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肝癌中PP2A B56家族成员对于预后的价值以及免疫浸润分析
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作者 向未来 吴红梅 +3 位作者 黄媛媛 许力 李迪 朱小年 《右江民族医学院学报》 2024年第3期320-327,共8页
目的探讨肝癌中蛋白磷酸酶2A(PP2A)B56家族成员对于预后的价值。方法利用GEPIA、Kaplan-Meier绘图仪、cBioPortal、GeneMANIA和TIMER分析肝癌患者PP2A B56的差异表达、预后价值、基因改变和免疫细胞浸润。结果肝癌组织中PPP2R5A、PPP2R5... 目的探讨肝癌中蛋白磷酸酶2A(PP2A)B56家族成员对于预后的价值。方法利用GEPIA、Kaplan-Meier绘图仪、cBioPortal、GeneMANIA和TIMER分析肝癌患者PP2A B56的差异表达、预后价值、基因改变和免疫细胞浸润。结果肝癌组织中PPP2R5A、PPP2R5C、PPP2R5D和PPP2R5E的表达水平升高,而PPP2R5E与肝癌患者的临床癌症分期和总生存期显著相关,PPP2R5B、PPP2R5D与肝癌患者的总生存期或者无病生存期显著相关,提示PPP2R5D、PPP2R5E可能是肝癌患者生存的潜在预后生物标志物。此外,差异表达的PP2A B56家族成员的功能主要是与其他如SGO1、PFKFB4、PPP2R1A、NKD1等蛋白分子参与的糖酵解、蛋白质丝氨酸/苏氨酸磷酸复合物、蛋白质去磷酸化、减数分裂、核苷酸代谢、JAK-STAT信号通路等有关。进一步分析发现PP2A B56的表达与肝癌中6种免疫细胞,包括B细胞、CD8^(+)T细胞、CD4^(+)T细胞、巨噬细胞、中性粒细胞和树突状细胞的免疫浸润显著相关。结论PPP2R5D、PPP2R5E可作为肝癌潜在的预后生物标志物。 展开更多
关键词 生物信息学分析 PP2a b56家族 肝细胞 生物标志物
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A Creation Model from the Gell-Mann Standard Model to the Creation of Bio Cells: Based on the Assumption of Homogeneous 5D Space-Time Universe
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作者 Kai Wai Wong Wan Ki Chow 《Journal of Modern Physics》 2020年第7期1058-1074,共17页
In this paper, we briefly go over the homogeneous 5D model field theory: from the 5D space-time inception, to its quantum field solutions given in terms of Higgs vacuum, filled with magnetic monopole bose fields of al... In this paper, we briefly go over the homogeneous 5D model field theory: from the 5D space-time inception, to its quantum field solutions given in terms of Higgs vacuum, filled with magnetic monopole bose fields of all energies. Then through the space dimension reduction projections, the Gell-Mann standard model was obtained as well as a quantum to Classical connection was made via introducing Bose distribution to the monopoles to obtain the Perelman entropy and Ricci Flow mappings. This provided us a picture to the creation of Astronomical objects, from galaxies to stars and planets. This method of splitting the monopole energy into ranges is extended to show that below the basic rest mass range of the electron and Quark, it still can be applied to explaining for the creation of the chemical elements periodic table. But perhaps the most interesting is in the lowest hundreds of Hz energy range, obtained from yet another 3 fold space symmetry breaking, into 2D × 1D, producing bio nitrogenous bases composed of 3 Carbon 12 in hexagon structures, due to preservation of the 1D monopole standing waves of this low frequencies. From that by imposing gauge changes the monopole states into DNA spectra. Since such spectra states retain the DLRO, it induces formation of charge carriers periodicity in a spherical bio cell.. It was then argued that due to cell’s surface proteins, the structure must contain partial filled VB, with “p” state hole density, and empty CB, separated from VB by a positive band gap. Such band structures resemble known HTC Cuprate ceramics. Since the HTC goes through a Superconductivity transition via the simultaneous bose exciton condensation, providing a Coulomb pressure, which reduces the band gap substantially, and induces the ODLRO transition of