The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoel...The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoelastic models,the Zener model and Voigt model,were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage.The results demonstrate that moderate fibrosis（≤F2） has a good correlation with liver viscoelasticity.The mean Zener elasticity E1 increases from（0.452±0.094） kPa（F0） to（1.311±0.717） kPa（F2）,while the mean Voigt elasticity E increases from（0.618±0.089） kPa（F0） to（1.701±0.844） kPa（F2）.The mean Zener viscosity increases from（3.499±0.186） Pa·s（F0） to（4.947±1.811） Pa·s（F2） and the mean Voigt viscosity increases from（3.379±0.316） Pa·s（F0） to（4.625±1.296） Pa·s（F2）.Compared with viscosity,the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used.Therefore,the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.展开更多
基金supported by the National Natural Science Foundation of China(Nos.61031003,81271651,and 61101025)the Shenzhen Basic Research Project(No.JC201005280501A),China
文摘The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoelastic models,the Zener model and Voigt model,were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage.The results demonstrate that moderate fibrosis（≤F2） has a good correlation with liver viscoelasticity.The mean Zener elasticity E1 increases from（0.452±0.094） kPa（F0） to（1.311±0.717） kPa（F2）,while the mean Voigt elasticity E increases from（0.618±0.089） kPa（F0） to（1.701±0.844） kPa（F2）.The mean Zener viscosity increases from（3.499±0.186） Pa·s（F0） to（4.947±1.811） Pa·s（F2） and the mean Voigt viscosity increases from（3.379±0.316） Pa·s（F0） to（4.625±1.296） Pa·s（F2）.Compared with viscosity,the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used.Therefore,the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.
