1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established...1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established in the mid-20th century,blunt body theories led to the creation of ablative heat shields that effectively manage thermal loads through thermo-chemo-mechanical decomposition.This paper revisits the development and application of ablative TPS materials,which are single-mission solutions capable of withstanding entry velocities surpassing 10 km/s.展开更多
The effect of drive laser wavelength on the growth of ablative Rayleigh–Taylor instability(ARTI)in inertial confinemen fusion(ICF)is studied with two-dimensional numerical simulations.The results show that in the pla...The effect of drive laser wavelength on the growth of ablative Rayleigh–Taylor instability(ARTI)in inertial confinemen fusion(ICF)is studied with two-dimensional numerical simulations.The results show that in the plasma acceleration phase,shorter wavelengths lead to more efficien coupling between the laser and the kinetic energy of the implosion fluid Under the condition that the laser energy coupled to the implosion flui is constant,the ARTI growth rate decreases as the laser wavelength moves toward the extreme ultraviolet band,reaching its minimum value near λ=65 nm,and when the laser wavelength continuously moves toward the X-ray band,the ARTI growth rate increases rapidly.It is found that the results deviate from the theoretical ARTI growth rate.As the laser intensity benchmark increases,the position of the minimum ARTI growth rate shifts toward shorter wavelengths.As the initial sinusoidal perturbation wavenumber decreases,the position of the minimum ARTI growth rate shifts toward longer wavelengths.We believe that the conclusions drawn from the present simulations and analysis will help provide a better understanding of the ICF process and improve the theory of ARTI growth.展开更多
In the direct drive inertial confinement fusion(ICF)scheme,a rippled interface between the ablator and the deuterium–tritium ice fuel can feed out and form perturbation seeds for the ablative Rayleigh–Taylor instabi...In the direct drive inertial confinement fusion(ICF)scheme,a rippled interface between the ablator and the deuterium–tritium ice fuel can feed out and form perturbation seeds for the ablative Rayleigh–Taylor instability,with undesirable effects.However,the evolution of this instability remains insufficiently studied,and the effects of high-Z dopant on this instability remain unclear.In this paper,we develop a theoretical model to calculate the feedout seeds and describe this instability.Our theory suggests that the feedout seeds are determined by the ablation pressure and the adiabatic index,while the subsequent growth depends mainly on the ablation velocity.Two-dimensional radiation hydrodynamic simulations confirm our theory.It is shown that targets with high-Z dopant in the outer ablator exhibit more severe feedout seeds,because of their higher ionization compared with undoped targets.The X-ray pre-ablation in high-Z doped targets significantly suppresses subsequent growth,leading to suppression of short-wavelength perturbations.However,for long-wavelength perturbations,this suppression is weakened,resulting in increased instability in high-Z doped targets.The results are helpful for understanding the innerinterface-initiated instability and the influence of high-Z dopant on it,providing valuable insights for target design and instability control in ICF.展开更多
The phytohormone auxin exerts control over remarkable developmental processes in plants.It moves from cell to cell,resulting in the creation of both extracellular auxin and intracellular auxin,which are recognized by ...The phytohormone auxin exerts control over remarkable developmental processes in plants.It moves from cell to cell,resulting in the creation of both extracellular auxin and intracellular auxin,which are recognized by distinct auxin receptors.These two auxin signaling systems govern different auxin responses while working together to regulate plant development.In this review,we outline the latest research advancements in unraveling these auxin signaling pathways,encompassing auxin perception and signaling transductions.We emphasize the interaction between extracellular and intracellular auxin,which contributes to the intricate role of auxin in plant development.展开更多
