以废打印机壳PC/ABS再生粒子(R-PC/ABS)为基体材料,对苯二酚双(二苯基磷酸脂)(HDP)和梯形倍半硅氧烷(TSQ)为阻燃剂,采用熔融共混制备了无卤阻燃PC/ABS,对其阻燃性能、力学性能、尺寸稳定性和负荷热变形温度(HDT)进行分析,结果发现,TSQ...以废打印机壳PC/ABS再生粒子(R-PC/ABS)为基体材料,对苯二酚双(二苯基磷酸脂)(HDP)和梯形倍半硅氧烷(TSQ)为阻燃剂,采用熔融共混制备了无卤阻燃PC/ABS,对其阻燃性能、力学性能、尺寸稳定性和负荷热变形温度(HDT)进行分析,结果发现,TSQ可以阻燃R-PC/ABS,并且,对力学性能、尺寸稳定性和HDT影响较小,R-PC/ABS/0.8TSQ的LOI为29.8%,阻燃达到3.0 mm V-0和2.0 mm V-1级;HDP可以有效地阻燃R-PC/ABS,但是,对力学性能、尺寸稳定性和HDT的负面影响较大,R-PC/ABS/12HDP的LOI为36.1%,阻燃可达到UL 941.0 mm V-0级,与R-PC/ABS相比,HDT、拉伸强度、弯曲强度、弯曲模量和缺口冲击强度分别降低了20.2℃、26.6%、14.5%、16.9%和60.9%;R-PC/ABS/0.8TSQ/6HDP的LOI为35.7%,阻燃级别达到UL 941.0 mm V-0级,与R-PC/ABS/12HDP相比,模后收缩率(PMS)降低了19.7%,HDT、拉伸强度、弯曲强度、弯曲模量和缺口冲击强度分别提高了13℃、21.0%、11.3%、14.3%和85.9%。展开更多
An accurate and simultaneous ab initio prediction for both light nuclei and nuclear matter has been a longstanding challenge in nuclear physics, due to the significant uncertainties associated with the three-nucleon f...An accurate and simultaneous ab initio prediction for both light nuclei and nuclear matter has been a longstanding challenge in nuclear physics, due to the significant uncertainties associated with the three-nucleon forces.In this Letter, we develop the relativistic quantum Monte Carlo methods for the nuclear ab initio problem, and calculate the ground-state energies of A ≤ 4 nuclei using the two-nucleon Bonn force with an unprecedented high accuracy. The present relativistic results significantly outperform the nonrelativistic results with only twonucleon forces. We demonstrate that both light nuclei and nuclear matter can be well described simultaneously in the relativistic ab initio calculations, even in the absence of three-nucleon forces, and a correlation between the properties of light A ≤ 4 nuclei and the nuclear saturation is revealed. This provides a quantitative understanding of the connection between the light nuclei and nuclear matter saturation properties.展开更多
Dysregulation of microRNA(miRNA)expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus(T2DM).Identifying differentially expressed miRNAs and their roles in regulatin...Dysregulation of microRNA(miRNA)expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus(T2DM).Identifying differentially expressed miRNAs and their roles in regulating glucose metabolism will provide a theoretical foundation for the molecular mechanisms underlying obesity-induced T2DM.Here,we perform a genome-wide association study involving 5 glycolipid metabolism traits in 1783 Kazakh and 1198 Uyghur individuals to identify miRNAs associated with fasting plasma glucose(FPG)levels.A miR-548ab mimic and inhibitor are administered to hepatocytes and adipocytes,as well as obese and diabetic mice,to determine miR-548ab-related downstream signalling pathways.The effects of miR-548ab on glucose metabolism are validated using the glucose tolerance test and insulin tolerance test.Collectively,these results indicate that miR-548ab is significantly associated with FPG levels and obesity-related T2DM in both Kazakh and Uyghur populations.The miR-548ab-GULP1/SLC25A21-GLUT4 network exerts regulatory effects on glucose metabolism,obesity,and T2DM,positioning it as a candidate risk factor,potential diagnostic marker,and therapeutic target for obesity-induced T2DM.Additionally,through evolutionary analysis,the authentic variants or haplotypes of GULP1 and SLC25A21 are categorized according to their genetic susceptibility to T2DM.The miR-548ab inhibitor shows beneficial effects in obese and diabetic mice.展开更多
