 20km and taking place in the upper crust. At the same time, for earthquakes with large magnitudes, the variation of precursor abnormities shows a periodic diurnal variation.
基金supported by the National "973" Program of China under Grant Nos.613186 and 2011CB711000
文摘A high-precision automatic state monitoring and abnormity alarm technique is proposed to solve the process improvement issues of fiber-optic coil winding and splicing. Industrial cameras are used to capture optical and hot images during the assembly of optical components of a fiber-optic gyroscope. A line and contour analysis technique is used to detect abnormal winding. By analyzing the intensity distribution of transmitted light, the graph cut model and multivariate Gaussian mixture model are used to detect and segment the splicing defects. The practical applications indicate the correctness and accuracy of our vision-based technique.
基金supported by Ho Chi Minh City Open University,Vietnam under grant number E2024.02.1CD and Suan Sunandha Rajabhat University,Thailand.
文摘The Financial Technology(FinTech)sector has witnessed rapid growth,resulting in increasingly complex and high-volume digital transactions.Although this expansion improves efficiency and accessibility,it also introduces significant vulnerabilities,including fraud,money laundering,and market manipulation.Traditional anomaly detection techniques often fail to capture the relational and dynamic characteristics of financial data.Graph Neural Networks(GNNs),capable of modeling intricate interdependencies among entities,have emerged as a powerful framework for detecting subtle and sophisticated anomalies.However,the high-dimensionality and inherent noise of FinTech datasets demand robust feature selection strategies to improve model scalability,performance,and interpretability.This paper presents a comprehensive survey of GNN-based approaches for anomaly detection in FinTech,with an emphasis on the synergistic role of feature selection.We examine the theoretical foundations of GNNs,review state-of-the-art feature selection techniques,analyze their integration with GNNs,and categorize prevalent anomaly types in FinTech applications.In addition,we discuss practical implementation challenges,highlight representative case studies,and propose future research directions to advance the field of graph-based anomaly detection in financial systems.
文摘BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifying the prevalence of these abnormalities and understanding their predictors is vital for optimizing pretransplant risk stratification and improving post-transplant outcomes.AIM To determine the prevalence of left ventricular hypertrophy(LVH),left ventricular systolic dysfunction(LVSD),diastolic dysfunction(DD),pulmonary hypertension(PH),and their predictors,and to assess their impact on graft function in pre-transplant candidates.METHODS The study included all successful transplant candidates older than 14 who had a baseline echocardiogram.Binary logistic regression models were constructed to identify factors associated with LVH,LVSD,DD,and PH.RESULTS Out of 259 patients,LVH was present in 64%(166),12%(31)had LVSD,27.5%(71)had DD,and 66(25.5%)had PH.Independent predictors of LVH included male gender[odds ratio(OR):2.51;95%CI:1.17-5.41 P=0.02],PH(OR=2.07;95%CI:1.11-3.86;P=0.02),DD(OR:2.47;95%CI:1.29-4.73;P=0.006),and dyslipidemia(OR=1.94;95%CI:1.07-3.53;P=0.03).Predictors for LVSD included patients with DD(OR=3.3,95%CI:1.41-7.81;P=0.006)and a family history of coronary artery disease(OR=4.50,95%CI:1.33-15.20;P=0.015).Peritoneal dialysis was an independent predictor for DD(OR=10.03;95%CI:1.71-58.94,P=0.011).The presence of LVH(OR=3.32,95%CI:1.05-10.55,P=0.04)and mild to moderate or moderate to severe mitral regurgitation(OR=4.63,95%CI:1.45-14.78,P=0.01)were significant factors associated with PH.These abnormalities had no significant impact on estimated glomerular filtration at discharge,6 months,1 year,or 2 years post-transplant.CONCLUSION Significant echocardiographic abnormalities persist in a potential transplant candidate despite cardiac clearance,although they don’t affect future graft function.Understanding the risk factors associated with these abnormalities may help clinicians address these factors pre-and post-transplant to achieve better outcomes.