特高压(ultra high voltage,UHV)换流站阀厅的金属屋面系统在风荷载作用下易发生屋面表层风揭事故。为深入探讨该类建筑屋面的风压极值特性,基于风洞试验分别探讨了大气边界层(atmospheric-boundary-layer,ABL)风、壁面射流、均匀湍流...特高压(ultra high voltage,UHV)换流站阀厅的金属屋面系统在风荷载作用下易发生屋面表层风揭事故。为深入探讨该类建筑屋面的风压极值特性,基于风洞试验分别探讨了大气边界层(atmospheric-boundary-layer,ABL)风、壁面射流、均匀湍流三种风场作用下的屋面风压特性,比较了平均风剖面、风速、风向、湍流强度等因素对屋面风压的影响。结果表明:阀厅屋盖迎风前缘负风压最大,且控制风向角在45°左右;壁面射流风场下平均风压系数与脉动风压系数均超过大气边界层风场的结果;风速对阀厅屋盖的负风压系数均值和极值影响较小,而湍流度对风压系数的极值影响较大;大气边界风场时,JGJ/T 481—2019《屋盖结构风荷载标准》的最不利风压系数建议值偏于安全;而在壁面射流风场下,阀厅屋盖全风向最不利风压系数在所有区域都大于JGJ/T 481—2019的建议值,设计中应加以重视。展开更多
Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of ...Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of pancreatic cancer.Data sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December 2022.Keywords used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were included.All articles were assessed for validity and relevant content.Results:Optimal doses and fractionation have not yet been defined.However,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to CRT.Furthermore,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic adenocarcinoma.Conclusions:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease control.SBRT opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.展开更多
High-resolution flow field data has important applications in meteorology,aerospace engineering,high-energy physics and other fields.Experiments and numerical simulations are two main ways to obtain high-resolution fl...High-resolution flow field data has important applications in meteorology,aerospace engineering,high-energy physics and other fields.Experiments and numerical simulations are two main ways to obtain high-resolution flow field data,while the high experiment cost and computing resources for simulation hinder the specificanalysis of flow field evolution.With the development of deep learning technology,convolutional neural networks areused to achieve high-resolution reconstruction of the flow field.In this paper,an ordinary convolutional neuralnetwork and a multi-time-path convolutional neural network are established for the ablative Rayleigh-Taylorinstability.These two methods can reconstruct the high-resolution flow field in just a few seconds,and further greatlyenrich the application of high-resolution reconstruction technology in fluid instability.Compared with the ordinaryconvolutional neural network,the multi-time-path convolutional neural network model has smaller error and canrestore more details of the flow field.The influence of low-resolution flow field data obtained by the two poolingmethods on the convolutional neural networks model is also discussed.展开更多
Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsul...Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsule(MAGIC)technology platform to address this clinical need.The MAGIC technology could also facilitate the clinical translation and adoption of the tethered capsule endomicroscopy(TCE)technology.Introduction:Recently developed optical coherence tomography(OCT)TCE technologies have shown a promising potential for surveillance of Barrett’s esophagus and esophageal cancer in awake patients without the need for sedation.However,it remains challenging with the current TCE technology for detecting early lesions and clinical adoption due to its suboptimal resolution,imaging contrast,and lack of visual guidance during imaging.Methods:Our technology reported here integrates dual-wavelength OCT imaging(operating at 800 and 1300 nm),an ultracompact endoscope camera,and an ablation laser,aiming to enable comprehensive surveillance,guidance,and potential ablative treatment of the esophagus.Results:The MAGIC has been successfully developed with its multimodality imaging and ablation capabilities demonstrated by imaging swine esophagus ex vivo and in vivo.The 800-nm OCT imaging offers exceptional resolution and contrast for the superficial layers,well suited for detecting subtle changes associated with early neoplasia.The 1300-nm OCT imaging provides deeper penetration,essential for assessing lesion invasion.The built-in miniature camera affords a conventional endoscopic view for assisting capsule deployment and laser ablation.Conclusion:By offering complementary and clinically viable functions in a single device,the reported technology represents an effective solution for endoscopic screening,diagnosis,and potential ablation treatment of the esophagus of a patient in an office setting.展开更多
文摘1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established in the mid-20th century,blunt body theories led to the creation of ablative heat shields that effectively manage thermal loads through thermo-chemo-mechanical decomposition.This paper revisits the development and application of ablative TPS materials,which are single-mission solutions capable of withstanding entry velocities surpassing 10 km/s.
