Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of...Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of clinical studies have shown that TCM has a significant effect in treating reflux esophagitis.Among them,Xuanfu Daizhe Decoction is a classic prescription that is widely used.This article reviews the aspects of simple prescription treatment,combined treatment of TCM prescriptions,combined treatment of TCM and Western,other related treatments,and microcosmic research of regulating the body by the prescription,so as to provide reference for the further study on improving the treatment of reflux esophagitis with Xuanfu Daizhe Decoction and other drugs.展开更多
Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of...Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of this study was from January 2019 to January 2020, and the specific subjects were 40 patients with gastroesophageal reflux admitted to our hospital. For these 40 patients, the grouping method chosen in this paper is digital randomization, which is divided into research group and control group. The control group is treated with rabeprazole enteric capsule, while the research group is treated with Xuanfu Daizhe decoction on the basis of the treatment of the control group. The treatment effect of two groups of patients was analyzed and recorded. Results: in terms of therapeutic efficacy, the improvement degree of the study group was more significant, P < 0.05, the difference was statistically significant. In addition, the TCM syndrome score index results of the two groups were analyzed, and the results showed that the data of the study group was better than that of the other group, while the data at this time showed P < 0.05, indicating that it was statistically significant. Finally, the adverse reactions occurred in different groups after treatment were observed, and it was found that the adverse reaction rate in the study group was relatively lower, so the difference was statistically significant in this study (P > 0.05). Conclusion: the application of Xuanfu Daizhe decoction combined with rabeprazole in the treatment of patients with gastroesophageal reflux can have obvious therapeutic effects, which is worthy of scientific research and clinical promotion.展开更多
目的建立旋覆代赭汤(Xuanfu Daizhe Decoction,XDD)中9种酚酸类成分一测多评(quantitative analysis of multicomponents by single marker,QAMS)定量测定方法,研究酚酸类成分的传递规律,结合基准关联度,分析配伍的影响,并探究“去渣再...目的建立旋覆代赭汤(Xuanfu Daizhe Decoction,XDD)中9种酚酸类成分一测多评(quantitative analysis of multicomponents by single marker,QAMS)定量测定方法,研究酚酸类成分的传递规律,结合基准关联度,分析配伍的影响,并探究“去渣再煎”的影响。方法制备15批XDD基准样品,以绿原酸为内标物,确定其他8种成分的相对校正因子(fs/i)并计算含量,同时采用外标法测定,比较两者结果差异,计算饮片-水煎液-基准样品的转移率,分析传递规律;制备不同配伍样品,以9种酚酸类成分转移率和指纹图谱相似度为评价指标,计算基准关联度;制备不同煎煮条件样品,检测9种酚酸类成分的转移率。结果QAMS法定量测定结果与外标法无显著差异。新绿原酸、绿原酸、隐绿原酸、咖啡酸、1,3-二咖啡酰奎宁酸、异绿原酸B、异绿原酸A、1,5-二咖啡酰奎宁酸、异绿原酸C的平均转移率分别为147.34%、42.60%、321.53%、131.49%、419.76%、172.93%、18.47%、25.06%、74.68%,酚酸类成分发生降解与异构化可能是部分成分转移率大于100%的主要原因;配伍、煎煮时间、浓缩对9种酚酸类成分的传递均有影响,其中旋覆花与半夏配伍后各指标成分和指纹图谱相似度的基准关联度均大于90%,而“去渣再煎”可以进一步促进酚酸类成分的降解与异构化。结论建立的QAMS法方便、稳定,初步明确从饮片到XDD基准样品中酚酸类有效成分群之间的变化、量值传递规律和可能的影响因素,为XDD的质量控制和制剂开发提供科学依据。展开更多