基金Supported by the National Natural Science Foundation of China(No.82070991).
文摘Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 1993.TM typically spares the foveal center,is asymptomatic,and is often detected incidentally during routine ophthalmic examinations.Through literature search,we did not identify racial or regional differences in TM.It predominantly affects children,with an estimated prevalence of 2 per 100000 in individuals under 16 ages[3].While previous reports have focused on pediatric and adult populations,this study presents four cases of TM in preterm infants.
文摘Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.
基金National Natural Science Foundation of China(No.41274079,No.42304080)Seismic Safety and Health Monitoring of Major Construction Projects-Bridge and Reservoir Seismic Monitoring(No.DZ2024083000001)State Key Research and Development Plan under Grant(No.2018YFE0208300,No.2018YFC0603500).
文摘This study analyzed data from the DEMETER satellite,collected 10 days before the Wenchuan M_(s)8.0 earthquake on May 12,2008.The time-frequency power spectrum of the data indicated a narrow-band radiative destabilization(below the cut-off frequency)6 days prior to the earthquake.A significant anomaly in the Ez component was observed 3 days before the event.However,similar phenomena were found over aseismic regions,suggesting a link between ionospheric changes and the earthquake generation process.
基金Key Research and Development Plan of Shaanxi Province(2023-YBGY-493)。
文摘As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven size distribution.Through electron backscattered diffraction(EBSD),the forged microstructure at various locations of as-forged WSTi6421 titanium alloy billet was analyzed,revealing that the strength of theβphase cubic texture generated by forging significantly influences the grain size afterβannealing.Heat treatment experiments were conducted within the temperature range from T_(β)−50°C to T_(β)+10°C to observe the macro-and micro-morphologies.Results show that the cubic texture ofβphase caused by forging impacts the texture of the secondaryαphase,which subsequently influences theβphase formed during the post-βannealing process.Moreover,the pinning effect of the residual primaryαphase plays a crucial role in the growth ofβgrains during theβannealing process.EBSD analysis results suggest that the strength ofβphase with cubic texture formed during forging process impacts the orientation distribution differences ofβgrains afterβannealing.Additionally,the development of grains with large orientations within the cubic texture shows a certain degree of selectivity duringβannealing,which is affected by various factors,including the pinning effect of the primaryαphase,the strength of the matrix cubic texture,and the orientation relationship betweenβgrain and matrix.Comprehensively,the stronger the texture in a certain region,the less likely the large misoriented grains suffering secondary growth,thereby aggregating the difference in microstructure and grain orientation distribution across different regions afterβannealing.
基金supported by the National Natural Science Foundation of China(No.82171599 and No.32270901)the National Key Research and Developmental Program of China(2022YFC2702601 and 2022YFA0806303)the Global Select Project(DJKLX-2022010)of the Institute of Health and Medicine,Hefei Comprehensive National Science Center.
文摘Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella(MMAF).Distinct projections encircling the central microtubules of the spermatozoal axoneme play pivotal roles in flagellar bending and spermatozoal movement.Mammalian sperm-associated antigen 17(SPAG17)encodes a conserved axonemal protein of cilia and flagella,forming part of the C1a projection of the central apparatus,with functions related to ciliary/flagellar motility,skeletal growth,and male fertility.This study investigated two novel homozygous SPAG17 mutations(M1:NM_206996.2,c.829+1G>T,p.Asp212_Glu276del;and M2:c.2120del,p.Leu707*)identified in four infertile patients from two consanguineous Pakistani families.These patients displayed the MMAF phenotype confirmed by Papanicolaou staining and scanning electron microscopy assays of spermatozoa.Quantitative real-time polymerase chain reaction(PCR)of patients’spermatozoa also revealed a significant decrease in SPAG17 mRNA expression,and immunofluorescence staining showed the absence of SPAG17 protein signals along the flagella.However,no apparent ciliary-related symptoms or skeletal malformations were observed in the chest X-rays of any of the patients.Transmission electron microscopy of axoneme cross-sections from the patients showed incomplete C1a projection and a higher frequency of missing microtubule doublets 1 and 9 compared with those from fertile controls.Immunofluorescence staining and Western blot analyses of spermatogenesis-associated protein 17(SPATA17),a component of the C1a projection,and sperm-associated antigen 6(SPAG6),a marker of the spring layer,revealed disrupted expression of both proteins in the patients’spermatozoa.Altogether,these findings demonstrated that SPAG17 maintains the integrity of spermatozoal flagellar axoneme,expanding the phenotypic spectrum of SPAG17 mutations in humans.