基金supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.12074399,12204500,and 12004403)the Key Projects of the Intergovernmental International Scientifi and Technological Innovation Cooperation(Grant No.2021YFE0116700)+1 种基金the Shanghai Natural Science Foundation(Grant No.20ZR1464400)the Shanghai Sailing Program(Grant No.22YF1455300)。
文摘The effect of drive laser wavelength on the growth of ablative Rayleigh–Taylor instability(ARTI)in inertial confinemen fusion(ICF)is studied with two-dimensional numerical simulations.The results show that in the plasma acceleration phase,shorter wavelengths lead to more efficien coupling between the laser and the kinetic energy of the implosion fluid Under the condition that the laser energy coupled to the implosion flui is constant,the ARTI growth rate decreases as the laser wavelength moves toward the extreme ultraviolet band,reaching its minimum value near λ=65 nm,and when the laser wavelength continuously moves toward the X-ray band,the ARTI growth rate increases rapidly.It is found that the results deviate from the theoretical ARTI growth rate.As the laser intensity benchmark increases,the position of the minimum ARTI growth rate shifts toward shorter wavelengths.As the initial sinusoidal perturbation wavenumber decreases,the position of the minimum ARTI growth rate shifts toward longer wavelengths.We believe that the conclusions drawn from the present simulations and analysis will help provide a better understanding of the ICF process and improve the theory of ARTI growth.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Science(Grant Nos.XDA25050200 and XDA25010100)the National Natural Science Foundation of China(Grant Nos.12175309,12475252,and 12275356)+2 种基金the Defense Industrial Technology Development Program(Grant No.JCKYS2023212807)the Natural Science Foundation of Hunan Province,China(Grant No.2025JJ20007)the Postgraduate Scientific Research Innovation Project of Hunan Province,China(Grant No.CX20230005).
文摘In the direct drive inertial confinement fusion(ICF)scheme,a rippled interface between the ablator and the deuterium–tritium ice fuel can feed out and form perturbation seeds for the ablative Rayleigh–Taylor instability,with undesirable effects.However,the evolution of this instability remains insufficiently studied,and the effects of high-Z dopant on this instability remain unclear.In this paper,we develop a theoretical model to calculate the feedout seeds and describe this instability.Our theory suggests that the feedout seeds are determined by the ablation pressure and the adiabatic index,while the subsequent growth depends mainly on the ablation velocity.Two-dimensional radiation hydrodynamic simulations confirm our theory.It is shown that targets with high-Z dopant in the outer ablator exhibit more severe feedout seeds,because of their higher ionization compared with undoped targets.The X-ray pre-ablation in high-Z doped targets significantly suppresses subsequent growth,leading to suppression of short-wavelength perturbations.However,for long-wavelength perturbations,this suppression is weakened,resulting in increased instability in high-Z doped targets.The results are helpful for understanding the innerinterface-initiated instability and the influence of high-Z dopant on it,providing valuable insights for target design and instability control in ICF.
基金supported by the National Natural Science Foundation of China(32130010).
文摘The phytohormone auxin exerts control over remarkable developmental processes in plants.It moves from cell to cell,resulting in the creation of both extracellular auxin and intracellular auxin,which are recognized by distinct auxin receptors.These two auxin signaling systems govern different auxin responses while working together to regulate plant development.In this review,we outline the latest research advancements in unraveling these auxin signaling pathways,encompassing auxin perception and signaling transductions.We emphasize the interaction between extracellular and intracellular auxin,which contributes to the intricate role of auxin in plant development.