the hole density. The same obviously applies to the bio cells. Because of the near continuous exciton levels generated, a matching to the DNA spectra then can always occur by selective choices of proteins on the cell surface. Judging from a numerical study, we did years ago on YBCO, with doping. We found with a large enough VB hole density, the exciton induced superconducting gap can easily lead to <em>T</em><em>c</em> in the room temperature range. In fact by EMF excitation can increase the exciton pressure and trigger the ODLRO transition <em>T</em><em>c</em> upward. In fact, numerical results then suggest there do exist coherent EMF spectra from three key elements: Water, Carbon and Hydrogen, together with Oxygen, as studied over the years by numerous people, starting from Schr<span style="white-space:nowrap;">&ouml;</span>dinger to most recently Geesink. 展开更多
关键词 5D Fermat’s Theorem Space Dimension Reduction Projections Perelman Mappings The Higgs Vacuum: a b.E. Condensed Monopole bosons Realization of Excitonic Induced Superconducting “p” Valence band Orbitals in bio Cells The Final Coherent building block EMF Spectra: Water Carbon Hydrogen and Oxygen
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Conductance Oscillations through an Aharonov Bohm Ring with a Quantum Gate
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作者 SHI Yao ming CHEN Hang de XU Shi yue (College of Sciences, Shanghai University) CHEN Hao (Department of Physics, Fudan University) 《Advances in Manufacturing》 SCIE CAS 1999年第3期203-207,共5页
Based on a one dimensional quantum wave guide theory, we investigate the ballistic conductance through an Aharonov Bohm ring with a quantum gate. The analytical expression of the conductance is exactly obtained as t... Based on a one dimensional quantum wave guide theory, we investigate the ballistic conductance through an Aharonov Bohm ring with a quantum gate. The analytical expression of the conductance is exactly obtained as the function of magnetic flux penetrating the ring and Fermi energy of indcident electrons. When Fermi energy equals that of bound states in the isolated stub, the conductance is fixed at a constant value which is only determined by the geometric structure of the ring system. We have found that there are a new kind of conductance oscillations for some special mesoscopic ring systems. As Fermi energy of incident electrons crosses that of bound state in the isolated stub, the conductance oscillations have no abrupt change of phase by π and are in phase. This striking feature is not in ageement with that of previous experiments and theories. The mechanism causing this new feature is discussed. 展开更多
关键词 conductance oscillation a b ring quantum gate
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河北沧州东北部南大港湿地晩全新世环境演变特征 被引量:4
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作者 赵永杰 由翰飞 +2 位作者 张振 杨光 李月丛 《第四纪研究》 CAS CSCD 北大核心 2024年第3期755-769,共15页