基金supported in part by the Chunhui Project of the Ministry of Education of China(HZKY20220429)the Department of Science&Technology of Liaoning Province(2022-MS-300)the Educational Department of Liaoning Province(LJKMZ20220561)
文摘Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate prediction of the state of charge(SOC)of lithium-ion batteries is of great importance in reducing the probability of abnormal accidents and ensuring flight safety.
文摘1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。
文摘The rapid integration of Internet of Things(IoT)technologies is reshaping the global energy landscape by deploying smart meters that enable high-resolution consumption monitoring,two-way communication,and advanced metering infrastructure services.However,this digital transformation also exposes power system to evolving threats,ranging from cyber intrusions and electricity theft to device malfunctions,and the unpredictable nature of these anomalies,coupled with the scarcity of labeled fault data,makes realtime detection exceptionally challenging.To address these difficulties,a real-time decision support framework is presented for smart meter anomality detection that leverages rolling time windows and two self-supervised contrastive learning modules.The first module synthesizes diverse negative samples to overcome the lack of labeled anomalies,while the second captures intrinsic temporal patterns for enhanced contextual discrimination.The end-to-end framework continuously updates its model with rolling updated meter data to deliver timely identification of emerging abnormal behaviors in evolving grids.Extensive evaluations on eight publicly available smart meter datasets over seven diverse abnormal patterns testing demonstrate the effectiveness of the proposed full framework,achieving average recall and F1 score of more than 0.85.
文摘BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary arteries.AIM To report the presence and implications of incidental congenital coronary artery anomalies that had been misinterpreted as coronary artery abnormalities(CAAs)on 2DE.METHODS Records of children diagnosed with KD,who underwent computed tomography coronary angiography(CTCA)at our center between 2013-2023 were reviewed.We identified 3 children with congenital coronary artery anomalies in this cohort on CTCA.Findings of CTCA and 2DE were compared in these 3 children.RESULTS Of the 241 patients with KD who underwent CTCA,3(1.24%)had congenital coronary artery anomalies on CTCA detected incidentally.In all 3 patients,baseline 2DE had identified CAAs.CTCA was then performed for detailed evaluation as per our unit protocol.One(11-year-boy)amongst the 3 patients had complete KD,while the other two(3.3-year-boy;4-month-girl)had incomplete KD.CTCA revealed separate origins of left anterior descending artery and left circumflex from left sinus[misinterpreted as dilated left main coronary artery(LCA)on 2DE],single coronary artery(interpreted as dilated LCA on 2DE)and dilated right coronary artery on 2DE in case of anomalous origin of LCA from the main pulmonary artery.The latter one was subsequently operated upon.CONCLUSION CTCA is essential for detailed assessment of coronary arteries in children with KD especially in cases where there is suspicion of congenital coronary artery anomalies.Relying solely on 2DE may not be sufficient in such cases,and findings from CTCA can significantly impact therapeutic decision-making.