脑玄府是脑部气、血、津、液升降出入的枢纽,神经血管单元(Neurovascular unit, NVU)是大脑最小的结构、功能单位,两者均参与维持脑部微环境的稳态。在中医整体观及辨证论治原则下,脑玄府与NVU在形态结构、生理功能、病理状态等方面均...脑玄府是脑部气、血、津、液升降出入的枢纽,神经血管单元(Neurovascular unit, NVU)是大脑最小的结构、功能单位,两者均参与维持脑部微环境的稳态。在中医整体观及辨证论治原则下,脑玄府与NVU在形态结构、生理功能、病理状态等方面均具有共性内涵,糖尿病认知功能障碍(Diabetic cognitive impairment, DCI)病位在脑,文中以脑玄府郁闭为核心病机,玄府亏虚、气滞玄府、火灼玄府、痰闭玄府、瘀阻玄府、毒壅玄府为重要病理反应,以“通”为核心治疗要素。通过将脑玄府与NVU类比,建立起中医理论与现代科学的脑部微观认识,从中西医角度为DCI的发病机制探寻类似致病环节,为中西医诊疗DCI的临床研究提供新思路。展开更多
基金National Natural Science Foundation of China(No.81460713)Huang Guihua Guangxi Famous Traditional Chinese Medicine Inheritance Studio Project[No.(2017)2]。
文摘Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of clinical studies have shown that TCM has a significant effect in treating reflux esophagitis.Among them,Xuanfu Daizhe Decoction is a classic prescription that is widely used.This article reviews the aspects of simple prescription treatment,combined treatment of TCM prescriptions,combined treatment of TCM and Western,other related treatments,and microcosmic research of regulating the body by the prescription,so as to provide reference for the further study on improving the treatment of reflux esophagitis with Xuanfu Daizhe Decoction and other drugs.
文摘Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of this study was from January 2019 to January 2020, and the specific subjects were 40 patients with gastroesophageal reflux admitted to our hospital. For these 40 patients, the grouping method chosen in this paper is digital randomization, which is divided into research group and control group. The control group is treated with rabeprazole enteric capsule, while the research group is treated with Xuanfu Daizhe decoction on the basis of the treatment of the control group. The treatment effect of two groups of patients was analyzed and recorded. Results: in terms of therapeutic efficacy, the improvement degree of the study group was more significant, P < 0.05, the difference was statistically significant. In addition, the TCM syndrome score index results of the two groups were analyzed, and the results showed that the data of the study group was better than that of the other group, while the data at this time showed P < 0.05, indicating that it was statistically significant. Finally, the adverse reactions occurred in different groups after treatment were observed, and it was found that the adverse reaction rate in the study group was relatively lower, so the difference was statistically significant in this study (P > 0.05). Conclusion: the application of Xuanfu Daizhe decoction combined with rabeprazole in the treatment of patients with gastroesophageal reflux can have obvious therapeutic effects, which is worthy of scientific research and clinical promotion.
文摘目的建立旋覆代赭汤(Xuanfu Daizhe Decoction,XDD)中9种酚酸类成分一测多评(quantitative analysis of multicomponents by single marker,QAMS)定量测定方法,研究酚酸类成分的传递规律,结合基准关联度,分析配伍的影响,并探究“去渣再煎”的影响。方法制备15批XDD基准样品,以绿原酸为内标物,确定其他8种成分的相对校正因子(fs/i)并计算含量,同时采用外标法测定,比较两者结果差异,计算饮片-水煎液-基准样品的转移率,分析传递规律;制备不同配伍样品,以9种酚酸类成分转移率和指纹图谱相似度为评价指标,计算基准关联度;制备不同煎煮条件样品,检测9种酚酸类成分的转移率。结果QAMS法定量测定结果与外标法无显著差异。新绿原酸、绿原酸、隐绿原酸、咖啡酸、1,3-二咖啡酰奎宁酸、异绿原酸B、异绿原酸A、1,5-二咖啡酰奎宁酸、异绿原酸C的平均转移率分别为147.34%、42.60%、321.53%、131.49%、419.76%、172.93%、18.47%、25.06%、74.68%,酚酸类成分发生降解与异构化可能是部分成分转移率大于100%的主要原因;配伍、煎煮时间、浓缩对9种酚酸类成分的传递均有影响,其中旋覆花与半夏配伍后各指标成分和指纹图谱相似度的基准关联度均大于90%,而“去渣再煎”可以进一步促进酚酸类成分的降解与异构化。结论建立的QAMS法方便、稳定,初步明确从饮片到XDD基准样品中酚酸类有效成分群之间的变化、量值传递规律和可能的影响因素,为XDD的质量控制和制剂开发提供科学依据。