滨海湿地是全球变化背景下受到严重威胁的生态脆弱带和环境变化敏感区。揭示滨海湿地在长期气候变化和人类活动影响下的演变规律,有助于确定生态系统失衡的阈值,实现对滨海湿地的保护和可持续利用。本研究在8个AMS 14C测年数据基础上,... 滨海湿地是全球变化背景下受到严重威胁的生态脆弱带和环境变化敏感区。揭示滨海湿地在长期气候变化和人类活动影响下的演变规律,有助于确定生态系统失衡的阈值,实现对滨海湿地的保护和可持续利用。本研究在8个AMS 14C测年数据基础上,基于孢粉、藻类、粒度、地球化学元素以及氧同位素等代用指标的变化,揭示了河北省沧州市东北部南大港湿地(剖面0~4 m)近4000年以来的环境演变过程及其驱动因素。结果表明:1)南大港湿地在3850~3570 cal.a B.P.期间,端元组分以EM3(海洋沉积)为主,沟鞭藻浓度较高,Cl元素含量和Sr/Ca值为研究段最高,Ti和K元素含量较低,说明沉积环境主要受到海洋影响,为开阔的浅海环境;3570~3450 cal.a B.P.期间,端元组分变为以EM1(河流沉积)为主,沟鞭藻浓度减少,Cl元素含量和Sr/Ca比值降低,Ti和K元素含量增加,陆源沉积物汇集明显,海洋影响减弱,此阶段应为潟湖环境;3450 cal.a B.P.以来,端元组分EM1(河流沉积)减少,EM2(风成或近源沉积)组分增加,沟鞭藻浓度明显减少,表明潟湖消亡,滨海湿地形成。2)南大港湿地岩芯钻孔孢粉组合特征显示3500 cal.a B.P.前后差异显著,3500 cal.a B.P.前孢粉组合以松属和栎属等木本植物为主,区域内木本植物盖度较大;而在3500 cal.a B.P.之后,孢粉组合中木本花粉含量明显减少,近源的草本花粉占据主导,包括藜科和禾本科这些典型的湿地草本植物大量增加,喜干旱环境的蒿属植物增加,指示森林植被占比下降,草地植被占比升高。3)约3500 cal.a B.P.之后木本花粉的减少及草本花粉的增加主要与3500 cal.a B.P.弱季风事件有关,该时期全球太阳辐射量降低,东亚夏季风减弱,气候向冷干化发展,使得渤海湾西部地区植被盖度下降,水土流失加剧,河流输沙能力增强并在海岸处大量沉积,相对海平面下降,南大港湿地形成。 展开更多
关键词 晩全新世 南大港湿地 沉积环境 花粉组合 3500 cal.a b.P.弱季风事件
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郭店简《语丛四》“叔鲔”考释
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作者 张新俊 《古文字研究》 2024年第1期384-388,共5页
郭店简《语丛四》第10号简有如下的一段文字(释文采用宽式,下同):车辙之AB,不见江湖之水。匹夫愚妇,不知其乡之小人君子。AB二字的原篆如下:A■ B■自1998年郭店简公布以来,至今已逾二十五年,学者们曾经对A B二字提出过多种释读意见,迄... 郭店简《语丛四》第10号简有如下的一段文字(释文采用宽式,下同):车辙之AB,不见江湖之水。匹夫愚妇,不知其乡之小人君子。AB二字的原篆如下:A■ B■自1998年郭店简公布以来,至今已逾二十五年,学者们曾经对A B二字提出过多种释读意见,迄今尚无定论。林清源《郭店楚简<语丛四>■考释》一文汇集了2008年以前的多种释读意见并加以分类。为减免学者翻检之劳,不妨把诸说撮要抄录于此。颜世铉读作“闭宥”或“密宥”,训作“拘宥”。林素清读作“密阂”,训作“封闭阻隔”。白于蓝读作“蔽晦”,训作“蒙蔽”。刘钊读作“蔽翳”或“蔽晦”,训作“遮蔽”。李零读作“■醢”,训作“肉羹”。 展开更多
关键词 a b 愚妇 郭店简 车辙 叔鲔
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The analytical model for crosstalk noise of current-mode signaling in coupled RLC interconnects of VLSI circuits
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作者 Peng Xu Zhongliang Pan 《Journal of Semiconductors》 EI CAS CSCD 2017年第9期74-81,共8页
With the continuous advancement of semiconductor technology, the interconnects crosstalk has had a great influence on the performances of VLSI circuits. To date, most of the research about the interconnects of VLSI ci... With the continuous advancement of semiconductor technology, the interconnects crosstalk has had a great influence on the performances of VLSI circuits. To date, most of the research about the interconnects of VLSI circuits focus on the voltage-mode signaling (VMS) scheme while the current-mode signaling (CMS) scheme is rarely analyzed. First of all, an equivalent circuit model of two-line coupled interconnects is presented in this paper, which is applicable to both the CMS and VMS schemes. The coupling capacitive and mutual inductive are taken into account in the equivalent circuit model. Secondly, the output noise of CMS and VMS schemes are investigated in the paper according to the decoupling technique and A B CD parameter matrix approach at local level, intermediate level and global level, respectively. Moreover, the experimental results show that the CMS interconnects have lesser noise peak, noise width and noise amplitude than the VMS interconnects in the same cases, and the CMS scheme is especially suitable for the global interconnects communication of VLSI circuits. It is found that the results obtained by A B CD parameter matrix approach are in good accordance with the simulation results of the advanced design system. 展开更多
关键词 VLSI circuits interconnects crosstalk noise current-mode signaling decoupling technique a b CD parameter matrix
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