Tibet has often been called the “Roof of the World”. The plateau is probably the largest and highest area ever to exist in Earth history, with an average elevation exceeding 5000m. The uplifting of the Tibetan Plate...Tibet has often been called the “Roof of the World”. The plateau is probably the largest and highest area ever to exist in Earth history, with an average elevation exceeding 5000m. The uplifting of the Tibetan Plateau is the result of continent\|continent collision. This process is still going on and is significant for us to understand the formation and the evolution of global continent.It’s generally accepted is act as the northern boundary of the Tibetan Plateau is the Altyn Tagh Fault. The Altyn Tagh Fault is recognized as a large\|scale left\|lateral strike\|slip fault, many studies indicate it is the northern margin of the eastward extruded of crustal blocks and the northern boundary of the Plateau as well. Compared to the knowledge on the southern plateau and the Himalaya, we know much less about the northern plateau and the Altyn Tagh Fault. Some people have already begun to realize the importance of the latter for the revealing the uplifting of the Plateau.展开更多
Neuropeptide Y gene transfection into normal rat brain tissue can provide gene overexpression, which can attenuate the severity of kainic acid-induced seizures. In this study, a recombinant adeno-associated virus carr...Neuropeptide Y gene transfection into normal rat brain tissue can provide gene overexpression, which can attenuate the severity of kainic acid-induced seizures. In this study, a recombinant adeno-associated virus carrying the neuropeptide Y gene was transfected into brain tissue of rats with kainic acid-induced epilepsy through stereotactic methods. Following these transfections, we verified overexpression of the neuropeptide Y gene in the epileptic brain. Electroencephalograms showed that seizure severity was significantly inhibited and seizure latency was significantly prolonged up to 4 weeks after gene transfection. Moreover, quantitative fluorescent PCR and western blot assays revealed that the mRNA and protein expression of the N-methyI-D-aspartate receptor subunits NR1, NR2A, and NR2B was inhibited in the hippocampus of epileptic rats. These findings indicate that neuropeptide Y may inhibit seizures via down-regulation of the functional expression of N-methyI-D-aspartate receptors.展开更多
文摘Tibet has often been called the “Roof of the World”. The plateau is probably the largest and highest area ever to exist in Earth history, with an average elevation exceeding 5000m. The uplifting of the Tibetan Plateau is the result of continent\|continent collision. This process is still going on and is significant for us to understand the formation and the evolution of global continent.It’s generally accepted is act as the northern boundary of the Tibetan Plateau is the Altyn Tagh Fault. The Altyn Tagh Fault is recognized as a large\|scale left\|lateral strike\|slip fault, many studies indicate it is the northern margin of the eastward extruded of crustal blocks and the northern boundary of the Plateau as well. Compared to the knowledge on the southern plateau and the Himalaya, we know much less about the northern plateau and the Altyn Tagh Fault. Some people have already begun to realize the importance of the latter for the revealing the uplifting of the Plateau.
文摘Neuropeptide Y gene transfection into normal rat brain tissue can provide gene overexpression, which can attenuate the severity of kainic acid-induced seizures. In this study, a recombinant adeno-associated virus carrying the neuropeptide Y gene was transfected into brain tissue of rats with kainic acid-induced epilepsy through stereotactic methods. Following these transfections, we verified overexpression of the neuropeptide Y gene in the epileptic brain. Electroencephalograms showed that seizure severity was significantly inhibited and seizure latency was significantly prolonged up to 4 weeks after gene transfection. Moreover, quantitative fluorescent PCR and western blot assays revealed that the mRNA and protein expression of the N-methyI-D-aspartate receptor subunits NR1, NR2A, and NR2B was inhibited in the hippocampus of epileptic rats. These findings indicate that neuropeptide Y may inhibit seizures via down-regulation of the functional expression of N-methyI-D-aspartate receptors.
