Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of...Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of clinical studies have shown that TCM has a significant effect in treating reflux esophagitis.Among them,Xuanfu Daizhe Decoction is a classic prescription that is widely used.This article reviews the aspects of simple prescription treatment,combined treatment of TCM prescriptions,combined treatment of TCM and Western,other related treatments,and microcosmic research of regulating the body by the prescription,so as to provide reference for the further study on improving the treatment of reflux esophagitis with Xuanfu Daizhe Decoction and other drugs.展开更多
Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of...Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of this study was from January 2019 to January 2020, and the specific subjects were 40 patients with gastroesophageal reflux admitted to our hospital. For these 40 patients, the grouping method chosen in this paper is digital randomization, which is divided into research group and control group. The control group is treated with rabeprazole enteric capsule, while the research group is treated with Xuanfu Daizhe decoction on the basis of the treatment of the control group. The treatment effect of two groups of patients was analyzed and recorded. Results: in terms of therapeutic efficacy, the improvement degree of the study group was more significant, P < 0.05, the difference was statistically significant. In addition, the TCM syndrome score index results of the two groups were analyzed, and the results showed that the data of the study group was better than that of the other group, while the data at this time showed P < 0.05, indicating that it was statistically significant. Finally, the adverse reactions occurred in different groups after treatment were observed, and it was found that the adverse reaction rate in the study group was relatively lower, so the difference was statistically significant in this study (P > 0.05). Conclusion: the application of Xuanfu Daizhe decoction combined with rabeprazole in the treatment of patients with gastroesophageal reflux can have obvious therapeutic effects, which is worthy of scientific research and clinical promotion.展开更多
旨在从玄府-脑络与神经血管单元(Neurovascular unit,NVU)相关性分析脑小血管病(Cerebral small vessel disease,CSVD)的病机治法。现有研究证实,NVU稳态失衡构成CSVD的核心病理特征,其涉及神经递质调控异常、免疫应答失调、炎症级联激...旨在从玄府-脑络与神经血管单元(Neurovascular unit,NVU)相关性分析脑小血管病(Cerebral small vessel disease,CSVD)的病机治法。现有研究证实,NVU稳态失衡构成CSVD的核心病理特征,其涉及神经递质调控异常、免疫应答失调、炎症级联激活、氧化应激失衡及其相互作用,较为复杂。玄府-脑络和NVU分别是传统医学和现代医学理论中的微观结构,两者具有极大相似性。本文从结构特性、生理功能进行相关性分析,发现“玄府闭阻,脑络失养”与NVU失稳态具有共性内涵,进而从玄府-脑络理论探讨CSVD的病机治法。CSVD病位在脑,病变在玄府,发病过程分为三个阶段,早期玄府失司,气络郁阻,中期虚实夹杂,郁虚并存,后期肾虚髓减,脑络失养。在治疗中当以调畅玄府,祛邪通络、补肾填精,开玄荣络为原则。本文通过将玄府-脑络与NVU相类比,在看似独立的发病机制中寻找相同致病环节,以期为CSVD等难治性疾病提供安全有效的中西医结合治疗方案。展开更多
目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表...目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表法分为常规组(58例)和中西联合组(58例),常规组接受常规西医治疗,中西联合组在常规组的基础上加用二妙玄府方联合三黄散外敷治疗。比较两组患者临床疗效、中医症状积分,治疗前后关节疼痛视觉模拟评分(VAS)、血尿酸(BUA)、24 h尿酸排出量(24 h UUA)、外周血Beclin-1、ELOVL6、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及不良反应。结果中西联合组治疗总有效率[93.10%(54/58)vs 79.31%(46/58)]高于常规组(P<0.05);治疗后,两组关节红肿、热痛、屈曲受限、发热口渴、口苦口黏评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组VAS评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组BUA均下降(P<0.05),24 h UUA均升高(P<0.05),且治疗后组间比较差异具有统计学意义(P<0.05);治疗后,两组Beclin-1、ELOVL6均升高(P<0.05),且治疗后中西联合组高于常规组(P<0.05);治疗后,两组IL-6、CRP、TNF-α均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);两组患者试验期间均未见严重恶心呕吐、胃痛、头晕、腹泻等不良反应。结论二妙玄府方联合三黄散外敷治疗AGA临床效果显著,可较好抑制机体炎症反应,缓解疾病进程,且安全可靠。展开更多
基金National Natural Science Foundation of China(No.81460713)Huang Guihua Guangxi Famous Traditional Chinese Medicine Inheritance Studio Project[No.(2017)2]。
文摘Reflux esophagitis is a chronic and refractory common disease.Western medicine usually adopts symptomatic treatment,which has a high recurrence rate and requires long-term or even life-long treatment.A large number of clinical studies have shown that TCM has a significant effect in treating reflux esophagitis.Among them,Xuanfu Daizhe Decoction is a classic prescription that is widely used.This article reviews the aspects of simple prescription treatment,combined treatment of TCM prescriptions,combined treatment of TCM and Western,other related treatments,and microcosmic research of regulating the body by the prescription,so as to provide reference for the further study on improving the treatment of reflux esophagitis with Xuanfu Daizhe Decoction and other drugs.
