Objective: To investigate the effect of sacubitril-valsartan combined with Zhenyuan capsule in the treatment of chronic heart failure comorbid anxiety and depression and its effect on the level of inflammatory factors...Objective: To investigate the effect of sacubitril-valsartan combined with Zhenyuan capsule in the treatment of chronic heart failure comorbid anxiety and depression and its effect on the level of inflammatory factors. Methods: A total of 106 patients with chronic heart failure comorbid anxiety and depression from February 2020 to March 2022 were continuously enrolled and divided into control group (36 cases), observation group A (36 cases) and observation group B (34 cases) according to treatment methods. All groups were given conventional treatment. On the basis of routine treatment, the control group, observation group A and observation group B were given valsartan, sacubitril-valsartan and sacubitril-valsartan plus Zhenyuan Capsules for the treatment of consecutive 8 weeks. The patients in the 3 groups were evaluated by the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) before and after treatment, and the clinical efficacy of heart failure was evaluated, and the detection of left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), N terminal brain natriuretic peptide (NT-proBNP), tumor necrosis factor alpha (TNF alpha), interleukin 6 (IL-6), c-reactive protein (CRP) was conducted. Results: The clinical efficacy rate and total effective rate of heart failure in observation group A and observation group B were significantly higher than those in the control group (P < 0.05), and the observation group B was higher than the observation group A (P < 0.05);SAS and SDS scores in observation group A and observation group B were significantly lower than the control group (P < 0.05), and observation group B was lower than observation group A (P < 0.05);The LVEF in the three groups was all increased compared with those before treatment, and the levels of LVESD, LVEDD, NT-proBNP, TNF-α, IL-6, and hs-CRP were all decreased compared with those before treatment;The changes of above indexes in observation group A and observation group B were more significant than those in control group (P < 0.05). Except for the LVEDD index, the observation group B had significant changes compared with the observation group A (P < 0.05). Conclusion: Sacubitril valsartan can improve cardiac function, reduce inflammatory response, and improve anxiety and depression in patients with chronic heart failure, and the treatment effect of combination with Zhenyuan Capsule is more significant.展开更多
The total ginsenosides of ginseng fruit are the main constituents of Zhenyuan capsule,which is mainly used for the treatment of cardiovascular diseases.It has been reported that ginsenoside can affect the activity of ...The total ginsenosides of ginseng fruit are the main constituents of Zhenyuan capsule,which is mainly used for the treatment of cardiovascular diseases.It has been reported that ginsenoside can affect the activity of CYP450 enzymes.Zhenyuan capsule and simvastatin may interact with each other through CYP3 A4 mediation,then affect the efficacy and even produce adverse reactions.However,no studies have investigated the effects of Zhenyuan capsule on the pharmacokinetics of simvastatin and its active metabolites.In this study,liquid chromatography–electrospray ionization–mass spectrometry(LC-MS/MS)was used to detect the pharmacokinetics of simvastatin and its active metabolites-simvastatin acid with or without Zhenyuan capsule in rats.Compared with the simvastatin alone,the pharmacokinetic parameters of simvastatin and simvastatin acid were significantly different in AUC0–24 and AUC0–∞,and they were decreased in varying degrees(P<0.05).It appeared that the Zhenyuan capsule might increase the activity of CYP3 A4 to some extent.展开更多
文摘Objective: To investigate the effect of sacubitril-valsartan combined with Zhenyuan capsule in the treatment of chronic heart failure comorbid anxiety and depression and its effect on the level of inflammatory factors. Methods: A total of 106 patients with chronic heart failure comorbid anxiety and depression from February 2020 to March 2022 were continuously enrolled and divided into control group (36 cases), observation group A (36 cases) and observation group B (34 cases) according to treatment methods. All groups were given conventional treatment. On the basis of routine treatment, the control group, observation group A and observation group B were given valsartan, sacubitril-valsartan and sacubitril-valsartan plus Zhenyuan Capsules for the treatment of consecutive 8 weeks. The patients in the 3 groups were evaluated by the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) before and after treatment, and the clinical efficacy of heart failure was evaluated, and the detection of left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), N terminal brain natriuretic peptide (NT-proBNP), tumor necrosis factor alpha (TNF alpha), interleukin 6 (IL-6), c-reactive protein (CRP) was conducted. Results: The clinical efficacy rate and total effective rate of heart failure in observation group A and observation group B were significantly higher than those in the control group (P < 0.05), and the observation group B was higher than the observation group A (P < 0.05);SAS and SDS scores in observation group A and observation group B were significantly lower than the control group (P < 0.05), and observation group B was lower than observation group A (P < 0.05);The LVEF in the three groups was all increased compared with those before treatment, and the levels of LVESD, LVEDD, NT-proBNP, TNF-α, IL-6, and hs-CRP were all decreased compared with those before treatment;The changes of above indexes in observation group A and observation group B were more significant than those in control group (P < 0.05). Except for the LVEDD index, the observation group B had significant changes compared with the observation group A (P < 0.05). Conclusion: Sacubitril valsartan can improve cardiac function, reduce inflammatory response, and improve anxiety and depression in patients with chronic heart failure, and the treatment effect of combination with Zhenyuan Capsule is more significant.
基金Research Fund Project of health and Family Planning Commission of Hebei Province(Grant No.20170571)。
文摘The total ginsenosides of ginseng fruit are the main constituents of Zhenyuan capsule,which is mainly used for the treatment of cardiovascular diseases.It has been reported that ginsenoside can affect the activity of CYP450 enzymes.Zhenyuan capsule and simvastatin may interact with each other through CYP3 A4 mediation,then affect the efficacy and even produce adverse reactions.However,no studies have investigated the effects of Zhenyuan capsule on the pharmacokinetics of simvastatin and its active metabolites.In this study,liquid chromatography–electrospray ionization–mass spectrometry(LC-MS/MS)was used to detect the pharmacokinetics of simvastatin and its active metabolites-simvastatin acid with or without Zhenyuan capsule in rats.Compared with the simvastatin alone,the pharmacokinetic parameters of simvastatin and simvastatin acid were significantly different in AUC0–24 and AUC0–∞,and they were decreased in varying degrees(P<0.05).It appeared that the Zhenyuan capsule might increase the activity of CYP3 A4 to some extent.
