Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc...Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc sulfate(ZnSO_(4))to be oyster peptide-zinc chelates(OPZs)that offer potential as a valuable zinc supplement.The complexation of zinc with oyster peptides induces conformational changes in the peptides,altering their overall spatial arrangement.This could potentially impact their functions and properties.OPZs have demonstrated enhanced physical and gastrointestinal stability,as they are resistant to digestion by pepsin and trypsin.The research has shown that OPZs can modulate the expression of key proteins involved in zinc binding(MT1),peptide transport(PePT1),and zinc transport(ZIP4 and ZnT1)in enterocytes.By regulating the proteins expression,OPZs have the potential to affect zinc absorption and homeostasis.Furthermore,OPZs have been found to enhance zinc absorption through dual pathways compared to the single pathway of inorganic zinc.Additionally,they have the potential to improve zinc bioaccessibility and bioavailability,meaning they can make zinc more easily absorbed by the body and readily available for use.展开更多
Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant transformation.This exclusion of zinc may be necessary for ...Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant transformation.This exclusion of zinc may be necessary for the viability of prostate cancer,as measures which increase the intracellular zinc content of prostate cancers lead to cell death,oxidative stress,and a marked reduction in ATP,suggestive of mitochondrial damage.The anti-fungal drug clioquinol,which can act as a zinc ionophore,can markedly slow the growth of human prostate cancer in nude mice,and has been proposed as a clinical therapy for prostate cancer.However,clioquinol is currently only available as a topical agent,as it was linked to subacute myelo-optic neuropathy with oral use.A more practical option for promoting zinc transport may be offered by the nutraceutical zinc dipicolinate,a stable chelate in which four coordination positions of zinc are occupied by two molecules of the tryptophan metabolite picolinic acid.Zinc dipicolinate is a highly effective supplemental source of zinc that has been shown to be more potent than soluble zinc salts for alleviating the symptoms of acrodermatitis enteropathica,a genetic zinc deficiency disorder reflecting homozygous loss of functional ZIP4 zinc importers in enterocytes.This suggests that the zinc dipicolinate complex is sufficiently stable and lipophilic to transfer zinc across cellular membranes.If so,it may have potential for“smuggling”zinc into prostate cancer cells.Hence,cell culture and rodent studies to evaluate the impact of zinc dipicolinate on human prostate cancer are warranted.展开更多
基金supported by the National Natural Science Foundation of China(32130085)the National Natural Science Foundation Youth Fund Project of China(32202021).
文摘Zinc is an essential mineral for human health,and its deficiency can lead to various health issues.Oysters(Crassostrea gigas)are known to be a rich source of protein-bound zinc.Oyster peptides were complexed with zinc sulfate(ZnSO_(4))to be oyster peptide-zinc chelates(OPZs)that offer potential as a valuable zinc supplement.The complexation of zinc with oyster peptides induces conformational changes in the peptides,altering their overall spatial arrangement.This could potentially impact their functions and properties.OPZs have demonstrated enhanced physical and gastrointestinal stability,as they are resistant to digestion by pepsin and trypsin.The research has shown that OPZs can modulate the expression of key proteins involved in zinc binding(MT1),peptide transport(PePT1),and zinc transport(ZIP4 and ZnT1)in enterocytes.By regulating the proteins expression,OPZs have the potential to affect zinc absorption and homeostasis.Furthermore,OPZs have been found to enhance zinc absorption through dual pathways compared to the single pathway of inorganic zinc.Additionally,they have the potential to improve zinc bioaccessibility and bioavailability,meaning they can make zinc more easily absorbed by the body and readily available for use.
文摘Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant transformation.This exclusion of zinc may be necessary for the viability of prostate cancer,as measures which increase the intracellular zinc content of prostate cancers lead to cell death,oxidative stress,and a marked reduction in ATP,suggestive of mitochondrial damage.The anti-fungal drug clioquinol,which can act as a zinc ionophore,can markedly slow the growth of human prostate cancer in nude mice,and has been proposed as a clinical therapy for prostate cancer.However,clioquinol is currently only available as a topical agent,as it was linked to subacute myelo-optic neuropathy with oral use.A more practical option for promoting zinc transport may be offered by the nutraceutical zinc dipicolinate,a stable chelate in which four coordination positions of zinc are occupied by two molecules of the tryptophan metabolite picolinic acid.Zinc dipicolinate is a highly effective supplemental source of zinc that has been shown to be more potent than soluble zinc salts for alleviating the symptoms of acrodermatitis enteropathica,a genetic zinc deficiency disorder reflecting homozygous loss of functional ZIP4 zinc importers in enterocytes.This suggests that the zinc dipicolinate complex is sufficiently stable and lipophilic to transfer zinc across cellular membranes.If so,it may have potential for“smuggling”zinc into prostate cancer cells.Hence,cell culture and rodent studies to evaluate the impact of zinc dipicolinate on human prostate cancer are warranted.
