An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[ 1,2-a]pyridines from easily available starting materials： Aromatic ketones, α/βunsaturated ketones,β-keto esters and 2- aminopyri...An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[ 1,2-a]pyridines from easily available starting materials： Aromatic ketones, α/βunsaturated ketones,β-keto esters and 2- aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined bv X-ray crystallographic analysis.展开更多
基金the National Natural Science Foundation of China (Nos. 21032001 and 21272085) for their generous financial supportthe excellent doctorial dissertation cultivation grant from Central China Normal University Wuhan, China (No. 2013YBYB63)
文摘An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[ 1,2-a]pyridines from easily available starting materials： Aromatic ketones, α/βunsaturated ketones,β-keto esters and 2- aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined bv X-ray crystallographic analysis.