基金supported by the Science and Technology Commission of Shanghai Municipality (grant no.22Y11900300)China Primary Health Care Foundation (grant no.MTP2022A0132)Project of Shanghai Administration of Traditional Chinese Medicine (ZXXT-202213)to EQM and LM。
文摘BACKGROUND:This study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.METHODS:This retrospective single-center study collected data from patients meeting the clinical criteria for systemic inflammatory response syndrome(SIRS) with a confirmed infection source.Patients with coagulation disorders or on medications affecting coagulation were excluded.Patients were divided into sepsis and non-sepsis groups based on a Sequential Organ Failure Assessment(SOFA) score of ≥2.Univariate and multivariate logistic regression identified indicators from routine coagulation tests that predict sepsis.Prognostic roles of coagulation indicators were analyzed within the sepsis group.RESULTS:A total of 512 patients were included,with 396 in the sepsis group and 116 in the non-sepsis group.The predictive factors in the sepsis prediction model encompass fibrin degradation products(FDP),D-dimer,lactate,procalcitonin(PCT) levels and the utilization of mechanical ventilation.Early elevation of FDP and D-dimer levels predicted sepsis onset.The model exhibited an area under the curve(AUC) of 0.943(95% CI:0.923–0.963).In the sepsis group,Cox regression analysis revealed an association between prothrombin time(PT) and in-hospital mortality.CONCLUSION:Abnormal high FDP and D-dimer levels in the early stages of sepsis provide a supplementary method for predicting sepsis.As the disease progresses,prolonged PT in the early stages of sepsis suggests a poor prognosis.
基金supported by the National Natural Science Foundation of China(NSFC)under grant No.62371187the Hunan Provincial Natural Science Foundation of China under Grant Nos.2024JJ8309 and 2023JJ50495.
文摘The integration of cloud computing into traditional industrial control systems is accelerating the evolution of Industrial Cyber-Physical System(ICPS),enhancing intelligence and autonomy.However,this transition also expands the attack surface,introducing critical security vulnerabilities.To address these challenges,this article proposes a hybrid intrusion detection scheme for securing ICPSs that combines system state anomaly and network traffic anomaly detection.Specifically,an improved variation-Bayesian-based noise covariance-adaptive nonlinear Kalman filtering(IVB-NCA-NLKF)method is developed to model nonlinear system dynamics,enabling optimal state estimation in multi-sensor ICPS environments.Intrusions within the physical sensing system are identified by analyzing residual discrepancies between predicted and observed system states.Simultaneously,an adaptive network traffic anomaly detection mechanism is introduced,leveraging learned traffic patterns to detect node-and network-level anomalies through pattern matching.Extensive experiments on a simulated network control system demonstrate that the proposed framework achieves higher detection accuracy(92.14%)with a reduced false alarm rate(0.81%).Moreover,it not only detects known attacks and vulnerabilities but also uncovers stealthy attacks that induce system state deviations,providing a robust and comprehensive security solution for the safety protection of ICPS.
基金Supported by Noor Ophthalmology Research Center.
文摘This study aimed to differentiate between the therapeutic and purely cosmetic aspects of keratopigmentation by examining the results of previous studies.Corneal opacity,corneal leukoma,and iris abnormalities represent the primary reasons for keratopigmentation in therapeutic settings.In therapeutic contexts,the most commonly reported adverse effects included inflammation,foreign body sensation,light sensitivity,reduced intraocular pressure,and neovascularization.The side effects most frequently noted in purely cosmetic applications were photophobia and ectasia.In therapeutic scenarios,patients who experience pre-operative vision impairment often report not only the absence of visual loss post-procedure but also an enhancement in visual acuity,accompanied by alleviation of symptoms such as glare.In purely cosmetic procedures,visual acuity tends to remain stable.Research indicates that dissatisfaction with keratopigmentation results is more prevalent in studies aimed at therapeutic interventions compared to cosmetic enhancements.Furthermore,instances of discoloration and fading are more frequently observed in therapeutic cases than in cosmetic ones,including the need for retouching.The use of keratopigmentation in both therapeutic and cosmetic settings produces positive and acceptable results,especially in cosmetic applications.Nevertheless,complications are more commonly observed in therapeutic situations,which underscores the importance of candidate selection for keratopigmentation procedures.