文摘以废打印机壳PC/ABS再生粒子(R-PC/ABS)为基体材料,对苯二酚双(二苯基磷酸脂)(HDP)和梯形倍半硅氧烷(TSQ)为阻燃剂,采用熔融共混制备了无卤阻燃PC/ABS,对其阻燃性能、力学性能、尺寸稳定性和负荷热变形温度(HDT)进行分析,结果发现,TSQ可以阻燃R-PC/ABS,并且,对力学性能、尺寸稳定性和HDT影响较小,R-PC/ABS/0.8TSQ的LOI为29.8%,阻燃达到3.0 mm V-0和2.0 mm V-1级;HDP可以有效地阻燃R-PC/ABS,但是,对力学性能、尺寸稳定性和HDT的负面影响较大,R-PC/ABS/12HDP的LOI为36.1%,阻燃可达到UL 941.0 mm V-0级,与R-PC/ABS相比,HDT、拉伸强度、弯曲强度、弯曲模量和缺口冲击强度分别降低了20.2℃、26.6%、14.5%、16.9%和60.9%;R-PC/ABS/0.8TSQ/6HDP的LOI为35.7%,阻燃级别达到UL 941.0 mm V-0级,与R-PC/ABS/12HDP相比,模后收缩率(PMS)降低了19.7%,HDT、拉伸强度、弯曲强度、弯曲模量和缺口冲击强度分别提高了13℃、21.0%、11.3%、14.3%和85.9%。
基金supported in part by the National Natural Science Foundation of China (Grant Nos. 12141501, 123B2080, 12435006, 12475117, and 11935003)the National Key Laboratory of Neutron Science and Technology (Grant No. NST202401016)+2 种基金the National Key R&D Program of China (Grant No. 2024YFE0109803)the High-performance Computing Platform of Peking Universitythe funding support from the State Key Laboratory of Nuclear Physics and Technology, Peking University (Grant No. NPT2023ZX03)。
文摘An accurate and simultaneous ab initio prediction for both light nuclei and nuclear matter has been a longstanding challenge in nuclear physics, due to the significant uncertainties associated with the three-nucleon forces.In this Letter, we develop the relativistic quantum Monte Carlo methods for the nuclear ab initio problem, and calculate the ground-state energies of A ≤ 4 nuclei using the two-nucleon Bonn force with an unprecedented high accuracy. The present relativistic results significantly outperform the nonrelativistic results with only twonucleon forces. We demonstrate that both light nuclei and nuclear matter can be well described simultaneously in the relativistic ab initio calculations, even in the absence of three-nucleon forces, and a correlation between the properties of light A ≤ 4 nuclei and the nuclear saturation is revealed. This provides a quantitative understanding of the connection between the light nuclei and nuclear matter saturation properties.
基金supported by the Natural Science Foundation of China(82160156,82260162,and 32370669)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040200)+1 种基金the Tianshan Talent Project in Xinjiang Autonomous Region(2023TSYCCX0116 and 2023TSYCQNTJ0032)the Scientific and Technological Research Project of Xinjiang Production and Construction Corps(2022ZD001,2021AB028,2022AB022,2023AB057,and 2023ZD037).
文摘Dysregulation of microRNA(miRNA)expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus(T2DM).Identifying differentially expressed miRNAs and their roles in regulating glucose metabolism will provide a theoretical foundation for the molecular mechanisms underlying obesity-induced T2DM.Here,we perform a genome-wide association study involving 5 glycolipid metabolism traits in 1783 Kazakh and 1198 Uyghur individuals to identify miRNAs associated with fasting plasma glucose(FPG)levels.A miR-548ab mimic and inhibitor are administered to hepatocytes and adipocytes,as well as obese and diabetic mice,to determine miR-548ab-related downstream signalling pathways.The effects of miR-548ab on glucose metabolism are validated using the glucose tolerance test and insulin tolerance test.Collectively,these results indicate that miR-548ab is significantly associated with FPG levels and obesity-related T2DM in both Kazakh and Uyghur populations.The miR-548ab-GULP1/SLC25A21-GLUT4 network exerts regulatory effects on glucose metabolism,obesity,and T2DM,positioning it as a candidate risk factor,potential diagnostic marker,and therapeutic target for obesity-induced T2DM.Additionally,through evolutionary analysis,the authentic variants or haplotypes of GULP1 and SLC25A21 are categorized according to their genetic susceptibility to T2DM.The miR-548ab inhibitor shows beneficial effects in obese and diabetic mice.
