The Yishui complex,located in the western Shandong area of the North China Craton,is representative of the Archean crystalline basement of the North China Craton to explore the early tectonic-thermal evolution history...The Yishui complex,located in the western Shandong area of the North China Craton,is representative of the Archean crystalline basement of the North China Craton to explore the early tectonic-thermal evolution history of the Earth.Detailed petrography,mineral chemistry,metamorphic evolution and zircon U-Pb dating are presented for felsic granulite and two-pyroxene granulite from the Yishui complex to contribute to new insights into the Neoarchean tectonic evolution of the North China Craton.Three mineral assemblages are recognized for these granulite samples,including the prograde(M1),peak(M2)and retrograde(M3)mineral assemblages.Conventional geothermobarometry and phase equilibrium modeling yield P-T conditions of 6.5-10.9 kbar/718-839℃ for the peak metamorphism,which define a medium-pressure granulite-facies metamorphism occurred at middle to lower crust.Anticlockwise P-T paths with near-isobaric cooling(IBC)retrograde segments were reconstructed.Zircon LA-ICP-MS U-Pb dating suggests that the protolith of the felsic granulite was emplaced at 2541±7 Ma and the subsequent medium-pressure granulite-facies metamorphism occurred at 2518-2494 Ma.A two-stage mantle plume related crustal-scale sagduction geodynamic regime is proposed in the western Shandong terrane in the Neoarchean.展开更多
Charnockite and granulite in Yishui area, Shandong Province are located in the middle part of the Tancheng Lujiang fault zone, eastern China. Field studies have shown that the charnockites, derived from the adjacent ...Charnockite and granulite in Yishui area, Shandong Province are located in the middle part of the Tancheng Lujiang fault zone, eastern China. Field studies have shown that the charnockites, derived from the adjacent granulites, are classified as three types: enderbite, garnet enderbite and hypersthene trondhjemite. In addition, two generations of minerals are present in the charnockites: the relic minerals such as garnet, hypersthene and clinopyroxene, and the neocrystallized minerals such as plagioclase and K feldspar. The relic minerals occurring in the granulite facies stage were affected by the later partial melting. The relic minerals, irregular and usually ragged in shape, occupy the interstitial positions in the neocrystalline minerals. The neocrystalline minerals are usually euhedral subhedral crystals. The study of petrology, mineralogy and geochemistry of charnokites concludes that the enderbite was formed by the anatexis of the two pyroxene plagioclase granulite, that the garnet enderbite was formed by the anatexis of sillimanite garnet gneiss, and that the hypersthene trondhjemite was formed by the anatexis of the leucocratic two pyroxene plagioclase granulite. The U Pb dating of the zircon indicates that the formation of the charnockite and granulite was related to the Archean Proterozoic upwelling of a mantle plume (hot spot) around 2 500 Ma, in Yishui area, Shandong Province.展开更多
The Yishui Eldon Textile Co. Ltd. is a joint venture company of limited liability set up by the Yishui Textile Mill of Shandong and Hongkong Eldon Development Co. Ltd. The total investment was 5.10 million dollars, wi...The Yishui Eldon Textile Co. Ltd. is a joint venture company of limited liability set up by the Yishui Textile Mill of Shandong and Hongkong Eldon Development Co. Ltd. The total investment was 5.10 million dollars, with registered capital of 3.88 million dollars. The company has imported from Germany advanced double-crank spinning machine and accessory equipment for annual production of 1.2 million meters of high quality decorative flannelette.展开更多