文摘特高压(ultra high voltage,UHV)换流站阀厅的金属屋面系统在风荷载作用下易发生屋面表层风揭事故。为深入探讨该类建筑屋面的风压极值特性,基于风洞试验分别探讨了大气边界层(atmospheric-boundary-layer,ABL)风、壁面射流、均匀湍流三种风场作用下的屋面风压特性,比较了平均风剖面、风速、风向、湍流强度等因素对屋面风压的影响。结果表明:阀厅屋盖迎风前缘负风压最大,且控制风向角在45°左右;壁面射流风场下平均风压系数与脉动风压系数均超过大气边界层风场的结果;风速对阀厅屋盖的负风压系数均值和极值影响较小,而湍流度对风压系数的极值影响较大;大气边界风场时,JGJ/T 481—2019《屋盖结构风荷载标准》的最不利风压系数建议值偏于安全;而在壁面射流风场下,阀厅屋盖全风向最不利风压系数在所有区域都大于JGJ/T 481—2019的建议值,设计中应加以重视。
文摘Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of pancreatic cancer.Data sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December 2022.Keywords used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were included.All articles were assessed for validity and relevant content.Results:Optimal doses and fractionation have not yet been defined.However,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to CRT.Furthermore,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic adenocarcinoma.Conclusions:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease control.SBRT opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.
基金National Natural Science Foundation of China(1180500311947102+4 种基金12004005)Natural Science Foundation of Anhui Province(2008085MA162008085QA26)University Synergy Innovation Program of Anhui Province(GXXT-2022-039)State Key Laboratory of Advanced Electromagnetic Technology(Grant No.AET 2024KF006)。
文摘High-resolution flow field data has important applications in meteorology,aerospace engineering,high-energy physics and other fields.Experiments and numerical simulations are two main ways to obtain high-resolution flow field data,while the high experiment cost and computing resources for simulation hinder the specificanalysis of flow field evolution.With the development of deep learning technology,convolutional neural networks areused to achieve high-resolution reconstruction of the flow field.In this paper,an ordinary convolutional neuralnetwork and a multi-time-path convolutional neural network are established for the ablative Rayleigh-Taylorinstability.These two methods can reconstruct the high-resolution flow field in just a few seconds,and further greatlyenrich the application of high-resolution reconstruction technology in fluid instability.Compared with the ordinaryconvolutional neural network,the multi-time-path convolutional neural network model has smaller error and canrestore more details of the flow field.The influence of low-resolution flow field data obtained by the two poolingmethods on the convolutional neural networks model is also discussed.
基金supported in part by the National Institutes of Health under grants R01 CA153023 and P41 EB032840.
文摘Objective and Impact Statement:A clinically viable technology for comprehensive esophagus surveillance and potential treatment is lacking.Here,we report a novel multifunctional ablative gastrointestinal imaging capsule(MAGIC)technology platform to address this clinical need.The MAGIC technology could also facilitate the clinical translation and adoption of the tethered capsule endomicroscopy(TCE)technology.Introduction:Recently developed optical coherence tomography(OCT)TCE technologies have shown a promising potential for surveillance of Barrett’s esophagus and esophageal cancer in awake patients without the need for sedation.However,it remains challenging with the current TCE technology for detecting early lesions and clinical adoption due to its suboptimal resolution,imaging contrast,and lack of visual guidance during imaging.Methods:Our technology reported here integrates dual-wavelength OCT imaging(operating at 800 and 1300 nm),an ultracompact endoscope camera,and an ablation laser,aiming to enable comprehensive surveillance,guidance,and potential ablative treatment of the esophagus.Results:The MAGIC has been successfully developed with its multimodality imaging and ablation capabilities demonstrated by imaging swine esophagus ex vivo and in vivo.The 800-nm OCT imaging offers exceptional resolution and contrast for the superficial layers,well suited for detecting subtle changes associated with early neoplasia.The 1300-nm OCT imaging provides deeper penetration,essential for assessing lesion invasion.The built-in miniature camera affords a conventional endoscopic view for assisting capsule deployment and laser ablation.Conclusion:By offering complementary and clinically viable functions in a single device,the reported technology represents an effective solution for endoscopic screening,diagnosis,and potential ablation treatment of the esophagus of a patient in an office setting.