文摘Objective: the patients with gastroesophageal reflux were treated with Xuanfu Daizhe decoction combined with Rabeprazole, and the specific application effect of the treatment was analyzed. Methods: the study period of this study was from January 2019 to January 2020, and the specific subjects were 40 patients with gastroesophageal reflux admitted to our hospital. For these 40 patients, the grouping method chosen in this paper is digital randomization, which is divided into research group and control group. The control group is treated with rabeprazole enteric capsule, while the research group is treated with Xuanfu Daizhe decoction on the basis of the treatment of the control group. The treatment effect of two groups of patients was analyzed and recorded. Results: in terms of therapeutic efficacy, the improvement degree of the study group was more significant, P < 0.05, the difference was statistically significant. In addition, the TCM syndrome score index results of the two groups were analyzed, and the results showed that the data of the study group was better than that of the other group, while the data at this time showed P < 0.05, indicating that it was statistically significant. Finally, the adverse reactions occurred in different groups after treatment were observed, and it was found that the adverse reaction rate in the study group was relatively lower, so the difference was statistically significant in this study (P > 0.05). Conclusion: the application of Xuanfu Daizhe decoction combined with rabeprazole in the treatment of patients with gastroesophageal reflux can have obvious therapeutic effects, which is worthy of scientific research and clinical promotion.
文摘旨在从玄府-脑络与神经血管单元(Neurovascular unit,NVU)相关性分析脑小血管病(Cerebral small vessel disease,CSVD)的病机治法。现有研究证实,NVU稳态失衡构成CSVD的核心病理特征,其涉及神经递质调控异常、免疫应答失调、炎症级联激活、氧化应激失衡及其相互作用,较为复杂。玄府-脑络和NVU分别是传统医学和现代医学理论中的微观结构,两者具有极大相似性。本文从结构特性、生理功能进行相关性分析,发现“玄府闭阻,脑络失养”与NVU失稳态具有共性内涵,进而从玄府-脑络理论探讨CSVD的病机治法。CSVD病位在脑,病变在玄府,发病过程分为三个阶段,早期玄府失司,气络郁阻,中期虚实夹杂,郁虚并存,后期肾虚髓减,脑络失养。在治疗中当以调畅玄府,祛邪通络、补肾填精,开玄荣络为原则。本文通过将玄府-脑络与NVU相类比,在看似独立的发病机制中寻找相同致病环节,以期为CSVD等难治性疾病提供安全有效的中西医结合治疗方案。
文摘目的探究二妙玄府方联合三黄散外敷治疗急性痛风性关节炎(AGA)患者临床疗效及对外周血Beclin-1、超长链脂肪酸延伸酶6(ELOVL6)的影响。方法选取2022年6月-2023年12月甘肃酒泉市人民医院收治的116例AGA患者作为研究对象,按照随机数字表法分为常规组(58例)和中西联合组(58例),常规组接受常规西医治疗,中西联合组在常规组的基础上加用二妙玄府方联合三黄散外敷治疗。比较两组患者临床疗效、中医症状积分,治疗前后关节疼痛视觉模拟评分(VAS)、血尿酸(BUA)、24 h尿酸排出量(24 h UUA)、外周血Beclin-1、ELOVL6、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及不良反应。结果中西联合组治疗总有效率[93.10%(54/58)vs 79.31%(46/58)]高于常规组(P<0.05);治疗后,两组关节红肿、热痛、屈曲受限、发热口渴、口苦口黏评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组VAS评分均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);治疗后,两组BUA均下降(P<0.05),24 h UUA均升高(P<0.05),且治疗后组间比较差异具有统计学意义(P<0.05);治疗后,两组Beclin-1、ELOVL6均升高(P<0.05),且治疗后中西联合组高于常规组(P<0.05);治疗后,两组IL-6、CRP、TNF-α均下降(P<0.05),且治疗后中西联合组低于常规组(P<0.05);两组患者试验期间均未见严重恶心呕吐、胃痛、头晕、腹泻等不良反应。结论二妙玄府方联合三黄散外敷治疗AGA临床效果显著,可较好抑制机体炎症反应,缓解疾病进程,且安全可靠。