Located on the upper part of the Yi River, Shandong Province, Yishui County has jurisdiction over 13 towns and 1, 219 administrative villages, with a total population of 1.13 million, covering an area of 2, 434.8 squa...Located on the upper part of the Yi River, Shandong Province, Yishui County has jurisdiction over 13 towns and 1, 219 administrative villages, with a total population of 1.13 million, covering an area of 2, 434.8 square kilometers. Because of its moderate climate and geographic advantages, the county is an ideal place for foreign investment. The county seat is 110 km from Rizhao Port, 240 km from Oingdao Port, 90 km展开更多
Yishui County Down Product Factory specializes in producing washed duck down and down products. It was originally set up by the Ministry of Commerce. Since it was founded in October 1987, the factory’s profits have g...Yishui County Down Product Factory specializes in producing washed duck down and down products. It was originally set up by the Ministry of Commerce. Since it was founded in October 1987, the factory’s profits have grown year by year. In 1993, it become a Sino-American joint venture with an annual production capacity of duck feathers of 350, 000 kg and down products of 300, 000 pieces, as well as fixed展开更多
OBJECTIVE:To investigate the efficacy and mechanism of Traditional Chinese Medicine Yishui Shengxue pills(益髓生血丸,YSSX)in mouse models of immunosuppression induced by three chemotherapy drugs.METHODS:We determined ...OBJECTIVE:To investigate the efficacy and mechanism of Traditional Chinese Medicine Yishui Shengxue pills(益髓生血丸,YSSX)in mouse models of immunosuppression induced by three chemotherapy drugs.METHODS:We determined an optimal intervention dose of YSSX to investigate efficacy.Changes in immune cell subpopulations were detected by flow cytometry,while immunofluorescence,immunohistochemistry,and other molecular biology methods,were used to verify pathway targets.We used PX-478,an inhibitor of hypoxia-inducible factor-1α(HIF-1α),to validate the mechanism of action.RESULTS:Analysis showed that YSSX enhanced the immunity of mouse models of immunosuppression.At the cellular level,YSSX reduced the numbers of myeloid-derived suppressor cells(MDSCs)and enhanced CD8+T cell infiltration.At the molecular level,YSSX reduced the expression levels of hypoxia-inducible factor-1α(HIF-1α),inducible nitric oxide synthase(iNOS),general control nonderepressible 2(GCN2),and eukaryotic initiation factor 2α(eIF2α)in mouse MDSCs,thereby reducing the transcription of HIF-1α,GCN2,and eIF2αmRNA.Collectively,these changes led to the increased secretion of interferon-γand interleukin 12,concomitant with a reduction in tumor necrosis factor-αlevel.CONCLUSIONS:YSSX improved MDSC-mediated immunosuppression in a mouse model after chemotherapy by inhibiting the HIF-1α/iNOS-GCN2/eIF2αsignaling axis.展开更多
基金supported by the Natural Science Foundation of Shandong Provence(Grant No.ZR2023MD058)National Natural Science Foundation of China(Grant Nos.42072219,41802201)。
文摘The Yishui complex,located in the western Shandong area of the North China Craton,is representative of the Archean crystalline basement of the North China Craton to explore the early tectonic-thermal evolution history of the Earth.Detailed petrography,mineral chemistry,metamorphic evolution and zircon U-Pb dating are presented for felsic granulite and two-pyroxene granulite from the Yishui complex to contribute to new insights into the Neoarchean tectonic evolution of the North China Craton.Three mineral assemblages are recognized for these granulite samples,including the prograde(M1),peak(M2)and retrograde(M3)mineral assemblages.Conventional geothermobarometry and phase equilibrium modeling yield P-T conditions of 6.5-10.9 kbar/718-839℃ for the peak metamorphism,which define a medium-pressure granulite-facies metamorphism occurred at middle to lower crust.Anticlockwise P-T paths with near-isobaric cooling(IBC)retrograde segments were reconstructed.Zircon LA-ICP-MS U-Pb dating suggests that the protolith of the felsic granulite was emplaced at 2541±7 Ma and the subsequent medium-pressure granulite-facies metamorphism occurred at 2518-2494 Ma.A two-stage mantle plume related crustal-scale sagduction geodynamic regime is proposed in the western Shandong terrane in the Neoarchean.
