Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G p...Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G protein-coupled receptor superfamily, adhesion Gprotein-coupled receptors (aGPCRs) have attracted extensive attention due to their uniqueextracellular domain and adhesion properties. In the past few decades, increasing evidencehas indicated that sensing mechanical stimuli may be one of the main physiological activitiesof aGPCRs. Here, we review the general structure and activation mechanisms of these receptors and highlight the lesion manifestations relevant to each mechanosensitive aGPCR.展开更多
基金supported by grants from the Natural Science Foundation of Hebei Province(China)(No.H2020206226)Hebei Province Science and Technology Support Program(China)(No.18277756D)+1 种基金the Science and Technology Research Project of Hebei Higher Education Institutions(China)(No.ZD2022010)High-level talent funding project of Hebei(China)(No.20231141)to W.W.
文摘Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G protein-coupled receptor superfamily, adhesion Gprotein-coupled receptors (aGPCRs) have attracted extensive attention due to their uniqueextracellular domain and adhesion properties. In the past few decades, increasing evidencehas indicated that sensing mechanical stimuli may be one of the main physiological activitiesof aGPCRs. Here, we review the general structure and activation mechanisms of these receptors and highlight the lesion manifestations relevant to each mechanosensitive aGPCR.