基金This study is supported by the Research Fund forthe Doctoral Pro- gram of Higher Education( No.970 4910 4)
文摘Charnockite and granulite in Yishui area, Shandong Province are located in the middle part of the Tancheng Lujiang fault zone, eastern China. Field studies have shown that the charnockites, derived from the adjacent granulites, are classified as three types: enderbite, garnet enderbite and hypersthene trondhjemite. In addition, two generations of minerals are present in the charnockites: the relic minerals such as garnet, hypersthene and clinopyroxene, and the neocrystallized minerals such as plagioclase and K feldspar. The relic minerals occurring in the granulite facies stage were affected by the later partial melting. The relic minerals, irregular and usually ragged in shape, occupy the interstitial positions in the neocrystalline minerals. The neocrystalline minerals are usually euhedral subhedral crystals. The study of petrology, mineralogy and geochemistry of charnokites concludes that the enderbite was formed by the anatexis of the two pyroxene plagioclase granulite, that the garnet enderbite was formed by the anatexis of sillimanite garnet gneiss, and that the hypersthene trondhjemite was formed by the anatexis of the leucocratic two pyroxene plagioclase granulite. The U Pb dating of the zircon indicates that the formation of the charnockite and granulite was related to the Archean Proterozoic upwelling of a mantle plume (hot spot) around 2 500 Ma, in Yishui area, Shandong Province.
文摘The Yishui Eldon Textile Co. Ltd. is a joint venture company of limited liability set up by the Yishui Textile Mill of Shandong and Hongkong Eldon Development Co. Ltd. The total investment was 5.10 million dollars, with registered capital of 3.88 million dollars. The company has imported from Germany advanced double-crank spinning machine and accessory equipment for annual production of 1.2 million meters of high quality decorative flannelette.
文摘Located on the upper part of the Yi River, Shandong Province, Yishui County has jurisdiction over 13 towns and 1, 219 administrative villages, with a total population of 1.13 million, covering an area of 2, 434.8 square kilometers. Because of its moderate climate and geographic advantages, the county is an ideal place for foreign investment. The county seat is 110 km from Rizhao Port, 240 km from Oingdao Port, 90 km
文摘Yishui County Down Product Factory specializes in producing washed duck down and down products. It was originally set up by the Ministry of Commerce. Since it was founded in October 1987, the factory’s profits have grown year by year. In 1993, it become a Sino-American joint venture with an annual production capacity of duck feathers of 350, 000 kg and down products of 300, 000 pieces, as well as fixed
基金Supported by High-end Talents Undertake Provincial Science and Technology Plan Projects(Yangtze River Scholars Award SchemeGankeji 2021:reference 20-9)Gansu Province Integrated Traditional Chinese and Western Medicine Tumor Clinical Medical Research Center(Reference:18JR2FA001)。
文摘OBJECTIVE:To investigate the efficacy and mechanism of Traditional Chinese Medicine Yishui Shengxue pills(益髓生血丸,YSSX)in mouse models of immunosuppression induced by three chemotherapy drugs.METHODS:We determined an optimal intervention dose of YSSX to investigate efficacy.Changes in immune cell subpopulations were detected by flow cytometry,while immunofluorescence,immunohistochemistry,and other molecular biology methods,were used to verify pathway targets.We used PX-478,an inhibitor of hypoxia-inducible factor-1α(HIF-1α),to validate the mechanism of action.RESULTS:Analysis showed that YSSX enhanced the immunity of mouse models of immunosuppression.At the cellular level,YSSX reduced the numbers of myeloid-derived suppressor cells(MDSCs)and enhanced CD8+T cell infiltration.At the molecular level,YSSX reduced the expression levels of hypoxia-inducible factor-1α(HIF-1α),inducible nitric oxide synthase(iNOS),general control nonderepressible 2(GCN2),and eukaryotic initiation factor 2α(eIF2α)in mouse MDSCs,thereby reducing the transcription of HIF-1α,GCN2,and eIF2αmRNA.Collectively,these changes led to the increased secretion of interferon-γand interleukin 12,concomitant with a reduction in tumor necrosis factor-αlevel.CONCLUSIONS:YSSX improved MDSC-mediated immunosuppression in a mouse model after chemotherapy by inhibiting the HIF-1α/iNOS-GCN2/eIF2αsignaling axis.
